iiinova — where your digital self keeps evolving

SBGrid Consortium @sbgrid.bsky.social · 18h

Request personal credentials to install & maintain a subset of software on laptops or home workstations. It's free for all users in SBGrid member groups & ensures that you have access to the same software tools whether at home or in the lab. Request credentials here: buff.ly/inuva2Q #StayConnected

buff.ly

https://sbgrid.org/registration/register/?utm_source=AdaptiveMailer&utm_medium=email&utm_campaign=SBGrid%20Newsletters&org=1935&lvl=100&ite=649&lea=37746&ctr=0&par=1&trk=a0NNv000002M9JdMAK

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SBGrid Consortium @sbgrid.bsky.social · 02/10/2026

Our September Tale features Shawn Zheng. At @biohub.org, Zheng's algorithm devevelopment team continues to develop AreTomoLive for reconstructing tomograms & data denoising, while casting an eye toward particle picking. Read more here: buff.ly/Ogt15Ms #Stayconnected #SBGridTales

buff.ly

Proteins at Work

Shawn Zheng

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SBGrid Consortium @sbgrid.bsky.social · 30/09/2026

SBGrid's eLife paper received a citation in August from Guy Schoehn from IBS Grenoble – Research group in Journal of Molecular Biology: High-resolution Structure of the Vaccinia Virus Phospholipase D-fold Endonuclease K4. Read more here: buff.ly/lADXxht #SBGrid #StayConnected

sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S0022283626003347?ctr=0&ite=648&lea=37746&lvl=100&org=1935&par=1&trk=a0NNv000002C9UbMAK&utm_campaign=SBGrid%20Newsletters&utm_medium=email&utm_source=AdaptiveMailer

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SBGrid Consortium @sbgrid.bsky.social · 29/09/2026

Upcoming events from our partners at @instruct-eric.bsky.social Instruct SI CryoEM Workshop 2026, Single Particle Analysis November 10-12, 2026 | National Institute of Chemistry, Ljubljana, Slovenia Application deadline: October 2, 2026 Register here: buff.ly/A834j32 #SBGrid #Collab

instruct.si

instruct.si is for sale

We're building something great. More details coming soon.

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SBGrid Consortium @sbgrid.bsky.social · 28/09/2026

SBGrid's eLife paper received a citation in August from Bo Liang from Emory University School of Medicine in Microorganisms MDPI: Unreacted RSV Polymerase Structures Expand the Post-Translocation Landscape of the Nucleotide Addition Cycle. Read more here: buff.ly/FIoDOHt #SBGrid #ScienceMatters

mdpi.com

Unreacted RSV Polymerase Structures Expand the Post-Translocation Landscape of the Nucleotide Addition Cycle

Respiratory syncytial virus (RSV) RNA synthesis relies on RNA-dependent RNA polymerase, a complex composed of the L and P proteins. We recently resolved four major structural states of the RSV…

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SBGrid Consortium @sbgrid.bsky.social · 24/09/2026

New Member Alert: @angelasteinauer.bsky.social from École Polytechnique Fédérale de Lausanne joined SBGrid in August. Welcome!!

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SBGrid Consortium @sbgrid.bsky.social · 24/09/2026

Technical Notes: XDS licensing change XDS is now licensed through DECTRIS & will remain freely available for nonprofit users w/ the added bonus that time-bound version limitations no longer apply. The first release from DECTRIS is out (see software changes below for details). #SBGrid #Updates

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SBGrid Consortium @sbgrid.bsky.social · 22/09/2026

Technical Notes: macOS 27 expected this fall Apple is expected to release macOS 27 in the fall, & as w/ many new operating system releases, we recommend that users delay updating until the bugs are worked out. Contact us at bugs@sbgrid.org to report any problems you encounter. #SBGrid #Updates

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SBGrid Consortium @sbgrid.bsky.social · 21/09/2026

New Member Alert: Stephen Ragsdale from @umich.edu Medical School joined SBGrid in August. Welcome!!

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SBGrid Consortium @sbgrid.bsky.social · 18/09/2026

SBGrid's eLife paper received a citation in August from Peter Dahlberg at Stanford University in @pubs.acs.org Nano: Cryo-Electron Tomography Reveals Nanoscale Thick Filament Disorganization in MYH7 P710R Hypertrophic Cardiomyopathy Cardiomyocytes. Read more here: buff.ly/XPuZ85a #SBGrid

pubs.acs.org

Cryo-Electron Tomography Reveals Nanoscale Thick Filament Disorganization in MYH7 P710R Hypertrophic Cardiomyopathy Cardiomyocytes

Abstract. Hypertrophic cardiomyopathy (HCM) is the most common monogenic inherited heart disease and is a major cause of sudden death in individuals under

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SBGrid Consortium @sbgrid.bsky.social · 16/09/2026

Fisk University student Cariuna Ellison's highlight features a @pnas.org paper from Kate Ferguson's lab at @yale.edu School of Medicine. Ferguson's group identifies the activation mechanisms of an important protein receptor, EGFR, linked to cancer. Read more here: buff.ly/iCcj7Wu #SBGrid #Protein

medium.com

Brake-ing Down Protein Activation and Signaling

This publication highlight is part of the SBGrid Communities Project focused on science education and demonstrating how structural biology…

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SBGrid Consortium @sbgrid.bsky.social · 15/09/2026

New Title Alert: OCTOPI- is a deep-learning framework for automated 3D particle picking in cryo-electron tomography, with tools for training and running 3D U-Net models and automatically exploring model configurations. More here: buff.ly/WXgAVEN #SBGrid #Software

github.com

GitHub - Biohub/octopi: Search for Protein 3D Coordinates in CryoET Tomograms

Search for Protein 3D Coordinates in CryoET Tomograms - Biohub/octopi

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SBGrid Consortium @sbgrid.bsky.social · 10/09/2026

The not so easy job of protecting our DNA: a publication in @natsmb.nature.com from the lab of Nikola Pavletich at @mskcancercenter.bsky.social in which researchers describe the structure of ATR-ATRIP complex bound to its two activators. Read more here: buff.ly/S5IWOVw #SBGrid #DNARepair

medium.com

The not so easy job of protecting our DNA

SBGrid member Nikola Pavletich reports on the structure of ATR-ATRIP complex bound to two activators, revealing key DNA-damage checkpoints.

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SBGrid Consortium @sbgrid.bsky.social · 09/09/2026

August's software push includes - AlphaFold3, AlphaPulldown, AmberTools, CCP4, Chromap, COOT, cryoDRGN, DIALS, Foldtree, ICM Browser, NMRFx-Anaylst, OpenFold3, Open Force Field Toolkit, OpenMM, pyCoAn, pytom-match-pick, RDKit, Scipion, Schrödinger, Warp, and XDS. More here: buff.ly/wN9LYyJ #SBGrid

sbgrid.org

SBGrid Consortium - Software Updates

The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…

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SBGrid Consortium @sbgrid.bsky.social · 08/09/2026

Community Announcement: Instruct.SI CryoEM Workshop 2026, Single Particle Analysis 11/10-11/12, 2026 | National Institute of Chemistry, Ljubljana, Slovenia Register here: buff.ly/cdTUjrU

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SBGrid Consortium @sbgrid.bsky.social · 08/09/2026

New Event Alert: The SBGrid CryoEM Cloud Tournament! Teams worldwide will analyze the same confidential, unpublished CryoEM dataset in a preconfigured AWS cloud environment, competing to deliver the most accurate, efficient, & scientifically useful results. More here: buff.ly/LvTjHbb #SBGrid #AWS

sbgrid.org

SBGrid Consortium - News and Events - Call to Participate: SBGrid CryoEM Cloud Tournament

The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…

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SBGrid Consortium @sbgrid.bsky.social · 07/09/2026

New Member Alert: In August, @yoonseokkim.bsky.social from École Polytechnique Fédérale de Lausanne joined SBGrid. Welcome!!

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SBGrid Consortium @sbgrid.bsky.social · 07/09/2026

Our software webinar series will resume in October with Beata Turoňová, Group Leader at the @mpibp.bsky.social, introducing cryoCAT. Until then, you can catch up on webinars you missed from our last series on the SBGrid YouTube channel. More here: buff.ly/p1w3J7S #SBGrid #Webinars

youtube.com

SBGrid Consortium

For structural biologists, by structural biologists! The SBGrid TV channel was developed with participation from many members of the structural biology community. We welcome suggestions for topics to…

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SBGrid Consortium @sbgrid.bsky.social · 04/09/2026

Our August Tale features Prof. Mihnea Bostina, who reflects on his scientific transit across the globe & finally making his home in New Zealand. From his laboratory at the @universityofotago.bsky.social. Read more here: buff.ly/Af3qVLc #SBGridTales #StayConnected

medium.com

Viruses for Good

Mihnea Bostina works from his New Zealand lab at University of Otago to harness the therapeutic potential lurking in viruses.

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SBGrid Consortium @sbgrid.bsky.social · 31/08/2026

New Member Alert: Taha Shahid from the @unibirmingham.bsky.social joined SBGrid in July. Welcome!!

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SBGrid Consortium @sbgrid.bsky.social · 26/08/2026

New Title Alert: Hax- is a package that includes several tools to study conformational heterogeneity from CryoEM data. More here: buff.ly/u9NPogU #SBGrid #Software #StructuralBiology

github.com

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SBGrid Consortium @sbgrid.bsky.social · 24/08/2026

New Member Alert: In July, Lisa Olshansky from University of Illinois at Urbana-Champaign joined SBGrid. Welcome!!

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SBGrid Consortium @sbgrid.bsky.social · 20/08/2026

Community Announcement: Mass Photometry to support Structural Biology Research 10/13/26 | Virtual Join to learn about how to access Mass Photometry technologies through Instruct-ERIC and hear from scientists who have used Mass Photometry in their research. Register here: buff.ly/0c3VcSn

instruct-eric.org

Instruct-ERIC Industry Webinar - Mass Photometry to support Structural Biology Research - In Collaboration with Refeyn

On Tuesday 13 October Instruct-ERIC are hosting a webinar in collaboration with Refeyn, to discuss Mass Photometry and how it can benefit your research. <p style="text-align:…

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SBGrid Consortium @sbgrid.bsky.social · 19/08/2026

New Title Alert: DisVis- is a Python package and command line tool to visualize and quantify the accessible interaction space of distance restrained binary biomolecular complexes. More here: buff.ly/3AlzIzu hashtag#SBGrid hashtag#Software hashtag#StructuralBiology

lnkd.in

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SBGrid Consortium @sbgrid.bsky.social · 18/08/2026

New Member Alert: Arthur Neuberger from @lmu.de joined SBGrid in July. Welcome!!

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SBGrid Consortium @sbgrid.bsky.social · 14/08/2026

New Member Alert: In July, Hector Aguilar-Carreno from @uofcalifornia.bsky.social, Los Angeles joined SBGrid. Welcome!!

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SBGrid Consortium @sbgrid.bsky.social · 12/08/2026

New Title Alert: copick- is a cross-platform, storage-agnostic & server-less dataset API for cryoET datasets. Access to the data is provided through an object-oriented API that abstracts away the underlying storage using the fsspec-family of libraries. More here: buff.ly/ZBe5Vpd #SBGrid #Software

copick.github.io

Bundled Page

Tools for collaborativecryoET annotation.\n \n\n \n □XY slice · z = {{ depthLabel }}\n \n \n \n \n \n \n \n \n \n…

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SBGrid Consortium @sbgrid.bsky.social · 11/08/2026

Community Announcement: @instruct-eric.bsky.social Webinar Series: Structure Meets Function 49 9/15/2026 | Virtual Join to hear an overview of services available through 2 facilities that recently joined Instruct-ERIC: the European XFEL and Forschungszentrum Jülich Register here: buff.ly/LEePbMx

instruct-eric.org

Instruct-ERIC Webinar Series: Structure Meets Function 49

The latest webinar in the Instruct-ERIC Structure Meets Function series this month includes speakers who have accessed cutting-edge structural biology services through Instruct. The webinar series…

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SBGrid Consortium @sbgrid.bsky.social · 10/08/2026

Welcome to Vina Nguyen of Lipscomb University, a new contributor to our student desk! Vina chose to highlight a publication from the lab of Mihnea Bostina at @universityofotago.bsky.social appearing in @jmolbiol.bsky.social. Read more here: buff.ly/ulnyjG8 #SBGrid #CryoEM #PhageTherapy

medium.com

Small viruses can have a big impact on human health

SBGrid member Mihnea Bostina reports on Bas18 and its potential uses in therapeutics, vaccines, and food safety.

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SBGrid Consortium @sbgrid.bsky.social · 07/08/2026

Technical Notes: July's software push includes updates to 20 titles:BCFtools, Blast+, Chimera, CcpNmr Analysis, Fiji, GROMACS, Icecream, IMOD, LigPlot+, MODELLER, NMRPipe, OpenEye, OpenFold3, RDKit, SAMtools, Schrödinger, Scipion, TEMPy-ReFF, tomoDRGN, and Warp. More here: buff.ly/sJAne31 #SBGrid

sbgrid.org

SBGrid Consortium - Software Updates

The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…

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SBGrid Consortium @sbgrid.bsky.social · 06/08/2026

Open the Floodgates: How NC1 Makes TRPM4 Destroy Cancer Cells: a highlight featuring a paper from Youxing Jiang at UT Southwestern Medical Center that appeared in Nature Communications. Read more here: buff.ly/HMAQINf #SBGrid #Necrosis #Cancer

medium.com

Open the Floodgates: How NC1 Makes TRPM4 Destroy Cancer Cells

SBGrid member Youxing Jiang investigates NC1, a small molecule that activates a cancer ion channel, causing overload and cancer cell death.

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SBGrid Consortium @sbgrid.bsky.social · 05/08/2026

New Title Alert: Leopard-EM (Location & oriEntatiOn of PARticles found using two-Dimensional tEmplate Matching) is a python package for running two-dimensional template matching (2DTM) on cryo-EM images. More here: buff.ly/FZ5bVfZ #SBGrid #Software #StructuralBiology

lucaslab-berkeley.github.io

Leopard-EM Homepage - Leopard-EM: Two-Dimensional Template Matching in Python

Overview of the Leopard-EM package for 2DTM in Python

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SBGrid Consortium @sbgrid.bsky.social · 04/08/2026

We finished our 2025-2026 Software Webinar season in July with a presentation from @mgflast.bsky.social on Ais, Pom, and easymode. In case you missed it, you can find the recorded version on the SBGridTV YouTube channel: buff.ly/kbQNcdx #Webinars #SBGrid #StructuralBiology

youtube.com

Ais, Pom, and easymode

SBGrid webinars are hosted with partial support from the NIH R25 Continuing Education for Structural Biology Mentors #GM151273, in collaboration with Co-PI Jamaine Davis of Belmont…

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SBGrid Consortium @sbgrid.bsky.social · 04/08/2026

New Title Alert: warpylib- is a Python library replicating core functionality from [WarpLib](buff.ly/t1bv8gU), a C# framework for cryo-electron tomography (cryo-ET) data processing. Built on PyTorch for GPU acceleration and automatic differentiation. More here: buff.ly/j81TW5L #SBGrid #Software

buff.ly

GitHub - warpem/warp

Contribute to warpem/warp development by creating an account on GitHub.

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SBGrid Consortium @sbgrid.bsky.social · 31/07/2026

New Member Alert: José Maria Valpuesta from @cnb-csic.bsky.social joined SBGrid in June. Welcome!!

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SBGrid Consortium @sbgrid.bsky.social · 31/07/2026

SBGrid's eLife paper received a citation in June from@cryoet.bsky.social from The Johns Hopkins University School of Medicine in @pnas.org: Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15. Read more here: buff.ly/nRGFvb0 #SBGrid #StayConnected

buff.ly

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 | PNAS

Tip links connect the stereocilia of mechanosensory hair cells in the inner ear and transmit force onto mechanotransduction (MET) channels. Tip lin...

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SBGrid Consortium @sbgrid.bsky.social · 30/07/2026

New Member Alert: Jose-Jesus Fernandez from Health Research Institute of Asturias (ISPA) joined SBGrid in June. Welcome!!

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