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Str8Grandmother

@str8grandmother.bsky.social
1.1K followers 1.2K following 8.9K posts

Active Supporter of Full Equal Civil Rights for Sexual Minorities.

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Euromaidan Press @euromaidanpress.bsky.social · 5h
Kyiv districts plunge into blackout after Russian 5am ballistic missile attack on a major substation, Thermal Power Plant 5 in Kyiv, Trypillylia TPP & other energy facilities in Kyiv Obl It is day 2 of Trump's "energy ceasefire" between Russia and Kyiv 📹 Scho Kyiv/TG
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Bloomberg News @bloomberg.com · 5h
President Donald Trump has pardoned two Alaska men who were convicted of violating the Clean Air Act for removing air pollution monitors from diesel vehicles.
bloom.bg
Trump Pardons Two Alaska Mechanics Over Clean Air Act Violations
President Donald Trump on Tuesday pardoned two Alaska men who were convicted of violating the Clean Air Act for removing air pollution monitors from diesel vehicles.
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Str8Grandmother @str8grandmother.bsky.social · 4h
the sole reason blue sky did not soar is the founders never used hashtags so nobody else did either and it continues to this day. It is the hashtags which make Twitter powerful. The did a slow rollout with just a few accounts no need to hashtag for 100 ppl. Everyone saw everything.
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Ron Filipkowski @ronfilipkowski.bsky.social · 11/10/2026
This was two years ago. And yet the senator who runs on Fox to condemn every Democrat who doesn’t unconditionally support Netanyahu has nothing to say right now.
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Philip Bump @pbump.com · 16h
That $366 million Elon is spending to try and convince voters that Congress should stay Republican? It's more money than McCain's 2008 campaign spent. But it's also, relative to Musk's net worth, the same as a household at the median income spending $32.
ctinsider.com
The 2026 question: Which is more powerful, money or people?
Elon Musk has spent $366 million this election cycle. Philip Bump examines what that kind of money can buy in American politics.
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4fuxake @blueheartedly1.bsky.social · 11/10/2026
That would be great 👇
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Mrs. Betty Bowers @mrsbettybowers.bsky.social · 11/10/2026
I keep reading that there have been no public executions in the United States for decades. Not true.
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Xela Hart @xelahart.bsky.social · 11/10/2026
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Bluesky Fanatic @blueskyfanatic.bsky.social · 11/10/2026
BREAKING NEWS ============= Trump is procuring Russian diesel fuel at DOUBLE the price available from Canada. Can ANYONE explain that logic? ------------------- Oh. And apparently Canada doesn't give a fuck ... because other countries are BEGGING for their cheaper diesel. -------------------
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Jess Piper @piperformissouri.bsky.social · 12/10/2026
…
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🦋 C.G., PhD 🐸 (🪖"Prima" AKA "Battle" to One)🌻 @tcrg2012.bsky.social · 10/10/2026
💪🏽 #ONEV1 #Pinks 🌸 #Voices4Victory
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Miaganga @miaganga.bsky.social · 12/10/2026
❣️🤍💙
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Ron Filipkowski @ronfilipkowski.bsky.social · 12/10/2026
Fox is garbage.
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Ron Filipkowski @ronfilipkowski.bsky.social · 12/10/2026
Greedy bastard.
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Roger Sollenberger @sollenbergerrc.bsky.social · 10/10/2026
This is the first time my dumb brain put “AI” and “election” together
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Gillian Brockell @gillianbrockell.com · 08/10/2026
BREAKING: A Trump-appointed judge has ruled DHS violated the Due Process Clause of the Fifth Amendment when it removed Ahmed Soliman to Equatorial Guinea and must facilitate his return to the US. prospect.org/2026/10/07/f...
prospect.org
Federal Judge Rules DHS Must Bring Back Gay Arizona Man Imprisoned in Africa - The American Prospect
A Trump-apppointed judge ordered Ahmed Soliman must be returned to the United States.
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Liz Szabo @lizszabo.bsky.social · 08/10/2026
CDC moving forward with “wholly unethical trial” in African babies. www.rollingstone.com/politics/pol...
rollingstone.com
CDC Is Moving Forward With a Previously Shelved Controversial Hepatitis B Vaccine Study
“It’s a wholly unethical trial, and it shouldn’t be allowed,” says Dr. Paul Offit of Guinea-Bissau study
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Adam Cohen (My Personal Views Only) @axidentaliberal.bsky.social · 08/10/2026
More than ten years after he promised to repeal and replace the Affordable Care Act with better, cheaper health insurance After he promised countless times that he would release a plan "in two weeks" After he took over $1 trillion from Medicaid And $500 billion from Medicare HE STILL HAS NO PLAN
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Justin Baragona @justinbaragona.bsky.social · 07/10/2026
It's important to note that with David Ellison pledging editorial independence, the day the Paramount merger closed, he visited the CBS newsroom and said he didn't want to politicize the company. Staffers at the time credited him for saying all the right things. We know how that turned out for CBS.
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Ron Filipkowski @ronfilipkowski.bsky.social · 06/10/2026
These Republican politician Trump groupies who wear their navy suits, white shirts and red ties to campaign events are pathetic. The Republican Party now has uniforms for their cult leaders.
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Craig Pittman @craigtimes.bsky.social · 06/10/2026
Op-ed: After 30 years of Republican control, #Florida has been left with corruption, higher costs, less freedom, more pollution, weaker protections & failures that put our children’s future, health & safety at risk. www.tallahassee.com/story/opinio...
tallahassee.com
More magical thinking won’t fix Florida | Opinion
A retired scientist argues that decades of Republican control have left Florida with policy failures.
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4fuxake @blueheartedly1.bsky.social · 04/10/2026
Truth 👇
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David French @davidfrenchjag.bsky.social · 05/10/2026
"Here’s one way to think of Paxton — he possesses all of Donald Trump’s corruption and none of Trump’s charisma." My dispatch from the most important Senate race in America: www.nytimes.com/2026/10/04/o...
nytimes.com
Opinion | The ‘God Gap’ Is Narrowing in Texas
It may not be enough for James Talarico to win. But might it also be a sign of a change to come?
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Jon Cooper @joncooper-us.bsky.social · 04/10/2026
Pete Buttigieg is barnstorming the nation in the final weeks before the midterms, boosting candidates in battlegrounds and even areas traditionally hostile to Democrats. Buttigieg is set to campaign in at least six states: North Carolina, Virginia, New Jersey, Georgia, Nevada and Michigan.
politico.com
Buttigieg goes big to help 2026 Dems
He is set to campaign in at least six states in the final stretch. As he does, he’s refining his message and thinking about what comes next.
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Miaganga @miaganga.bsky.social · 04/10/2026
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Mark Jacob @markjacob.bsky.social · 04/10/2026
Dictator Move of the Day.
Trump posts against anti-arch protesters: “Do these people not have jobs?”
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Str8Grandmother @str8grandmother.bsky.social · 03/10/2026
@youranoncentral.bsky.social It is so nice to have the person running the anon account write in a normal conversational style. For a long time someone who was running it wrote prose as if they were trying to get a Pulitzer. I told them to knock it off and write normal, they told me to take a hike.
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Anonymous @youranoncentral.bsky.social · 01/10/2026
Trump himself disclosed buying at least $51 million in bonds in March, including companies central to the AI boom: Nvidia, Meta, Microsoft and Broadcom. The White House claims Trump and his family don’t control the portfolio’s investments.
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Anonymous @youranoncentral.bsky.social · 01/10/2026
Then there’s Trump Media. Trump’s trust holds 114.75 million shares in the company, which agreed to a $6+ billion merger with TAE Technologies. The pitch? Building an energy business capable of powering AI data centers.
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Sarah Burris @sarahburris.bsky.social · 01/10/2026
Y'all I just caught the Kennedy Center claiming it isn't closing while telling vendors it's closing and now they're selling all of their Steinway pianos www.alternet.org/alternet-exc...
alternet.org
Kennedy Center moves to sell all of its Steinway pianos
Photos show piano movers rolling massive Steinway grand pianos through the red-carpeted halls of the Kennedy Center this week.
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MeidasTouch @meidastouch.com · 18/09/2026
🚨 MAJOR NEWS: Reps. Thomas Massie and Ro Khanna say they have now secured commitments for all 218 signatures needed to force a House vote on Epstein Files Transparency Act II.
meidasnews.com
Massie, Khanna Say They Have Secured 218 Signatures for New Epstein Files Vote
The announcement comes hours after MeidasTouch reported the discharge petition was just two signatures short of the threshold needed to force a House vote.
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Bill Corbett @billcorbett.bsky.social · 02/10/2026
🚮🚮🚮🚮🚮🚮
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pastajoe.bsky.social @pastajoe.bsky.social · 01/10/2026
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Norm Eisen @normeisen.bsky.social · 30/09/2026
BIG WIN for making the Epstein Files public Judge Kollar-Kotelly grants summary judgment to us at @democracydefendersfund.org Orders DOJ to get busy giving us the docs. We will hold their feet to the fire!
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Christopher Webb @cwebbonline.com · 30/09/2026
Big Tech wants us to subsidize the AI takeover too. This is exactly why we need guardrails. #GuardrailsForAI
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Zach Everson @zacheverson.com · 29/09/2026
The order ran through a Coast Guard ad contract with LMD. On Sept. 21, that contract was changed to let CBP use it and its ceiling was raised by $25 million. www.usaspending.gov/award/CONT_I...
usaspending.gov
USAspending.gov
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Ron Filipkowski @ronfilipkowski.bsky.social · 10/09/2026
A Democrat should file a bill on Monday for everyone to get $5,000 checks right now to see if Mike Johnson, John Thune and congressional Republicans will advance and pass it. Call their bluff. Pass the bill.
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Mike Levin @mikelevin.org · 11/09/2026
Donald Trump’s 250-foot triumphal arch near Arlington National Cemetery doesn’t have congressional approval. It doesn’t even have final sign-off from the commission that oversees DC’s monuments.  But of course, that’s not deterring the president or his apologists.
nytimes.com
Trump to Break Ground on Arch Before Getting Approval (Gift Article)
Doug Burgum, the interior secretary, announced plans to start work on the site of the 250-foot-tall triumphal arch. Final approval of the project is still pending.
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Ron Filipkowski @ronfilipkowski.bsky.social · 11/09/2026
Since Trump posted this 6 weeks ago, the Houthis have escalated attacks exponentially while Trump has done absolutely nothing. The guy is such a bumbling buffoon that people he threatens just laugh at him now and do it more.
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jamelle @jamellebouie.net · 11/09/2026
i think it is bad that the president is that helm of a deranged cult of personality
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Alejandra Caraballo @esqueer.net · 10/09/2026
Looks like OpenAI may have stolen another mathematicians work.
Screenshot of an X post by user Valerio Capraro (@ValerioCapraro) featuring text followed by an embedded photo of a man in glasses and a dark sweater against a forested outdoor background.
The post text reads:
"BREAKING: OpenAI might have stolen another major proof.
In a detailed Mastodon post, which I report in full in the comments, Andreas Thom presents several pieces of evidence suggesting that OpenAI may have trained Astra on conversations in which he and Gábor Kun were working on Gromov's soficity conjecture, one of the ten problems OpenAI later announced Astra had solved.
I know Andreas. We met several times early in our careers. He is an exceptional mathematician, a leading expert on sofic and hyperlinear groups, and one of the most respected scholars in the field. He has spent two decades working on this problem.
If his account is correct, this is not a minor dispute over attribution. It would mean that unpublished human work was absorbed into a model and then presented to the world as a breakthrough by the model itself.
And if the allegations raised by Levent Alpöge, Tristan Buckmaster, and now Andreas Thom are all substantiated, we are no longer looking at isolated incidents.
We may be looking at one of the greatest intellectual scandals in the history of science.
AI is not discovering new mathematics.
AI is stealing human discovery."
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Sarah Szalavitz💡 @dearsarah.bsky.social · 10/09/2026
Switzerland—joining a growing list of European countries that no longer want to do business with Microsoft & other US tech giants—has budgeted $11 million to build an openDesk suite to replace Microsoft 365, Outlook and Teams for government workers. flip.it/B5zlli
flip.it
Switzerland is paying $11 million to stop using Outlook and Teams
Federal authorities of the Swiss Confederation recently launched a pilot program to replace Microsoft 365 tools with open-source alternatives. The Federal Chancellery's plan calls for investing 9...
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Mike Luckovich @mluckovich.bsky.social · 09/09/2026
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Alt CDC (they/them) @altcdc.altgov.info · 09/09/2026
1/ CDC success stories 🧪 This study👇 found that 41 years after participants got hepatitis B vaccine series, 91% of the original vaccine responders still had evidence of protection. Plus, in an area where Hep B is common, 0️⃣ people developed chronic infection. Wow. Vaccine rockstar behavior. 💉⭐
journals.lww.com
Long-term protection following a primary series... : Hepatology Communications
Background:Vaccination is effective at preventing chronic HBV infection and its complications, but the duration of protection and need for booster...
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Salty MacTavish @saltymactavish.bsky.social · 31/12/2024
We were poor and couldn’t afford Slinkys so we just threw ourselves down the stairs
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David Sirota @davidsirota.com · 09/09/2026
🚨NEWS: Amid safety alarms, @gavinnewsom.bsky.social sided with his tech donors & vetoed Democratic legislation to impose "kill switch" safeguards on AI companies whose whistleblowers now warn of an impending disaster. Newsom is likely to rely on those donors to now bankroll his White House bid.
levernews.com
Newsom Killed The AI Kill Switch
Before Big Tech researchers warned of a superintelligence doomsday, 2028 hopeful Gov. Gavin Newsom (D-Calif.) vetoed a bill that would have made AI “kill switches” mandatory.
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Matt Burgess (WIRED) @mattburgess1.bsky.social · 09/09/2026
Another update:
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𝕊𝕦𝕟𝕕𝕒𝕖 𝔾𝕦𝕣𝕝 @sundaedivine.lol · 09/09/2026
Even the crickets were embarrassed.
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Timothy Burke @bubbaprog.xyz · 09/09/2026
Her husband spent a career as an immunology statistician who played a major role in the development of the first dengue fever vaccine. Her daughter is a former nurse who, driven to right wrongs she saw daily, became a health care lawyer. and she's the first dengue fever death here in a century
**Bob Small**  
**Anna Small**

Bob Small died on June 3, 2023, after living life to the fullest and doing what he loved.

He was known for his love of and commitment to his family, his desire to play a significant role in his grandchildren’s lives, his lengthy bike rides all over the world, his habit of starting every day with a cup of coffee and at least one newspaper, his ability to do advanced math equations on paper napkins, his love of the Baltimore Colts, his dry sense of humor, his ornithological knowledge, and his ability to talk about anything—baseball, how the moon affects the tides, politics, history, or the many places he traveled. He enjoyed all the Star Wars movies with his children and grandchildren and was always willing to share a glass of wine or bowl of ice cream with friends or family.

Bob was the first in his family to go to college and attended the University of Maryland, College Park, where he met Gay. He earned a master’s degree from New Mexico State University and a PhD in biostatistics from North Carolina State University.

Bob was a fellow of the American Statistical Association and accomplished much professionally, giving him an interesting and rewarding career in the pharmaceutical industry. He made important contributions to vaccine development, especially global COVID-19 vaccines at CEPI. He refused to retire, and his work and cycling were his hobbies.

Bob was doing what he loved until the day he died. In January, he spent a week in Curaçao with his family and went scuba diving. In February, he hosted a dinner and wine party with friends and family from the Netherlands, New York, and Florida. In May, he celebrated his 79th birthday with his family and a few glasses of wine. He had recently returned from a business trip to London and was enjoying his consulting work. He was riding his bike when he collapsed.

While we had hoped to share more years with Bob, we take comfort in his full life and his not suffering at the end. We consider ourselves extremely fortunate to have had Bob as a husband, father, grandfather, and family member.Neutralizing Antibody Correlates Analysis of Tetravalent Dengue Vaccine Efficacy Trials in Asia and Latin America

Zoe Moodie 1, Michal Juraszka 1, Ying Huang 1 2, Yingying Zhuang 2, Youyi Fong 1 2, Lindsay N Carpp 1, Steven G Self 1 2, Laurent Chambonneau 3, Robert Small 4, Nicholas Jaison 5, Fernando Noriega 4, Peter B Gilbert 1 2

Affiliations  
1 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.  
2 Department of Biostatistics, University of Washington, Seattle.  
3 Sanofi Pasteur, Marcy-L'Etoile, France.  
4 Sanofi Pasteur, Swiftwater, Pennsylvania.  
5 Sanofi Pasteur, Lyon, France.

PMID: 29194547 PMCID: PMC5854020 DOI: 10.1093/infdis/jix609

Abstract  
Background: In the CYD14 and CYD15 Phase 3 trials of the CYD-TDV dengue vaccine, estimated vaccine efficacy (VE) against symptomatic, virologically confirmed dengue (VCD) occurring between months 13 and 25 was 56.5% and 60.8%, respectively.

Methods: Neutralizing antibody titers to the 4 dengue serotypes in the CYD-TDV vaccine insert were measured at month 13 in a randomly sampled immunogenicity subcohort and in all VCD cases through month 25 (2848 vaccine, 1574 placebo) and studied for their association with VCD and with the level of VE to prevent VCD.

Results: For each trial and serotype, vaccinees with higher month 13 titer to the serotype had significantly lower risk of VCD with that serotype (hazard ratios, 0.19-0.43 per 10-fold increase). Moreover, for each trial, vaccinees with higher month 13 average titer to the 4 serotypes had significantly higher VE against VCD of any serotype (P < .001).

Conclusions: Neutralizing antibody titers postdose 3 correlate with CYD-TDV VE to prevent dengue. High titers associate with high VE for all serotypes, baseline serostatus groups, age groups, and both trials. However, lowest titers do not fully correspond to zero VE, indicating that other factors influence VE.

Keywords: case cohort; immune correlate of protection; neutralizing antibodies; surrogate endpoint; vaccine efficacy trial.```
RESEARCH ARTICLE

Microneutralization assay titer correlates analysis in two phase 3 trials of the CYD-TDV tetravalent dengue vaccine in Asia and Latin America

Lindsay N. Carpp1,6, Youyi Fong1,2, Matthew Bonaparte3, Zoe Moodie1, Michal Juraszka1, Ying Huang1,2, Brenda Price2, Yingying Zhuang2, Jason Shao1, Lingyi Zheng3, Laurent Chambonneau4, Robert Small5, Saranya Sridhar4, Carlos A. DiazGranados6, Peter B. Gilbert1,2,*

1 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 2 Department of Biostatistics, University of Washington, Seattle, Washington, United States of America, 3 Global Clinical Immunology, Sanofi Pasteur, Swiftwater, Pennsylvania, United States of America, 4 Clinical Sciences, Sanofi Pasteur, Marcy-L'Etoile, France, 5 Sanofi Pasteur, Orlando, Florida, United States of America, 6 Clinical Sciences, Sanofi Pasteur, Swiftwater, Pennsylvania, United States of America

* These authors contributed equally to this work. * pgilbert@scharp.org

Abstract

We previously showed that Month 13 50% plaque reduction neutralization test (PRNT50) neutralizing antibody (nAb) titers against dengue virus (DENV) correlated with vaccine efficacy (VE) of CYD-TDV against symptomatic, virologically-confirmed dengue (VCD) in the CYD14 and CYD15 Phase 3 trials. While PRNT is the gold standard nAb assay, it is time-consuming and costly. We developed a next-generation high-throughput microneutralization (MN) assay and assessed its suitability for immune-correlates analyses and immuno-bridging applications. We analyzed MN and PRNT50 titers measured at baseline and Month 13 in a randomly sampled immunogenicity subset, and at Month 13 in nearly all VCD cases through Month 25. For each serotype, MN and PRNT50 titers showed high correlations, at both baseline and Month 13, with MN yielding a higher frequency of base-line-seronegativities. For both assays, Month 13 titer correlated inversely with VCD risk. Like PRNT50, high Month 13 MN titers were associated with high VE, and estimated VE increased with average Month 13 MN titer. We also studied each assay as a valid surrogate endpoint based on the Prentice criteria, which supported each assay as a valid surrogate for DENV-1 but only partially valid for DENV-2, -3, and -4. In addition, we applied Super-Learner to assess how well demographic, Month 13 MN, and/or Month 13 PRNT50 titers could predict Month 13–25 VCD outcome status; prediction was best when using demographic, MN, and PRNT50 information. We conclude that Month 13 MN titer performs comparably to Month 13 PRNT50 titer as a correlate of risk, correlate of vaccine efficacy, and surrogate endpoint. The MN assay could potentially be used to assess nAb titers in immunogenicity studies, immune-correlates studies, and immuno-bridging.
```Refining the characterization of the Sanofi Pasteur dengue vaccine’s efficacy profile using machine learning

Dorigatti I¹, Donnelly CA¹, Laydon DJ¹, Small R², Jackson N³, Coudeville L⁴, Ferguson NM¹  
¹MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG  
²Sanofi Pasteur, 2501 Discovery Dr, Orlando, FL 32826, USA  
³Sanofi Pasteur, 1541 Avenue Marcel Mérier, 69280 Marcy l'Étoile, France  
⁴Sanofi Pasteur, 2 Avenue Pont Pasteur, 69367 Lyon Cedex 07, France  
Corresponding author: i.dorigatti@imperial.ac.uk  

**Abstract**

**Background**  
CYD-TDV is the first licensed dengue vaccine for individuals 9 – 45 (or 60) years of age. Based on a subset of subjects for which baseline serostatus was measured with PRNT50 (12% of trial subjects) in the phase-2b and phase-3 trials, the vaccine was found to confer good protection against virologically-confirmed dengue in subjects pre-exposed to dengue but lower protection in individuals seronegative to dengue at baseline. A complete characterization of how efficacy varies by pre-vaccination dengue serostatus is lacking and can be informed by machine learning.

**Methods**  
We applied Boosted Regression Tree to impute the baseline serostatus for a subset of the subjects with missing information (i.e. those with post-dose 3 PRNT50 titres) in the phase-2b and phase-3 trials of CYD-TDV. By merging individual-level imputations with group-level predictions of baseline serostatus, we provide more precise estimates of how efficacy varies with serostatus, age and serotype during active surveillance.

**Findings**  
Over all ages and in the 9-16 age-group, we found that CYD-TDV is protective against dengue serotypes 1, 3 and 4 regardless of baseline serostatus, while efficacy against dengue serotype 2 is positive for dengue pre-exposed subjects. Most notably, we find support for age variation in efficacy independent of serostatus.
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Heranimos Swingle, Padded Gambeson Man @pashaspider.bsky.social · 08/09/2026
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