iiinova — where your digital self keeps evolving

Reposted by Dave Truong

Max Haase @maxhaase.bsky.social · 18/02/2026

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

nature.com

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature

Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

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Dave Truong @davidmtruong.bsky.social · 17/09/2025

🚨 Preprint Alert! The era of human genome writing begins… We developed REWRITE for human iPSCs, enabling 100–209 kb rewriting of all 3 HLA genes - or anywhere. ➡️ On-demand HLA hiPSCs ➡️ Off-the-shelf cells ➡️ Extensible cell engineering 🧵⬇️ www.biorxiv.org/content/10.1...

biorxiv.org

Genomic REWRITE of Immune Interfaces Reveals Heritable Epigenetic Memory in Human Stem Cells

Human leukocyte antigen (HLA) polymorphism hinders allogeneic therapies. We developed REWRITE, a modular platform for iterative, scar-minimized genome writing of synthetic constructs >100 kb in human ...

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Dave Truong @davidmtruong.bsky.social · 21/08/2025

The Truong lab @nyuniversity (Programmable Regenerative Immunity) has an opening for a Postdoctoral Fellow to work in Mammalian Synthetic Biology in human iPSCs: apply.interfolio.com/172424 This project uses large-scale human genome "rewriting" to build a Synthetic Thymus.

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Reposted by Dave Truong

Drug Monkey @drugmonkey.bsky.social · 18/02/2025

Many of us in academic science will default to “business as usual” as our response. We will feel that our power should be used to maintain a semblance of normalcy. To live to fight another day.

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Reposted by Dave Truong

bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 21/12/2024

Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing www.biorxiv.org/content/10.1101/202…

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Reposted by Dave Truong

Amy @lolennui.bsky.social · 12/12/2024

Snapdragons are my favorite flower to grow. They do however produce seed pods that look like the screaming skulls of the damned.

( Not my picture) Snapdragon seed pod dried on the plant. There are five pods that resemble tiny human skulls with open mouths.

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Dave Truong @davidmtruong.bsky.social · 25/11/2024

We are looking for two new colleagues (open rank tenure-track) in neuro-engineering for the Dept of Biomedical Engineering @nyutandon.bsky.social! Priority applications due Dec 8th, rolling till January. Neuro-Cell/Tissue apply.interfolio.com/159312 Neuro-Devices apply.interfolio.com/159320

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Reposted by Dave Truong

Ardem Patapoutian @ardemp.bskyverified.social · 22/11/2024

Hey folks! I got a tattoo of my beloved PIEZO ion channel on my arm! Now I can show how they activate (flatten) under pressure by flexing—Will add a bit of performance art to my science talks 🧪🧠.

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Dave Truong @davidmtruong.bsky.social · 16/11/2024

Bluesky, new beginnings. Let's hope this place is about positive science developments and not rage bait!

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