Reposted by Russ at UFMark Cuban @mcuban.bsky.social · 22/03/2025From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA 708319698473
Russ at UF @rthepple.bsky.social · 21/03/2025Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...science.orgIn-cell architecture of the mitochondrial respiratory chainMitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin... 0204
Reposted by Russ at UFKaryn @kaesser.bsky.social · 13/03/2025Yet another report on the economic value of NIH investments The indiscriminate and large cuts are illogical and harmful I am angry www.forbes.com/sites/michae...forbes.comNIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New ReportNational Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research. 1308
Russ at UF @rthepple.bsky.social · 12/03/2025Fascinating new work from @abigailmackey1.bsky.social onlinelibrary.wiley.com/doi/full/10....onlinelibrary.wiley.comMuscle fibroblasts and stem cells stimulate motor neurons in an age and exercise‐dependent mannerMuscle biopsies were taken from males and females differing in age and exercise habits. Mononucleated cells were isolated and purified into muscle stem cells (MuSC) and muscle fibroblasts (FIB). Neur... 1184
Russ at UF @rthepple.bsky.social · 10/03/2025New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/pubmed.ncbi.nlm.nih.govSerum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians - PubMedPhysical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into... 053
Reposted by Russ at UFChristoph Handschin @c-handschin.bsky.social · 03/03/2025... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging: doi.org/10.1038/s415... 3/3doi.orgBiomarkers of aging: functional aspects still trump molecular parameters - npj AgingBiomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio... 1124
Reposted by Russ at UFDeena Snoke @snoke-phd.bsky.social · 24/02/2025Our new review on longitudinal body comp in lung cancer is now in print! journals.physiology.org/doi/full/10....journals.physiology.orgBody composition alterations in patients with lung cancer | American Journal of Physiology-Cell Physiology | American Physiological SocietyMost patients with lung cancer experience cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting. Knowledge of body composition changes in patients is limited, however, because... 042
Reposted by Russ at UFScience Magazine @science.org · 19/02/2025Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals. So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LADscim.ag‘I really wanted something to happen.’ The students behind the Stand Up for Science protestsNew group hopes to turn out researchers for 7 March demonstrations against Trump administration policies 2722360
Reposted by Russ at UFGilles Gouspillou @gillesgouspillou.bsky.social · 20/02/2025www.nature.com/articles/s41...nature.comDual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 - NatureWe find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, ... 022
Reposted by Russ at UFNature @nature.com · 20/02/2025A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. go.nature.com/41a7Zzjgo.nature.comRare genetic disorder treated in womb for the first timeThe child, who is now almost three years old, shows no signs of the often fatal motor neuron disease. 5365106
Reposted by Russ at UFKevin Murach @kevinmurachphd.bsky.social · 16/02/2025@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth #myoblue www.sciencedirect.com/science/arti...sciencedirect.comA primer on global molecular responses to exercise in skeletal muscle: Omics in focusAdvances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level. Over the past 2 decades, tran… 0105
Reposted by Russ at UFVincent Marcangeli @vincentmarcangeli.bsky.social · 11/02/2025When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️ www.cell.com/cell-reports...cell.comImpact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in menCefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis... 143
Reposted by Russ at UFCraig A. Goodman @craigagoodman1.bsky.social · 11/02/2025 Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS www.cell.com/cell-reports...cell.comPolyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALSRuggieri et al. developed a spatial transcriptomics dataset of skeletal muscle from the SOD1G93A ALS mouse model. Their findings highlight polyamine metabolism’s role in muscle fiber vulnerability, sh... 052
Reposted by Russ at UFGilles Gouspillou @gillesgouspillou.bsky.social · 11/02/2025www.nature.com/articles/s41...nature.comMitofusin 2 displays fusion-independent roles in proteostasis surveillance - Nature CommunicationsMitochondria influence cellular proteostasis, though the proteins that mediate this role are not well described. Here they show that the mitochondrial protein MFN2 interacts with the proteasome and wi... 074
Reposted by Russ at UFCraig A. Goodman @craigagoodman1.bsky.social · 02/02/2025 Skeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit Remodeling www.sciencedirect.com/science/arti...sciencedirect.comSkeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit RemodelingThis review explores the intricate processes of motor unit remodeling with a specific focus on the influence of reactive oxygen species (ROS) and oxid… 061
Reposted by Russ at UFSilvia von Karstedt @vonkarstedtlab.bsky.social · 28/01/2025Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez! rdcu.be/d7L66rdcu.beFerroptosis triggers mitochondrial fragmentation via Drp1 activationCell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation 02611
Russ at UF @rthepple.bsky.social · 28/01/2025Fascinating new paper relating to motoneuron changes in muscles regulating swallowing with aging. This likely has implications for limb muscle too. physoc.onlinelibrary.wiley.com/doi/full/10....physoc.onlinelibrary.wiley.comDendritic alterations precede age‐related dysphagia and nucleus ambiguus motor neuron deathAbstract figure legend Here, we evaluate the effects of ageing on the timing and pressure generation during naturalistic water bolus swallows, using Millar catheters placed in the pharynx (purple: to... 043
Reposted by Russ at UFJuan C. Landoni @jclandoni.bsky.social · 24/01/2025Thank you for the awesome probe, and big shout-out to @lycasworks.bsky.social for the STED wizardry ✨ 1112
Russ at UF @rthepple.bsky.social · 22/01/2025Want to come work with us to understand the role of mitochondrial permeability transition in skeletal muscle? Postdoc position available at UF on the BREATHE T32 (US citizens and permanent residents eligible). breathe.phhp.ufl.edu/training/bre...breathe.phhp.ufl.eduBREATHE Application » Breathing Research and Therapeutics Center » College of Public Health and Health Professions » University of Florida. 043
Reposted by Russ at UFAbigail Mackey @abigailmackey1.bsky.social · 09/12/2024Nice summary of our paper by #AdvancedScienceNews🤩 www.advancedsciencenews.com/exercising-e... @ismcopenhagen.bsky.social #BispebjergHospitaladvancedsciencenews.comWhy exercising early in life is key to keeping muscles strong as we age - Advanced Science NewsStudy shows that starting exercise early helps condition cells to preserve motor neurons before age-related loss. 0212
Reposted by Russ at UFMark Peifer (He, him) @peiferlabunc.bsky.social · 05/12/2024A renewed reminder to anyone applying for a PhD or postdoc position in a lab--indicate your interest in the email/cover letter by talking a bit about that lab's work and why it would be a good fit. I answer any query that includes this information but do not answer those that do not. 613329
Reposted by Russ at UFMichael Kamal @michaelkamal.bsky.social · 23/11/2024AMPK regulates the maintenance and remodelling of the neuromuscular junction by @ngseany.bsky.social @mikhaiai.bsky.social @stephmattina.bsky.social www.sciencedirect.com/science/arti...sciencedirect.comAMPK regulates the maintenance and remodelling of the neuromuscular junctionThe neuromuscular junction (NMJ) is an electrochemical signaling apparatus essential for facilitating muscle contraction and counteracting neurodegene… 0115