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sliverdaemon.bsky.social

@sliverdaemon.bsky.social
53 followers 292 following 116 posts

"Then how should I begin To spit out all the butt-ends of my days and ways? And how should I presume?" - TS Eliot, Love Song of J. Alfred Prufrock I like ML, quantitive biology, and medicine.

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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 30/07/2025
thought is a miracle www.nature.com/articles/d41...
nature.com
The brain fires up immune cells when sick people are nearby
When people viewed virtual avatars with coughs or rashes, their brains triggered an immune response.
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Laura Helmuth @laurahelmuth.bsky.social · 28/07/2025
Bacteria from a Yellowstone hot spring do something no other organism has been found to do: breathe oxygen and sulfur at the same time. 🧪 It's both aerobic and anaerobic, a beautiful freaky creature from a beautiful freaky place
quantamagazine.org
The Cells That Breathe Two Ways | Quanta Magazine
In a hot spring at Yellowstone National Park, a microbe does something that life shouldn’t be able to do: It breathes oxygen and sulfur at the same time.
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Society for Developmental Biology @socdevbio.bsky.social · 26/07/2025
🐌💫 Snail embryos never looked so fabulous! Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball. Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 22/07/2025
whole genome doubling is common in cancers, below you can see how that manifests in single cell transcriptomics (of ovarian cancer)
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Journal of Cell Biology @jcb.org · 21/07/2025
Aceitón, Riobó, Del Valle Batalla, Yuseff et al show that B cells respond to mechanical cues at the immune synapse through ATAT1-dependent microtubule acetylation to coordinate cytoskeletal dynamics & lysosome positioning, enhancing antigen extraction and presentation rupress.org/jcb/article/...
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Frank Schnorrer @frankschnorrer.bsky.social · 21/07/2025
Microtubules: the architect of muscles. Watch how microtubules transport mitochondria in proximity to energy consuming sarcomeres in muscles of flies and mice. @jeromeavellaneda.bsky.social @nunoluis.bsky.social @ibdm.bsky.social with @gomeslabo.bsky.social www.sciencedirect.com/science/arti...
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Nimesh Chahare @onenimesa.bsky.social · 03/07/2025
Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025... 🧵 with pressure control, multiscale buckling, controlled wrinkling
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 03/07/2025
what a time to be alive! (you know, as far image processing is concerned)
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 02/07/2025
dogma now absurd first
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Dr Ellie Murray, ScD @epiellie.bsky.social · 28/06/2025
I am once again reminded of my favorite @edyong209.bsky.social quote: “…a tiny wise decision can do exponential good.”
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 28/06/2025
Developing lenacapavir, the drug newly approved to protect against HIV for six months in one shot, took basic science, sophisticated chemistry, and perseverance www.science.org/cont...
science.org
Always ‘one atom away’: The long, rocky journey to an HIV prevention breakthrough
Developing lenacapavir, the drug newly approved to protect against HIV for six months in one shot, took basic science, sophisticated chemistry, and perseverance
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Rabih Alameddine @rabihalameddine.bsky.social · 26/06/2025
The inferno of the living is not something that will be; if there is one, it is what is already here, the inferno where we live every day, that we form by being together. There are two ways to escape suffering it. 1/3
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 27/06/2025
nerve cells give their mitochondria to cancer cells. yeah, really. www.nature.com/articles/s41... 🤯
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Plant Cell Atlas @plantcellatlas.bsky.social · 26/06/2025
Meet The Speakers of the Single-Cell Approaches in Plant Biology GRC Conference! To Apply to the GRC: lnkd.in/gvkMxuKR To Learn More About Dr. Shahan's Research: sites.lifesci.ucla.edu/mcdb-shahan/ @rachelmshahan.bsky.social
Promotional image for the "Single-Cell Approaches in Plant Biology GRC Conference" focusing on meeting the speakers. This promo includes an image of Dr. Rachel Shahan from UCLA with a short bio on Dr. Shahan.
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Jean-Michel Ané @jeanmichelane.bsky.social · 25/06/2025
If we can develop cheap, effective and stable inoculants... Effect of Arbuscular Mycorrhyzal Fungi in Improving Soybean Growth in Ultisol Soil | Applied Research in Science and Technology
sco.lt
Effect of Arbuscular Mycorrhyzal Fungi in Improving Soybean Growth in Ultisol Soil
Background: Soybean is one of the most popular agricultural commodities in Indonesia, but its production is still low. Thus, it is necessary to make efforts to expand its agriculture in the form of marginal land development. Aims: This study aims to examine the effect and obtain the best treatment dose of arbuscular mycorrhizal fungi (AMF) in ultisol soil to increase the growth of soybean plants (Glycine max (L.) Merill). Methods: This experimental study employed a complete randomized design (CRD) with the treatment of arbuscular mycorrhizal fungi (AMF). The AMF treatment comprised five levels: no AMF, 4 g/polibag, 8 g/polibag, 12 g/polibag and 16 g/polibag. Each treatment was repeated four times, resulting in 20 experimental units and each experimental unit comprised three polybags so that this study used 60 polybags. The data were analyzed using Analysis of Variance (ANOVA) and continued with Duncan's New Multiple Range Test (DNMRT) at the 5% level. Result: AMF treatment is able to increase the growth of soybean plants in the parameters of plant height, number of productive branches, flowering age, number of flowers, and harvest age. The AMF treatment dose of 12 g/polybag is proven to give the best results in increasing the growth of soybean plants. The use of AMF can be an effective strategy in optimizing soybean production, especially on marginal lands.
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Andrea Love, PhD | Biomedical Scientist @drandrealove.bsky.social · 24/06/2025
If we trust genetic engineering to save a child from leukemia, why reject it when it could save a child from blindness, malnutrition, or death? We cure cancer with genetic engineering but ban it on the farm. Celebrating one but demonizing the other fuels disinformation that costs lives. 1/
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 24/06/2025
I've seen this disease firsthand; believe me when I say this is an incredibly important moment for those who have EB. Bravo Stanford!
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 22/06/2025
"cells grow long signaling filopodia called cytonemes [...] visible extending from the orange cell"
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Leland McInnes @lelandmcinnes.bsky.social · 22/06/2025
Explore Wikipedia through a data map. Pages are grouped by semantic similarity, for topic clusters. Hover to see details, zoom to explore more fine-grained topics, click to go to a page. Search by page name to find interesting starting points for exploration. lmcinnes.github.io/datamapplot_...
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Maik Bischoff @maikbischoff.bsky.social · 20/06/2025
For today's #FluorescenceFriday I'm thrilled to share that ScienceAdvances was so nice to pick my picture as this week's featured image! It's actually a still of a video😊 Check out the paper to learn more science.org/doi/10.1126/... #cellbio #devbio #cellmigration #science Thank you @aaas.org
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Stefan Luschnig @luschnig.bsky.social · 19/06/2025
Spectacular work by @maikbischoff.bsky.social @peiferlabunc.bsky.social showing how Plexin/Semaphorin-guided collective cell migration of muscle precursor cells shapes the developing testis. Look at the movies! 😱 | Science Advances www.science.org/doi/10.1126/...
science.org
Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance
An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.
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Mike Levin @drmichaellevin.bsky.social · 17/06/2025
Final version of this paper with Alexis Pietak (allencenter.tufts.edu/our-team/ale..., www.researchgate.net/profile/Alex...) is now out: www.sciencedirect.com/science/arti... "Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine"
sciencedirect.com
Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine
Gene regulatory networks (GRNs) are critically important for efforts in biomedicine and biotechnology. Here, we introduce the Regulatory Network Machi…
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 16/06/2025
article: www.nature.com/articles/s41...
nature.com
Cross-tissue multicellular coordination and its rewiring in cancer - Nature
Comprehensive single-cell transcriptomic analysis of 35 human tissues reveals 12 cross-tissue coordinated cellular modules that exhibit intramodule communication and dynamic changes with ageing, and w...
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Nikolai Slavov @slavov-n.bsky.social · 15/06/2025
Machine learning often performs unexpectedly poorly when deployed in real-world domains. This article suggests that underspecification is a key reason for the poor performance.
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 16/06/2025
"So do all who live to see such times, but that is not for them to decide. All we have to do decide is what to do with the time that is given us. There is more than the will of evil at work in this world, Frodo." knowing good is alive and active in the world is also an encouragement be that good
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 16/06/2025
love the first chapter
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 15/06/2025
"It is the part of the scientist -- of the intelligent and honest man of letters and of the intelligent and honest clergyman as well -- to entertain heretical and forbidden opinions experimentally, even if he is finally to reject them." -- Norbert Wiener in "God & Golem, Inc" (free from MIT press) 👇
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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 13/06/2025
Spatial multi-omics and deep learning reveal fingerprints of immunotherapy response and resistance in hepatocellular carcinoma www.biorxiv.org/content/10.1101/202…
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 13/06/2025
authors developed a transcriptomics perturbation protocol for plants that does not require genetic tools 🤯
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John Wallingford @jbwallingford.bsky.social · 11/06/2025
We all know scientists who are also musicians In fact, one of my favorites just dropped a new album last month. I was surprised me, though, since she died over 800 years ago. Turns out she might also be the first woman to ever write about developmental biology. 🧵 1/16
An Icon of St. Hildegard, from Wikipedia
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Johns Hopkins University @jhu.edu · 09/06/2025
Hai-Quan Mao and his team at Johns Hopkins are creating new ways to treat cancer, malaria, and nerve damage. By combining mRNA with cutting-edge biomaterials, their work is opening new frontiers in patient care. And it’s all made possible by NIH support. 1/2 #ResearchSavesLives
Hai-Quan Mao (front row, third from left) stands with members of his research team in a Johns Hopkins lab. The group conducts NIH-funded materials science research to develop new treatments for cancer, malaria, and tissue damage. Lab equipment and supplies are visible in the background.
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 10/06/2025
aboslutely beautiful figure. in my dreams, the embryo's collective state and decision-making can be expresed as it develops as transitions between toward more capable toposes. this kind of work gives me hope that the mathematics of embryo cognition can be truly discovered and fleshed out.
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Ted Pavlic (he/him/his) @tedpavlic.bsky.social · 08/06/2025
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪 www.richmondscientific.com/how-a-discov...
richmondscientific.com
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 08/06/2025
"newly identified nitrogen-oxygen-sulfur (NOS) linkages [...] discovered between the amino acid pairs arginine-cysteine and glycine-cysteine"
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Zebrafish Rock! @zebrafishrock.bsky.social · 01/06/2025
Development of a transgenic zebrafish embryo. Credit to Dr. Mario Mendieta-Serrano. #ZebrafishZunday 🧪
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 28/05/2025
fungal matchmakers
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danapeer.bsky.social @danapeer.bsky.social · 26/05/2025
The Single-cell Analytics Innovation Lab @mskcancercenter.bsky.social is expanding and looking for ML-oriented computational biologists. Join our team based in NYC to work on cutting-edge single-cell & spatial transcriptomics methods in collaboration with leading research labs. bit.ly/4lTEr2t
bit.ly
Computational Biologist (Single-cell Genomics / ML) – Single-cell Analytics Innovation LabChaligne Lab Website
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 26/05/2025
siphonophores are one of my viscerally favorite organisms. you can almost "see the math". they blew my mind when I learned that, as colonial organisms, they're composed of both medusiods and polypoids. but even these two specialize further within them. image credit: en.wikipedia.org/wiki/Siphono...
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Akaash Kumar @akaashkumar.bsky.social · 20/05/2025
Today's light sheet video of actin dynamics in cytotoxic t cells... so much fun to come!
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John Holbein @johnholbein1.bsky.social · 15/05/2025
#RDDers: check it out. rd2d: Causal Inference in Boundary Discontinuity Designs "This article introduces the R package rd2d, which implements and extends the...results developed in Cattaneo et al. (2025) for boundary discontinuity designs [like geographic RDDs]" arxiv.org/abs/2505.07989
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 13/05/2025
proteins often interact in a tissue-specific way
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 10/05/2025
Studying a trio of non-coding RNA molecules produced abundantly in bacterial cells, researchers discovered extravagant, multistrand complexes made entirely of RNA – structures they didn’t know were possible without the support of proteins www.newswise.com/art...
newswise.com
SLAC, Stanford Researchers Discover Large Protein-Free RNA Structures | Newswise
Cryogenic electron microscopy showed for the first time that large RNA complexes can assemble without the help of proteins, expanding our understanding of RNA folding and function.
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Jascha Achterberg @achterbrain.bsky.social · 10/05/2025
Super interesting work with a computational model of how auditory hallucinations may arise: journals.plos.org/plosbiology/... #neuroscience #compneuro
journals.plos.org
Impaired motor-to-sensory transformation mediates auditory hallucinations
Can the absence of inhibition lead to auditory hallucinations? This study shows that the impairment of motor-based sensory predictions causes erroneous monitoring of imprecise internal auditory repres...
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Lars Velten @larsplus.bsky.social · 08/05/2025
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis 🧬🩸 screen of fully synthetic enhancers in blood progenitors 🤖 AI that creates new cell state specific enhancers 🔍 negative synergies between TFs lead to specificity! www.cell.com/cell/fulltex... 🧵
cell.com
Design principles of cell-state-specific enhancers in hematopoiesis
Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...
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Stanford Medicine @stanfordmedicine.bsky.social · 09/05/2025
After two decades of research, a gene therapy skin graft for a rare, painful skin condition has earned FDA approval. Dermatologist Jean Tang discusses Stanford Medicine’s role in developing a treatment for dystrophic epidermolysis bullosa. stan.md/3GA3ojd
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sliverdaemon.bsky.social @sliverdaemon.bsky.social · 09/05/2025
doing some good in the world👏
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ML for Protein Engineering Seminar @ml4proteins.bsky.social · 09/05/2025
Next Tues (5/13) at 4PM ET, we will have Anna Lauko and Sam Pellock present "Computational design of serine hydrolases" Paper: www.science.org/doi/10.1126/... Sign up on our website for zoom links!
science.org
Computational design of serine hydrolases
The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of ...
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Tuuli Lappalainen @tuuliel.bsky.social · 05/05/2025
The brain is particularly cool, with its well-defined substructure. We see the expected neuropsych enrichment in cortex, while Alzheimer’s genes are enriched in white matter, thalamus and choroid plexus. Spatial correlation shows subclusters of disease genes in distinct spatial domains.
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