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Sarah Guest

@sarahmoeba.bsky.social
241 followers 331 following 37 posts

Postdoc in the Fritz-Laylin lab, fascinated by obscure protists. Evolutionary Cell Bio research on amoebae & cytoskeleton. Sometimes art. she/her.

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Reposted by Sarah Guest
FocalPlane @focalplane.bsky.social · 25/09/2026
ICYMI: the recording of our second webinar on emergent models and quantitative analysis of cell migration is now available. 🔬🎥Check it out to see talks from @ankita13jha.bsky.social, @raphclement.bsky.social and @katrinavelle.bsky.social focalplane.biologists.com/2026/09/25/f...
focalplane.biologists.com
FocalPlane features... cell migration recordings with Ankita Jha, Raphaël Clément and Katrina Velle - FocalPlane
FocalPlane features... cell migration recordings with Ankita Jha, Raphaël Clément and Katrina Velle - News
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Chung Hyun Cho @chc-evobio.bsky.social · 04/07/2026
Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...
biorxiv.org
Emergence of histone-based chromatin complexity in Asgard archaea
The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...
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Katrina Velle @katrinavelle.bsky.social · 09/06/2026
After a long hiatus, happy #MicroscopyMonday! Here are some amoebae squeezing themselves into narrow channels (part of a video for our preprint pubmed.ncbi.nlm.nih.gov/41377514/). Sound effects by Dillon (my 4 month old who may have had a little to do with the bluesky hiatus!)
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Nigel Goldenfeld @nigelgoldenfeld.bsky.social · 13/06/2026
Eukaryotic evolution via massive HGT "Our relative timing estimates suggest early interactions between an Asgard archaea and a Planctomycete (bacterium) ... Thus, the prokaryotic-to-eukaryotic transition was probably a gradual and complex process, with a constant flow of HGT from diverse sources."
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Dylan Burnette @mag2art.bsky.social · 13/06/2026
Not all cells do the whole membrane blebbing thing the same. Some of them get weird about it. This is a single cell videoed through a DIC microscope. #CellBiology
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c0nc0rdance @c0nc0rdance.bsky.social · 11/06/2026
What in the name of Beetlejuice ARE these things? They're zebra morphs of 'squat lobsters', likely in genus Allogalathea. They're not true lobsters & are more closely related to hermit crabs. Now which one is white with black stripes & which is black with white stripes? (📷: hoopderscotch)
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franz @franzanth.bsky.social · 09/06/2026
the only character creation sliders that matter #InvertebrateShitposting
a badly drawn quadrant. the top axis is marked leggy, bottom no leggy. right side lomg, left side no lomg. on the top right, lomg leggy, is a badly drawn centipede, bottom right lomg no leggy is a worm, top left no lomg leggy is an isopod, bottom left no lomg no leggy is a blobby sea urchin with visible butthole
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EMBO @embo.org · 09/06/2026
Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! 🧪 www.embo.org/press-releases/embo-go…
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Dylan Burnette @mag2art.bsky.social · 19/05/2026
A dividing cell videoed through a microscope. Hot tip: Don't mess around with myosin II paralogs if you don't want your cells to freak out. #CellBiology www.cell.com/cell-reports...
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Ben Larson @blarson.bsky.social · 19/05/2026
And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered. www.pnas.org/doi/10.1073/... Stay tuned for what is shaping up to be some fascinating follow-up in the lab...
Scanning electron microscopy image of the ciliate Euplotes gigatrox on the cover of the journal PNAS. Distinct punk rock vibes
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ISEP @isepprotists.bsky.social · 20/04/2026
New #ISEPpapers by @ankarn.bsky.social et al.! Living together: evolutionary and ecological dimensions of #protist endosymbiosis academic.oup.com/microlife/ar... #Protists #Microbes #Symbiosis #Evolution
illustration of five different microbial cells and some of the chemicals they exchange with their environment
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Brendan Harley @profharley.bsky.social · 18/03/2026
That's almost 4 years of funding for the NIH. Across the country, labs are shutting down and the next generation of scientists are seeing their futures destroyed. But let's just go buy a lot of bombs....
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Sainsbury Laboratory Cambridge University (SLCU) @slcuplants.bsky.social · 12/03/2026
Hiding in plain sight! 2.3M conserved non-coding sequences traced back 300M years across 284 plant species Ground-breaking study out in First Release @science.org from labs of @madelaineb.bsky.social, @idane.bsky.social & Zach Lippman ▶️ doi.org/10.1126/scie... ▶️ www.slcu.cam.ac.uk/news/hiding-...
Phylogeny of the 284 species of plants included in Conservatory data set. Conservatory uncovered ~2.3 million conserved non-coding DNA sequences across 284 plant species from 72 families including eudicots, monocots, gymnosperms, and algae. Illustrations by Professor Madelaine Bartlett.
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Marco Grillo @mgrillo.bsky.social · 12/03/2026
Do you work with a strange model species and are frustrated by the lack of antibodies for immunos? Here's a web app that does some computational pre-screening for you. sixpack-abscan.serve.scilifelab.se
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Sophie G Martin @sophiemartinlab.bsky.social · 03/03/2026
You are finishing your PhD and looking to continue in science? The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro.... Thanks for reposting!
mocel.unige.ch
Contact/Job - Department of Molecular and Cellular Biology - UNIGE
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John Burns @burnsajohn.bsky.social · 20/02/2026
Do the dance, do the algal dance.
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Sergio Muñoz-Gómez @sergiophyceae.bsky.social · 23/12/2025
End-of-year preprint dump! A collaboration with @messorensen.bsky.social and German and Korean colleagues: "The phylogenetic context for the origin of a unique purple-green photosymbiosis " doi.org/10.64898/202...
P. tenue, its symbionts, and natural habitat
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Sarah Guest @sarahmoeba.bsky.social · 22/12/2025
Happy solstice! These ice crystals on our windshield might have delayed the morning trek into lab, but they're at least pretty to look at! ❄️
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Philip Donoghue @phil-donoghue.bsky.social · 03/12/2025
Our latest, led by the inimitable Chris Kay "Dated gene duplications elucidate the evolutionary assembly of eukaryotes" in which we used gene duplications to test hypotheses of eukaryogenesis. TLDR? They're all wrong. With @tweethinking.bsky.social @anya1.bsky.social @ssolo.bsky.social Davide Pisani
nature.com
Dated gene duplications elucidate the evolutionary assembly of eukaryotes - Nature
Analysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.0–2.25 billion years ago as a result of mitochondrial endosymbiosis with complex ar...
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Gautam Dey @gautamdey.bsky.social · 26/11/2025
Our attempt to give multinucleate cells the spotlight they deserve (seriously, they’re everywhere), led by the fearless @mrosjac.bsky.social and with @Markus Ganter doi.org/10.32942/X2M... We’d love your feedback while this goes through the peer review process! #MicroEvoSky #ProtistsonSky 🧪🌏
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H. B. Beryl Rappaport @hbrappap.bsky.social · 25/11/2025
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth! #protistsonsky 🧵
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Sarah Guest @sarahmoeba.bsky.social · 17/11/2025
Our work on Naegleria Myosin 2 is out! Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea. Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling. Read more: www.cell.com/current-biol...
cell.com
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage
Myosin 2-dependent actin contractility—the force that powers cell division and migration in animals, fungi, and other Amorphea—had been previously unknown outside this single eukaryotic group. Guest e...
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Kirk Amundson @kirkamundson.bsky.social · 10/11/2025
Finally out! We measured mutations in tetraploid potato. Highlights: - higher mutation rates in L1 than L2 - even higher rates and a distinct oxidative stress signature outside of meristems - lower mutation rates in genes everywhere we looked More 👇 www.pnas.org/doi/10.1073/pnas.2514507122
nam10.safelinks.protection.outlook.com
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Tanmay Bharat @tbharat-lab.bsky.social · 07/11/2025
An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...
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Katrina Velle @katrinavelle.bsky.social · 06/11/2025
Just under a month left—apply by December 5 through the link on my website!
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 31/10/2025
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...
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Kirk Amundson @kirkamundson.bsky.social · 31/10/2025
Our lab’s variegated peperomia makes green flecks on leaves, but only on the abaxial side. It’s the typical sandwich: L1 green-L2 yellow-L3 green, so guessing flecks are L1-derived cells dividing periclinally into L2. But how only on the abaxial side? Something to do with the super thick epidermis?
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Sarah Guest @sarahmoeba.bsky.social · 29/10/2025
Just for fun, here's a game I like to call "Find the neuron" with examples of olfactory sensory neuron images from Šmít et al 2017 (doi.org/10.7554/eLif...) and Filoreta ramosa, a free-living syncytial amoeba from a salt marsh.
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Sarah Guest @sarahmoeba.bsky.social · 29/10/2025
My PhD work is up on bioRxiv! Read all about the #actin and #microtubule #cytoskeleton of the Rhizarian #amoeba Filoreta ramosa here: www.biorxiv.org/content/10.1...
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Sarah Guest @sarahmoeba.bsky.social · 25/10/2025
Autumn is just the best
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John Burns @burnsajohn.bsky.social · 17/06/2025
This is glorious! And diatoms are as weird as ever!
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Jürgen Strassert @strassert.bsky.social · 13/06/2025
Happy to have contributed to this great article: #Protist genomics: key to understanding eukaryotic evolution. Congrats Alexandra Schoenle et al. #ProtistsOnSky authors.elsevier.com/sd/article/S...
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Journal of Eukaryotic Microbiology @jeukmicro.bsky.social · 05/06/2025
Highlighted paper! Daisuke Yamagishi, et al. open a new front in the drive to understand photosymbiosis in protists. Article➡️ doi.org/10.1111/jeu.... #protistsonsky
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Sarah Guest @sarahmoeba.bsky.social · 03/06/2025
An amoeba movie I made: "hungry" #protistsonsky #amoeba
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Ben Larson @blarson.bsky.social · 15/05/2025
I contributed an essay and some images to the new Living Futures series, an outgrowth of the fantastic Living Histories series organized by Sri Biswas and others. medium.com/@thelhseries... iyerbiswas.com/outreach/liv... 1/3
medium.com
Microbial Marvels, Microscopes, Math, and Mentorship
by Ben Larson for Living Futures
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Sarah Guest @sarahmoeba.bsky.social · 02/06/2025
Poor dude can't catch dinner #protistsonsky #amoeba
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Peter Gleick @petergleick.bsky.social · 31/05/2025
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.
Graphs showing 25 years of budgets for the National Institute of Health, NASA, and the NSF. In all cases, the proposed budget for next year is far, far below any year of the previous quarter century.
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Sarah Guest @sarahmoeba.bsky.social · 30/05/2025
Another bog friend #protistsonsky
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John Burns @burnsajohn.bsky.social · 12/03/2024
The inside of our net was coated with these tiny jelly balls. I asked @blancobercial.bsky.social if they were some kind of ctenophore, but he said (enthusiastically) "No! These are #Rhizaria!" He is holding a single cell here. #marinelife #protistsonsky
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Kenneth Dumack @dumack.bsky.social · 23/05/2025
Evidence for #recombination, and maybe #meiosis, in free-living #Rhizaria! I wish the results were clearer. As so often we raised more questions than we could answer :) If you are into #sex and the #meiosis-toolkit, this is an important read! #ProtistsOnSky link.springer.com/article/10.1...
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Hugh Ford @dictyostelium.bsky.social · 21/05/2025
New paper out in @pnas.org We followed cells migrating along signalling gradients in 3D, and found they collectively behave as a living droplet - a self-propelling fluid that grows. www.pnas.org/doi/10.1073/...
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bioRxivpreprint @biorxivpreprint.bsky.social · 19/05/2025
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage www.biorxiv.org/content/10.1101/202…
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Sarah Guest @sarahmoeba.bsky.social · 28/05/2025
A quick craft project: hand-cut phase annuli from construction paper to fit an "adopted" microscope that was missing ph1 ph2 and ph3
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Sarah Guest @sarahmoeba.bsky.social · 21/05/2025
Acanthocystis (maybe?) from the same bog sample. Sometimes amoebae don't need phase contrast, especially if they're full of zoochlorellae/plastids! #protistsonsky #bogblog
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Sarah Guest @sarahmoeba.bsky.social · 21/05/2025
A lucky find- Lesquereusia in the middle of division! When finished, it will fill the second test (shell) that it built. Local bog sample. #testateamoebae #protistsonsky
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Katrina Velle @katrinavelle.bsky.social · 12/04/2025
It was a very productive week in lab! We now have Naegleria fowleri (brain-eating amoeba) cultures growing, in addition to the Naegleria gruberi (harmless relative) cultures we have been using as a model. Put side-by-side, it is impossible to tell them apart.
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Kenneth Dumack @dumack.bsky.social · 04/04/2025
🧠🦠🚨 New preprint alert! We’ve built the first trait database for Amoebozoa, and showcase ecological insights and evolutionary patterns. If you're into protists, soil ecology, or functional biodiversity - this is for you! #ProtistsOnSky #MicroSky 🧵👇
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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 21/03/2025
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)
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Elizabeth Beston @elizabethbeston.bsky.social · 26/03/2025
SHUT UP! Did I just see this? *rubs eyes*. How amazing are these amoebae??? This is a timelapse and I adore seeing their pseudopodia stretch out as they head towards each other. Was it the food? Was it defence? Was it love? What do you think? 🦑 #plankton #protistsonsky
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Vasily Zlatogursky @zlatogursky.bsky.social · 28/03/2025
@amoebadiscovery.bsky.social made an iteresting interview with me about #heliozoa and #centrohelids - I think these organisms are really important, understudied and gorgeous 😍 Also lots other intresting reading and beatiful pictures! #protistsonsky link: tinyurl.com/adiscovery1
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