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Seth Bordenstein

@symbionticism.bsky.social
3.9K followers 420 following 629 posts

Scientist, Huck Professor: Microbiome, Virome, Symbiosis, Evolution, Genetics, Phylosymbiosis, Holobiont, Wolbachia, Phage | Director of One Health Microbiome Center @psumbiome.bsky.social | SciEd: @wolbachiaproj.bsky.social | @holobiontbiology.bsky.social

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Seth Bordenstein @symbionticism.bsky.social · 3h
Capturing perspectives from both the host and microbiome is sorely need for studying interactions in the holobiont. Here's a multiset correlation and factor analysis approach to integrate and analyze five layers of holo-omic data across 800,000+ features. journals.asm.org/doi/10.1128/...
journals.asm.org
Integrative holo-omic data analysis predicts interactions across the host-microbiome axis | Microbiology Spectrum
While study systems involving mammalian hosts and their microbiomes are inherently complex, multi- and holo-omic analyses promise to provide interpretable results with translational value for the anim...
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Seth Bordenstein @symbionticism.bsky.social · 04/10/2026
Transplant experiments in deep-sea vesicomyid clam holobionts? Impressive. A new @science.org Advances study finds tiered molecular adaptations and resilience. Symbionts shift metabolic pathways while hosts regulate lysosomal dynamics to adapt to environmental stress www.science.org/doi/10.1126/...
science.org
In situ evidence of tiered adaptations buffering a chemosynthetic clam holobiont against environmental sulfide fluctuations
Deep-sea holobionts adapt to extreme environmental fluctuations, but the molecular mechanisms underlying resilience remain poorly understood. We investigated the vesicomyid clam Archivesica marissinic...
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Seth Bordenstein @symbionticism.bsky.social · 04/10/2026
bioengineer.org/microbes-may...
bioengineer.org
Microbes May Hold the Key to Protecting Crops from Insect Pests
Insect herbivores destroy a staggering share of the world’s harvests every year, and the chemical arsenal deployed against them is steadily losing its edge. Pesticide resistance keeps evolving, e
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Seth Bordenstein @symbionticism.bsky.social · 02/10/2026
Adding value to the microbiome field, @pennstateuniv.bsky.social graduated the 1st PhD in the microbiome sciences…with 30 more @psumbiome.bsky.social students now in the curriculum. The mission is accredit and identify microbiome science PhDs - front and center. 🎓 www.psu.edu/news/researc...
psu.edu
Microbiome sciences doctoral program celebrates first graduate | Penn State University
Penn State’s microbiome sciences dual-title doctoral program has reached a milestone with the graduation of its first student. The program is the first doctoral degree program worldwide focused specif...
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Lee Henry @henrylabsymbio.bsky.social · 01/10/2026
Excited to see our work out in @pnas.org! We asked how mobile genetic elements generate functional diversity in symbionts and found a plasmid that protects aphids from lethal pathogens, helping to explain variation in defence across natural aphid populations. See @ben-parker.bsky.social thread👇
pnas.org
Phenotypic divergence is driven by mobile genetic elements in a heritable insect symbiont | PNAS
Heritable microbes profoundly influence insect biology, yet the traits they confer often evolve rapidly and differ among closely related symbiont s...
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Holly Moeller @mixotrophe.bsky.social · 02/10/2026
We updated our lab values (moellerlab.org/values/) and our lab membership (moellerlab.org/members/) for the year. It's sad but joyful to say "goodbye" as lab members head off on new adventures. But we're looking for new friends! Get in touch to join us as a technician or as a postdoc!
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Seth Bordenstein @symbionticism.bsky.social · 02/10/2026
Thank you Santa Barbarans for the glimmering science and homegrown hospitality! Your thinking caps in Ecology, Evolution, and Marine Biology and Molecular, Cellular, and Developmental Biology are as top notch as the beaches and sunshine. @ucsantabarbara.bsky.social
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George Schaible @quantaofgeorge.bsky.social · 01/10/2026
Great seminar today at #UCSB by @symbionticism.bsky.social discussing 100+ years of work on #Wolbachia! An impressive animal -> microbe -> virus interaction!
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Seth Bordenstein @symbionticism.bsky.social · 01/10/2026
I’m giving a second seminar today on the west coast - close by to this beautiful spot - Bridging Micro and Macro: The Holobiont Perspective on Eco-Evolutionary Systems. Come on over.
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One Health Microbiome Center @psumbiome.bsky.social · 28/09/2026
Another Matters Microbial hosted by @markowenmartin.bsky.social features one of our own, Jasna Kovac! This episode dives into the interactions between Listeria and other microbes and how these relationships can influence its survival. ▶️ Watch here: www.youtube.com/watch?v=6A1b...
youtube.com
Matters Microbial #139: How Listeria Gets By With a Little Help From Its Friends
YouTube video by MicrobeTV
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Seth Bordenstein @symbionticism.bsky.social · 28/09/2026
Tralin’ in a happy place this weekend. In nature, we are all students of finding our place.
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Joshua Weitz @joshuasweitz.bsky.social · 28/09/2026
“I’ve heard from a bunch of people in our field who say, ‘Uh oh, are they training on my prompts?’” Dr. Shipman said. “We can’t not think about it.” ... '[A]fter Anthropic’s announcement last week, he is winding down his projects with Claude.' “I’m shutting down everything,” [Dr. Mestre] said.
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 26/09/2026
Pls share: Two tenure-track positions in Molecular Microbiology at Virginia Tech. I had a great visit there a couple of years ago! jobs.apply.vt.edu/jobs/assista...
jobs.apply.vt.edu
Assistant/Associate Professor - Blacksburg, Virginia, United States
Job Description The Department of Biological Sciences in the College of Science at Virginia Tech seeks applicants for two (2) tenure-track research and teaching positions at the Assistant/Associate ...
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Seth Bordenstein @symbionticism.bsky.social · 25/09/2026
Dolly Parton: "If your actions create a legacy that inspires others to dream more, learn more, do more and become more, then you are an excellent leader". Felicitations to @jacquesravel.bsky.social - awardee of the 2026 Microbiome Medal, an annual honor for research and impact on the next gen.
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Seth Bordenstein @symbionticism.bsky.social · 25/09/2026
The cantilever overhang at @pennstateuniv.bsky.social Millennium Science Complex is insane structural engineering. We science in this starship.
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Mark O. Martin @markowenmartin.bsky.social · 23/09/2026
It’s Wednesday. Time for a new episode of the #MattersMicrobial podcast. Dr. Jasna Kovac joins the #QualityQuorum to talk about Listeria, biofilms, sociomicrobiology, and food processing. Please spread the #GoodMicrobialWord! @asm.org @microbetv.bsky.social youtu.be/6A1bgRmss6U?...
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holobiontbiology.bsky.social @holobiontbiology.bsky.social · 24/09/2026
"pattern is observed in all components of the holobiont (host phenotype, epigenome, gene expression, symbiont photosynthetic efficiency, & microbiome composition) & underscores the potential for probiotic therapy" @reefgenomics.bsky.social @peixotoraquel.bsky.social www.nature.com/articles/s41...
nature.com
Bacterial inoculation elicits changes to the coral epigenome - Nature Communications
Pocillopora verrucosa corals were inoculated with a bacterial pathogen and/or a coral probiotic, then subjected to heat stress. Pathogen inoculation induced epigenetic and gene expression changes that...
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Mark O. Martin @markowenmartin.bsky.social · 25/09/2026
@symbionticism.bsky.social has always seen parts of me that are not evident to me. But I certainly am a microbial enthusiast, a microbial evangelist, and stalwart proponent of microbial outreach. Thank you, Seth. As always.
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Seth Bordenstein @symbionticism.bsky.social · 19/09/2026
Our own modeling backs this paper up. There are more mathematical paths to speciation in a holobiont setting when we run the equations or the lab experiments. Strict, host-centric models put the blinders on to biological reality and potential. Great piece.
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Dmitri Petrov @petrovadmitri.bsky.social · 17/09/2026
We are searching for an Assistant Professor in Evolutionary Biology! Looking for colleagues asking fundamental questions relating to evolutionary processes and drivers of evolutionary patterns. If you think it is you, please do apply! And please repost. facultypositions.stanford.edu/jobs/assista...
facultypositions.stanford.edu
Assistant Professor in Evolutionary Biology - Stanford University, California, United States
The Department of Biology at Stanford University seeks applicants for a tenure-track Assistant Professor in Evolutionary Biology. A successful candidate will conduct research that asks fundamental que...
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Seth Bordenstein @symbionticism.bsky.social · 17/09/2026
www.nature.com/articles/s41...
nature.com
Bacterial symbionts and the lightness of being a prokaryote - Nature Microbiology
Silvia Bulgheresi muses on how studying bacterial symbionts of worms and mammals made her question whether the absence of a nucleus enables cellular freedom, potentiating architectural innovation and ...
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Jason Rasgon @vectorgen.bsky.social · 17/09/2026
Banger of a new RasgonLab study by Drs. Najmeh Nejat and Travis van Warmerdam on a new arthropod germline CRISPR delivery system. Knock-out AND knock-in by ORAL delivery! No more injections! Germline Engineering by Viral transduction (GEValT)
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Vaughn Cooper @vscooper.micropopbio.org · 16/09/2026
Authors!🚨 While you scramble for scarce $ 🤔 “Springer Nature reports revenue growth of 6.2%..and adjusted operating profit growth of 7.7%. They reported even more stunning submission growth of 30% and published article growth of 13%.” Publishing in society journals helps YOU not them👇🏻. Pass it on.
static.klipy.com
Man Lying on a Pile of Money
ALT: Man Lying on a Pile of Money
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Harmit Singh Malik @harmitmalik.bsky.social · 10/09/2026
Reposting this ongoing search (any discipline of biology) for an Assistant to Associate level colleague in the Division of Basic Sciences at Fred Hutch. Great city, great colleagues, great core facilities, great trainees.
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Harmit Singh Malik @harmitmalik.bsky.social · 05/09/2026
Very cool 🧵 and findings 🧪
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Tyler J. Carrier @tylerjcarrier.bsky.social · 05/09/2026
New paper entitled “Phagocytosis of microbial symbionts supports embryonic nutrition in the sponge Halichondria panicea” is out now in @microbiomej.bsky.social! link.springer.com/article/10.1...
link.springer.com
Phagocytosis of microbial symbionts supports embryonic nutrition in the sponge Halichondria panicea - Microbiome
Background Animal development is frequently supported by microbial symbionts that contribute to host nutrition, metabolism, and physiology. While the functional importance of microbiomes in adult host...
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Seth Bordenstein @symbionticism.bsky.social · 05/09/2026
Fancy relative abundance measurements in your sequencing analyses and yet know there’s a problem with that? Our very own @inschool4life.bsky.social hammers this message and offers a robust solution. @psumbiome.bsky.social youtu.be/2KGJumvaKz0?...
youtu.be
Beyond Compositionality: Scale-Reliant Inference and ALDEx3 for Microbiome Data | Justin Silverman
YouTube video by One Health Microbiome Center at Penn State
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Harmit Singh Malik @harmitmalik.bsky.social · 04/09/2026
Structure and sequence fill evolutionary gaps for essential centromeric proteins. Work by @jeremyahollis.bsky.social, @irinakitop.bsky.social, & Jason Stonick. Article by Kelsey Woodruff. www.fredhutch.org/content/www/... Paper: www.science.org/doi/10.1126/...
fredhutch.org
Structure and sequence fill evolutionary gaps for essential centromeric proteins
Researchers in the Basic Sciences Division track evolutionary origins for an essential protein
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Joe Zackular @joeyzacks.bsky.social · 03/09/2026
Excited to share new work from my lab showing that early-life colonization with C. difficile remodels the developing infant gut, published today in @science.org! This study was co-led by two truly amazing scientists: @haidermanzer.bsky.social and Alexa Semon. www.science.org/doi/10.1126/...
science.org
Early-life colonization with Clostridioides difficile remodels the developing gut
Clostridioides difficile causes severe disease in adults but commonly colonizes infants asymptomatically. The consequences of early-life colonization on host development remain unknown. In a neonatal ...
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Patrick R. Secor @prsecor.bsky.social · 02/09/2026
This job ad is now live! Please share or apply here: jobs.montana.edu/postings/52780 Screening of applicants begins Sept 15, 2026 #MicroSky #PhageSky #ScienceJobs
jobs.montana.edu
Postdoctoral Researcher - Lyme Disease Bacteriophage Biology
The Secor Lab seeks a postdoctoral researcher to investigate bacteriophage biology in the Lyme disease spirochete Borrelia burgdorferi. The successful candidate will help define how phiBB-1 controls h...
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Seth Bordenstein @symbionticism.bsky.social · 01/09/2026
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Seth Bordenstein @symbionticism.bsky.social · 31/08/2026
Good tools lower activation energy. The @ehologenome.bsky.social Initiative profiles host and microbial genomes, and now EHItk makes exploring them effortless: a sleek Python toolkit to filter, query, and download a wild vertebrate hologenome with ease. academic.oup.com/bioinformati...
academic.oup.com
EHItk: a toolkit for accessing Earth Hologenome Initiative data resources
AbstractMotivation. The Earth Hologenome Initiative (EHI) is generating standardized datasets that jointly capture host genomic and microbial metagenomic—n
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Seth Bordenstein @symbionticism.bsky.social · 31/08/2026
When the high priest of microbiology issues a proclamation, you do two things. Listen and Implement.
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Seth Bordenstein @symbionticism.bsky.social · 29/08/2026
“The farther one gets into the wilderness, the greater is the attraction of its lonely freedom.” – Theodore Roosevelt
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Seth Bordenstein @symbionticism.bsky.social · 28/08/2026
One of my favorite humans and microbiome scientists! @mysorekarlab.bsky.social visited the @psumbiome.bsky.social awards luncheon to celebrate our “one” community today; we walked through campus and into the secret science starship behind us.
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Seth Bordenstein @symbionticism.bsky.social · 27/08/2026
Science on - How can one not be positive about that lineup? @psumbiome.bsky.social seminars are coming fast, including the Microbiome Medal Laureate Jacques Ravel, a founder in the microbiome field.
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One Health Microbiome Center @psumbiome.bsky.social · 27/08/2026
A brand new Matters Microbial hosted by @markowenmartin.bsky.social features our very own @stl.bsky.social! This podcast dives into the role that the soil microbiome can play in terms of agriculture, moderating temperature, and protecting specific environments. ▶️: www.youtube.com/watch?v=WE7p...
youtube.com
Matters Microbial #137: The Living Skin of Our Planet
YouTube video by MicrobeTV
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Carl Zimmer @carlzimmer.com · 26/08/2026
Nature honors Dolly Parton's scientific legacy. www.nature.com/articles/d41...
nature.com
Dolly Parton dies aged 80 – researchers celebrate her contributions to science
The country singer was an advocate for vaccines, public health, literacy and marginalized communities.
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STCmicrobeblog @stcmicrobeblog.bsky.social · 26/08/2026
ribosomologists of all colors take note 👇 a 28S rRNA variant that does not promote mRNA translation but 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝘀 it by blocking of the ribosomal exit tunnel 👀 «everything that can be regulated will be regulated» (murphy's law of molecular biology)
Figure 3. ... (c) Three-dimensional structure of the canonical P. falciparum A-type ribosome (left, PDB: 9J9H) and detailed view of the ribosomal exit tunnel (right). The insertion site of the LSUFPTC hairpin is highlighted in red (see also panel a).
source: https://www.biorxiv.org/content/10.64898/2026.06.17.732804v2.full
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ASM @asm.org · 21/08/2026
Become part of the ASM community! Join the world's leading microbial science community and receive 50% off 2026 membership when you use code 50OFF2026 at checkout. Don't miss this limited-time opportunity—offer ends Sept 30. asm.social/33n
Microbes Make Our World. Join ASM and Save 50%. Use code: 50OFF2026
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APC Microbiome Ireland @apcmicrobiomeirel.bsky.social · 22/08/2026
We are recruiting a Post-Doctoral Researcher (Immunologist) for Microbe2Mind at APC Microbiome Ireland and UCC. Study immune mechanisms in microbiota-gut-brain communication with @jfcryan.bsky.social. 24 months | €47,273 to €53,925 | Apply by 12:00, 24 Sep: buff.ly/3TkUQyp #Postdoc #ResearchJobs
Hiring: Postdoctoral Researcher for the Microbe2Mind initiative decoding brain–body communication; 24-month position at UCC Cork, PhD required; apply by 24 Sept 2026 — graphic shows a smiling researcher in a lab and a small portrait of the supervisor.
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Seth Bordenstein @symbionticism.bsky.social · 22/08/2026
Science on! ⬇️ if you’re looking for some great stuff in the microbiome space.
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Seth Bordenstein @symbionticism.bsky.social · 21/08/2026
One of the reasons I love Science is for moments like today. We have reached a pivotal finding in our lab’s research that is just “Wowza”.
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Seth Bordenstein @symbionticism.bsky.social · 17/08/2026
Tour-de-force compilation that uses the foundations of marine and holobiont biology to reveal the autonomy and reciprocal interaction of systems on different levels. It reveals the often inseparability of marine environment and biotic factors @memartino.bsky.social & Co. doi.org/10.32942/X23...
doi.org
Marine holobionts: a model arena for host–microbe biology, from ecosystem function to biotechnology
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Christian R Voolstra @reefgenomics.bsky.social · 12/08/2026
very excited about our new article: Can evolution keep up with the Anthropocene? .. or better: how can evolution keep up? we propose a predictive framework to begin to understand what is required to rebuild biodiversity! @uni-konstanz.de
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Seth Bordenstein @symbionticism.bsky.social · 15/08/2026
Optimism is when teachers on the frontlines continue to bring the hard work of authentic research discoveries into their classroom for learning, growth, and publication. Bob thrives on it. He took @wolbachiaproj.bsky.social and gave it back to the classroom over and over. Hats off. A must follow.
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Nicole Dubilier @nicoledubilier.bsky.social · 13/08/2026
Hiding in plain sight: Animals eat the natural bioplastic PHA We discovered that many animals can break down PHA. And many of these enzymes had been sitting unnoticed in genome databases. www.nature.com/articles/s41...
nature.com
Animal degradation of microbial storage polyhydroxyalkanoates - Nature Ecology & Evolution
This study shows that the degradation of microbial storage polyhydroxyalkanoates is not just restricted to microorganisms by finding that some animals also have the enzymes required to break down thes...
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Seth Bordenstein @symbionticism.bsky.social · 13/08/2026
Mom does know best; her gut microbial community plays a central role in establishing the infant microbiome. This paper is a fresh look at uniparental transmission of gut microbes.
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STCmicrobeblog @stcmicrobeblog.bsky.social · 10/08/2026
Evolving Through Ecology by Mechas — Ecological perspective crosses fields.
smallthingsconsidered.blog
Evolving Through Ecology
by Mechas — Ecological perspective crosses fields.
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Ran Blekhman @blekhman.bsky.social · 09/08/2026
Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague! Full announcement: uchicago.app.box.com/s/ckih9zv3rj...
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