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Mikael Palner @mikaelpalner.bsky.social · 17/02/2026

We were trying to confirm the precens of DMT in the brain and in particularly in serotonin neurons. But to our surprice, DMT is neither in the brain or taken up by serotonin nerve terminals! www.sciencedirect.com/science/arti...

sciencedirect.com

N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain

Mammalian brain may contain an endogenous pool of the psychedelic substance N,N-dimethyltryptamine (DMT), which may act as a co-transmitter with serot…

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Mikael Palner @mikaelpalner.bsky.social · 21/09/2025

Was interviewed by Double Blind Magazine about the mushrooms extend lifespan hype. They wrote a delightful piece about how much mushroom was given. To quote them "That’s a fuckton of mushrooms for 95% of people". I wonder about how the last 5% are doing? doubleblindmag.com/was-the-life...

doubleblindmag.com

Was the Life-Extending Psilocybin Study All Hype?

One academic says yes. PLUS an interview with an Onanya, AI generated DMT visuals, and psilocybin's impact on shame.

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Mikael Palner @mikaelpalner.bsky.social · 28/08/2025

Psilocybin as an longevity drug? Not really! I wrote a piece in @theconversation.com about why this claim is way out of proportions. theconversation.com/why-the-magi...

theconversation.com

Why the magic mushroom anti-ageing claims are overblown

The magic mushroom longevity study that’s too good to be true.

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Reposted by Mikael Palner

Zero-Noise Lab @zeronoiselab.bsky.social · 31/07/2025

What shifts in our brain when our consciousness shifts? On Sept 8-9, we will explore this question at ESI-SyNC 2025 - with exciting talks, posters and discussions on the neural dynamics of altered consciousness, from psychedelics to breathwork, near-death experiences and meditation. (1/2)

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Reposted by Mikael Palner

Alex Kwan @alexkwan.bsky.social · 17/07/2025

We worked so well as a team for the #GRCPsychedelics @vyazovskiy.bsky.social @viditavaidya.bsky.social @melissaherman.bsky.social and congrats to @theborislab.bsky.social and @mikaelpalner.bsky.social, who will be the future vice-chairs!

Chairs and vice chairs for the Psychedelics GRC

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Reposted by Mikael Palner

Alex Kwan @alexkwan.bsky.social · 17/07/2025

Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪

Climbing with fellow scientists at Psychedelics GRC

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Reposted by Mikael Palner

James W. Jesso | Adventures Through The Mind @jameswjesso.bsky.social · 26/02/2025

One more clip from my interview with @mikaelpalner.bsky.social. In this one, he outlines a neurological definition for a psychedelic "microdose" according to binding occupancy at the serotonin receptor. And, of course, what that means. youtu.be/gG3JmDo_liU

youtu.be

A neural level definition of psychedelic microdosing, with Dr. Mikael Palner

YouTube video by Adventures Through The Mind

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Mikael Palner @mikaelpalner.bsky.social · 24/02/2025

I love my new office hallway mates, DEI 💪

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Mikael Palner @mikaelpalner.bsky.social · 17/02/2025

Visited @jameswjesso.bsky.social **Adventures Through The Mind** podcast to talk about microdosing, psilocybin and translation of psychedelic science from rats to humans. #microdosing #psilocybin

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Reposted by Mikael Palner

James W. Jesso | Adventures Through The Mind @jameswjesso.bsky.social · 14/02/2025

I talk with Dr. Mikael Palner from Southern Denmark University about his research on the effects of chronic low dose (microdose) psilocybin on stress resiliency and compulsive behaviours. www.jameswjesso.com/microdosing-... #psychedelics #microdosing #psychedelicscience

jameswjesso.com

Microdosing Psilocybin; Effects on Stress Resiliency and Compulsive Behaviours | Dr. Mikael Palner ~ ATTMind 194

Dr. Mikael Palner discusses his research on the effects of microdosing psilocybin on stress resiliency and compulsions.

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Mikael Palner @mikaelpalner.bsky.social · 27/01/2025

Really feeling the #wcbr, if you are around join us for the panel on micodosing tomorrow afternoon. New research will be presented 🏂🏻

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Mikael Palner @mikaelpalner.bsky.social · 23/01/2025

With president Trump hitting hard on science in the US, I want to let all my fellow US researchers know that Danish foundation provides quite a lot of postdoctoral and sabattical funding for visiting US citizens. Reach out if you want to know more or collaborate while this goes down.

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Mikael Palner @mikaelpalner.bsky.social · 12/01/2025

Are you thinking of measuring synaptic plasticity in the living rat brain? Maybe after psychedelic-induced neuroplasticity, as David E Olson suggests in his recent commentary in the American Journal of Psychiatry Check out our SV2A images using [18F]SynVest-1 #psychedelic #neuroplasticity #invivo

SV2A imaging in the living rat brain using the tracer 18F-SynVest-1

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Mikael Palner @mikaelpalner.bsky.social · 15/12/2024

Do serotonergic psychedelics (like LSD, psilocybin, and 2C-B) all induce the same acute changes in brain activity? Our research in rats says they have some common features but also some distinctly different ones. The images below are from our newest preprint.

Differences in the acute effects of Psilocybin, LSD and 2C-B on sugar metabolism

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Mikael Palner @mikaelpalner.bsky.social · 11/12/2024

Klemens Egger analyzed the effects of pharmahuasca on whole-brain metabolism in rats. Interestingly, while the combination of harmine and DMT increased the levels of DMT in the brain significantly, we could measure 5-HT2A occupancy. Additionally, all conditions increased thalamic activity. #dmt

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Mikael Palner @mikaelpalner.bsky.social · 28/11/2024

Last year, we used 5-HT2A PET (see my previous post) to establish science-backed psilocybin microdosing in rats based on human occupancy data from Madsen et al. (2019). We proved that microdosing of psilocybin induces behavioral and neurobiological changes in rats! www.nature.com/articles/s41...

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Mikael Palner @mikaelpalner.bsky.social · 25/11/2024

Moving to a new lab is fantastic. 🐀 Reconnecting the cables, installing the machines and taking photos through a plastic bag is challenging 🤔

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Mikael Palner @mikaelpalner.bsky.social · 23/11/2024

In 2008, Matthias Herth produced [18F]MHMZ, a PET tracer I love. My lab uses it extensively to map the 5-HT2A receptors in living rat brain and measure occupancy of psychedelics, like psilocybin below. Don't tell me 1mg/kg is not enough ;)

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Mikael Palner @mikaelpalner.bsky.social · 22/11/2024

How will the world look in 25 years if my research turns out to be a breakthrough? That question was posed to me by Third Ear Studio and Denis Rivin 🔹🔺🔸. In their latest series "2049". We're talking about mental illnesses and psychedelic substances. thirdear.studio/da/pods/2049

thirdear.studio

2049 | Third Ear Studio

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