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Siobhan Gaynor

@siobhangaynor.bsky.social
487 followers 832 following 26 posts

Metastatic Breast Cancer patient and researcher. Stage 4 Cancer advocate for better care, research, epidemiology and clinical guidelines. Irish. #oncsky #bcsm

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Reposted by Siobhan Gaynor
@doublewhammied @doublewhammied.bsky.social · 20/12/2024
Did you miss #SABCS24 last week? No worries! Here's my @fredhutch.bsky.social SABCS24 wrap story w/insights into #cancer treatments & #cannabis; #ctDNA; #obesity & #epigenetics, #FES-PET & much more. #cansky #oncocsky #medsky #bcsm @thankscancer.bsky.social www.fredhutch.org/en/news/cent...
fredhutch.org
What’s new in breast cancer research? SABCS24 looks at ctDNA, AI and ‘right-sizing’ treatment
More than 11,000 researchers, clinicians, patient advocates and drugmakers gathered last week at the San Antonio Breast Cancer Symposium to share the latest treatments, tricks and tools to take down b...
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Heidi & Mand @laughbeforedeath.bsky.social · 20/12/2024
Message from Mand 👇 She lifted it from another social account; not sure of its origin but we love the message. #IamStillHere #MetastaticCancer #Cansky Mand is a #CancerDinosaur
Cancer ribbon (symbol) with the following text: I’m still here. Living with Metastatic Breast Cancer.
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Kelly Shanahan @stage4kelly.bsky.social · 12/12/2024
Now, on to liver mets with Dr Peter Vermeulen: not all liver mets are equal. #SABCS24
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Kelly Shanahan @stage4kelly.bsky.social · 12/12/2024
Congratulations to DR Steffi Oesterreichs @oesterreichs on her AACR Award. She has done sooooo much for people with ILC, not just through her brilliant research, but through her embrace of and collaboration with advocates. @metavivor is so proud to have funded her! #SABCS24
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Oncology Brothers @oncbrothers.bsky.social · 11/12/2024
#SABCS24 Day 1 Highlights #CommunityOnc: 1. @FDAOncology Reviews recent approvals: #Ribociclib & #Inavolisib 2. #PADMA: HR+ ET + CDK4/6i vs Chemo 1L 3. #DB06: HR+ TDXd 4. #KN522: biomarker analysis #OncSky #CanSky @sabcs.bsky.social @drsarahsammons.bsky.social @dr-rshatsky.bsky.social 1/5
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@doublewhammied @doublewhammied.bsky.social · 11/12/2024
Next up, @fredhutch.bsky.social's Dr. Sara Hurvitz moderates a packed panel on clinical approaches to ER+ #metastatic #breastcancer. Happy to see patient advocates on so many panels! #AmyBeumer will be bringing in the patient voice here. #bcsm @oncoalert.bsky.social #sabcs24 #cansky #oncosky
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Hayley Gullen @hayleygullen.com · 12/12/2024
I’m so glad I listened to the oncologist on this. It felt counterintuitive to go for a walk when I was so fatigued from chemo. But it really did help. 1/2 #graphicmedicine #cansky #breastcancer #lifewriting
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Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 12/12/2024
The food you eat may be affecting your body's ability to fight cancer cells. MSK's gastroenterologist Dr. Robin Mendelsohn explains what may be the cause (via @cnn.com ) ⬇️ #cansky
cnn.com
Certain foods may disrupt your body’s fight against cancer cells, study says | CNN
Higher levels of omega-6 fatty acids often found in ultraprocessed foods may interfere with the immune system’s fight against cancer cells, a new study says.
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Reposted by Siobhan Gaynor
Sid Sadler @sadlersnaps.bsky.social · 12/12/2024
Remember for my YAs out there particularly…. More and more advocacy work is needed to show that with a YA #Cancer diagnosis there is much more at play. -time off work -fertility -financially planning -social circle pressure Just some of the things🫶🏻 #Cansky #Oncsky
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Annwen Jones @jonesannwen.bsky.social · 12/12/2024
How chemotherapy has an impact on #ovariancancer and the potential for maintaining its efficacy with immunotherapy. Still early stage research but potentially very promising. #cansky #ovcasky #medsky #TCells healthcare-in-europe.com/en/news/chem...
healthcare-in-europe.com
How chemotherapy affects ovarian cancer tumours
Researchers have discovered how chemotherapy can change tumours, making them more vulnerable to new types of treatments.
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Hannah R. Abrams @hannahrabrams.bsky.social · 12/12/2024
Managing cancer care (appts, meds, messages, billing) is often a full-time job. This survey shows how admin burdens like #PriorAuth make people delay/forgo care. While most (gen non-elderly population) don't encounter billing, >1/3 who do delay/miss care because of it. #CanSky #OncSky #MedSky
Figure showing percentage of patients delaying or forgoing care by admin issue type. 7% delayed care because of prior authorization.

Figure caption: Percent of total respondents who reported any burden, any delayed care, or any foregone care, by administrative task type. Authors' analysis of Q1 2019 Health Reform Monitoring Survey. Percentages are survey‐weighted, unadjusted descriptive statistics. Denominator for all categories is the total sample (n = 4155) There was an inverse relationship between task prevalence and percent of people doing the task who experienced a burden. About one in four people reported delayed and/or missed care related to common tasks such as seeking appointments (24.7%) or seeking information (25.7%). In contrast, delayed and/or missed care was reported by more than a third of people who dealt with a billing problem (36.4%) or prior authorization (37.6%) and nearly half (45.6%) of people who dealt with a premium problem. While people dealing with premium problems were far more likely to report delayed and/or missed care than people seeking appointments, the prevalence of each of these tasks meant that in absolute terms, more people experienced delayed and/or missed care related to appointment seeking (15.7% of the total sample) than to premium problems (3.9% of the total sample).
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@doublewhammied @doublewhammied.bsky.social · 12/12/2024
The study looked at men going thru "active surveillance" 4 their low-risk #prostatecancer. Cool potential here 4 reducing the pt burden since active surveillance involves going in 4 many biopsies, blood draws, MRIs. Today at #SABCS24, active monitoring 4 low-risk #DCIS came up. 👍#cansky #oncosky
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Mike Linn @mike-linn.bsky.social · 13/12/2024
The holidays are stressful. The holidays with cancer are especially stressful. I wrote a blog/made a vlog about some ways to manage this. Easier said than done, but well worth attempting. Blog: mantacares.com/blogs/newsle... Vlog: www.youtube.com/watch?v=VQVk... #thankscancer #cansky #oncosky
mantacares.com
Cancer and Holiday Stress: ‘Tis the Season to Be Kind to Yourself
Guest post by Mike Linn. Opinions are those of the author. Being a cancer patient is easily the most stressful thing I’ve ever gone through. Combining holiday stress with my diagnosis has been a uniqu...
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Claire Saxton @clarinetsax.bsky.social · 13/12/2024
Top reasons #BreastCancer patients gave CancerSupportCommunity.org for not following their treatment plan 👇👇👇 Erica Fortune, PhD, presented findings about treatment tolerability & adherence at #SABCS24. Full poster: bit.ly/3VwuXyq #bcsm #GRASP #SABCS #cansky #oncsky
Reasons for not adhering to treatment plan:

80% To avoid side effects of treatment
67% Treatment interfered with work or daily activities 
62% Treatment interfered with personal life
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Prof Sheena Cruickshank @sheencr.bsky.social · 13/12/2024
Disinformation and Misinformation shared by Steven Bartlett in his so-called health podcast has multiple dubious claims, debunked ‘experts’ including Malhotra and people with stakes in wellness including the host who also makes £££ from the podcasts. 😡😡😡🧪
bbc.co.uk
Steven Bartlett sharing harmful health misinformation on Diary of CEO podcast
Disproven health claims are accepted with little challenge by host on number one podcast, BBC investigation finds.
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Siobhan Gaynor @siobhangaynor.bsky.social · 11/12/2024
www.irishexaminer.com/news/arid-41...
irishexaminer.com
'We are invisible': Survey finds gaps in treatment of women with advanced breast cancer
The survey carried out with Cancer Trials Ireland found one in five women cannot pay their monthly bills and 87% face mental illnesses
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Cancer Trials Ireland @cancertrialsie.bsky.social · 10/12/2024
Can precision cancer care become accessible to all? In this talk, Dr Benedikt Westphalen explores the challenges of access, expertise, and infrastructure and how AI could unlock its potential. 📺 Watch now to learn more: bit.ly/3ZvtlpH #PrecisionOncology #AI
bit.ly
Scaling Precision Oncology – In or Out of Reach?
With Dr. Benedikt Westphalen. Precision oncology offers hope by tailoring cancer treatments to individual molecular and genetic profiles, but how close are we to making it accessible for all? This video explores the challenges and opportunities in scaling precision oncology amidst a global cancer crisis, with 20 million new cases and 10 million deaths annually. Key Discussion Points: 🔬 Challenges: Unequal access to molecular profiling and diagnostics. Limited expertise in interpreting test results. Barriers to accessing targeted therapies. Infrastructure limitations for scaling diagnostics and treatment. 🌟 Opportunities: Harnessing AI and advanced technologies for diagnostics. Integrating genomic testing into standard care practices. Enhancing global collaboration to ensure equal access. Discover how systemic changes, technological innovations, and collaborative efforts could reshape cancer care and unlock the full potential of precision oncology for patients worldwide.
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Science News @scinews.bsky.social · 10/12/2024
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor. #Cell www.cell.com/cell/abstrac...
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Carole (Ducky) (IrPsych) @caroleducky.bsky.social · 10/12/2024
National Cancer Registry Ireland Annual Report 2024. ‘Cancer in Ireland 1994-2022’. www.ncri.ie/sites/ncri/f...
ncri.ie
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Irish Examiner @irishexaminer.bsky.social · 10/12/2024
dlvr.it
Gisèle Pelicot trial: 'This level of depravity? I have never seen anything like it'
Stéphane Babonneau had to watch thousands of videos of Gisèle Pelicot being raped, before disclosing their horror to her. He explains how she found the courage to cope – and to change the world for other survivors
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Dr Kathryn Mannix @drkathrynmannix.bsky.social · 06/12/2024
Without discussing sudden death, pain control with morphine, needing more rest, looking back with gratitude or forward with adjusted hopes, we were able to discuss every aspect of her care with her. Her metaphor. And our astonishing privilege.
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Carole (Ducky) (IrPsych) @caroleducky.bsky.social · 10/12/2024
‘Ireland’s midwest has lowest survival rate for common cancers, report finds.’ www.irishtimes.com/health/2024/...
irishtimes.com
Ireland’s midwest has lowest survival rate for common cancers, report finds
Cancer registry’s annual report examined variation in incidence and survival over a 10-year period
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Hayley Gullen @hayleygullen.com · 10/12/2024
If I’ve learned anything, it’s that our sense of identity (and how we feel other people perceive us) is crucial to our ability to heal. #graphicmedicine #cansky #breastcancer
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Adam Pennycuick @adampennycuick.bsky.social · 10/12/2024
Patients always ask what they can do to improve outcomes. Meta-analysis shows exercise improves fatigue, QoL and dyspnoea in advanced lung cancer buff.ly/3ZHjNcD Found with researchbriefing.com
buff.ly
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Janice Cowden @janicetnbcmets.bsky.social · 10/12/2024
View from the Marriott Rivercenter! All is calm, all is bright ~ the action begins tomorrow! Excited for another fabulous week of education, information, & connection at #SABCS24! Let’s do this! #bcsm @oncoalert.bsky.social #metastaticbreastcancer #PatientAdvocates @sabcs.bsky.social
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Arlene Harris @arleneharris.bsky.social · 10/12/2024
#journorequest - looking to talk to people in Ireland who will be working on Christmas Day - perhaps in hospitality, healthcare, travel, emergency services etc. DM today if any thoughts. RTs appreciated. @dublinairport.bsky.social
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𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡 @arnaudjlegrand.bsky.social · 10/12/2024
📰A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor #CanSky #OncoSky www.cell.com/cell/fulltex...
cell.com
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
Characterization of a common germline variant in PCSK9 unveils a hereditary basis underlying breast cancer metastasis and suggests that PCSK9 inhibition therapy could be a promising strategy for breast cancer metastasis prevention.
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TRAstonDrs @castltrastondrs.medsky.network · 09/12/2024
#MedSky🧪 #OncoSky #publichealth Could #breastcancer survival rates be improved simply by timing treatment to a specific stage of the menstrual cycle? 🐁 & human data suggest sensitivity to #chemotherapy is affected by fluctuations in ovarian hormones. www.nature.com/articles/d41...
nature.com
What is the best time of the month to treat breast cancer?
Sensitivity to chemotherapy is affected by hormonal fluctuations.
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Amy Beumer @amybeumer.bsky.social · 09/12/2024
Re: SONIA results (CDK 4/6i 1st or 2nd line). Post-hoc analysis of lobular v. ductal stuck out for almost favoring 1st line in lobular. Small numbers, tight line in the forest plot --> even more intriguing. Follow up needed and/or consider this in decision making? Thoughts? #lobmob #oncsky #bcsm
nature.com
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer - Nature
The phase 3 SONIA trial challenges the benefits of using cyclin-dependent kinase 4 and 6 inhibitors as a first-line compared with second-line treatment.
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TheBlindboyPodcast @blindboyboatclub.bsky.social · 09/12/2024
I see things like this and I can't help but think that giftedness was a nice way to tell wealthy American parents that their kids were autistic
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Rare Disease Clinical Trial Network @rarediseasectn.bsky.social · 09/12/2024
🌐 Looking for in-depth information on rare disease research? Our website is packed with resources, from ongoing clinical trials to patient involvement and much more! 💡 Explore all that we have to offer 👉 www.rarediseaseresea... #RareDiseases #ResearchMatters #HealthInnovation
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Making Lemonade and Memories @kwadrans.ca · 07/12/2024
The holiday season can be magical, but for those of us with cancer or other challenges, it can feel overwhelming. Feeling rattled, I revisited my 2019 blog post. I hope it helps others navigating cancer during the holidays. buff.ly/3ZsZsGL #Cansky #oncsky #ThanksCancer
buff.ly
What I’m doing about the cancer Grinch who almost stole my Christmas
I love Christmas. I always have. I love the eggnog, decorating the tree with the silver ornaments my parents gave me as an annual Christmas gift, listening to holiday songs. My daughter was also bo…
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Aniket Deshpande @aniketdeshpande.bsky.social · 07/12/2024
Spot on! We all need to be clued on & aware of the possibility of cancer, even in the younger population. Gone are the days when cancer was only considered a disease of the aged…increased research is throwing more light, better testing can pick up cancers early & result in better outcomes
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Rod Ritchie @malefitness.bsky.social · 07/12/2024
This is the best explanation of breast cancer in men published to date. www.mdanderson.org/cancerwise/m... #Cansky #Oncosky #CancerBS
mdanderson.org
Can men get breast cancer? 10 things to know
Breast cancer is often thought of as a woman’s disease. But men can get breast cancer, too. Breast medical oncologist Sharon Giordano, M.D., shares insights about male breast cancer.
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Deb Maes🇨🇦 @dmaes.bsky.social · 07/12/2024
Men get breast cancer too . Please give this a read #cansky#oncsky
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Colm O’Gorman @colm.bsky.social · 06/12/2024
Very low and slow in the oven in a covered heavy or cast iron casserole dish. 150c in a fan oven until the meat is falling off the bone, about 4.5 hours will do to. Baste it every 2 hours and test after 4 hours.
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Cancer Research UK Manchester Institute @cruk-mi.bsky.social · 06/12/2024
For #FollowFriday this week we suggest @ash-hematology.bsky.social - the American Society of Hematology They are very active on @bsky.app ahead of #ASH24, their major annual conference Check out this custom feed: bsky.app/profile/did:... #Oncosky #Cansky (Plus poetry via the #ASHaiku hashtag!)
bsky.app
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Nadine Smith @nadinesmith.bsky.social · 05/12/2024
You are going to be hearing a lot about this book.
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Rare Disease Clinical Trial Network @rarediseasectn.bsky.social · 06/12/2024
Want regular insights into #raredisease research and collaborations? Our newsletter is packed with the latest news, upcoming events, and stories from the #raredisease research community. Subscribe now and never miss an update! eepurl.us8.list-manage.com/subscribe?u=...
A white background with the RDCTN logo and the words 'Autumn Newsletter'
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Hayley Gullen @hayleygullen.com · 06/12/2024
I blamed myself so much when I was diagnosed. This was a) a waste of time and b) entirely understandable, from an emotional perspective. But it wasn’t my fault. And if you’ve been diagnosed it’s not your fault, either. #cansky #breastcancer #lifewriting #graphicmedicine #booksky
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Mater Hospital Foundation @materfoundation.bsky.social · 05/12/2024
"I needed to find a way to get myself back in control. The 1st step I took is a tip I would give all cancer sufferers – #findyourtribe!" Kate is one of the many amazing people who took on our Nov Squat Challenge to support breast cancer care. Read her story - www.materfoundation.ie/mater-storie...
materfoundation.ie
Patient Stories - Kate Byrne - Mater Foundation
Kate was a busy working Mum of 7 adult kids, who felt in control of her body and her world. Then a breast cancer diagnosis from a routine mammogram shocked and angered her, and set her on a journey to...
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Heidi & Mand @laughbeforedeath.bsky.social · 05/12/2024
“Your podcast is funny AND sad” (Feedback on Laugh Before Death) Our podcast is for our #CancerCommunity. We also want family and friends to become the best #CancerAllies they can be. Have a listen and share with your people 😁 open.spotify.com/show/4L343Uh... #cansky #onsky #cancer
open.spotify.com
Laugh before death
Podcast · Heidi Keeling and Mand Black · Imagine being told "you have incurable cancer". How do people 'keep going' despite being told they are dying? This podcast is about cancer, it is about the wi...
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Arlene Harris @arleneharris.bsky.social · 05/12/2024
In today's @belfasttelegraph.co.uk I spoke to a woman about how she has finally distanced herself from the 'toxic' friendship she had been putting up with since childhood and how, thanks to her husband & good friends, she now feels confident and happy. m.belfasttelegraph.co.uk/life/feature...
m.belfasttelegraph.co.uk
Toxic friendships: ‘My friendship with her changed once I met my husband’
For 15 years, they had been the best of friends, with proof of their rapport radiating from our TV screens every day as they sat together on the This Morning sofa.
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Kelly Shanahan @stage4kelly.bsky.social · 04/12/2024
I have a great way for you to donate $15 to METAvivor this #GivingTuesday AND get a gift for yourself or others!! Ageless Zen has put together a sampler pack of their yummy skin care products for only $45, of which $15 is donated to METAvivor!! azcommunitypartnership.com/metavivor-co...
azcommunitypartnership.com
Metavivor Community Partner | AZ Community Partnership
METAvivor Community Partner, supporting those with metastatic breast cancer through advocacy, awareness, and research funding.
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Cancer Trials Ireland @cancertrialsie.bsky.social · 03/12/2024
🌟 New Podcast episode! 🌟 Join Prof. Michaela Higgins and @gerryhanna.bsky.social as they share their journeys from global institutions back to Ireland, highlighting the unique strengths of Irish clinical trials 🇮🇪 🎧 Listen now: bit.ly/4fOXgja #CancerTrials #Podcast
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Siobhan Gaynor @siobhangaynor.bsky.social · 03/12/2024
Patient Survey: www.surveymonkey.com/r/YGNKN5T Partner Survey: www.surveymonkey.com/r/2WC2J38
surveymonkey.com
24-45 PRO-ACT Survey (Patient Version) (Live)
Take this survey powered by surveymonkey.com. Create your own surveys for free.
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Trish Greenhalgh @trishgreenhalgh.bsky.social · 01/12/2024
Loving this new paper on complexity in medicine, using pediatrics as the worked example. Too many medical authors (and the MRC) run fast and loose with the terms 'complexity' and 'complex interventions'. They should read this paper. #medsky #academicsky #philsci 🧪 www.nature.com/articles/s41...
nature.com
If things were simple, word would have gotten around. Can complexity science help us improve pediatric research? - Pediatric Research
Pediatric Research - If things were simple, word would have gotten around. Can complexity science help us improve pediatric research?
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Jarushka Naidoo @drjnaidoo.bsky.social · 01/12/2024
Pleased to share our paper on the impact of severe irAEs in adv NSCLC #TheOncologist - 3211pts, ConcertAI database - 8.6% s-irAEs: diarrhea 3.5%, pneu 1.4% - s-irAEs req steroids/immunosuppression=53%⬆️risk death v no irAE @oncoalert.bsky.social #MedSky #OncSky #LCSM academic.oup.com/oncolo/advan...
academic.oup.com
Management of severe immune-related adverse events and outcomes in patients with advanced non-small cell lung cancer receiving immune checkpoint inhibitors
AbstractBackground. Immune checkpoint inhibitors (ICIs) are associated with severe immune-related adverse events (s-irAEs) that result in hospitalization,
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Joris van de Haar, MD, PhD @joris-vd-haar.bsky.social · 01/12/2024
1/3 In this week’s NEJM: Andre et al report very positive results of dual ICB in MSI cancers. Logical, right? But why is this very interesting from an immunological point of view? About 75% lacks HLA class I. Likely innate immune mechanisms are centrally involved dx.doi.org/10.1158/1078...
dx.doi.org
The Innate Immune Landscape of dMMR/MSI Cancers Predicts the Outcome of Nivolumab Treatment: Results from the Drug Rediscovery Protocol
AbstractPurpose:. The treatment efficacy of nivolumab was evaluated in patients with advanced, treatment-refractory solid mismatch repair deficiency/microsatellite-instable (dMMR/MSI) tumors, and in-d...
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Dr Kathryn Mannix @drkathrynmannix.bsky.social · 30/11/2024
How do we enhance public understanding of #OrdinaryDying? #PalliativeCare peeps, will you be at Palliative Care Congress 2025? Who has ideas & experience about public engagement? Suggest wise voices & effective campaigns from around the globe - there's lots to learn if we listen to each other.
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