iiinova — where your digital self keeps evolving

Russ at UF @rthepple.bsky.social · 22/03/2025

We should also have one for Canadian scientists in US. Stronger together regardless of borders. You know, the way it was before all this 51st state rhetoric. For the record, I love my American colleagues (that’s why I moved here) and think the current situation is an insult to us all.

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Russ at UF @rthepple.bsky.social · 22/03/2025

Thanks to @droch.bsky.social for correction - this should be Novo Nordisk not Roche

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Russ at UF @rthepple.bsky.social · 22/03/2025

Thanks Julien. I questioned this after I hit send and was going to try to edit.

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Russ at UF @rthepple.bsky.social · 22/03/2025

But I think your statement only applies if academia generates a compound because a process or pathway cannot be patented and any returns on compound go to university not NIH. I was thinking of what happens with Roche in Denmark but I am not versed in roadblocks here in US

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Mark Cuban @mcuban.bsky.social · 22/03/2025

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

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Russ at UF @rthepple.bsky.social · 22/03/2025

Begging the question of why it is not mandated that a return of a percentage of profits on said drugs go back to fund NIH research.

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Russ at UF @rthepple.bsky.social · 21/03/2025

Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...

science.org

In-cell architecture of the mitochondrial respiratory chain

Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...

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Russ at UF @rthepple.bsky.social · 12/03/2025

Please congratulate Casper and rest of your team for me!

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Russ at UF @rthepple.bsky.social · 10/03/2025

New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/

pubmed.ncbi.nlm.nih.gov

Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians - PubMed

Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into...

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Russ at UF @rthepple.bsky.social · 21/02/2025

Just drop me a line, Vincent! Gilles knows how to reach me.

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Science Magazine @science.org · 19/02/2025

Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals. So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD

scim.ag

‘I really wanted something to happen.’ The students behind the Stand Up for Science protests

New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies

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Nature @nature.com · 20/02/2025

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. go.nature.com/41a7Zzj

go.nature.com

Rare genetic disorder treated in womb for the first time

The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

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Kevin Murach @kevinmurachphd.bsky.social · 16/02/2025

@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth #myoblue www.sciencedirect.com/science/arti...

sciencedirect.com

A primer on global molecular responses to exercise in skeletal muscle: Omics in focus

Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level. Over the past 2 decades, tran…

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Russ at UF @rthepple.bsky.social · 15/02/2025

We should try to partner with MoTrPAc to get comparator data on younger participants. Just a thought.

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Russ at UF @rthepple.bsky.social · 15/02/2025

Sounds like a plan! I think an important component will be to address heterogeneity. My sense is that some will be responsive and others not so much.

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Russ at UF @rthepple.bsky.social · 13/02/2025

It is this period when preservation of oxphos might become the cause of greater voluntary exercise rather than the result. Let’s call it a hypothesis 😊

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Russ at UF @rthepple.bsky.social · 13/02/2025

Thanks for the very thoughtful reply, Gilles! I have no issue about exercise increasing oxphos except to make the point that I am not aware of any data addressing those >75 y, a time when the anabolic response to strength training is lost. pubmed.ncbi.nlm.nih.gov/18448613/

pubmed.ncbi.nlm.nih.gov

Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity - PubMed

The purpose of this study was to investigate whole muscle and single muscle fiber adaptations in very old men in response to progressive resistance training (PRT). Six healthy independently living old...

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Russ at UF @rthepple.bsky.social · 13/02/2025

Great work Gilles and team! To what degree do you think those who remain active with aging do so because they maintain mitochondrial oxphos capacity, rather than maintained oxphos being the outcome of being active?

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Silvia von Karstedt @vonkarstedtlab.bsky.social · 28/01/2025

Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez! rdcu.be/d7L66

rdcu.be

Ferroptosis triggers mitochondrial fragmentation via Drp1 activation

Cell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation

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Juan C. Landoni @jclandoni.bsky.social · 24/01/2025

Thank you for the awesome probe, and big shout-out to @lycasworks.bsky.social for the STED wizardry ✨

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Russ at UF @rthepple.bsky.social · 22/01/2025

Want to come work with us to understand the role of mitochondrial permeability transition in skeletal muscle? Postdoc position available at UF on the BREATHE T32 (US citizens and permanent residents eligible). breathe.phhp.ufl.edu/training/bre...

breathe.phhp.ufl.edu

BREATHE Application » Breathing Research and Therapeutics Center » College of Public Health and Health Professions » University of Florida

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 05/12/2024

A renewed reminder to anyone applying for a PhD or postdoc position in a lab--indicate your interest in the email/cover letter by talking a bit about that lab's work and why it would be a good fit. I answer any query that includes this information but do not answer those that do not.

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Russ at UF @rthepple.bsky.social · 05/12/2024

Since it seems that mito fusion can occur during an acute bout of exercise pubmed.ncbi.nlm.nih.gov/31398297/, I wonder if that response becomes impaired with aging and explains the more fragmented mito morphology in older humans?

pubmed.ncbi.nlm.nih.gov

Human muscular mitochondrial fusion in athletes during exercise - PubMed

The main objective of this work was to investigate whether mitochondrial fusion occurs in the skeletal muscle of well-trained athletes in response to high-intensity exercise. Well-trained swimmers (<i...

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Russ at UF @rthepple.bsky.social · 05/12/2024

Sounds like interesting stuff. I will see you there!

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Russ at UF @rthepple.bsky.social · 20/11/2024

Count me in. We use mouse models of aging, cancer cachexia and sepsis.

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Russ at UF @rthepple.bsky.social · 17/11/2024

I made a crawfish gumbo, chicken jambalaya and a pork verde stew for my lab group party yesterday. No pics of the food but I have a stack of pots that I cleaned today that I could submit!

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