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Stephen Floor

@snf.bsky.social
2.4K followers 375 following 436 posts

Dad, partner, scientist, music lover. I am passionate about developing RNA technologies to impact human health.

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Stephen Floor @snf.bsky.social · 06/12/2025
It’s an inversion of liberty to deny citizenship to people who have overcome so much, it’s a betrayal of the American experiment
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Stephen Floor @snf.bsky.social · 09/11/2025
Maybe is yeah, but why inland? And why not just say sea salt?
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Stephen Floor @snf.bsky.social · 09/11/2025
I am assuming water powder is pretty rare, it being the dehydrated form of water
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Stephen Floor @snf.bsky.social · 09/11/2025
ok I have a mystery. What is the food ingredient “inland sea water powder”?
Ingredient list with “inland sea water powder” highlighted
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Stephen Floor @snf.bsky.social · 26/09/2025
Precisely the kind of necessary historical revision enabled by the Ministry of Truth
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Stephen Floor @snf.bsky.social · 08/09/2025
“FIFA could rake in a record $4.4 billion” exploitation. trash organization
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Stephen Floor @snf.bsky.social · 27/08/2025
congrats! bioRxiv has massively changed science for the better
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Stephen Floor @snf.bsky.social · 26/08/2025
I am once again reminded that the loudest person in the room is not necessarily the smartest or most qualified
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Stephen Floor @snf.bsky.social · 26/08/2025
I’d ride a Gronk vaccine party cruise
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Stephen Floor @snf.bsky.social · 25/08/2025
Reader, we would not like a dictator in the “land of the free and home of the brave”
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Stephen Floor @snf.bsky.social · 14/08/2025
I stop for questions in the middle and at the end
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Stephen Floor @snf.bsky.social · 14/08/2025
great paper - love to see this mechanistic connection for AU-rich elements!
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Eugene Valkov @eugenevalkov.bsky.social · 13/08/2025
Delighted to present our second paper of the year. This one explores the molecular mechanism of TTP, a key post-transcriptional regulator of AU-rich mRNAs. Work led and coordinated by @filippekovic.bsky.social, in collaboration with Perry Blackshear. www.nature.com/articles/s41...
nature.com
Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin - Nature Communications
Deadenylation leads to mRNA decay, with PABPC1 protecting the poly(A) tail, while tristetraprolin and CCR4–NOT promote deadenylation. Here, the authors describe how these three proteins interact to re...
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Stephen Floor @snf.bsky.social · 12/08/2025
some of the blends in this are 🤯
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Stephen Floor @snf.bsky.social · 31/07/2025
I remember when OS updates were like "we will protect your computer from viruses and make it faster" and now they lead with
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Stephen Floor @snf.bsky.social · 25/07/2025
congrats and excited to dig in!
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Vikram Agarwal @vagar.bsky.social · 25/07/2025
Paper 2 -- Translational co-regulation detected in mammalian cells www.nature.com/articles/s41... A deeper explanation of the human story, scientific conclusions, and Github/Zenodo links to use the pre-trained models: www.linkedin.com/feed/update/...
nature.com
Translation efficiency covariation identifies conserved coordination patterns across cell types - Nature Biotechnology
Matched ribosome profiling and RNA sequencing data quantify translation efficiency patterns across 140 human and mouse cell lines.
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Vikram Agarwal @vagar.bsky.social · 25/07/2025
Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies: Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l
url.de.m.mimecastprotect.com
Predicting the translation efficiency of messenger RNA in mammalian cells
Nature Biotechnology - A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.
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Stephen Floor @snf.bsky.social · 25/07/2025
Another example of spurious effects when you try to interpret RNA biology from DNA introduced into cells without confirming exactly what RNA processing is happening. Important and common confounder - great paper!
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Stephen Floor @snf.bsky.social · 24/07/2025
watch out for the proximity mine near that door
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Mike Feigin 🥯 @mikefeigin.bsky.social · 23/07/2025
“With these considerations, we expect to fund through the 4th percentile.” There it is, in black and white, the destruction of cancer research in the US.
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Stephen Floor @snf.bsky.social · 12/07/2025
apropos of nothing, a strong rec for “The Tyranny of Merit”, in which Sandel notes a putative meritocracy “fosters a sense of entitlement among the successful while humiliating those who do not succeed, ultimately undermining the common good and social solidarity” bookshop.org/p/books/the-...
bookshop.org
The Tyranny of Merit: Can We Find the Common Good?
Can We Find the Common Good?
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Stephen Floor @snf.bsky.social · 12/07/2025
this is an example of the so-called meritocracy that’s threatened by introspection on who gets into college and why
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Stephen Floor @snf.bsky.social · 11/07/2025
the vibes seem off
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Stephen Floor @snf.bsky.social · 11/07/2025
super curious what these people are like irl, like are they arguing with someone in the grocery store because they're buying organic (or not organic)? someone at the gas station who chooses low octane fuel? someone at a pharmacy who's getting vaccinated? or are they just internet warriors
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Stephen Floor @snf.bsky.social · 07/07/2025
great review on the myriad ways that genetic variation in mRNA untranslated regions can cause disease!
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Stephen Floor @snf.bsky.social · 04/07/2025
This July 4 I celebrate my country born by separation from a tyrannical king, with the principles that all people are created equal and that the government represents the will of the People, not a monarch. The unalienable rights of Life, Liberty, and the pursuit of Happiness. Let freedom ring!
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Stephen Floor @snf.bsky.social · 24/06/2025
absolutely love this new tour of the cosmos using the Skyviewer app built using new images off the Vera Rubin telescope - gorgeous and great explanations skyviewer.app/tours
skyviewer.app
Astronomical Tours | Skyviewer
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Stephen Floor @snf.bsky.social · 18/06/2025
whenever I need some sunshine I turn to cientotres 103.1 FM out of San José, Costa Rica radios-de-costa-rica.com/1031-fm
radios-de-costa-rica.com
103.1 FM Cientotres en vivo, Costa Rica
103.1 FM es una emisora de radio de Costa Rica que emite en San José. Escucha gratis música dinámica para jóvenes del género rock y pop.
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Carl Zimmer @carlzimmer.com · 16/06/2025
A federal judge on Monday declared the Trump administration’s move to cut hundreds of grants issued by the National Institutes of Health illegal, accusing the government of discrimination against minorities and L.G.B.T.Q. individuals. nyti.ms/4jSIjOG
nyti.ms
Trump’s Cuts to N.I.H. Grants Are Illegal, Federal Judge Rules
The judge accused the Trump administration of discriminating against minorities and L.G.B.T.Q. people and ordered the government to restore much of the funding.
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jamelle @jamellebouie.net · 15/06/2025
the story today is of a profoundly low energy military parade being met with millions of americans in nationwide protests denouncing the dictatorial pretensions of the president
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Stephen Floor @snf.bsky.social · 15/06/2025
Traveling for a soccer tournament and there’s a rally of maybe 500 people here in South Lake Tahoe today, too. Solidarity. No kings, no tyrants 🇺🇸
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Stephen Floor @snf.bsky.social · 14/06/2025
Racism and xenophobia is already turning the US into a backwater to avoid
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Stephen Floor @snf.bsky.social · 13/06/2025
Sonicator - living the @infinitescream.bsky.social dream
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Stephen Floor @snf.bsky.social · 12/06/2025
people will literally die because of this
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Stephen Floor @snf.bsky.social · 10/06/2025
"all the best" 💩🤡
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/06/2025
I urge others to similarly support our patriots at NIH who use their training and talents to improve human health and position the US as the world’s leader in biomedical discovery, innovation and technology development 🙏
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Stephen Floor @snf.bsky.social · 05/06/2025
fully agree - the real question is: will Trump let the DOGEs out?
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Jeff Leek @jtleek.bsky.social · 04/06/2025
These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.
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Stephen Floor @snf.bsky.social · 02/06/2025
right but the pairwise is underpowered to detect differences across the series and one has to correct for multiple testing on the individual points. I’m sure you’re doing this I just see a lot of … not doing it
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Stephen Floor @snf.bsky.social · 02/06/2025
local yay area man discusses choices, when to go (dumb), how to be sprinkled with game, and gouda + broccoli
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Stephen Floor @snf.bsky.social · 02/06/2025
this is the best way I’ve seen, I’m thankful for this thread so maybe there will be less of doing a t-test on each time point and labeling each with asterisks
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Stephen Floor @snf.bsky.social · 30/05/2025
if the US wants to be competitive on the world stage, investing in education, science, and technology is the way. one doesn’t simply discriminate your way to the top
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Stephen Floor @snf.bsky.social · 29/05/2025
prelim phase 1/2 trial results of the Moderna H5N1 vaccine program included no (none) dose-limiting toxicity and 97.8% (NINETY SEVEN POINT EIGHT PERCENT) of participants reaching protective antibody levels. defunding this program makes America sicker endpts.com/trump-axes-m...
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Ariel Wittenberg @arielwittenberg.bsky.social · 27/05/2025
Thinking of this @propublica.org reporting today about stillbirths of unvaccinated parents during the Delta wave, before CDC had explicitly recommended COVID vaccines for pregnant people and the damage the virus did to the placentas. www.propublica.org/article/covi...
propublica.org
“God, No, Not Another Case.” COVID-Related Stillbirths Didn’t Have to Happen.
A lack of testing data and government guidance led many to avoid the COVID-19 vaccine during pregnancy, unwittingly increasing their chances of a stillbirth.
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Stephen Floor @snf.bsky.social · 27/05/2025
today’s anti-vaccination, pro-disease decision by RFK in the Orwellian name of “making America healthy again” will lead to more moms dying and more unhealthy babies why anyone would choose to not protect moms and babies as best we can is beyond my comprehension
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Stephen Floor @snf.bsky.social · 23/05/2025
reminiscing over simpler times when controversy involved whether figures belong inline or at the end of paper drafts
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Derek Lowe @dereklowe.bsky.social · 23/05/2025
This is exactly it. I’ve said the same thing in nearly the same words myself. The memory of this man and his very name should be a curse for future generations.
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Stephen Floor @snf.bsky.social · 21/05/2025
more of this will be coming in the near term as budgets dry up, and in the long term as diminished academic research leads to fewer startups. ample evidence in our faces that DOGE and the Trump administration are derailing American science, innovation, and our economy
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Stephen Floor @snf.bsky.social · 21/05/2025
Eikon lays off ~15% of staff citing "external forces. For example, government funding cuts have constrained the budgets of academic institutions, necessitating that we pause development of our advanced instruments ... The market for these instruments has clearly evaporated."
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