iiinova — where your digital self keeps evolving

Reposted by Martin P. Paulus

NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 20/08/2026

How do we move AI from raw model performance to effective and impactful mental health care? Building on insights from a pivotal @acnporg.bsky.social study group, the authors set 5️⃣ priorities to embed AI into clinical workflows with safety and equity at the core. 🧠💻 www.nature.com/articles/s44...

nature.com

Responsible and innovative AI for mental health care: five priority themes - NPP—Digital Psychiatry and Neuroscience

This paper synthesizes insights from a 2026 American College of Neuropsychopharmacology (ACNP) study group examining how to responsibly translate AI into clinical mental health care. Building on this ...

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Martin P. Paulus @mpwpaulus.bsky.social · 15/05/2026

AI is becoming clinically relevant for mood and anxiety care—but the evidence is uneven, and enthusiasm must be matched by guardrails. The priority now is not “AI everywhere,” but actionable, validated, clinically accountable tools that improve care. www.sciencedirect.com/science/arti...

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Martin P. Paulus @mpwpaulus.bsky.social · 18/03/2026

Great new review by Adrienne Taren at LIBR: www.tandfonline.com/doi/full/10....

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Martin P. Paulus @mpwpaulus.bsky.social · 15/01/2026

The 73rd Nebraska Symposium on Motivation explores the mechanistic intersections of interoception, conditioning, and addictive behaviors. Consider submitting posters to join us in modeling the neural substrates of internal state processing. motivation.unl.edu

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Reposted by Martin P. Paulus

Sahib Khalsa @skhalsa.bsky.social · 26/11/2025

Perceptual Dysregulation in Psychiatric Nosology has been released! I'm pleased to see that the cover is pretty close to my initial mockup. You can find the entire collection here: link.springer.com/book/10.1007...

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Martin P. Paulus @mpwpaulus.bsky.social · 21/10/2025

The latest CTBN dives deep into the neural systems of fear and anxiety — from mitochondria to machine learning. • Animal & human circuit models • Risk, sex, and developmental factors • Cutting-edge treatments (CBT, TMS, neuromodulation) • Co-occurring disorders (PTSD, autism, schizophrenia)

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Martin P. Paulus @mpwpaulus.bsky.social · 23/04/2025

Great work by Hamed to pull this together.

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Martin P. Paulus @mpwpaulus.bsky.social · 03/04/2025

A labor of love with my friend & long-time collaborator Murray B. Stein. Addressing Difficult-to-Treat Anxiety: A review integrating computational psychiatry, systems neuroscience, & novel interventions. Mechanistic insights for precision psychiatry. www.biologicalpsychiatrycnni.org/article/S245...

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Martin P. Paulus @mpwpaulus.bsky.social · 03/04/2025

Great work by Wes Thompson, Evan White and Chun Chieh Fan at LIBR as well as others: The promise of population neuroscience: understanding brains across diverse groups.

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Martin P. Paulus @mpwpaulus.bsky.social · 28/03/2025

I am excited to share a new feature on our LIBR website. In response to a query from one of our research participants who expressed interest in our work and asked whether there were podcasts available about what "LIBR is working on", we have launched a new project.

notebooklm.google.com

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Martin P. Paulus @mpwpaulus.bsky.social · 28/03/2025

Exploring options to counter US tariffs? Consider the impact of adjusting Treasury holdings. A nuanced approach, but with potential financial leverage. #EconomicStrategy #GlobalFinance #USTreasuries

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Reposted by Martin P. Paulus

Russ Poldrack @russpoldrack.org · 16/03/2025

Amazing story

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Reposted by Martin P. Paulus

Jeremy Berg @jeremymberg.bsky.social · 06/03/2025

Compelling pushback from @jmgrohneuro.bsky.social and the Board of Scientific Counselors at the National Institute on Mental Health (NIMH) regarding termination of tenure-track investigators driven by DOGE. 1/2

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Reposted by Martin P. Paulus

Siri Leknes @sirileknes.bsky.social · 18/02/2025

As the world grows scarier, let's talk about social connection! We review its role in addiction & how it's influenced by opioids, now out in Biological Psychiatry (special issue on social homeostasis) It's @loseth.bsky.social's brainchild & covers A LOT🧠 doi.org/10.1016/j.bi... #neuroscience

doi.org

Redirecting

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Martin P. Paulus @mpwpaulus.bsky.social · 14/02/2025

A tour-de-force by Leandra Figueroa-Hall: A comparison of EV isolation methods from human serum & plasma reveals a trade-off: Precipitation methods (e.g., ExoQuick) yield more EVs, but size-exclusion (SmartSEC, qEV) offers greater purity.

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Reposted by Martin P. Paulus

Eric Topol @erictopol.bsky.social · 11/02/2025

A Direct Hit, by @holdenthorp.bsky.social @science.org www.science.org/doi/full/10.... "This is a moment to unite."

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Martin P. Paulus @mpwpaulus.bsky.social · 08/02/2025

My GPT friend tells me: "NIH’s 15% indirect cost cap can be legally challenged under the APA, contract law, & Takings Clause to block this policy. Congress must intervene to protect U.S. science. #FundResearch #NIH"

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Martin P. Paulus @mpwpaulus.bsky.social · 26/12/2024

📢 This is an interesting new preprint. 💡 The authors developed a framework using LLMs to boost creativity in scientific research. 🧪 The approach recombines existing knowledge to generate novel ideas, grounded in Boden's theory of combinatorial creativity. arxiv.org/abs/2412.14141

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Martin P. Paulus @mpwpaulus.bsky.social · 21/12/2024

🚀 Interesting preprint about AI agent simulations? #LMAgent! A multimodal agent society powered by LLMs, simulating 10,000+ agents in e-commerce scenarios. Realistic behaviors, herd effects, & 40% efficiency boost—paving the way for next-gen social science! 🌐🛍️ #AI #Research arxiv.org/abs/2412.092...

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Martin P. Paulus @mpwpaulus.bsky.social · 20/12/2024

Interesting piece about Illbeing ≠ Wellbeing: the study shows overlapping genetic influences but distinct environmental factors shaping mental health. The authors suggest that integration is key for future interventions. #MentalHealth #Wellbeing

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Martin P. Paulus @mpwpaulus.bsky.social · 17/12/2024

OpenAI's o1-preview achieves superhuman performance in clinical reasoning: Diagnoses correct in 78.3% of cases, outperforming GPT-4 (88.6% vs 72.9%). Excels in diagnostic & management tasks, scoring 99% on reasoning tests. #AIinMedicine arxiv.org/abs/2412.108...

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Martin P. Paulus @mpwpaulus.bsky.social · 16/12/2024

In a new preprint Van Calster et al. provides comprehensive guidance on evaluating predictive AI in healthcare. Recommends core metrics: AUROC, calibration plots, net benefit via decision curve analysis. Essential reading for robust AI model validation! 🔗 arxiv.org/abs/2412.10288 #AIHealth #MedAI

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Martin P. Paulus @mpwpaulus.bsky.social · 16/12/2024

Deep learning in medical imaging often takes shortcuts, finding spurious patterns instead of meaningful insights (e.g., predicting diet from knee X-rays 🤯). To mitigate this: diversify datasets, mask confounders, use adversarial training, and validate across distributions. #AIethics

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Martin P. Paulus @mpwpaulus.bsky.social · 14/12/2024

Woo-Young Ahn ccs-lab.github.io/team/young-a... gave a fantastic talk at LIBR www.laureateinstitute.org about his work on inverse reinforcement learning and the need for better model-based assessments to make a real difference in mental health. 2024.ccneuro.org/pdf/466_Pape...

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Martin P. Paulus @mpwpaulus.bsky.social · 12/12/2024

I want to thank all of those who I had stimulating conversations with at #ACNP2024 always generates tremendous ideas for the future, thank you!

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Martin P. Paulus @mpwpaulus.bsky.social · 11/12/2024

For those that are still around at #ACNP2024 consider attending our study group on challenges and opportunities of population neuroscience

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Martin P. Paulus @mpwpaulus.bsky.social · 11/12/2024

Want to thank Carolyn Rodriguez and all participants for a great mini panel at #ACNP2024

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Martin P. Paulus @mpwpaulus.bsky.social · 08/12/2024

Hello all at #ACNP2024 hope to see you at our mini-panel tomorrow, great presentations on how generative AI may change the way we study and treat mental health conditions:

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Reposted by Martin P. Paulus

Hugo Spiers @hugospiers.bsky.social · 25/11/2024

Opposite responses to reward with dopamine (up) and serotonin (down) in nucleus accumbens boost reinforcement learning. Impressive work in Nature: www.nature.com/articles/s41...

nature.com

Opponent control of reinforcement by striatal dopamine and serotonin - Nature

Nature - Opponent control of reinforcement by striatal dopamine and serotonin

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Martin P. Paulus @mpwpaulus.bsky.social · 23/11/2024

We had a little bird in the house, surprisingly challenging getting it out.

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Martin P. Paulus @mpwpaulus.bsky.social · 23/11/2024

I found this new review on Bayesian methods in cardiovascular clinical trials very helpful! 🫀📊 This paper breaks down the advantages of Bayesian analysis, from incorporating prior knowledge to interpreting results. doi.org/10.1016/j.cj...

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Martin P. Paulus @mpwpaulus.bsky.social · 22/11/2024

OK, I made the jump, same handle, now on Bluesky.

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