A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...

Abstract. Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is the most common form of valvular heart disease, affecting 2% of those o

The agency long benefited from broad bipartisan support. But Republican criticism has intensified, and new choices for top health posts hope to upend the organization.

A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals.

SARS-CoV-2 infection can lead to long-lasting neurological sequelae, but underlying mechanisms are unclear. Rong et al. report that SARS-CoV-2 spike protein persists in the skull-meninges-brain axis, ...

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

SARS-CoV-2 infection can lead to long-lasting neurological sequelae, but underlying mechanisms are unclear. Rong et al. report that SARS-CoV-2 spike protein persists in the skull-meninges-brain axis, ...

Disrupted endothelial function underlies the multiorgan complications of COVID-19

Researchers reviewed the benefits, practicalities, and harms of masks and masking, finding that masks are effective in reducing respiratory disease transmission despite some adverse effects, and empha...

The landmark move is expected to shorten wait times for organs for all patients and reduce hurdles to life-saving care for those with HIV.

Concentrations of RNAs and proteins provide important determinants of cell fate. Robust gene circuit design requires an understanding of how the combined actions of individual genetic components influ...

Abstract. The coronavirus disease (COVID-19) pandemic has occurred in Massachusetts in multiple waves led by a series of emerging variants. While the evide

As the director of the National Institutes of Health, Dr. Jay Bhattacharya would oversee the world’s premier medical research agency, with a $48 billion budget and 27 separate institutes and centers.

Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The S1P-S1PR signalling axis is...

Hänggi et al. investigate how tumor necroptosis regulates anti-tumor immunity and find an unexpected role for interleukin-1α (IL-1α) release by dying cells in promoting tumor growth by driving recruit...

Microbial biofilms contain subpopulations of cells that display metabolic and transcriptional diversity. Here, Korshoj & Kielian present an optimized bacterial single-cell RNA sequencing method an...

imageimageTranscriptome-wide measurement of subcellular mRNA dynamics in mouse ES cells reveals that nuclear retention is the rate-limiting step in the life-cycle of most mRNAs and provides a resource...

Chromothripsis (CT) is a type of genome instability which is prevalent in medulloblastoma with germline TP53 mutations (Li-Fraumeni syndrome, LFS). Here the authors combine single-cell genomic and tra...