Researchers are decoding how signals move between body and brain, with implications for how we understand and treat conditions from obesity to anxiety.

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Nature Metabolism, Published online: 12 January 2026; doi:10.1038/s42255-025-01442-3In this Review, Smith et al. summarize the most recent findings on AMPK and emphasize its role as a nutrient sensor and in regulating metabolic homeostasis, as well as how AMPK dysregulation contributes to various diseases.

Human consciousness intertwines awareness and self-recognition, diverging in meaning among neuroscientists and philosophers. It encompasses states like wakefulness, sleep, and alertness, influenced by physiological processes. The exploration of consciousness includes understanding sleep's restorative functions and self-awareness's role in interactions, highlighting the balance between scientific and moral aspects of human experience.

Nature Metabolism, Published online: 05 January 2026; doi:10.1038/s42255-025-01427-2Sex profoundly shapes liver metabolism, with oestrogens conferring protection against metabolic liver disease. In this study, Yang, Wang and colleagues identify the orphan G protein-coupled receptor GPR110 as a liver-specific brake on oestrogen signalling, bridging GPCR and nuclear receptor pathways, thus pointing to GPR110 as a target for sex-specific therapy in liver disease.

With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.

Stress profoundly impacts systemic metabolism, yet the central circuits linking stress responses to peripheral metabolic regulation remain poorly defined. Here, we identify the preBötzinger complex (p...

Mount Sinai is hiring a Postdoctoral Fellow-MSH-13400-363 in New York, NY. Review all of the job details and apply today!