Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

Vinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5–13 human meninges and perform comparative studies with meningioma data.

To, Pett, Dufva et al. perform single-nucleus RNA and ATAC sequencing, as well as spatial transcriptomics, to study human meninges at 6–21 weeks post conception.

Recent changes in Genentech’s scientific organization, occurring as the company makes artificial intelligence (AI) increasingly central to its research strategy, highlight a broader question facing bi...

Le et al. show that in Xenopus embryos, local ectodermal tissue flows provide a directional cue that polarizes and guides embryonic myeloid cells migration via cell-on-cell interactions.

The detailed study of membrane contact sites is challenging owing to their small size and highly dynamic nature. This Review highlights advanced imaging methods and available biosensors that can be us...

This Perspective highlights the use of current proteomics technologies in defining stage-specific reprogramming events to understand reproductive ageing, improve oocyte quality, and refine the outcome...

Li, Jihad and colleagues develop an organoid co-culture system, alongside patient tissue and mouse model analyses, to model, characterize and compare cellular interactions between epithelia and stroma...

This Perspective discusses emerging evidence for non-cell-autonomous propagation of ferroptotic cell death and highlights the mechanisms that underlie its restriction in tissues, as well as ferroptosi...

Successful pregnancy rates decline with maternal age, even when embryos appear genetically normal. We show that maternal ageing changes the physical properties of the embryo, which reduces implantatio...

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

Advances in electron microscopy instrumentation and methods continue to drive progress in the physical and life sciences. The 4th edition of this conference will bring together researchers from physic...

Li et al. report that FLT3 inhibition impairs selenoprotein translation and induces ferroptosis to suppress FLT3-mutant leukaemia. This can be counteracted by dietary vitamin E, which may disrupt the ...

Mistry et al. propose that Dnmt3a-mutant haematopoietic cells induce mesenchymal stromal cell senescence. Removal of senescent non-haematopoietic cells reduces Dnmt3a-mutant haematopoiesis.

Using a dynamic fluorescent reporter, Tang et al. demonstrate that cancer stem cells are hyper-responsive to microenvironmental cues, which they sense and adapt to through YAP/TAZ signalling, thereby ...

Yao, Li, Gai et al. profile normal coronary artery and early and advanced coronary atherosclerosis samples from humans using single-cell transcriptomics and identify a progenitor-like endothelial subt...

Johnson et al. combine single-cell and spatial transcriptomics approaches to build a spatially resolved atlas of the developing human intestine and intestinal organoids, uncovering spatial organizatio...

Yao, Li, Gai et al. profile normal coronary artery and early and advanced coronary atherosclerosis samples from humans using single-cell transcriptomics and identify a progenitor-like endothelial subt...

Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...

Bae et al. identify MED4 as a regulator of tumour dormancy from a genome-wide CRISPR screen, and show that loss of MED4 alters the enhancer landscape and induces extracellular matrix remodelling to dr...

Von Economo neurons are linked to higher cognition but remain poorly understood. A study now combines Patch-seq and transcriptomics in macaques to define their molecular identity, diversity and signal...

Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...

Because of their ability to simulate certain aspects of embryonic development, stem cell-based embryo models can be a promising tool in our efforts to better ...

The annual meeting of the International Society for Stem Cell Research (ISSCR) is coming up July 8-11. If you are interested in stem cells, please tune into the sneak peek podcast of this meeting. And...

Nature Cell Biology - Efforts to construct stem cell-based embryo models are thriving, with numerous potential implications for basic and translational research. We now introduce a Collection of...

Because of their ability to simulate certain aspects of embryonic development, stem cell-based embryo models can be a promising tool in our efforts to better ...

Efforts to construct stem cell-based embryo models are thriving, with numerous potential implications for basic and translational research. We now introduce a Collection of articles that highlight rec...

Cao, Lin, Feng, Chen, Wu and colleagues develop a mouse developmental single-cell atlas covering 2-cell stage through to birth.

An international gathering of the brightest minds in stem cell research and regenerative medicine across disciplines. Join us for the 2026 ISSCR Annual Meeting 8-11 July 2026 in Montréal, Canada.

He, Wang, Ding and colleagues report a transcriptomic atlas of human female reproductive tract segments from fetuses at gestational weeks 10 to 25.

Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and ext...

A deep-learning model trained on electrocardiogram (ECG) waveforms identifies an easily visible biomarker that predicts sudden cardiac death more accurately than the current clinical state of the art.

Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and ext...

Wei et al. show that Meg3+ haematopoietic stem cells (HSCs) expand upon ageing and present with an increase in H3K23ac levels observed already at middle age. Inhibiting H3K23ac ameliorates megakaryocy...

This Review discusses the roles of ferroptosis in shaping the immune landscape in glial tumours and highlights potential strategies that combine ferroptosis induction with immunotherapy for a durable ...