Molecular Psychiatry - Early oligodendrocyte dysfunction signature in Alzheimer’s disease: Insights from DNA methylomics and transcriptomics

Molecular Psychiatry - Early oligodendrocyte dysfunction signature in Alzheimer’s disease: Insights from DNA methylomics and transcriptomics

Current research is increasingly highlighting the role of oligodendrocytes in neurodegeneration and specifically in dementia. Explore this theme across disease areas in the upcoming symposium White…

Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...

C9orf72 repeat expansion, a leading cause of ALS/FTD, triggers selective neuronal death. Using a Drosophila model, Shen et al. identified vulnerable and resistant neuronal populations. Resistance corr...

Dr Imre Lengyel at Queen's University Belfast is seeking a PhD Student to explore 'Revolutionizing Multiple Sclerosis and Alzheimer’s disease Monitoring: The Role of Retinal Imaging in Understanding D...

Myeloid cells undergo large changes to their gene expression profile in response to inflammatory stimulation. This includes an increase in post-transcriptional modifications carried out by adenosine-t...

DNA methylation drives parental expression differences at imprinted genes. Here, the authors uncover hundreds of ubiquitous and tissue-specific differentially methylated regions, offering insights int...

Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels increased survival of Droso...

Within the CNS, lipids have vital roles in numerous cellular functions and the maintenance of lipid homeostasis is essential for brain health. Bogie and colleagues explore the mechanisms that regulate...

The UCL Genetic Therapy Accelerator Centre is seeking a Research Assistant to work on translational AAV gene therapy project for Parkinson’

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Dr Nurun Fancy at Imperial College London is seeking a PhD Student to explore the role of LRRK2 in cellular senescence in Parkinson's Disease

MSH3 lowering by antisense oligonucleotides dose-dependently reduces CAG repeat expansions in iPSC-derived neurons from a patient with HD.

Professor Siddharthan Chandran at The University of Edinburgh is seeking a Postdoc Fellow to work on understanding the biology of MND for Drug Discovery.

Induced pluripotent stem cell (iPSC) models are powerful tools for neurodegenerative disease modelling, as they allow mechanistic studies in a human genetic environment and they can be differentiated ...