Abstract. Microbial symbioses are the operating system of marine biology. Nearly every macroscopic organism in the ocean exists as a holobiont, the consort

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A study published in Science Advances by HKUST-led researchers details how deep-sea clams and their bacterial symbionts employ a tiered adaptation strategy—including metabolic reprogramming and host-r...

Plants pass transgenerational inheritance through genetic and epigenetic information; however, the soil's role as the host environment in this memory …

The gut-airway axis is increasingly recognised as an important determinant of respiratory health in livestock. However, the interactions among respiratory infections, microbial communities, mucosal ba...

While study systems involving mammalian hosts and their microbiomes are inherently complex, multi- and holo-omic analyses promise to provide interpretable results with translational value for the anim...

Type 1 diabetes affects more than 9 million people worldwide, including 1.8 million children and adolescents.

Deep-sea holobionts adapt to extreme environmental fluctuations, but the molecular mechanisms underlying resilience remain poorly understood. We investigated the vesicomyid clam Archivesica marissinic...

BackgroundAdipose deposition is a complex trait shaped by both host genetics and environmental factors, including the gut microbiota. While quantitative trai...

Soil-transmitted helminths (STHs) refer to a group of parasitic nematode worms that infect humans and are transmitted primarily via soil contaminated with eggs or larvae passed in the feces of infected individuals. The STH species include Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), Ancylostoma duodenale, and Necator americanus (hookworms), and Strongyloides stercoralis. Globally, these infections remain among the most prevalent neglected tropical diseases, affecting an estimated 1.5 billion people, or ~24% of the world’s population, predominantly in low- and middle-income countries (1). Among these, A. lumbricoides and T. trichiura contribute substantially to the global burden, with an estimated 772–892 million and 429–508 million infections, respectively (1, 2).

Pocillopora verrucosa corals were inoculated with a bacterial pathogen and/or a coral probiotic, then subjected to heat stress. Pathogen inoculation induced epigenetic and gene expression changes that...

Background Extensive research on the diversity and functional roles of the microorganisms associated with reef-building corals has been promoted as a consequence of the rapid global decline of coral r...

Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas mult...

Horticultural crop improvement is moving from a plant-centred model toward a soil-plant-microbiome framework in which host genotype, root-zone biology and the production environment are considered tog...

AbstractMotivation. The Earth Hologenome Initiative (EHI) is generating standardized datasets that jointly capture host genomic and microbial metagenomic—n

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Abstract. Coccolithophores are major marine phytoplankton that contribute to ocean carbon cycling through both organic carbon fixation and calcium carbonat

The bovine respiratory disease complex (BRDC) is a major health and welfare challenge driven by multifactorial interactions among pathogens, the host, the microbiota, and environmental pressures, refl...

Abstract. Symbiont-bearing benthic foraminifera, like corals, rely on endosymbionts for growth and nutrition and experience bleaching under heat stress. So

The traditional model of plant–arbuscular mycorrhizal (AM) fungal coevolution, based solely on interactions between plants and AM fungi, became obsolete with the discovery of the critical roles that belowground microbiomes play in the function of mycorrhizal symbiosis. Based on insights into hyphosphere microbiota, we expand the plant–AM fungus–bacterium continuum into a multipartite AM fungal-orchestrated holobiont (H-AMF) framework, where AM fungi integrate plant roots with soil microbiota into a cross-kingdom ecological unit. A division of labor exists among plants, AM fungi, and hyphosphere microbes in the mycocentric H-AMF perspective. We summarize mechanisms by which AM fungi sustain cooperative relationships with plants and hyphosphere microbiota and propose holobiont-scale methodologies to advance understanding of plant–fungal–microbial interactions and their ecological functions.

Abstract. Coccolithophores are major marine phytoplankton that contribute to ocean carbon cycling through both organic carbon fixation and calcium carbonat

Positive species interactions underpin ecological resilience, which is critical for counteracting anthropogenic pressures on ecosystems. Current research focuses on intra-holobiont interactions betwee...

Abstract. Marine ecosystem engineers such as corals, seaweeds, and seagrasses are foundational to coastal ecosystems, yet are declining at unprecedented ra

bioRxiv · 13 Aug 2026 — Microbial symbioses drive the evolutionary and functional diversification of eukaryotic clades, from single-celled protists to large invertebrates. However, our knowledge of ho...

Uniting life’s seen and unseen realms guides a conceptual advance in research

Soil salinisation poses a formidable threat to global agricultural productivity. It induces osmotic stress, ion toxicity and systemic oxidative damage in crops. Breeding salt-tolerant varieties is ti....

Marine bacterial microbiomes comprise an invisible infrastructure of ecosystem resilience. As climate stressors drive coral reef dysbiosis, microbial-based tools, from probiotics to bioengineering and...

Scientific Reports - Functional partitioning among core and peripheral bacteria shapes the giant kelp holobiont

The traditional model of plant–arbuscular mycorrhizal (AM) fungal coevolution, based solely on interactions between plants and AM fungi, became obsolete with the discovery of the critical roles that belowground microbiomes play in the function of mycorrhizal symbiosis. Based on insights into hyphosphere microbiota, we expand the plant–AM fungus–bacterium continuum into a multipartite AM fungal-orchestrated holobiont (H-AMF) framework, where AM fungi integrate plant roots with soil microbiota into a cross-kingdom ecological unit. A division of labor exists among plants, AM fungi, and hyphosphere microbes in the mycocentric H-AMF perspective. We summarize mechanisms by which AM fungi sustain cooperative relationships with plants and hyphosphere microbiota and propose holobiont-scale methodologies to advance understanding of plant–fungal–microbial interactions and their ecological functions.

ALT: Animated Circles Divide and Multiply

Only by understanding the complex interplay of ageing, physiology and the microbiome will we understand colorectal cancer risk says Filipe Cabreiro

Microbial chitinases act as versatile effector proteins in the plant holobiont, shaping microbiota composition, fungal competition, and plant immune evasio

Multi-marker metabarcoding (16S rRNA, 18S rRNA, ITS2) of the fog-dependent grit crust in the Atacama Desert reveals a community structured by lichen symbioses rather than typical soil-derived microbi...

Background Secondary adaptation of amphibians to marine environments is exceptionally rare. The crab-eating frog, Fejervarya cancrivora, is the only known amphibian capable of completing its life cycl...

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