iiinova — where your digital self keeps evolving

Rockefeller University Press @rupress.org · 3h

In @jem.org, Jiaojiao Zhang, Tian Zhao, Hong Lei, Rui Gan et al. identify the transcription factor GABPA as a critical regulator of STING expression, pivotal for antiviral defense and inflammatory diseases. rupress.org/jem/article/... #InnateImmunity #inflammation #Lupus #SLE

000

Rockefeller University Press @rupress.org · 4h

In @jhumimmunity.org, Swamy et al. describe an Australian/New Zealand cohort where identification of monogenic #InbornErrorsOfImmunity through next-generation sequencing resulted in management change in 84% of cases including guiding #HSCT & initiating targeted treatment. rupress.org/jhi/article/...

000

Rockefeller University Press @rupress.org · 4h

In @jem.org, Thornton et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, and Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose -specific #autoimmunity. rupress.org/jem/article/...

000

Rockefeller University Press @rupress.org · 30/09/2026

In @jhumimmunity.org, Galli, Recher et al. describe two patients w/ hypogammaglobulinemia associated w/ #MyotonicDystrophy type 1 (DM1), a rare and underdiagnosed monogenic neuromuscular disorder & provide clues to aid clinical immunologists in making a correct diagnosis. rupress.org/jhi/article/...

rupress.org

Antibody deficiency in myotonic dystrophy type 1: A differential diagnosis below the radar

Galli, Recher et al. describe two patients with hypogammaglobulinemia associated with myotonic dystrophy type 1 (DM1), a rare and underdiagnosed monogenic

001

Rockefeller University Press @rupress.org · 30/09/2026

In @jcborg, Elfarkouchi, Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...

000

Rockefeller University Press @rupress.org · 28/09/2026

In @jem.org, Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults w/ HSV encephalitis (5%) compared w/ the general population rupress.org/jem/article/...

100

Rockefeller University Press @rupress.org · 25/09/2026

In @jem.org, Yang Yu, Yanling Zhao, Zhongcheng Shi, Larry L. Wang et al. demonstrate that CAMKV, previously classified as a nonfunctional pseudokinase, possesses intrinsic kinase activity driven by MYC/MYCN oncogenes to promote #neuroblastoma growth. rupress.org/jem/article/...

000

Rockefeller University Press @rupress.org · 25/09/2026

Insights @jem.org: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. By Hee Yeun Won & Jung-Hyun Park rupress.org/jem/article/...

011

Rockefeller University Press @rupress.org · 25/09/2026

In @jem.org, Tomás Huerta, Kevin Tracey, Isaac Chiu, and @changsbrain.bsky.social review the organization and function of vagal neuroimmune circuits, from afferent cytokine sensing to organ-specific efferent immune control. rupress.org/jem/article/... #BioelectronicMedicine #Neuroimmunology

010

Rockefeller University Press @rupress.org · 25/09/2026

In @jcb.org, Sydir, Lee, Pellman et al. @harvard.edu @danafarber.bsky.social identify an #ESCRT-independent pathway for #NuclearEnvelope assembly in S. japonicus that involves the conserved proteins, Vid27 and Alx1. rupress.org/jcb/article/... #CellCycle #CellDivision #Genetics #Biochemistry

010

Rockefeller University Press @rupress.org · 24/09/2026

In @jhumimmunity.org, Patel, Cooper, Zimmerman et al. describe an elderly woman w/ severe chronic #neutropenia caused by mosaic #TLR8 GOF, broadening a primarily pediatric, male disease spectrum & highlighting somatic mosaicism as an important diagnostic consideration rupress.org/jhi/article/...

000

Rockefeller University Press @rupress.org · 18/09/2026

In @jhumimmunity.org, Chong et al. examine the clinical utility of skin biopsy, an inexpensive & widely available test, in 16 patients and show that dyskeratotic keratinocytes in the superficial layers are useful for diagnosing #AOSD. rupress.org/jhi/article/...

012

Rockefeller University Press @rupress.org · 18/09/2026

In @jem.org, Ovezgeldiyev, Trefzer, Doolan, @boucheryt.bsky.social et al. reveal a metabolic pathway linking lipid mediator production to #macrophage activation during #helminth immunity. rupress.org/jem/article/... #Metabolism #InnateImmunity #inflammation #InfectiousDisease #HostDefense

000

Rockefeller University Press @rupress.org · 16/09/2026

Read Dr. Koike and colleagues’ JGP article, “A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness Open Access.” hubs.la/Q04t83Z60 Find more commentary in Research News coverage, “The origins of oscillations.” hubs.la/Q04t83WG0

000

Rockefeller University Press @rupress.org · 16/09/2026

“JGP is one of the increasingly rare journals where editorial decisions remain firmly centered on scientific merit.” — Chieko Koike, Ritsumeikan University Learn more about @jgp.org: hubs.la/Q04t83Z10

100

Rockefeller University Press @rupress.org · 16/09/2026

In @jem.org, Florez-Paz & Mentis demonstrate the presence of supernumerary synapses during development, resulting in miswired immature spinal circuits. Two molecularly distinct mechanisms are responsible for their refinement, incl. a surprising CD47-dependent mechanism rupress.org/jem/article/...

000

Rockefeller University Press @rupress.org · 16/09/2026

In @jhumimmunity.org, Taniguchi et al find the prevalence of autoantibodies neutralizing type I IFNs is significantly higher in Japanese patients w/ hepatitis C than in age-matched healthy controls, & is even higher in those treated w/ IFN-α than in untreated individuals rupress.org/jhi/article/...

000

Rockefeller University Press @rupress.org · 16/09/2026

In @jem.org, Zhang et al. identify RalA-dependent signaling as a regulator of age-related #skeletalmuscle dysfunction. Novel compound UA-30 inhibits RalA activity, reduces muscle fibrosis, improves mitochondrial function & mobility & extends health span & survival in mice rupress.org/jem/article/...

000

Rockefeller University Press @rupress.org · 16/09/2026

In @jcb.org, Pengwei Zhao, Mengyuan Zhang, Rongbin Ding et al. develop constitutive and inducible #Golgi reporter mice that enable in vivo visualization of Golgi architecture and Golgiphagy at single-cell resolution. rupress.org/jcb/article/... #Technology #Organelles

000

Rockefeller University Press @rupress.org · 15/09/2026

In @jhumimmunity.org, Tomomasa et al. describe a clustering of patients w/ IRAK4 deficiency identified in Okinawa, Japan. All affected families carried the homozygous c.123_124insA variant, which suggests a founder effect & supports the implementation of newborn screening rupress.org/jhi/article/...

000

Reposted by Rockefeller University Press

Tim @timisstuck.bsky.social · 11/09/2026

For the 125th birthday of @rockefeller.edu my colleagues at @rupress.org created this beautiful booklet ✨✨

112

Rockefeller University Press @rupress.org · 11/09/2026

Dr. Daniel Kastner, former NHGRI Scientific Director, was a visionary physician-scientist whose discoveries transformed the understanding of innate immunity and established the modern field of autoinflammatory diseases. Gupta et al. pay tribute @jhumimmunity.org: rupress.org/jhi/article/...

011

Rockefeller University Press @rupress.org · 11/09/2026

In @jcb.org, Gourkanti et al. @neal-lab.bsky.social show that the rhomboid protease Rhbdl2 restrains #macrophage recruitment & wound repair in #zebrafish, positioning Rhbdl2 as a potential brake on macrophage-driven repair rupress.org/jcb/article/... #Migration #motility #Immunology

021

Rockefeller University Press @rupress.org · 10/09/2026

Heart rate is controlled, in part, by the opening and closing of the ion channel HCN4. In @jgp.org, Blecker, Bankston and colleagues describe the functionally relevant domains of both the channel and its ER-resident potentiator, IRAG. rupress.org/jgp/article/... #Biophysics #IonChannels

000

Rockefeller University Press @rupress.org · 10/09/2026

In @jem.org, Michalets et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. rupress.org/jem/article/...

000

Rockefeller University Press @rupress.org · 10/09/2026

📢 Attention #undergraduates, #gradstudents, and early-career #postdocs! Apply for @jcb.org's Alan Hall & Norton B. Gilula Travel Awards ✈️ that support your attendance at #CellBio2026 (Dec. 12-15) in San Diego! Apply by October 18 👉 rupress.org/jcb/pages/al... @ascbiology.bsky.social

000

Rockefeller University Press @rupress.org · 09/09/2026

Perspective @jcb.org: Lo, Parton et al. provide a perspective on the role of #skeletalmuscle #caveolae, focusing on the cellular processes impaired by caveola dysfunction in muscle disease. They propose a new classification for disease-associated CAV3 variants. rupress.org/jcb/article/...

000

Rockefeller University Press @rupress.org · 09/09/2026

In @jcb.org, Jessica Sheu-Gruttadauria et al. show that the material properties of the #nucleolus are shaped by the assembly state of ribosomal precursors, which tune nucleolar dynamics and morphology through their interactions with the nucleolar scaffolding protein NPM1. rupress.org/jcb/article/...

000

Rockefeller University Press @rupress.org · 09/09/2026

New @jem.org study by Li et al. identifies that the ATPase Vps4B controls caspase-1 dynamics at the ASC speck to promote #inflammasome activation. This self-rejuvenating mechanism of the ASC speck opens up new avenues for therapeutic intervention in inflammatory diseases. rupress.org/jem/article/...

000

Rockefeller University Press @rupress.org · 09/09/2026

In @jcb.org, Vignogna (@rvig.bsky.social) and Fromme (@fromme-lab.bsky.social) identify GAP activity in several DENN domain proteins, revealing unexpected functional diversity within this protein family. rupress.org/jcb/article/... #GolgiTime #GTPases #Biochemistry #StructuralBiology #Golgi

000

Rockefeller University Press @rupress.org · 09/09/2026

000

Rockefeller University Press @rupress.org · 09/09/2026

“JGP’s standards are trusted internationally, publication in the journal can lead to lasting visibility and recognition well beyond the immediate field.” — Chieko Koike, Ritsumeikan University Learn more about @jgp.org: hubs.la/Q04t83Z10

100

Rockefeller University Press @rupress.org · 08/09/2026

In @jcb.org, Qian, Good et al. determine that proper spatial patterning of zygotic genome activation is required for #embryogenesis and the existence of a surveillance system for embryo quality control exquisitely tuned to spatiotemporal ordering of genome activation. rupress.org/jcb/article/...

072

Rockefeller University Press @rupress.org · 08/09/2026

HLA-DQ2.5, the major genetic risk for #celiacdisease, is present across diverse populations. In @jhumimmunity.org, Xin Long et al. from the Kong lab (UTSW) show that its linkage with HLA-B8 varies by genetic ancestry and contributes to differences in disease prevalence. rupress.org/jhi/article/...

000

Rockefeller University Press @rupress.org · 08/09/2026

Spotlight @jcb.org: Kops previews work from Tran, @dumontlabucsf.bsky.social et al. (rupress.org/jcb/article/...), which uses super resolution live imaging to show that #condensin is required for local structural organization and microtubule attachment of #kinetochores. rupress.org/jcb/article/...

000

Rockefeller University Press @rupress.org · 08/09/2026

In @jem.org, Bolaños, Melero et al. @unav.edu show that tumor necrosis factor sensing by cancer cells through TNFR1 sets in motion forms of immunosuppressive protumor #inflammation that mediate escape from immune surveillance against tumors. rupress.org/jem/article/... #TumorImmunology

000

Rockefeller University Press @rupress.org · 08/09/2026

HYOU1 deficiency links ER #proteostasis failure to human #immunodeficiency. In @jhumimmunity.org, Idani, @seiamak.bsky.social et al. identify defective B-cell development, persistent #neutrophil abnormalities, & #interferon pathway dysregulation as key disease mechanisms rupress.org/jhi/article/...

010

Rockefeller University Press @rupress.org · 08/09/2026

In @jcb.org: Using iPSC-derived human #neurons gene-edited to express pathogenic #KIF1A variants, @aikenlab.bsky.social et al. demonstrate that distinct alterations in KIF1A motor function disrupt synaptic development through divergent cellular mechanisms. rupress.org/jcb/article/...

000

Rockefeller University Press @rupress.org · 07/09/2026

JHI's September cover (rupress.org/jhi/issue/2/5) shows flow-cytometric characterization of TCR Vδ2 cells from two healthy controls & a patient carrying a TCRγδ-specific somatic STAT5B gain-of-function mutation based on expression of 10 different surface markers. Meyer et al. doi.org/10.70962/jhi...

000

Rockefeller University Press @rupress.org · 07/09/2026

On @jgp.org's September cover (rupress.org/jgp/issue/15...): Gaitán‑Peñas et al. (doi.org/10.1085/jgp....) show how the VRAC inhibitor DCPIB binds the extracellular selectivity filter through adaptable interactions, providing new insights into the molecular basis of channel inhibition.

000

Rockefeller University Press @rupress.org · 07/09/2026

@jem.org September cover (rupress.org/jem/issue/22... ) depicts a confocal image of Ramos B cells extracting surface-bound antigen from plasma membrane sheets. Sheets are labeled w/ fluorescent surrogate antigen (magenta); B cells are marked by CD19 (orange). Berzosa et al.: doi.org/10.1084/jem....

011

Rockefeller University Press @rupress.org · 07/09/2026

On @jcb.org September cover (rupress.org/jcb/issue/22...): immunofuorescence image of the anterior part of a #zebrafsh embryo showing the blood vasculature in magenta and endothelial nuclei in cyan. From Janssen and Angulo-Urarte et al. @huveneerslab.bsky.social: doi.org/10.1083/jcb....

000

Rockefeller University Press @rupress.org · 04/09/2026

Fagniez et al. identify new patients with inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT and iNKT cells, reduced numbers of TH17, TH1*, and CD8+ T cells, and defective IFN-γ and IL-17 immunity against #Mycobacterium & #Candida. rupress.org/jem/article/...

100

Rockefeller University Press @rupress.org · 03/09/2026

Spotlight @jcb.org: @felixmendu.bsky.social et al (rupress.org/jcb/article/...) show that the #Golgi responds to the mechanical force of cell spreading by increasing its secretory output, sustaining spreading thru a self-reinforcing feedback loop. From Hausser: rupress.org/jcb/article/...

032

Rockefeller University Press @rupress.org · 03/09/2026

In @jhumimmunity.org, Kadirkamanathan et al use base editors to modify DNA sequences in order to study newly identified mutations, or those of unknown significance, that may be responsible for inherited errors in the cutting & joining of DNA during immune cell development rupress.org/jhi/article/...

000

Rockefeller University Press @rupress.org · 03/09/2026

In @jcb.org, Chi, Saeki, Yokomizo et al. demonstrate that 12-HHT-BLT2 signaling protects alveolar epithelial cells from pore-forming toxin-induced damage by promoting membrane repair, suggesting a new therapeutic strategy for bacterial infections. rupress.org/jcb/article/... #Biochemistry #Membrane

010

Rockefeller University Press @rupress.org · 03/09/2026

Read a new @jcb.org collection of recent articles to accompany @embo.org workshop, Lipid Code to Life. Selected articles explore mechanisms underlying lipid transport, endosome biogenesis, & the maintenance of lipid homeostasis at ER–plasma membrane contact sites. rupress.org/jcb/collecti...

010