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Amanda Sierra

@sierralab.bsky.social
940 followers 209 following 60 posts

Research professor at Achucarro Basque Center for Neuroscience. Microglial lover, passionate about science outreach. ORCID: 0000-0001-8415-096X Lab website: www.achucarro.org/es/laboratory/gli…

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Amanda Sierra @sierralab.bsky.social · 19/12/2025
Reach out if you want to discuss!
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Amanda Sierra @sierralab.bsky.social · 19/12/2025
We discuss limitations of current protocols (including statistical analysis!) and provide recommendations on validating the immunicompetence of microglia in the brain organoids.
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Amanda Sierra @sierralab.bsky.social · 19/12/2025
Our recent review on #microglia and brain #organoids is getting a good reception! 🧠🧪 onlinelibrary.wiley.com/doi/full/10....
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Amanda Sierra @sierralab.bsky.social · 04/09/2025
🧠🧪Funded PhD job offer ok neddylation in glial cells @achucarro.bsky.social Pls repost
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Amanda Sierra @sierralab.bsky.social · 13/08/2025
Join us if you want to learn about #microglia!
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Amanda Sierra @sierralab.bsky.social · 08/08/2025
"Sisterly love" Proliferating neural stem cells🧪🧠
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Amanda Sierra @sierralab.bsky.social · 24/07/2025
Are you interested in human brain #organoids to study #microglia but don't know where to start?🧠🧪 #neuroskyence Here's our piece of advice on "Building Immunocompetent Cerebral Organoids From a Developmental Perspective" onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Building Immunocompetent Cerebral Organoids From a Developmental Perspective
Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statist...
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Reposted by Amanda Sierra
Ʌʗʜʋʗɑɼɼʘ @achucarro.bsky.social · 14/07/2025
The @sierralab.bsky.social lab is hiring! Postdoctoral position in #microglial development (#IKUR) www.achucarro.org/job/postdoct...
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Amanda Sierra @sierralab.bsky.social · 11/07/2025
Reaching Marseille was quite an odissey because of the wildfires, but the #Euroglia meeting was quite a success! Tons of science, friends and fun!
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Reposted by Amanda Sierra
Ʌʗʜʋʗɑɼɼʘ @achucarro.bsky.social · 02/06/2025
@sierralab.bsky.social reflexiona sobre si se puede parar la #menopausia www.elcorreo.com/vivir/salud/...
elcorreo.com
¿Y si pudiéramos evitar la menopausia? | El Correo
Se están desarrollando terapias para rejuvenecer los ovarios y evitar los efectos negativos sobre la salud
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Amanda Sierra @sierralab.bsky.social · 30/05/2025
Pero cámbiate el handle que no sabía que eras tú!
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Amanda Sierra @sierralab.bsky.social · 30/05/2025
Congrats dear Alberto! You rock!
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Amanda Sierra @sierralab.bsky.social · 04/05/2025
This sounds sooo familiar So, maybe, "The next time we hear a crazy/bitch narrative about a senior woman, let's ask ourselves: How much first-hand evidence do we personally have to back it up -- does it resonate with our own direct observations and interactions with her?"
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Carsen Stringer @computingnature.bsky.social · 12/02/2025
#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...
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Amanda Sierra @sierralab.bsky.social · 29/03/2025
Congrats Marisol, you rock!
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Reposted by Amanda Sierra
The Transmitter @thetransmitter.bsky.social · 25/03/2025
Even in the absence of formal instruction to do so, we should continue to hold ourselves and our neuroscience colleagues accountable for “Sex as a Biological Variable” practices, writes @docbecca.bsky.social. #neuroskyence www.thetransmitter.org/sex-differen...
thetransmitter.org
Amid NIH upheaval, how to keep sex as a biological variable
Even in the absence of formal instruction to do so, we should continue to hold our colleagues accountable for SABV practices.
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Amanda Sierra @sierralab.bsky.social · 15/03/2025
My heart is with my fellow american scientists... Politics interfering with science at this level is something I could have never expected
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Amanda Sierra @sierralab.bsky.social · 08/03/2025
Fantastic defense by the ever amazing @martapiglesias.bsky.social! Watch out for more great things to come from her!
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Amanda Sierra @sierralab.bsky.social · 08/03/2025
Thank you Carles!
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Reposted by Amanda Sierra
Eric Topol @erictopol.bsky.social · 01/03/2025
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...
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Amanda Sierra @sierralab.bsky.social · 01/03/2025
Of course, the field has been focused on pruning for too long, disregarding other roles. It's not good for discovery!
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Nuno Miguel Gonçalves @scinuno.bsky.social · 25/02/2025
🗣️ℹ️How do we prevent misinformation? By talking about it, without reservations and full openness. 🧫🐁It is the same with science communication and #AnimalResearch specifically. 💉💡Even if you somehow oppose it… know why it is still needed.
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Amanda Sierra @sierralab.bsky.social · 26/02/2025
Thanks for reaching out! The distinction between hunters or gatherers (culling or scavening) is mechanistic and needs to be experimentally determined. Pruning and gardening are poetic terms but not accurate enough in my opinion. They do not help understanding how microglia actually remove synapses
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Reposted by Amanda Sierra
Federico Soria @soriafn.bsky.social · 04/02/2025
This is today. No recording, so it won't be available in our website. Don't miss it!
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Reposted by Amanda Sierra
Christian Frezza @frezzalab.bsky.social · 31/01/2025
I would love to hear your views on this article. I discuss some hurdles I faced when thinking about experiments and projects design. This is something no one formally teaches you. network.febs.org/posts/thinki...
network.febs.org
Thinking like a scientist: not that trivial
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Amanda Sierra @sierralab.bsky.social · 02/02/2025
🧪🧠
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Reposted by Amanda Sierra
Agnes Nadjar @agnesnadjar.bsky.social · 30/01/2025
Interested in pursuing a PhD in neuroimmunology and metabolism? Apply to this call to work on a collaborative project between my group and @cmadore.bsky.social !
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Amanda Sierra @sierralab.bsky.social · 29/01/2025
"Note, for all the seemingly sophisticated thought and language, the moral indifference born of unintelligence. Here, ChatGPT exhibits something like the banality of evil: plagiarism and apathy and obviation".
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Amanda Sierra @sierralab.bsky.social · 29/01/2025
"On the contrary, the human mind is a surprisingly efficient and even elegant system that operates with small amounts of information; it seeks not to infer brute correlations among data points but to create explanations".
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Amanda Sierra @sierralab.bsky.social · 29/01/2025
"The human mind is not, like ChatGPT a lumbering statistical engine for pattern matching, gorging on terabytes of data and extrapolating the most likely conversational response, most probable answer to a scientific question" Noam Chomsky: The False Promise of ChatGPT www.nytimes.com/2023/03/08/o...
nytimes.com
Opinion | Noam Chomsky: The False Promise of ChatGPT (Published 2023)
The most prominent strain of A.I. encodes a flawed conception of language and knowledge.
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Reposted by Amanda Sierra
European Microglia Webinar Series @microgliaseries.bsky.social · 28/01/2025
📢New webinar coming soon📢  Dr. Gilbert Di Paolo from Denali Therapeutics will be our next speaker on February 4th. Check all the information in the flyer and add it to your calendar!
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Amanda Sierra @sierralab.bsky.social · 16/01/2025
Contact me if you are interested in pursuing an independent position in Neuroscience 🧪🧠 at Achucarro @achucarro.bsky.social calls.ikerbasque.net
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Amanda Sierra @sierralab.bsky.social · 15/01/2025
Any #SpatialTranscriptomics people out there interested in studying #microglial development? We need a collaborator based in the Americas or Asia to apply for a #HSPF grant www.hfsp.org/funding/hfsp...
hfsp.org
Research Grants | Human Frontier Science Program
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Amanda Sierra @sierralab.bsky.social · 14/01/2025
Gorgeous!
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Amanda Sierra @sierralab.bsky.social · 14/01/2025
The floor is open for discussion!
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Reposted by Amanda Sierra
Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 12/01/2025
“‘It’s very easy to assume that science is going to change organically towards equality — and what this study shows is that that’s not happening…It is an ‘important reminder for us that we need to stay vigilant in working towards equality in science’” @crsugimoto.bsky.social 🧪 #AcademicSky 👩🏽‍🔬
nature.com
Who’s quitting academia? Data reveal gender gaps in surprising fields
Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.
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Amanda Sierra @sierralab.bsky.social · 08/01/2025
I think the field needs to reconsider the widespread concept that microglia are The most important factor controlling synaptic pruning.🧠🧪 We offered our Perspective on whether they are hunters or gatherers of synaptic debris here www.nature.com/articles/s41...
nature.com
Microglia as hunters or gatherers of brain synapses - Nature Neuroscience
How microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting synapses shed off by neuro...
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Amanda Sierra @sierralab.bsky.social · 11/12/2024
A very controversial topic in the field, based on a recent survey in twitter
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Amanda Sierra @sierralab.bsky.social · 11/12/2024
Happy to share our Perspective on #microglia #pruning and help to answer the questions of whether they are hunters or gatherers of brain #synapses 🧠🧪 #neuroskyence nature.com/articles/s4159…
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Amanda Sierra @sierralab.bsky.social · 09/12/2024
The call is now open! Junior postdocs deadline: Jan 17 Senior postdocs deadline: Jan 21
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Amanda Sierra @sierralab.bsky.social · 09/12/2024
Thanks for sharing this. I do as much as I can to create a supporting, generous, and uplifting scientific culture in my institution but sometimes I feel I am the dumb one. Certainly, others who only work for themselves do better in terms of publications, awards, etc.
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Amanda Sierra @sierralab.bsky.social · 05/12/2024
Super cool, congrats!
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Amanda Sierra @sierralab.bsky.social · 05/12/2024
🧪🧠 #neuroskyence
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Amanda Sierra @sierralab.bsky.social · 05/12/2024
Mice models, iPSCs, xenotransplants, and organoids in the near future, combined with multimodal microscopy, epigenetics and metabolomics. And lots of pretty pictures!
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Amanda Sierra @sierralab.bsky.social · 05/12/2024
#Microglia lovers, winter is coming and along will come the #JuanDeLaCierva and #RamonyCajal calls for junior and senior postdocs! DM or email me if you are interested in learning how risk genes for neurodegenerative diseases affect microglial early development.
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Amanda Sierra @sierralab.bsky.social · 05/12/2024
Hi Nicola, could you please add the account of the Microglia European Webinar series? @microgliaseries.bsky.social
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Amanda Sierra @sierralab.bsky.social · 05/12/2024
Here is the new account in Bluesky that every #microglia lover or afficionado should follow.🧪 You can find a repository of previous talks at www.achucarro.org/es/european-...
achucarro.org
European Microglia Webinar Series - Achucarro Basque Center for Neuroscience
European Microglia Webinar Series As from October 2023 a group of researchers of the University of Lausanne (CH) and ACHUCARRO have taken over the organization of the European Microglia webinar series...
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Amanda Sierra @sierralab.bsky.social · 03/12/2024
Anybody else experiencing problems with #primerblast? It takes forever or doesn't work at all! Alternatives for designing #qPCR primers, anybody? 🧪
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Amanda Sierra @sierralab.bsky.social · 03/12/2024
Look @eara.eu , another example of animal research succesfully leading to human therapies
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