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Russ at UF

@rthepple.bsky.social
396 followers 166 following 26 posts

Scientist, lifelong athlete, home cook, music lover and amateur musician, husband, father, brother, son. Research interests: aging, cancer cachexia, sepsis, skeletal muscle and mitochondria. Did I mention mitochondria?

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Reposted by Russ at UF
Mark Cuban @mcuban.bsky.social · 22/03/2025
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
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Russ at UF @rthepple.bsky.social · 21/03/2025
Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...
science.org
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
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Reposted by Russ at UF
Karyn @kaesser.bsky.social · 13/03/2025
Yet another report on the economic value of NIH investments The indiscriminate and large cuts are illogical and harmful I am angry www.forbes.com/sites/michae...
forbes.com
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
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Russ at UF @rthepple.bsky.social · 12/03/2025
Fascinating new work from @abigailmackey1.bsky.social onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise‐dependent manner
Muscle biopsies were taken from males and females differing in age and exercise habits. Mononucleated cells were isolated and purified into muscle stem cells (MuSC) and muscle fibroblasts (FIB). Neur...
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Russ at UF @rthepple.bsky.social · 10/03/2025
New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/
pubmed.ncbi.nlm.nih.gov
Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians - PubMed
Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into...
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Reposted by Russ at UF
Christoph Handschin @c-handschin.bsky.social · 03/03/2025
... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging: doi.org/10.1038/s415... 3/3
doi.org
Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging
Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...
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Reposted by Russ at UF
Deena Snoke @snoke-phd.bsky.social · 24/02/2025
Our new review on longitudinal body comp in lung cancer is now in print! journals.physiology.org/doi/full/10....
journals.physiology.org
Body composition alterations in patients with lung cancer | American Journal of Physiology-Cell Physiology | American Physiological Society
Most patients with lung cancer experience cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting. Knowledge of body composition changes in patients is limited, however, because...
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Reposted by Russ at UF
Science Magazine @science.org · 19/02/2025
Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals. So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
scim.ag
‘I really wanted something to happen.’ The students behind the Stand Up for Science protests
New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies
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Reposted by Russ at UF
Gilles Gouspillou @gillesgouspillou.bsky.social · 20/02/2025
www.nature.com/articles/s41...
nature.com
Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 - Nature
We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, ...
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Reposted by Russ at UF
Nature @nature.com · 20/02/2025
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. go.nature.com/41a7Zzj
go.nature.com
Rare genetic disorder treated in womb for the first time
The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
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Reposted by Russ at UF
Kevin Murach @kevinmurachphd.bsky.social · 16/02/2025
@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth #myoblue www.sciencedirect.com/science/arti...
sciencedirect.com
A primer on global molecular responses to exercise in skeletal muscle: Omics in focus
Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level. Over the past 2 decades, tran…
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Reposted by Russ at UF
Vincent Marcangeli @vincentmarcangeli.bsky.social · 11/02/2025
When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️ www.cell.com/cell-reports...
cell.com
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...
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Reposted by Russ at UF
Craig A. Goodman @craigagoodman1.bsky.social · 11/02/2025
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS www.cell.com/cell-reports...
cell.com
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
Ruggieri et al. developed a spatial transcriptomics dataset of skeletal muscle from the SOD1G93A ALS mouse model. Their findings highlight polyamine metabolism’s role in muscle fiber vulnerability, sh...
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Reposted by Russ at UF
Gilles Gouspillou @gillesgouspillou.bsky.social · 11/02/2025
www.nature.com/articles/s41...
nature.com
Mitofusin 2 displays fusion-independent roles in proteostasis surveillance - Nature Communications
Mitochondria influence cellular proteostasis, though the proteins that mediate this role are not well described. Here they show that the mitochondrial protein MFN2 interacts with the proteasome and wi...
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Reposted by Russ at UF
Craig A. Goodman @craigagoodman1.bsky.social · 02/02/2025
Skeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit Remodeling www.sciencedirect.com/science/arti...
sciencedirect.com
Skeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit Remodeling
This review explores the intricate processes of motor unit remodeling with a specific focus on the influence of reactive oxygen species (ROS) and oxid…
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Russ at UF @rthepple.bsky.social · 30/01/2025
How cool is this?!
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Reposted by Russ at UF
Silvia von Karstedt @vonkarstedtlab.bsky.social · 28/01/2025
Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez! rdcu.be/d7L66
rdcu.be
Ferroptosis triggers mitochondrial fragmentation via Drp1 activation
Cell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation
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Russ at UF @rthepple.bsky.social · 28/01/2025
Fascinating new paper relating to motoneuron changes in muscles regulating swallowing with aging. This likely has implications for limb muscle too. physoc.onlinelibrary.wiley.com/doi/full/10....
physoc.onlinelibrary.wiley.com
Dendritic alterations precede age‐related dysphagia and nucleus ambiguus motor neuron death
Abstract figure legend Here, we evaluate the effects of ageing on the timing and pressure generation during naturalistic water bolus swallows, using Millar catheters placed in the pharynx (purple: to...
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Reposted by Russ at UF
Juan C. Landoni @jclandoni.bsky.social · 24/01/2025
Thank you for the awesome probe, and big shout-out to @lycasworks.bsky.social for the STED wizardry ✨
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Russ at UF @rthepple.bsky.social · 22/01/2025
Want to come work with us to understand the role of mitochondrial permeability transition in skeletal muscle? Postdoc position available at UF on the BREATHE T32 (US citizens and permanent residents eligible). breathe.phhp.ufl.edu/training/bre...
breathe.phhp.ufl.edu
BREATHE Application » Breathing Research and Therapeutics Center » College of Public Health and Health Professions » University of Florida
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Reposted by Russ at UF
Abigail Mackey @abigailmackey1.bsky.social · 09/12/2024
Nice summary of our paper by #AdvancedScienceNews🤩 www.advancedsciencenews.com/exercising-e... @ismcopenhagen.bsky.social #BispebjergHospital
advancedsciencenews.com
Why exercising early in life is key to keeping muscles strong as we age - Advanced Science News
Study shows that starting exercise early helps condition cells to preserve motor neurons before age-related loss.
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Reposted by Russ at UF
Mark Peifer (He, him) @peiferlabunc.bsky.social · 05/12/2024
A renewed reminder to anyone applying for a PhD or postdoc position in a lab--indicate your interest in the email/cover letter by talking a bit about that lab's work and why it would be a good fit. I answer any query that includes this information but do not answer those that do not.
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Reposted by Russ at UF
Michael Kamal @michaelkamal.bsky.social · 23/11/2024
AMPK regulates the maintenance and remodelling of the neuromuscular junction by @ngseany.bsky.social @mikhaiai.bsky.social @stephmattina.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
AMPK regulates the maintenance and remodelling of the neuromuscular junction
The neuromuscular junction (NMJ) is an electrochemical signaling apparatus essential for facilitating muscle contraction and counteracting neurodegene…
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