How strand-asymmetric processes such as replication and transcription interact with DNA damage to drive mechanisms of repair and mutagenesis is explored.

Spatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogeneity. However, current...

The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions. Human induced pluripotent stem cells are uniquely suited to ...

Site-specific nucleosome engagement by pluripotency factors reveals how transcription factors distort nucleosomes at chromatinized motifs.

Identifying chemical compounds that target trans-regulatory networks (TRNs) underlying molecular programs of cells for directed cellular conversion (i.e. differentiation, reprogramming, transdifferent...

The field of spatial transcriptomics is rapidly evolving, with increasing sample complexity, resolution, and tissue size. Yet the field lacks comprehensive solutions for automated integration and anal...

Learn how to use the tools you need to apply bioinformatics techniques in your own research.

Hematopoietic stem cells (HSCs) derived from human induced pluripotent stem cells (iPS cells) have important biomedical applications. We identified differentiation conditions that generate HSCs defined by robust long-term multilineage engraftment in ...

Our mission: Marsupial conservation and de-extinction of the thylacine Over the past decade, the concept of de-extinction has transitioned out of the realm

The rapid growth of single-cell transcriptomic technology has produced an increasing number of datasets for both embryonic development and in vitro pluripotent stem cell-derived models. This avalanche of data surrounding pluripotency and the process ...

In this article, Wells and colleagues present the first systematic FAIR evaluation of stem cell data infrastructures. Case studies from, but not limited to, the United States, Japan, Europe, and Austr...

Keynote Day 2 Session Chair: Shyam Prabhakar Speaker: