iiinova — where your digital self keeps evolving

Reposted by Araki Lab

Rockefeller University Press @rupress.org · 25/09/2026

Insights @jem.org: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. By Hee Yeun Won & Jung-Hyun Park rupress.org/jem/article/...

011

Reposted by Araki Lab

Journal of Experimental Medicine @jem.org · 25/09/2026

Insights: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic #TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. From Hee Yeun Won & Jung-Hyun Park: rupress.org/jem/article/...

041

Reposted by Araki Lab

Waggoner Lab @labwaggoner.bsky.social · 31/08/2026

Congrats Koichi Araki, @cincyresearch.bsky.social! Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses @jem.org rupress.org/jem/article-...

063

Reposted by Araki Lab

Journal of Experimental Medicine @jem.org · 31/08/2026

Sajiki et al. @cincyresearch.bsky.social reveal functional heterogeneity & plasticity within naïve #CD8 #Tcells, identifying functionally superior subsets that can emerge from less potent cells & drive robust immune responses thru. enhanced survival of effector progeny rupress.org/jem/article/...

043

Araki Lab @arakilab.bsky.social · 31/08/2026

A nice overview of our new study. Thanks to our media team for putting together this summary! scienceblog.cincinnatichildrens.org/what-makes-s...

scienceblog.cincinnatichildrens.org

What Makes Some Naïve T Cells Better Responders? - Research Horizons

000

Araki Lab @arakilab.bsky.social · 31/08/2026

Excited to share our new study! We uncover functional heterogeneity and plasticity within naïve CD8 T cells, showing that highly potent subsets can emerge from less potent cells and promote stronger, more durable immune responses. rupress.org/jem/article-...

rupress.org

Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses

Our study reveals functional heterogeneity and plasticity within naïve CD8 T cells, identifying functionally superior subsets that can emerge from less pot

000

Araki Lab @arakilab.bsky.social · 28/05/2026

Our new study uncovers a key limitation in virtual memory CD8 T cell responses to chronic antigen stimulation, with important implications for chronic infection and cancer. www.frontiersin.org/journals/imm...

frontiersin.org

Frontiers | Limited adaptability of virtual memory CD8 T cells to chronic viral infection

Antigen-inexperienced CD8 T cells include naïve and virtual memory (VM) subsets. VM CD8 T cells exhibit a memory-like phenotype despite lacking prior exposur...

040