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D. Parker Kelley, PhD

@sequencemyneuro.bsky.social
299 followers 215 following 61 posts

Associate Research Scientist in Picard lab @ Columbia University Irving Medical Center Mitochondrial Psychobiology, Psychoneuroimmuno, Stress, PTSD & Psychedelics youtube.com/playlist?list=PL4Ay4xZz…

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Reposted by D. Parker Kelley, PhD
Eric Topol @erictopol.bsky.social · 30/07/2026
Inflammation is a driver of age-related diseases (inflammaging) and this new NYT magazine article gets deep into the progress that is being made to track and block it gift link www.nytimes.com/interactive/...
nytimes.com
Inflammation Keeps Us Alive. It's Also Making Us Sick. (Gift Article)
The discovery that chronic inflammation is a cause of myriad illnesses could be this century's biggest medical breakthrough.
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 17/07/2026
I love this so much. All biomedical research institutions should pay homage to our model organisms who have and will continue to save countless lives and advance our understanding of ourselves into the future!
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 24/06/2026
Super excited about my talk today at PNIRS: Effects of Psilocybin on Biomarkers of Mitochondrial Stress and Inflammation in an open label pilot study of Parkinson’s Disease
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Reposted by D. Parker Kelley, PhD
Meade Krosby @meadekrosby.bsky.social · 08/04/2026
Things that help calm the nervous system, quickly: - Box breathing (in for 4, hold for 4, out for 4, hold for 4, repeat) - Immerse your face in cold water (activates mammalian dive reflex) - Humming (stimulates vagus nerve) - Exercise (anything helps, outside even better) - Impeachment and removal
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 01/04/2026
Wow! This is so cool
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Reposted by D. Parker Kelley, PhD
PessoaBrain @pessoabrain.bsky.social · 01/04/2026
*Neuroscience and philosophy* Given the philosophical/conceptual naivete of all of neuroscience I will be retiring from my faculty position. I'm now looking for positions at philosophy departments and am happy to start at any level. I went from faculty to postdoc before and am ready again.
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Reposted by D. Parker Kelley, PhD
Phil Corlett @philcorlett.bsky.social · 01/04/2026
Lovely work on autoimmunity and its link to psychosis. I wonder what effect this modulation of NMDA receptors has on HALIPs? Less PPI would seem to be the opposite of a strong prior?
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Reposted by D. Parker Kelley, PhD
Eiko Fried @eikofried.bsky.social · 18/03/2026
Overall, I am very grateful to EIC Dost Ongur for letting me write the paper I wanted to write! Feedback very welcome—I submitted a medium size personalize grant on this topic in the Netherlands now to do this 'HPCing' in large-scale data.
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Reposted by D. Parker Kelley, PhD
Eiko Fried @eikofried.bsky.social · 18/03/2026
Hey friends, my new paper was just published in JAMA Psychiatry. I draw on biological species classification to sketch a new framework for psychiatric nosology. Brief summary follows below. Full text link: jamanetwork.com/journals/jam... 🧪 #PsychSciSky #MentalHealth
jamanetwork.com
Mental Disorders as Homeostatic Property Clusters
This narrative review explores the idea of understanding mental disorders according to homeostatic property clusters rather than through typical classification systems.
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Reposted by D. Parker Kelley, PhD
PessoaBrain @pessoabrain.bsky.social · 22/01/2026
𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻? "High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions." Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones. NB: study in the mouse #neuroskyence doi.org/10.1038/s415...
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 23/01/2026
Please use full factorial designs in preclinical psychedelic research! I'm guilty of not doing so in the past, but it will be critical for understanding their MOA going forward. We need to be able to directly compare effects in pathology to those healthy organisms
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Reposted by D. Parker Kelley, PhD
Metabolic Wellth Lisa @metabolicwellth.bsky.social · 27/12/2025
Excellent interview... VERY interesting insights on stress vs mitochodrial energy balance. I wonder how much impact on stress adaptation can be gained by increasing mitochondrial resilience w keto/low carb/ Fasting and the right amount of Exercise stress (hiit, resistance trng)
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 10/12/2025
I had a fantastic discussion about our Allostatic Triage Model of Psychopathology (ATP Model) and the potential mitochondrial and metabolic effects of psychedelics with @metabolicmind.bsky.social Thanks so much for having me on! Check er out: youtu.be/-e49-DwCZ9A?...
youtu.be
Could Stress Be The Hidden Driver of Mental Illness?
YouTube video by Metabolic Mind
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 06/11/2025
Congrats @carmensandi10.bsky.social !!
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Reposted by D. Parker Kelley, PhD
Martin Picard @martinpicardenergy.bsky.social · 30/10/2025
Metabolism is an energetic circuitry that transcends cellular and organellar boundaries www.nature.com/articles/s42...
nature.com
The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease - Nature Metabolism
Bolaños and Magistretti illustrate how intercellular metabolic cooperation underpins brain function and provide examples of how disruption of the neuron–astrocyte metabolic unit contributes to disease...
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 23/10/2025
Wait so midazolam is an antidepressant? Wut?
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Parker Singleton @parkersingleton.bsky.social · 20/10/2025
Hot off the press!
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Reposted by D. Parker Kelley, PhD
Martin Picard @martinpicardenergy.bsky.social · 17/10/2025
The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria. The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social www.sciencedirect.com/science/arti...
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 20/10/2025
🚨Publication alert! 🚨 Why does stress drive psychopathology & transdiagnostic disease? We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens. www.sciencedirect.com/science/arti...
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josh hardman @josh-hardman.bsky.social · 28/08/2025
Pα+ Psychedelic Bulletin #207 - Lykos Rebrands to Resilient - Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision - AbbVie-Gilgamesh Deal Viewed as Validation - Psilocybin Rescheduling Petition Heads to HHS - Much, much more... psychedelicalpha.com/news/p%ce%b1...
psychedelicalpha.com
Pα+ Psychedelic Bulletin #207: Lykos Rebrands to Resilient; Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision; AbbVie-Gilgamesh Deal Viewed as Validation - Psychedelic Alpha
Lykos Therapeutics Rebrands to Resilient Pharmaceuticals • Pharma Pushes Back on Norway’s Off-Label Ketamine Decision • AbbVie–Gilgamesh Deal Viewed as Validation for Short-Acting Psychedelics •
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Reposted by D. Parker Kelley, PhD
Parker Singleton @parkersingleton.bsky.social · 26/08/2025
I'm near certain sLFOs are big for psychedelics.
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Reposted by D. Parker Kelley, PhD
Ted Satterthwaite @ted-satterthwaite.bsky.social · 18/08/2025
Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!
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Drug Monkey @drugmonkey.bsky.social · 18/08/2025
It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit. You all have my sympathies. Unfair doesn’t even begin to describe it.
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Parker Singleton @parkersingleton.bsky.social · 18/08/2025
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...
SYPRES (Synthesis of Psychedelic Research Studies) logo
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 18/08/2025
Such a beautiful project! This is the exact sort of framework we need to advance progress going forward.
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josh hardman @josh-hardman.bsky.social · 29/07/2025
Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) Reporting by @jasteralaina.bsky.social. The entire Dispatch is now free to read. psychedelicalpha.com/news/dispatc...
psychedelicalpha.com
Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) - Psychedelic Alpha
In this second Dispatch from the inaugural Neurobiology of Psychedelics Gordon Research Conference, Dr. Alaina Jaster recaps Days 2 through 4, highlighting cutting-edge research on neuroplasticity…
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Reposted by D. Parker Kelley, PhD
Alaina Jaster, PhD @jasteralaina.bsky.social · 30/07/2025
Since its founding in 2021 by myself and Zarmeen Zahid as Your Brain on Science, it's expanded into Psychedelic Brain Science, to encompass the larger goal of including all things psychedelic including research, policy and culture. Now we’re expanding further to provide services! Check it out!
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Reposted by D. Parker Kelley, PhD
Micah G. Allen @micahgallen.com · 30/07/2025
I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!
nature.com
Stomach–brain coupling indexes a dimensional signature of mental health - Nature Mental Health
Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and i...
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Alaina Jaster, PhD @jasteralaina.bsky.social · 23/07/2025
Check out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social psychedelicalpha.com/news/dispatc...
psychedelicalpha.com
Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Plasticity, Psychotherapy, and Perception (Part 1) - Psychedelic Alpha
Here, we share Dr. Alaina Jaster’s observations from the inaugural Neurobiology of Psychedelics Gordon Research Conference, where leading scientists gathered to explore various realms of psychedelic…
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Leah Mayo @mayoonthebrain.bsky.social · 19/07/2025
Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶 Per usual, I took no pics - but luckily Missy had it covered for me 😂
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Keira Aubin @keiraaub.bsky.social · 18/07/2025
Attending the first psychedelic GRC organized by @alexkwan.bsky.social & @vyazovskiy.bsky.social was surreal. The internationally representative panels ensure we are collectively/efficiently advancing our understanding of psychedelics. Special thanks to @mayoonthebrain.bsky.social for bringing me ❤️
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Alaina Jaster, PhD @jasteralaina.bsky.social · 18/07/2025
Bring out the dancing lobsters 🦞🕺 #GRCPsychedelics @sequencemyneuro.bsky.social @fredbarrettphd.bsky.social @tanner-anderson.bsky.social
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Alex Kwan @alexkwan.bsky.social · 18/07/2025
Everyone approves of the dinner to end the #GRCPsychedelics 🦞 @deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart
Dinner at GRC Psychedelics
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 17/07/2025
Obviously the mitochondria is the best organelle. 1 can leave cell, but stays 2 own genome 3 regulates nuclear gene expression 4 can kill whole cell 5 makes energy, distributes it to orchestrate cellular processes 6 controls whole organisms behavior 7 makes (sex, growth, stress, etc) steroids
organelle.xn--its-so0a
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Alex Kwan @alexkwan.bsky.social · 17/07/2025
Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪
Climbing with fellow scientists at Psychedelics GRC
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Alex Kwan @alexkwan.bsky.social · 17/07/2025
Great panel this morning on the human and clinical studies of psychedelics - my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics
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Nate Heller @nate-h-heller.bsky.social · 17/07/2025
@sofiyahupalo.bsky.social @cllantz.bsky.social @sequencemyneuro.bsky.social @oliverk28.bsky.social @christineliu.art @matt-spec.bsky.social @svmahler.bsky.social @callimcflurry.bsky.social @torbenott.bsky.social @mikaelpalner.bsky.social @ramosneuro.bsky.social
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Nate Heller @nate-h-heller.bsky.social · 17/07/2025
🌈🧠 The Trip Between Bedside and Bench 🌈🧠 Join us at #SfN2025 for a deep dive into cross-species research in psychedelic neuroscience! 🧬 Posters, 🎤 panels, 🔑 keynotes, 🍸 cocktails, and 🥟 tasty apps await. RSVP, explore speaker profiles, and help spread the word: 👉 hopkinspsychedelic.org/sfn2025
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Argel Aguilar Valles @argelaguilarvalles.bsky.social · 16/07/2025
I had a great time at #GCRpsychedelics, discussing our data on the non-hallucinogenic derivative of LSD, alongside a stellar panel of researchers! Very grateful to @alexkwan.bsky.social and @vladvysotsky.bsky.social for inviting me and putting together a very exciting program!
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Alex Kwan @alexkwan.bsky.social · 15/07/2025
Thank you #NIMH #NIDA and #BrainInitiative for an informal panel at the #GRCPsychedelics to answer questions regarding grant funding. 🙏
NIH funding opportunities panel at the psychedelics GRC conference.
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Alex Kwan @alexkwan.bsky.social · 14/07/2025
Poster session in full swing. Lots of exciting unpublished work. #GRCPsychedelics
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Vinny Costa @vincentcostaphd.bsky.social · 13/07/2025
Going to open an escape room where hippocampus researchers have to solve riddles without using space as an explanation for everything
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 27/05/2025
Psilocybin only enhances fear extinction when its hippocampus-dependent (trace/context), and only in a sub-population of mice. Anybody have an explanation? I’ve got ideas, but curious what other are thinking about this ? www.nature.com/articles/s41...
nature.com
Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles - Nature Neuroscience
Rogers et al. show that psilocybin enhances fear extinction, suppresses fear neurons and recruits extinction neurons in the retrosplenial cortex in mice, providing evidence that its effects are linked...
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Saganism @sagan.bsky.social · 30/04/2025
This is from The Tonight Show with Johnny Carson aired on May 20th, 1977. Carl Sagan says something very important, a strong message that didn't lose any validity since then.
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 29/04/2025
Wowzers, a peripheral mitokine,GDF-15 mediates anxiety behavior caused by restraint stress through the GFRAL receptor in the brain stem! “Anxiety-like behaviour elicited by adrenaline or restraint stress is eliminated in mice lacking the GDF15 receptor GFRAL” www.nature.com/articles/s42...
nature.com
GDF15 links adipose tissue lipolysis with anxiety - Nature Metabolism
Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 29/04/2025
Incredibly grateful to have had the opportunity to visit the Shulgin lab last weekend. Sasha Shulgin discovered the empathogenic properties of MDMA and first synthesized DOI, an important tool for psychedelic research, among myriad other important compounds.
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Bryan Roth @zenbrainest.bsky.social · 02/04/2025
' this study provides evidence of a dementia-preventing or dementia-delaying effect from zoster vaccination ' www.nature.com/articles/s41...
nature.com
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 02/04/2025
Fascinating! Do we think this vaccine is cross reacting with another virus that contributes to dementia, or that this is explained by other off target effects unrelated to viral pathogens?
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D. Parker Kelley, PhD @sequencemyneuro.bsky.social · 20/03/2025
Yuge paper! Long awaited CryoEM structures for seven psychedelics.
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Doby Rahnev @dobyrahnev.bsky.social · 25/02/2025
I'm not sure that our study necessarily implies that one should not average trials - averaging will always have its place. However, our results do show that there is substantial and meaningful variability across trials that is lost when averaging. #neuroscience #neuroskyence
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