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Benjamin Ambrose

@single-mole.bsky.social
672 followers 512 following 32 posts

Single-molecule Biophysicist at London Institute of Medical Sciences 🧬🔬✨ My research interests are all things single-molecule fluorescence and nucleic acids. Other hobbies: archery, chess, sci-fi

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Reposted by Benjamin Ambrose
Anita Meier @anitafmeier.bsky.social · 03/07/2026
Our latest paper is out! 🎉 We show that the HSV-1 origin binding protein UL9 tethers dsDNA thereby forming intramolecular DNA loops and intermolecular DNA tethers. 🤝 www.nature.com/articles/s41...
nature.com
HSV-1 origin binding protein UL9 forms intermolecular DNA tethers and intramolecular DNA loops - Nature Communications
The mechanism of herpes simplex virus type 1 (HSV-1) genome replication remains not fully understood. Here, the authors find that the HSV-1 origin binding protein UL9 does not mediate DNA looping but ...
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Benjamin Ambrose @single-mole.bsky.social · 01/07/2026
KymoSketch started out as a GUI for our kymotracker script, but after I added DeepDiffusion to it I got suggestions to add more features and it’s since become a more fleshed out analysis platform (1/6)
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Reposted by Benjamin Ambrose
Korak Ray @korakray.bsky.social · 30/06/2026
🚨 Preprint alert 🚨 Excited to share our latest bioRxiv preprint introducing DeepDiffusion, a tool for analysing facilitated 1D diffusion! 🔗 Preprint: www.biorxiv.org/content/10.6... (1/3)
biorxiv.org
DeepDiffusion: a Physics-Informed Neural Network for Heterogeneous Facilitated 1D Diffusion
Single-molecule fluorescence microscopy combined with optical tweezers has enabled the direct observation of diffusing proteins on tethered DNA. These and complementary techniques reveal facilitated o...
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Reposted by Benjamin Ambrose
Steve Quinn @steve-quinn-lab.bsky.social · 22/01/2026
Congrats to Jamie et al! Our latest @york.ac.uk work dissecting the structural landscape of the Rep Helicase is now out in Nucleic Acids Research! 🧬🔬 @timcraggs.bsky.social @agnesnoy.bsky.social @bpsiyork.bsky.social @dr-mahmoud.bsky.social @single-mole.bsky.social 👇 tinyurl.com/bdznxur3
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Benjamin Ambrose @single-mole.bsky.social · 02/06/2025
Life is better with more colours!
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Reposted by Benjamin Ambrose
Alex Klotz @aklotz.bsky.social · 18/12/2024
A thread on optical phenomena in The Simpsons
Lenny with a pinhole projection of the sun approaching the Drinking Time line
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Reposted by Benjamin Ambrose
Erin E. Cutts @eecutts.bsky.social · 16/12/2024
Please share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes! Contact me at e.cutts@sheffield.ac.uk For details on how to apply: www.findaphd.com/phds/project...
findaphd.com
Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield on FindAPhD.com
PhD Project - Developing Imaging Solutions to Study the Dynamics of Human Condensin I at University of Sheffield, listed on FindAPhD.com
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Benjamin Ambrose @single-mole.bsky.social · 13/12/2024
Artificial intelligence is going to revolutionise chemistry
Google AI overview result explaining that anhydrous water is water that is free of water
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Benjamin Ambrose @single-mole.bsky.social · 04/12/2024
Whenever I see people talking about how they want to see raw data I can't help but think that everyone means something different when they say raw
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Reposted by Benjamin Ambrose
Manuel Thery @manuelthery.bsky.social · 27/11/2024
Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)
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Reposted by Benjamin Ambrose
Andrew Steele @statto.bsky.social · 21/11/2024
There’s more to rainbows than the human eye can see: here’s how a rainbow extends into the infrared and ultraviolet. Photos: 1. Infrared 2. Visible (obviously) 3. Ultraviolet, and 4. A composite showing how UV is beyond the violet in a rainbow, and IR beyond the red end. 🧪 #photography
An infrared photo of a rainbow: a strange, ghostly-looking rainbow in a mostly black and white photo, with a faintly red outer edge and a cyan inner edge, and what look like a few even fainter ‘echo’ bows insideA regular visible-light pic of a rainbowAn ultraviolet picture of a rainbow: a dark, foreboding landscape with a deep purple stripe emanating from it, and a grey stripe insideA composite of the three preceding photos, showing that the infrared bow is ‘outside’ the visible light rainbow, and the ultraviolet bow ‘inside’
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Reposted by Benjamin Ambrose
DrLachie @drlachie.bsky.social · 19/11/2024
Manuscript: "Using a simple optical setup ... "
The simple optical setup (an infinite optical breadboard with hundreds of optical components placed randomly upon it)
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Benjamin Ambrose @single-mole.bsky.social · 17/11/2024
The starter packs are good but when do we get booster packs
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Benjamin Ambrose @single-mole.bsky.social · 13/11/2024
Lots of people following me this morning even though so far I have only posted a picture of my cat, so I am raising the stakes and posting TWO cats
two fuzzy creatures
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Reposted by Benjamin Ambrose
Johannes Hohlbein @hohlbeinlab.bsky.social · 13/11/2024
First attempt in a (loosely defined) Single-Molecule Biophysics starter pack. Please share and (self-) nominate. go.bsky.app/CteFZM5
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Reposted by Benjamin Ambrose
Korak Ray @korakray.bsky.social · 20/10/2023
🚨 Preprint news!! 🚨 The collaboration with @ckinzthompson on a novel definition of resolution and how it can be used to calculate the local atomic resolution and map-to-model correspondence in cryoEM structures is finally on bioRxiv!!!! www.biorxiv.org/content/10.1... 🧵(1/6)
biorxiv.org
Scale-dependent hierarchical resolution: applications to atomic resolution and model validation in c...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Benjamin Ambrose @single-mole.bsky.social · 30/08/2023
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Benjamin Ambrose @single-mole.bsky.social · 12/08/2023
If you put a ring on the floor a cat will get in it
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Benjamin Ambrose @single-mole.bsky.social · 10/08/2023
This was very useful although it occasionally finds completely the wrong person.
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