Mouse experiments show that Alzheimer’s disease and corticobasal degeneration tau filaments retain their distinct structures during templated seeding, supporting strain-specific tau propagation a...

Avoiding a diet rich in simple sugars during treatment with antibiotics may mitigate microbiota disruption.

Paper2Agent converts research papers into interactive artificial intelligence agents by turning manuscripts, code and data into model context protocol-based tool-invoking systems that reproduce origin...

Explicit support for white nationalism is uncommon overall, but higher among young white men, disadvantaged and politically disaffected white people, conservatives, Republicans, and those with primari...

Semaglutide treatment for 3 months in female mice improved physiological function, attenuated hallmarks of ageing and modulated nutrient sensors and conserved genetic regulators of ageing.

Integrating satellite-derived war-damage data with text-based fatality records through improvement, enrichment and fusion mitigates limitations inherent in each source, revealing complex vio...

Remote phone-based targeted tutoring in five countries produced large, cost-effective learning gains during school closures, outperforming text messaging and working effectively when delivered by gove...

Efficient degradation of fucoidans depends on complementary bacterial guilds that cooperatively break backbone and side-chain sugars, revealing a conserved, globally relevant mechanism that shapes mar...

Restudy of a challenging fossil using cross-polarized light imaging and phylogenetic reconstruction identifies Chosha praecursor, a probable early-diverging insect, helping to bridge the longstanding ...

Aquatic invertebrates are exceptionally nutrient dense, supplying the equivalent annual vitamin B12 and selenium requirements for over 5 billion people.

Global photovoltaic waste will reach 297–402 million tonnes by 2060, and regionally adapted recycling strategies and international cooperation will be needed to provide equitable and scalable PV waste...

Substantial intraspecific variation, together with species turnover, drives coordinated shifts in drought resistance such as increased embolism resistance and wider stomatal safety margins in drier fo...

By combining a meta-analysis of CO2 enrichment experiments with three decades of southern African savanna observations, an increase in biomass production by C4 grasses under rising CO2 levels in ...

A Nature conference reimagining what it means to deliver truly personalised care in the next decade.

Early Cambrian Eoceras shaanxiense gen. et sp. nov. preserves septa and a segmented tube resembling a primordial siphuncle, extending cephalopod origins and revealing early assembly of chambered shell...

Using canopy-penetrating LiDAR data, the northern part of southwestern Amazonia appears to contain as many earthworks as previously estimated for the whole of Amazonia.

A well-preserved fossil snake from the Late Cretaceous of Brazil shows early ecological and brain shape disparity in the group.

Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females t...

An immunopeptidomics analysis identifies numerous Plasmodium T cell antigens that are conserved across malaria parasite species and expressed at several phases of the parasite’s life cycle, with possi...

Diet shapes obesity-associated therapeutic responses to immune checkpoint inhibitors through gut microbial metabolism and host anti-tumour immunity, demonstrated in mouse custom-diet models&...

The biocultural heritage of the Amazon, its plant species, plant services and cultures are at risk from climate change.

Large language models can be used to estimate the results of social science experiments about as accurately as a group of human forecasters—even for experiments published after the...

The EUROPE-IGM-ATLAS reveals spatiotemporal trends that characterize the changing geography of opportunity in Europe and its relationship with regional innovation.

SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.

Four antibiotic compounds produced in Streptomyces bacteria attack multiple parts of an essential metabolic pathway.

A deep-learning model trained on electrocardiogram (ECG) waveforms identifies an easily visible biomarker that predicts sudden cardiac death more accurately than the current clinical state of the art.

Researchers uncovered an enormous deep-sea accumulation of whale remains in the southeastern Indian Ocean, showing long-term, specialized ecosystems and an extensive fossil record that offers new insi...

Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.

One in six Internet-using adolescents in parts of Africa and Asia faced technology-facilitated sexual abuse in 2020–21. As digital access expands globally, better protection is crucial.

Chloroplast plastoglobules act as nitrogen-assimilation hubs in maize, with key enzymes enhancing nitrogen-use efficiency and offering new strategies for developing high-yield, sustainable crops.

Extensive mining activity leads to large-scale deforestation of dense tropical forests across sub-Saharan Africa, driven particularly by key energy transition minerals such as cobalt.

A machine-learning model that uses smartphone cameras to measure heart rate in the background during normal daily phone use and subsequently estimate resting heart rate could make it easier for p...

Integrated palaeontological, sedimentological and geochemical analyses of ancient rocks from Australia show that early eukaryotes were largely restricted to oxygenated benthic habitats, probably posse...

Quantification of links among insect pollinators, crop plants, nutrient intake and income of smallholder communities in Nepal show that pollinators substantially contribute to their income and micronu...

In the hippocampus, complex processing of sensory stimuli occurs even in the unconscious state.

The Amazon forest faces a near system-wide transition of 62−77% of the area under a combination of 1.5–1.9 °C global warming and 22−28% deforestation.

Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

Wild meat is a fundamental component of the diets of rural Central African populations, accounting for 20% of the recommended daily protein intake, compared with 13% and 6% for those living in towns a...

A longitudinal study shows that racial diversity in higher education is associated with higher student salaries at graduation, indicating that policies to increase or leverage racial diversity enhance...

Decade-long warming increased soil antibiotic-resistance genes by about 24%, enriching resistant microbes and gene transfer, driven by selection for thermal tolerance and linked traits, with implicati...

Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than being...

MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome pr...

Synthetic super-enhancers enable specific delivery of anticancer payloads, achieving tumour elimination after a single dose in a mouse model of aggressive glioblastoma.

Big reproducibility efforts describe how methods and analysts shape results in behavioural and social sciences.

A machine-learning model that integrates data from wearable devices (such as smartwatches) with blood biomarkers and demographic data can predict whether someone has insulin resistance, enabling timel...

A locally tailored, big-push intervention to educate unmarried adolescent girls in 18 communities in northern Nigeria reduced rates of marriage from 86% to just 21%. Interventions that address complex...