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Sofiya Hupalo

@sofiyahupalo.bsky.social
656 followers 390 following 112 posts

Neuroscientist interested in supporting mental health research & early career scientists. Posts ≠ endorsement.

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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 18/09/2026
Clinical trials in psychiatry rely on measures of symptomatology, not biology. This @acnporg.bsky.social position paper lays out why validated biomarkers in psychiatry have lagged behind fields like Alzheimer's and ALS, and what it will take to close the gap. www.nature.com/articles/s44...
nature.com
Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper - NPP—Digital Psychiatry and Neuroscience
Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can...
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Reposted by Sofiya Hupalo
Neuropsychopharmacology @npp-journal.bsky.social · 25/08/2026
#TWiNPP Here, findings suggesting that thalamo-prefrontal circuit dysfunction is a potential mechanism linking SETD1A-associated genetic risk to working memory impairments in schizophrenia / @sofiyahupalo.bsky.social www.nature.com/articles/s41...
nature.com
Altered thalamo–prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition - Neuropsychopharmacology
Neuropsychopharmacology - Altered thalamo–prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 20/08/2026
How do we move AI from raw model performance to effective and impactful mental health care? Building on insights from a pivotal @acnporg.bsky.social study group, the authors set 5️⃣ priorities to embed AI into clinical workflows with safety and equity at the core. 🧠💻 www.nature.com/articles/s44...
nature.com
Responsible and innovative AI for mental health care: five priority themes - NPP—Digital Psychiatry and Neuroscience
This paper synthesizes insights from a 2026 American College of Neuropsychopharmacology (ACNP) study group examining how to responsibly translate AI into clinical mental health care. Building on this ...
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 18/05/2026
*Last chance* to apply for our New Investigator Award 👇 www.nature.com/dpn/announce...
nature.com
Announcements | NPP—Digital Psychiatry and Neuroscience
Announcements
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Reposted by Sofiya Hupalo
Dr. Becca @docbecca.bsky.social · 19/04/2026
Those of us doing research related to women’s health have been hit particularly hard by the govt’s sabotage of the NIH. I spoke to WaPo for this piece, as painful as it was to discuss the reality my lab is facing. www.washingtonpost.com/science/2026...
washingtonpost.com
Where U.S. science has been hit hardest after Trump’s first year
The Trump administration has slashed the number of grants from the National Institutes of Health, with far fewer focused on women, cancer and mental health.
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 17/04/2026
One month left to apply 👇👇👇 Wondering if you're eligible or have other questions? DM us or email dpnjournal@acnp.org
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Sofiya Hupalo @sofiyahupalo.bsky.social · 13/04/2026
Just wow 🤩
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 09/04/2026
Interested in writing a Primer that bridges psychiatry and neuroscience? 💫 Email us your idea at dpnjournal@acnp.org 💫
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 01/04/2026
Can LLMs help the mental healthcare system keep up with growing demand? This Deep Dive explores whether a RoBERTa LLM can detect anxiety or depression in text, showing accuracy similar to human experts & paving the way for more accessible mental health evaluation. youtu.be/TJ4IKAIU0Ss?...
youtu.be
Can large language models help the mental healthcare system keep up with growing demand?
YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN)
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Sofiya Hupalo @sofiyahupalo.bsky.social · 20/03/2026
Yeah, it’s unfortunately a lose-lose situation these days given the dysfunction/understaffing at NIH. Burn a year at current U or move the lab to the new U and wait ~6-12 months for the grant to transfer.
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Sofiya Hupalo @sofiyahupalo.bsky.social · 20/03/2026
Yep, a lot depends on the institution relinquishing the grant, while the new institution moves quickly to put in the transfer. ICs have incentive to process transfers as 'anniversary transfers' if it's close to end of budget year (less work for them), which is why ICs sometimes delay transfers
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Sofiya Hupalo @sofiyahupalo.bsky.social · 20/03/2026
Depends on IC and staffing levels in Program/GM. Also depends on timing - how close you are to the move & the end of fiscal year. If award is approved for payment & end of FY is nearing, NIH will move to award more quickly. Could also talk to PO & frame the move as hypothetical to get more intel
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 19/03/2026
📢 We’re excited to announce the next call for applications for the DPN Editors' New Investigator Award! This award waives the article processing charge ($2290) for new investigators who aim to publish an original report in DPN. Apply by May 18th! Details: www.nature.com/dpn/announce...
abstract image of brain made up of colorful interconnected blocks
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Sofiya Hupalo @sofiyahupalo.bsky.social · 19/03/2026
If you’re a new PI in the field of digital psychiatry/computational neuro and are preparing a manuscript, consider applying for this award 👇🏻
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Reposted by Sofiya Hupalo
Drug Monkey @drugmonkey.bsky.social · 17/03/2026
NOFO are dead...and that is not the actual problem drugmonkey.wordpress.com/2026/03/16/n...
drugmonkey.wordpress.com
NOFO are dead…and that is not the actual problem
A substack blog entry from NIH Program Officer Elizabeth Ginexi outlines the sharp discontinuation in the issuance of Notices of Funding Opportunity (NOFO) at the NIH in 2025 and 2026. These NOFO (…
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Reposted by Sofiya Hupalo
Mark Histed @markhisted.org · 16/03/2026
The next few yrs are likely to be EXTREMELY bad for science funding. Given what we've seen from this admin. Expect the grant system to work differently for years into future, unless stopped: Much lower success rates, $ sent to Trump allies and away from univs and blue areas
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Sofiya Hupalo @sofiyahupalo.bsky.social · 16/03/2026
💯 Unlike a year ago, we now know the strategies this administration is using to defund/disrupt US biomedical research. Sadly, other current events mean this issue is not getting enough media attention.
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 19/02/2026
🌟Announcing the next cohort of the DPN Editor’s New Investigator Waiver Award recipients🌟 Dr. Nicole Zürcher, @nicolerzurcher.bsky.social Dr. Jennifer Goldschmied, @jengoldschmiedphd.bsky.social Dr. Sarah Sperry, @drsarahsperry.bsky.social Congratulations! We're proud to support your work👏
Abstract image of building blocks making up a brain
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 11/02/2026
Our new Deep Dive covers a study by @carterfunkhouser.bsky.social, @dpagliaccio.bsky.social & colleagues, which linked EEG-based brain connectivity patterns with emotional expression from text messages to identify neural markers of depressive symptoms in teens youtu.be/a_yXb3wERfo
youtu.be
Tracking teen depression risk through brain connectivity and text message data
YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN)
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Sofiya Hupalo @sofiyahupalo.bsky.social · 08/02/2026
Very cool, congrats!!!
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Sofiya Hupalo @sofiyahupalo.bsky.social · 05/02/2026
Could you share publication(s) supporting the antidepressant actions of 5HT2A receptor antagonists in humans (statement #3)?
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Reposted by Sofiya Hupalo
DrGlitterbear @drglitterbear.bsky.social · 05/02/2026
Happy to see this conversation happening. As someone who withdrew from their 1st attempt at PhD due to mental health, way back in the mid-90's, it was very difficult to overcome that obstacle when applying to PhD programs again. I was always seen as a risk...even after completing a masters degree.
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Sofiya Hupalo @sofiyahupalo.bsky.social · 05/02/2026
Diversity supplements weren’t just for folks from underrepresented racial/ethnic backgrounds. Eligibility extended to first gen college students and researchers with disabilities, among others Cancelling these supplements limits opportunities for the next generation of scientists, as explained here
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 04/02/2026
Recapping the #ACNP2026 study group, “Centering Lived Experience in Psychiatric Neuroscience Research” We asked the panelists, what could NIH leadership do to be more supportive of trainees with non-traditional career paths, which is common among researchers with lived experience of mental illness?
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Reposted by Sofiya Hupalo
Max Kozlov @maxkozlov.bsky.social · 03/02/2026
I'm on Capitol Hill watching NIH director Jayanta Bhattacharya testify to the Senate HELP committee. Thankfully I haven't been escorted out of this event (yet). Here's what I'm following. You can also watch live here: www.help.senate.gov/hearings/mod...
help.senate.gov
Modernizing the National Institutes of Health: Faster Discoveries, More Cures | The U.S. Senate Committee on Health, Education, Labor & Pensions
Full Committee Hearing on February 3, 2026 at 5:00 AM
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Sofiya Hupalo @sofiyahupalo.bsky.social · 03/02/2026
Excellent, I didn’t see it come out, thanks for sharing 😁
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Sofiya Hupalo @sofiyahupalo.bsky.social · 03/02/2026
Absolutely! I have been meaning to revisit this poster in the ACNP portal, there was lots of good data in there !
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Sofiya Hupalo @sofiyahupalo.bsky.social · 03/02/2026
A huge thank you to Dave Kupferschmidt — my co-first author — who continued the momentum on this project after I left the Gordon Lab and shepherded it to the finish line ✨
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Sofiya Hupalo @sofiyahupalo.bsky.social · 03/02/2026
We observed that SETD1A haploinsufficiency disrupts beta (and to lesser extent gamma) synchrony between the PFC and thalamic nucleus reuniens during working memory performance. Unlike some other SCZ genetic risk models, we did not observe broader hippocampal–prefrontal synchrony deficits.
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Sofiya Hupalo @sofiyahupalo.bsky.social · 03/02/2026
Excited to share this preprint of my postdoc work, only several years late to the party 🎉 We examined how loss of function in SETD1A, a high confidence schizophrenia risk gene, impacts neural synchrony across circuits supporting working memory in mice. www.biorxiv.org/content/10.6...
biorxiv.org
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Sofiya Hupalo @sofiyahupalo.bsky.social · 03/02/2026
Very cool! Just out of curiosity, what proportion of prelimbic gabaergic interneurons are positive for cortistatin? Is that similar to what’s seen in human brain?
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Reposted by Sofiya Hupalo
Michael Totty @mictott.bsky.social · 02/02/2026
New paper out on cortistatin neurons and their role in regulating fear and cortical hyperexcitability in the prelimbic cortex! This one has been a fun ride 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Sofiya Hupalo
The Transmitter @thetransmitter.bsky.social · 02/02/2026
Should neuroscience focus on big team science or the traditional model? Explore what survey respondents had to say about it: www.thetransmitter.org/funding/shou... #neuroskyence #StateOfNeuroscience
thetransmitter.org
Survey: Should neuroscience focus on big team science?
Learn which types of projects are better for big team science versus smaller-group support.
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 02/02/2026
🆕in DPN: Bargagna et al used a probabilistic deep learning model to automate MRI segmentation of the choroid plexus, demonstrating accurate results in an autism cohort and quantifying model confidence across multiple datasets. www.nature.com/articles/s44...
nature.com
A probabilistic deep learning approach for choroid plexus segmentation in autism spectrum disorder - NPP—Digital Psychiatry and Neuroscience
The choroid plexus plays an important role in brain health and immunity and may be altered in autism spectrum disorder (ASD). To analyze large imaging datasets, a method to automatically delineate thi...
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 27/01/2026
Our latest Deep Dive covers a study that developed a deep learning model to classify sleep stages from single channel EEG recordings in rats🐀. It predicted key parameters of sleep architecture, reducing the need for labor-intensive manual annotation. youtu.be/kEgCbyqC0jU?... @dranap.bsky.social
youtu.be
New deep learning tool allows automated analysis of sleep patterns using EEG data
YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN)
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Sofiya Hupalo @sofiyahupalo.bsky.social · 23/01/2026
media.tenor.com
a woman with a snl shirt on makes a funny face
Alt: SNL’s Debbie downer zoom in
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Sofiya Hupalo @sofiyahupalo.bsky.social · 22/01/2026
I am not sure POs are clear on these issues either…
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Reposted by Sofiya Hupalo
Britton Barbee @brittonrae.bsky.social · 18/01/2026
still talking about this study group - one for the books 📚 🫶🏻
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Haley Vecchiarelli @haleyv.bsky.social · 16/01/2026
I couldn't pick just one, but I had such a great time at #ACNP2026! Thank you so much for the past travel award support!! Always amazing to see the reviewers for @npp-journal.bsky.social and @dpn-journal.bsky.social each year (and to be a top reviewer again this year).
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Dr. Millie Rincón-Cortés @madrelabutd.bsky.social · 15/01/2026
Thrilled to share that I was promoted to Full Member! 🎉 🙌Grateful for the incredible mentorship, support, and community that made this milestone possible. Thanks to everyone who believed in me, including Tony Grace + @jaredwyoung.bsky.social for their letters, and to @acnporg.bsky.social 🙏 #ACNP2026
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Keri Martinowich @martinowk.bsky.social · 16/01/2026
I should have taken a selfie after #SachinSays poured a drink all over me last night in classic fashion. But, alas, I did not, so here is a #ACNP2026 Atlantis hippocampus. Thanks to everyone for a great meeting - so many friends to catch up with, exciting science convos & a little too much fun 😴
Seahorse on a wall of a building in front of the beach
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Reposted by Sofiya Hupalo
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 16/01/2026
Thank you all for an unforgettable #ACNP2026 full of cutting-edge science, insightful discussions, and positive energy! See you next year in San Diego for #ACNP2027!
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Sofiya Hupalo @sofiyahupalo.bsky.social · 16/01/2026
So good to see you and catch up!! Hope we cross paths again soon 😆
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ACNP @acnporg.bsky.social · 16/01/2026
📸 One last favor: Share your favorite photo from the meeting and tag us! We’d love to see #ACNP2026 through your eyes. Until next year... stay inspired!
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Sofiya Hupalo @sofiyahupalo.bsky.social · 16/01/2026
I had a fabulous time learning about new science and spending quality time with my favorite people at #ACNP2026. Until next time! @acnporg.bsky.social @madrelabutd.bsky.social @brainbodylab.bsky.social
Picture of conference attendees at ACNP 2026 annual meeting Picture of conference attendees at ACNP 2026 annual meeting Picture of conference attendees at ACNP 2026 annual meeting Picture of conference attendees at ACNP 2026 annual meeting
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Sofiya Hupalo @sofiyahupalo.bsky.social · 15/01/2026
Last day of #ACNP2026! Head over to Poseidon III-IV this morning from 9-11 to hear about how cross-species functional brain biomarkers are being used to improve translation and facilitate drug development in psychiatry 🧠
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Sofiya Hupalo @sofiyahupalo.bsky.social · 13/01/2026
What a powerful conversation about what it’s like to navigate life and a research career with lived experience of mental illness. I’m deeply grateful for the speakers being willing to share their experiences and how we can all be more supportive of our colleagues #ACNP206 @acnporg.bsky.social
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Dr. Connor Haggarty @connorhaggarty.bsky.social · 12/01/2026
Love some swag #ACNP2026
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NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 13/01/2026
Day 2 of #ACNP2026 trivia starts now!
Screenshot of trivia question at ACNP annual meeting
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Susanne Ahmari @ahmarilab.bsky.social · 13/01/2026
Ok seriously, if you’re not at the Lived Experience study group, you need to be. What an amazing panel-these researchers with lived experience have incredible insights to share about the benefits of integrating lived experience into research. Maya Schumer:it’s additive, not adversarial #ACNP2026
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