BACKGROUND: Calcific aortic valve disease, commonly manifesting as aortic stenosis, is a leading cause of mortality with no effective therapy. We previously identified CROT (carnitine O-octanoyltransf...

This is a Research Topic initiated by ISACB, the International Society for Applied Cardiovascular Biology. This collection will showcase cutting-edge advance...

This is a Research Topic initiated by ISACB, the International Society for Applied Cardiovascular Biology. Despite significant advances in global health, Rhe...

This is a Research Topic initiated by ISACB, the International Society for Applied Cardiovascular Biology. Aortic stenosis, largely driven by calcific aortic...

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BACKGROUND: Calcific aortic valve stenosis is a global clinical burden, impacting around 2% of the population over 65 years of age. No pharmacotherapeutics exist, with surgical repair and transcathete...

BACKGROUND: Carotid atherosclerosis is orchestrated by cell-cell communication that drives progression along a clinical continuum (asymptomatic to symptomatic). Extracellular vesicles (EVs) are cell-d...

BACKGROUND: Carotid atherosclerosis is orchestrated by cell-cell communication that drives progression along a clinical continuum (asymptomatic to symptomatic). Extracellular vesicles (EVs) are cell-d...

Early-career researchers describe how they juggled workloads, emotions and finances after having children.

BACKGROUND: Calcific aortic valve stenosis (CAVS) is a global clinical burden, impacting around 2% of the population over 65 years of age. No pharmacotherapeutics exist, with surgical repair and trans...

Abstract. Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is the most common form of valvular heart disease, affecting 2% of those o

Abstract. Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is the most common form of valvular heart disease, affecting 2% of those o

Aortic stenosis (AS) due to fibrosis and calcification of the aortic valve is a hazardous component of cardiovascular disease burden—after developing symptomatic AS, patients survive for an average of...

The design and proteomics-based assessment of a high-throughput 3D-bioprinted model of calcific aortic valve disease is reported.

BACKGROUND: Fewer than 50% of patients who develop aortic valve calcification have concomitant atherosclerosis, implying differential pathogenesis. Although circulating extracellular vesicles (EVs) a