Capturing perspectives from both the host and microbiome is sorely need for studying interactions in the holobiont. Here's a multiset correlation and factor analysis approach to integrate and analyze five layers of holo-omic data across 800,000+ features.
journals.asm.org/doi/10.1128/...
journals.asm.org
Integrative holo-omic data analysis predicts interactions across the host-microbiome axis | Microbiology Spectrum
While study systems involving mammalian hosts and their microbiomes are inherently
complex, multi- and holo-omic analyses promise to provide interpretable results with
translational value for the anim...