Amanda Sierra @sierralab.bsky.social · 19/12/2025We discuss limitations of current protocols (including statistical analysis!) and provide recommendations on validating the immunicompetence of microglia in the brain organoids. 131
Amanda Sierra @sierralab.bsky.social · 19/12/2025Our recent review on #microglia and brain #organoids is getting a good reception! 🧠🧪 onlinelibrary.wiley.com/doi/full/10.... 1111
Amanda Sierra @sierralab.bsky.social · 04/09/2025🧠🧪Funded PhD job offer ok neddylation in glial cells @achucarro.bsky.social Pls repost 0810
Amanda Sierra @sierralab.bsky.social · 08/08/2025"Sisterly love" Proliferating neural stem cells🧪🧠 0274
Amanda Sierra @sierralab.bsky.social · 24/07/2025Are you interested in human brain #organoids to study #microglia but don't know where to start?🧠🧪 #neuroskyence Here's our piece of advice on "Building Immunocompetent Cerebral Organoids From a Developmental Perspective" onlinelibrary.wiley.com/doi/10.1002/...onlinelibrary.wiley.comBuilding Immunocompetent Cerebral Organoids From a Developmental PerspectiveConventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statist... 1143
Reposted by Amanda SierraɅʗʜʋʗɑɼɼʘ @achucarro.bsky.social · 14/07/2025The @sierralab.bsky.social lab is hiring! Postdoctoral position in #microglial development (#IKUR) www.achucarro.org/job/postdoct... 005
Amanda Sierra @sierralab.bsky.social · 11/07/2025Reaching Marseille was quite an odissey because of the wildfires, but the #Euroglia meeting was quite a success! Tons of science, friends and fun! 0100
Reposted by Amanda SierraɅʗʜʋʗɑɼɼʘ @achucarro.bsky.social · 02/06/2025@sierralab.bsky.social reflexiona sobre si se puede parar la #menopausia www.elcorreo.com/vivir/salud/...elcorreo.com¿Y si pudiéramos evitar la menopausia? | El CorreoSe están desarrollando terapias para rejuvenecer los ovarios y evitar los efectos negativos sobre la salud 011
Amanda Sierra @sierralab.bsky.social · 30/05/2025Pero cámbiate el handle que no sabía que eras tú! 000
Amanda Sierra @sierralab.bsky.social · 04/05/2025This sounds sooo familiar So, maybe, "The next time we hear a crazy/bitch narrative about a senior woman, let's ask ourselves: How much first-hand evidence do we personally have to back it up -- does it resonate with our own direct observations and interactions with her?" 062
Reposted by Amanda SierraCarsen Stringer @computingnature.bsky.social · 12/02/2025#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41... 613749
Reposted by Amanda SierraThe Transmitter @thetransmitter.bsky.social · 25/03/2025Even in the absence of formal instruction to do so, we should continue to hold ourselves and our neuroscience colleagues accountable for “Sex as a Biological Variable” practices, writes @docbecca.bsky.social. #neuroskyence www.thetransmitter.org/sex-differen...thetransmitter.orgAmid NIH upheaval, how to keep sex as a biological variableEven in the absence of formal instruction to do so, we should continue to hold our colleagues accountable for SABV practices. 1237
Amanda Sierra @sierralab.bsky.social · 15/03/2025My heart is with my fellow american scientists... Politics interfering with science at this level is something I could have never expected 031
Amanda Sierra @sierralab.bsky.social · 08/03/2025Fantastic defense by the ever amazing @martapiglesias.bsky.social! Watch out for more great things to come from her! 020
Reposted by Amanda SierraEric Topol @erictopol.bsky.social · 01/03/2025Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u... 6131241380
Amanda Sierra @sierralab.bsky.social · 01/03/2025Of course, the field has been focused on pruning for too long, disregarding other roles. It's not good for discovery! 010
Reposted by Amanda SierraNuno Miguel Gonçalves @scinuno.bsky.social · 25/02/2025🗣️ℹ️How do we prevent misinformation? By talking about it, without reservations and full openness. 🧫🐁It is the same with science communication and #AnimalResearch specifically. 💉💡Even if you somehow oppose it… know why it is still needed. 043
Amanda Sierra @sierralab.bsky.social · 26/02/2025Thanks for reaching out! The distinction between hunters or gatherers (culling or scavening) is mechanistic and needs to be experimentally determined. Pruning and gardening are poetic terms but not accurate enough in my opinion. They do not help understanding how microglia actually remove synapses 110
Reposted by Amanda SierraFederico Soria @soriafn.bsky.social · 04/02/2025This is today. No recording, so it won't be available in our website. Don't miss it! 001
Reposted by Amanda SierraChristian Frezza @frezzalab.bsky.social · 31/01/2025I would love to hear your views on this article. I discuss some hurdles I faced when thinking about experiments and projects design. This is something no one formally teaches you. network.febs.org/posts/thinki...network.febs.orgThinking like a scientist: not that trivial 93811
Reposted by Amanda SierraAgnes Nadjar @agnesnadjar.bsky.social · 30/01/2025Interested in pursuing a PhD in neuroimmunology and metabolism? Apply to this call to work on a collaborative project between my group and @cmadore.bsky.social ! 0118
Amanda Sierra @sierralab.bsky.social · 29/01/2025"Note, for all the seemingly sophisticated thought and language, the moral indifference born of unintelligence. Here, ChatGPT exhibits something like the banality of evil: plagiarism and apathy and obviation". 000
Amanda Sierra @sierralab.bsky.social · 29/01/2025"On the contrary, the human mind is a surprisingly efficient and even elegant system that operates with small amounts of information; it seeks not to infer brute correlations among data points but to create explanations". 100
Amanda Sierra @sierralab.bsky.social · 29/01/2025"The human mind is not, like ChatGPT a lumbering statistical engine for pattern matching, gorging on terabytes of data and extrapolating the most likely conversational response, most probable answer to a scientific question" Noam Chomsky: The False Promise of ChatGPT www.nytimes.com/2023/03/08/o...nytimes.comOpinion | Noam Chomsky: The False Promise of ChatGPT (Published 2023)The most prominent strain of A.I. encodes a flawed conception of language and knowledge. 130
Reposted by Amanda SierraEuropean Microglia Webinar Series @microgliaseries.bsky.social · 28/01/2025📢New webinar coming soon📢 Dr. Gilbert Di Paolo from Denali Therapeutics will be our next speaker on February 4th. Check all the information in the flyer and add it to your calendar! 142
Amanda Sierra @sierralab.bsky.social · 16/01/2025Contact me if you are interested in pursuing an independent position in Neuroscience 🧪🧠 at Achucarro @achucarro.bsky.social calls.ikerbasque.net 054
Amanda Sierra @sierralab.bsky.social · 15/01/2025Any #SpatialTranscriptomics people out there interested in studying #microglial development? We need a collaborator based in the Americas or Asia to apply for a #HSPF grant www.hfsp.org/funding/hfsp...hfsp.orgResearch Grants | Human Frontier Science Program 027
Reposted by Amanda SierraNeedhi Bhalla 💅🏽 @needhibhalla.bsky.social · 12/01/2025“‘It’s very easy to assume that science is going to change organically towards equality — and what this study shows is that that’s not happening…It is an ‘important reminder for us that we need to stay vigilant in working towards equality in science’” @crsugimoto.bsky.social 🧪 #AcademicSky 👩🏽🔬nature.comWho’s quitting academia? Data reveal gender gaps in surprising fieldsEven in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years. 14430191
Amanda Sierra @sierralab.bsky.social · 08/01/2025I think the field needs to reconsider the widespread concept that microglia are The most important factor controlling synaptic pruning.🧠🧪 We offered our Perspective on whether they are hunters or gatherers of synaptic debris here www.nature.com/articles/s41...nature.comMicroglia as hunters or gatherers of brain synapses - Nature NeuroscienceHow microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting synapses shed off by neuro... 05920
Amanda Sierra @sierralab.bsky.social · 11/12/2024A very controversial topic in the field, based on a recent survey in twitter 020
Amanda Sierra @sierralab.bsky.social · 11/12/2024Happy to share our Perspective on #microglia #pruning and help to answer the questions of whether they are hunters or gatherers of brain #synapses 🧠🧪 #neuroskyence nature.com/articles/s4159… 44110
Amanda Sierra @sierralab.bsky.social · 09/12/2024The call is now open! Junior postdocs deadline: Jan 17 Senior postdocs deadline: Jan 21 021
Amanda Sierra @sierralab.bsky.social · 09/12/2024Thanks for sharing this. I do as much as I can to create a supporting, generous, and uplifting scientific culture in my institution but sometimes I feel I am the dumb one. Certainly, others who only work for themselves do better in terms of publications, awards, etc. 061
Amanda Sierra @sierralab.bsky.social · 05/12/2024Mice models, iPSCs, xenotransplants, and organoids in the near future, combined with multimodal microscopy, epigenetics and metabolomics. And lots of pretty pictures! 170
Amanda Sierra @sierralab.bsky.social · 05/12/2024#Microglia lovers, winter is coming and along will come the #JuanDeLaCierva and #RamonyCajal calls for junior and senior postdocs! DM or email me if you are interested in learning how risk genes for neurodegenerative diseases affect microglial early development. 161
Amanda Sierra @sierralab.bsky.social · 05/12/2024Hi Nicola, could you please add the account of the Microglia European Webinar series? @microgliaseries.bsky.social 000
Amanda Sierra @sierralab.bsky.social · 05/12/2024Here is the new account in Bluesky that every #microglia lover or afficionado should follow.🧪 You can find a repository of previous talks at www.achucarro.org/es/european-...achucarro.orgEuropean Microglia Webinar Series - Achucarro Basque Center for NeuroscienceEuropean Microglia Webinar Series As from October 2023 a group of researchers of the University of Lausanne (CH) and ACHUCARRO have taken over the organization of the European Microglia webinar series... 01710
Amanda Sierra @sierralab.bsky.social · 03/12/2024Anybody else experiencing problems with #primerblast? It takes forever or doesn't work at all! Alternatives for designing #qPCR primers, anybody? 🧪 310
Amanda Sierra @sierralab.bsky.social · 03/12/2024Look @eara.eu , another example of animal research succesfully leading to human therapies 081