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Takaku Lab

@takakulab.bsky.social
31 followers 41 following 8 posts

Associate Professor at UND School of Medicine and Health Sciences Chromatin and epigenetic regulation in cancer Website: sites.google.com/view/takakulab/mot… Google Scholar: scholar.google.com/citations?user=E…

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Reposted by Takaku Lab
Wataru Kobayashi @wkobayashi.bsky.social · 16/10/2026
Interested in exploring the molecular mechanisms of early mammalian development? Fully funded 4-year PhD opportunity at the University of Dundee! We are seeking a motivated PhD student to lead a biochemical and structural biology project. See the link www.findaphd.com/phds/project...
findaphd.com
EastBio - Molecular basis of transcriptional regulation during mammalian pre-implantation development at University of Dundee on FindAPhD.com
PhD Project - EastBio - Molecular basis of transcriptional regulation during mammalian pre-implantation development at University of Dundee, listed on FindAPhD.com
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Reposted by Takaku Lab
Archana Dhasarathy @adhasarathy.bsky.social · 05/10/2026
Many thanks to all the amazing authors for contributing to this book! And to the wonderful @takakulab.bsky.social for help with editing this book with me! link.springer.com/book/10.1007...
link.springer.com
Cancer Epigenetics
This book explores tools to study epigenetics in cancer and manipulate the proteins involved for mechanisms in cancer initiation and progression research.
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Reposted by Takaku Lab
Teif lab @teiflab.bsky.social · 23/09/2026
Zeng et al, 2026. Transcription factors read a second regulatory code in chromatin www.biorxiv.org/content/10.6... "our findings establish that TFs interpret two complementary layers of genomic information: the primary DNA sequence and a second code written into the nucleosome architecture"
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Reposted by Takaku Lab
Epigenome Technologies @epigenometech.bsky.social · 19/05/2026
Epigenetics Update - Widespread DNA off-targeting confounds RNA chromatin occupancy studies go.nature.com/3PmKDVa Pieter Mestdagh (Ghent University) and igorulitsky.bsky.social (Weizmann Institute of Science) in natbiotech.nature.com #Epigenetics #Chromatin #OffTarget --- epigenometech.com
go.nature.com
Widespread DNA off-targeting confounds RNA chromatin occupancy studies - Nature Biotechnology
Many long noncoding RNA–DNA binding peaks detected using common assays arise from technical artifacts.
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Takaku Lab @takakulab.bsky.social · 07/05/2026
This was a wonderful collaboration with Dr. Takada. Special thanks to our graduate student and co-first author Sakuntha Gunarathna (@sakuntha.bsky.social).
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Takaku Lab @takakulab.bsky.social · 07/05/2026
Our new paper is out in Communications Medicine! By analyzing circulating chromatin fragments (cfDNA) from patients with metastatic breast cancer, we captured treatment-associated fragmentomics changes after CDK4/6 inhibitor therapy. Grateful to all collaborators! www.nature.com/articles/s43...
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Reposted by Takaku Lab
Harmit Singh Malik @harmitmalik.bsky.social · 03/03/2026
My awesome colleague, @yarimura.bsky.social, is recruiting a postdoc to start at the end of 2026 or early 2027! His lab uses cryo-EM to uncover structural basis of key chromatin events using native complexes isolated from human cells or Xenopus egg extracts! careers-fhcrc.icims.com/jobs/30706/p...
careers-fhcrc.icims.com
Fred Hutchinson Cancer Center
Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.
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Reposted by Takaku Lab
Sarah Hainer @hainerlab.bsky.social · 27/02/2026
Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar. Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse. www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Takaku Lab
@PhysGenCenter @physgencenter.bsky.social · 13/02/2026
Friday Feb. 27 at 12pm CT, Prof. Steve Henikoff presents the Monthly Seminar on Physical Genomics: "Histone Overexpression In Cancer" live on Zoom! Registration is free at tinyurl.com/2rw8n7bt #northwestern #cancer #genomics #research #chromatin #dna #science #biology #cpge #fredhutch #research
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Takaku Lab @takakulab.bsky.social · 22/01/2026
Thank you so much for the wonderful talk and engaging discussion! We really enjoyed the interaction and appreciate you taking the time to join us remotely. We hope to continue the conversation and collaborations in the future.
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Reposted by Takaku Lab
Archana Dhasarathy @adhasarathy.bsky.social · 22/01/2026
Thank you so much for the great talk and wonderful science conversations! @takakulab.bsky.social and our students and other faculty really appreciated your sharing your science with us!
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Takaku Lab @takakulab.bsky.social · 13/11/2025
Our first cell-free DNA paper is now published! Thank you to all co-authors and collaborators for their contributions.
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Reposted by Takaku Lab
Daniel Lipka @dblipka.bsky.social · 25/08/2025
+++ Postdoc Opportunity +++ My lab is looking for researchers interested in combining cutting edge #genomics, #epigenetics and #AI for precision oncology in pediatric #leukemia. www.dkfz.de/fileadmin/us... Applications via the #DKFZ postdoc program: www.dkfz.de/en/karriere/...
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Reposted by Takaku Lab
Evgeny Kvon @evgenykvon.bsky.social · 23/06/2025
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
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Takaku Lab @takakulab.bsky.social · 16/06/2025
Structural basis of the hepatitis B virus X protein in complex with DDB1 | PNAS www.pnas.org/doi/10.1073/...
pnas.org
Structural basis of the hepatitis B virus X protein in complex with DDB1 | PNAS
A cure for chronic hepatitis B requires eliminating or permanently silencing covalently closed circular DNA (cccDNA). A pivotal target of this appr...
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Takaku Lab @takakulab.bsky.social · 16/06/2025
RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/...
science.org
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
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Reposted by Takaku Lab
Jackson Hoffman @jxhoffman.bsky.social · 10/06/2025
Congrats on the new paper to Krystal who "doesn't do social media" but does do a ton of ATAC and Cut&Run to show how GATA3 pioneers enhancers with BRG1 and sometimes AP-1! #NIEHS #NAR doi.org/10.1093/nar/...
doi.org
Pioneering new enhancers by GATA3: role of facilitating transcription factors and chromatin remodeling
Abstract. Pioneer transcription factors (PTFs) bind to inaccessible chromatin and recruit collaborating transcription factors to promote chromatin accessib
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Reposted by Takaku Lab
Broad Institute @broadinstitute.org · 29/05/2025
A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-situ @jbuenrostro.bsky.social
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Takaku Lab @takakulab.bsky.social · 24/03/2025
Our second cell-free DNA manuscript is here! In collaboration with Dr. Takada’s group, we explore how abemaciclib treatment response in metastatic breast cancer can be monitored via circulating chromatin fragments: www.researchsquare.com/article/rs-5...
researchsquare.com
Exploring Mechanism of Action of Abemaciclib in Breast Cancer Through Circulating Chromatin Fragment
Cell free DNA (cfDNA) analysis has a large potential for cancer patient diagnosis. Given the evidence that cfDNA partially preserves chromatin architecture of tumor cells, it potentially allows the de...
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Reposted by Takaku Lab
Wataru Kobayashi @wkobayashi.bsky.social · 20/02/2025
🚀Excited to share preprint as my last work in the Tachibana lab! Our study shows how the pioneer factor NR5A2 ensures robust gene activation through feed-forward regulatory loops with lineage-determining factors. A quick summary follows (1/n) www.biorxiv.org/content/10.1...
biorxiv.org
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Reposted by Takaku Lab
Susanne Ahmari @ahmarilab.bsky.social · 14/02/2025
🚨Amidst all the uncertainty at NIH Welcome Leap just launched an important new $50M program in Women’s Health👩🏻‍🔬🧠 CARE focuses on the link between Alzheimer’s and perimenopausal hormonal changes wellcomeleap.org/care/ Note: full indirects! Please share widely to support women’s health 🙏🏼
wellcomeleap.org
CARE Program Details | Wellcome Leap: Unconventional Projects. Funded at Scale.
NEW $50M Program in Women's Health care Cutting Alzheimer's Risk through EndocrinologyWe are pleased to announce the selected performers.Sabine Vollstädt-Klein, Central Institute of Mental Health ...
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Takaku Lab @takakulab.bsky.social · 14/01/2025
Excited to share our first preprint on cell-free DNA! Led by our talented grad student Sakuntha, we have developed a machine learning pipeline guided by ATAC-seq to identify unique nucleosomal fragment patterns in cancer patients. www.researchsquare.com/article/rs-5...
researchsquare.com
ATAC-seq Guided Interpretable Machine Learning Reveals Cancer-Specific Chromatin Features in Cell-free DNA
Cell-free DNAs (cfDNAs) are DNA fragments found in blood. In healthy individuals, cfDNAs are primarily derived from immune cells, while in cancer patients, a significant fraction of cfDNAs originates ...
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