The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.

The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.

Secretion of ligands of the human epidermal growth factor (EGFR) family of receptors or erythroblastic leukemia viral oncogene family (ERBB1-4) is a feature common to many cancer cells. However, our u...

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

Kovalski et al. perform a genome-wide CRISPRi screen for selective MYC mRNA translation regulators and identify RBM42 as a ribosome-associated protein that modulates translation of MYC and an oncogeni...

Metabolic adaptations are key to cancer cell survival in nutrient-limited microenvironments, but strategies for coping with arginine scarcity are poorly understood. Dunlap et al. use CRISPR screening and metabolomics to identify the plasma membrane transporter SLC7A5 as a citrulline transporter essential for cancer cell growth under arginine limitation.

ALT: a stack of gift boxes with the words happy boxing day below

ALT: bart simpson is talking to santa claus who is laying in a chair

Morrison and colleagues show long-chain fatty acid oxidation has context-dependent effects on hematopoietic stem cells (HSCs). It is dispensable for HSC function in young mice. It becomes necessary for normal HSC function and hematopoiesis in older mice. A high-fat diet increases fatty acid oxidation, and this impairs HSC function.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Intent to Publish a Funding Opportunity Announcement for Academic Career Excellence (ACE) Award (K32 - Indepe...

Pancreatic ductal adenocarcinoma (PDA) evades immune detection partly via autophagic capture and lysosomal degradation of major histocompatibility complex class I (MHC-I). Why MHC-I is susceptible to ...

Pancreatic ductal adenocarcinoma (PDAC) tumors are deficient in glutamine, an amino acid that tumor cells and CAFs use to sustain their fitness. In PDAC, both cell types stimulate macropinocytosis as ...

Congratulations to Ashani T. Weeraratna, PhDTME Working Group Chair-elect 2025-2026 Our thanks to Ashani T. Weeraratna, PhD, and Marina Pasca di Magliano, PhD, for standing for election, and to the TM...