Reposted by Sebastián Palacios MartínezItai Yanai @itaiyanai.bsky.social · 10/10/20261. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists following their curiosity, and this is one huge reason why we must keep funding basic research! 10618218
Reposted by Sebastián Palacios MartínezPeter Godfrey-Smith @petergs.bsky.social · 05/10/2026I wrote an article about the possibility of dreaming in cephalopods. It has been published by @pioneerwork.bsky.social in an extremely beautiful way. Watch the videos through a layer of water. Become the tiny scuba-diving trackpad-pointer. Open access. pioneerworks.org/broadcast/ce...pioneerworks.orgThe Dreams of Octopus and Cuttlefish | BroadcastHow the skin reveals a world within. 04620
Sebastián Palacios Martínez @spalaciosm.bsky.social · 01/10/2026It's even made it to the BBC... www.bbc.com/news/article...bbc.comTiny image sparks big backlash in Nikon photo contestDr Ning Xu denies he broke the rules of Nikon's annual Small World In Motion contest. 010
Reposted by Sebastián Palacios MartínezJoachim Goedhart @joachimgoedhart.bsky.social · 04/09/2026Freshly acquired image of a biosensor that is targeted to the endoplasmic reticulum - seems a good fit for #FluorescenceFriday #invertedLUT #inferno 1429
Reposted by Sebastián Palacios MartínezPhil Abitua @ohnolog.bsky.social · 30/06/2026Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil 720357
Reposted by Sebastián Palacios MartínezJournal of Cell Biology @jcb.org · 19/06/2026KIF2A stabilizes intercellular bridge #microtubules to maintain mouse embryonic stem cell #cytokinesis. From Lieke Stockmann, Sreya Basu, Niels Galjart and colleagues: rupress.org/jcb/article/... 📕 Part of our #Microtubules collection: rupress.org/jcb/collecti... #EESMicrotubules 044
Reposted by Sebastián Palacios MartínezSaravanan Palani @syncellbiolab.bsky.social · 12/06/2026Our new paper in @plosbiology.org introduces IntAct-U-ExM enabling isoform-specific imaging of actin at nanoscale across yeast, mammalian cells & primary neurons. Fabulous work spearheaded by @anubhavdhar.bsky.social along with an amazing team! #actin #U-ExM journals.plos.org/plosbiology/... 27025
Sebastián Palacios Martínez @spalaciosm.bsky.social · 12/06/2026Aren't monolayers fun? I think I have a new desktop background now. #FluorescenceFriday #Microscopy 092
Reposted by Sebastián Palacios MartínezMwahahahahahadScientist @mads100tist.bsky.social · 17/04/2026You know how bakers make croissants? This is like if croissants made bakers 4416
Reposted by Sebastián Palacios MartínezJoachim Goedhart @joachimgoedhart.bsky.social · 13/04/2026📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social : Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging www.biorxiv.org/content/10.6... 14317
Reposted by Sebastián Palacios MartínezEMBL @embl.org · 19/02/2026Our cells are experts at navigating inherently noisy and complicated environments. EMBL researchers are using theoretical physics approaches to uncover fundamental principles behind how cells use complex information to self-organise. www.embl.org/news/science... 03113
Sebastián Palacios Martínez @spalaciosm.bsky.social · 06/02/2026Fun with protein isolation beads. #FluorescenceFriday 0101
Reposted by Sebastián Palacios MartínezJoachim Goedhart @joachimgoedhart.bsky.social · 27/01/2026Join us in Amsterdam for a FEBS advanced course on "Functional Imaging of cellular dynamics" from 31st of May - 6th of June 2026 Info: microscopy2026.febsevents.org 02416
Reposted by Sebastián Palacios MartínezNicolas Minc @minclab.bsky.social · 26/01/2026Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development! @ijmonod.bsky.social www.biorxiv.org/content/10.6... 09631
Reposted by Sebastián Palacios MartínezFabien Burki @fburki.bsky.social · 21/11/2025Each such discovery is a game changer for our understanding of eukaryote evolution, and this paper is no exception. Meet Solarion, which displays yet again novel types of subcellular structures. Congrats to all authors on a fascinating story. #protistsonsky www.nature.com/articles/s41...nature.comRare microbial relict sheds light on an ancient eukaryotic supergroup - NatureThe discovery of an unusual protist named Solarion arienae, which has a mitochondrial genome with some intriguing features, provides insight into the early radiation of eukaryotic groups. 25615
Sebastián Palacios Martínez @spalaciosm.bsky.social · 17/11/20254 years later the new owners are in deep debt anyway: www.insidehighered.com/news/tech-in...insidehighered.comThree years later, has the $800M edX deal lost its luster?2U’s acquisition of online course provider edX was once seen as a major win—and potentially even larger disrupter—in the OPM industry. Things didn’t go as planned. 000
Reposted by Sebastián Palacios MartínezNature @nature.com · 11/11/2025Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology go.nature.com/4p2hyuago.nature.comHow genetically encoded sensors have lit up neuroscienceTools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain. 13511
Reposted by Sebastián Palacios MartínezMarija Matejčić (mateytch-itch) @marija-matejcic.bsky.social · 07/11/2025Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday Part of our TrepatLab preprint: www.biorxiv.org/content/10.1... Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social 1278
Reposted by Sebastián Palacios MartínezNature @nature.com · 01/11/2025Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government go.nature.com/47hn0n5go.nature.com7 basic science discoveries that changed the worldOzempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government. 5372146
Reposted by Sebastián Palacios MartínezKelsey Tyssowski @kelseytea.bsky.social · 22/10/2025🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity! We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have: (1) more corticospinal neurons (CSNs) (2) better hand dexterity (3) more dexterous climbing, which is linked to CSN number🧵 19380124
Reposted by Sebastián Palacios MartínezeLife @elife.bsky.social · 22/10/2025A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of nonhuman primates. buff.ly/WHU3w3s 071
Reposted by Sebastián Palacios MartínezTaylor Mitchell Brown @tmitchellbrown.bsky.social · 15/10/2025Scientists just found several fossil bumblebees covered in pollen that directly matches fossil flowers nearby. The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated. #Paleontology #NationalFossilDay 🧪🏺 New at @sciencenews.bsky.socialsciencenews.orgThese ancient bumblebees were found with their pollen sourceInsects have long pollinated plants, but evidence of ancient pairing is rare. Fossils now show bees and linden trees goes back 24 million years. 12452111
Reposted by Sebastián Palacios MartínezKevin Terretaz @kwolbachia.bsky.social · 04/10/2025I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager! I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo... 69835
Reposted by Sebastián Palacios MartínezNature @nature.com · 02/10/2025Jane Goodall, known for her pioneering work with chimpanzees, has passed away aged 91 go.nature.com/46K10jago.nature.comJane Goodall’s legacy: three ways she changed scienceThe primatologist challenged what it meant to be a scientist. 213744
Reposted by Sebastián Palacios MartínezNick Desnoyer @nickdesnoyer.bsky.social · 01/10/2025I find that so many biologists are also talented artists. @hsuanpai.bsky.social is a skilled technician and apparently good at any artistic media she touches.. even LB. 3327
Reposted by Sebastián Palacios MartínezJoachim Goedhart @joachimgoedhart.bsky.social · 29/09/2025My initial assessment of this paper ⬇️ was brief, so let’s have a better look at it: 🧵 23514
Sebastián Palacios Martínez @spalaciosm.bsky.social · 22/08/2025Another #FluorescenceFriday, another movie of the cytoskeleton. This time around EB3-mScarlet3 and LifeAct-mStayGold co-expressed in U2Os cells! LUTs here (Ink collection)--> sites.imagej.net/JDM_LUTs/luts/ 1256
Reposted by Sebastián Palacios MartínezMichael R Photography 🌿 @msriffle.bsky.social · 07/08/2025Today is National Lighthouse Day honoring the historical and cultural significance of lighthouses. I've posted this image before but have reprocessed it. It is the lighthouse at St. Marks Florida. #photography #landscape #EastCoastKin #bnw #blackandwhitephotography #infrared #fullspectrum #clouds 2325112636
Reposted by Sebastián Palacios MartínezNew England Society for Microscopy @nesmicroscopy.bsky.social · 21/07/2025🐙 This Octopus shifts from deep to active rest while "dreaming" for #MicroscopyMonday. REM‑like sleep (color bursts and twitches) filmed in real time by Horst Obenhaus @octoscience.bsky.social, currently a 2025 Whitman Fellow at @mblscience.bsky.social. #NESM #Octopus #Neuro #SleepScience #MBL 15857208
Reposted by Sebastián Palacios MartínezeLife @elife.bsky.social · 01/07/2025One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics. buff.ly/pMGXJVM 0112
Sebastián Palacios Martínez @spalaciosm.bsky.social · 28/06/2025Plasmid here 🧬➡️ www.addgene.org/Dorus_Gadella/addgene.orgAddgene: Dorus Gadella Lab Materials 010
Sebastián Palacios Martínez @spalaciosm.bsky.social · 28/06/2025A very late #FluorescenceFriday. Reposting one of my favorite timelapses from the past year: EB3-mScarlet3 in a HeLa cell, look at those microtubules grow! 1375
Sebastián Palacios Martínez @spalaciosm.bsky.social · 28/06/2025News article on the project:bbc.comPhage therapy: I found a bacteria-eating virus in my looIt's hoped phages could give us new ways of treating infections which are immune to antibiotics. 000
Sebastián Palacios Martínez @spalaciosm.bsky.social · 28/06/2025Shout-out to The Phage Collection Project run by @fnobrega.bsky.social You can order your very own samplng kit and help with the discovery of new phages to combat antibiotic resistance! Check their website for more info ➡️ www.phage-collection.orgphage-collection.orgThePhageCollectionProject 213
Sebastián Palacios Martínez @spalaciosm.bsky.social · 25/06/2025Proud to work with and learn from an extraordinary biologist 🔬 110
Reposted by Sebastián Palacios MartínezChristophe 🔬 Leterrier @christlet.bsky.social · 22/06/2025Great nod to the photography work of Bernd and Hilla Becher 29916
Reposted by Sebastián Palacios MartínezHao Yin @haoyin.bsky.social · 20/06/2025Leukocyte #TransEndothelialMigration #TransPericyteMigration hotspots at a glance 😍 Jaap van Buul Lab @jcellsci.bsky.social 2025 journals.biologists.com/jcs/article-... 1176
Sebastián Palacios Martínez @spalaciosm.bsky.social · 24/03/2025Seems like you tagged the wrong Sebastián Palacios, but happy to learn there's many of us doing fun cell bio! 010
Reposted by Sebastián Palacios MartínezArjun Raj @arjunraj.bsky.social · 20/03/2025I miss when the biggest controversy about mRNA was whether it correlated with protein or not. 1031539
Reposted by Sebastián Palacios MartínezAnkita Jha @ankita13jha.bsky.social · 10/03/2025As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration www.biorxiv.org/content/10.1...biorxiv.orgCD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migrationCells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the... 129631
Reposted by Sebastián Palacios MartínezJoachim Goedhart @joachimgoedhart.bsky.social · 07/03/2025I had to try this (see preprint), so here's a result with milk ± ampyrone and it just works!! 2288
Sebastián Palacios Martínez @spalaciosm.bsky.social · 12/02/2025Does biofluorescence enhance visual signals in birds-of-paradise?: short answer, yes! Birds of paradise show fluorescence in the 520-560nm range. royalsocietypublishing.org/doi/10.1098/... 051
Reposted by Sebastián Palacios MartínezJournal of Cell Biology @jcb.org · 24/01/2025Tubulin arginylation regulates #microtubule dynamics. New study from MacTaggart, @annakashina.bsky.social and colleagues identifies an ATE1-dependent #arginylation site at E77 of α-tubulin and show that this modification regulates the binding of MAP1S to #microtubules. buff.ly/4jqLqhT 0104
Sebastián Palacios Martínez @spalaciosm.bsky.social · 15/01/2025Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments by Pasolli et al. Very exciting to see tool development for the less well-studied components of the cytoskeleton. www.biorxiv.org/content/10.1... 000
Reposted by Sebastián Palacios MartínezStephan Huveneers @huveneerslab.bsky.social · 14/01/2025Curvature-sensing BAR proteins control junction turnover to promote collective migration of endothelial cells in angiogenesis. rdcu.be/d6a04 1163
Sebastián Palacios Martínez @spalaciosm.bsky.social · 08/01/2025And an exciting preprint: Novel Far-Red ERK Biosensors by DeCuzzi et al. (Far-) Red biosensors open many mutliplexing and optogenetic possibilities for studying signaling pathways. www.biorxiv.org/content/10.1...biorxiv.orgTwo Novel Red-FRET ERK Biosensors in the 670-720nm RangeCell fate decisions are regulated by intricate signaling networks, with Extracellular signal-Regulated Kinase (ERK) being a central regulator. However, ERK is rarely the only signaling pathway involve... 093