Wie bleibt man auch im hohen Alter so lange wie möglich gesund? Diese Frage stellen sich immer mehr Personen. Von Rotlicht-Therapie über Eisbaden und Peptide bis zu 100 verschiedenen Supplements pro T...

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Exercise stimulates the release of bioactive factors, termed exerkines, that contribute to local and systemic adaptation. Circulating exerkines are often interpreted as direct readouts of muscle secretion, overlooking regulatory processes within tissues that shape their production, transformation, and release. Using skeletal muscle and endurance exercise as a model system, we define a local–systemic secretome axis shaped by spatial organization, stimulus-specific programs, temporal dynamics, extracellular processing, and paracrine circuitry. By integrating evidence from recent transcriptomics, proteomics, interstitial fluid, and extracellular vesicle studies, we outline how these processes govern signal propagation from muscle to circulation and inform the interpretation of circulating exerkines as biomarkers and therapeutic targets.

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The authors explore the molecular signature of skeletal muscle adaptations to an acute bout of exercise in mice, providing a valuable resource that includes transcriptomic, epigenetic, proteomic and p...

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Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...

Federal research funding delays and policy shifts are putting science careers and innovation at risk.

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And blowing its credibility in the process.

Endurance training is known to elicit numerous changes in skeletal muscle to enhance performance and function. Many of these adaptations are controlle…

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Facing an extreme budget, the National Academies hosted an event that ignored it.

Many countries face an unprecedented challenge in aging demographics. This has led to an exponential growth in research on aging, which, coupled to a massive financial influx of funding in the private and public sectors, has resulted in seminal insights into the underpinnings of this biological process. However, critical validation in humans has been hampered by the limited translatability of results obtained in model organisms, additionally confined by the need for extremely time-consuming clinical studies in the ostensible absence of robust biomarkers that would allow monitoring in shorter time frames. In the future, molecular parameters might hold great promise in this regard. In contrast, biomarkers centered on function, resilience, and frailty are available at the present time, with proven predictive value for morbidity and mortality. In this review, the current knowledge of molecular and physiological aspects of human aging, potential antiaging strategies, and the basis, evidence, and potential application of physiological biomarkers in human aging are discussed.

Opinion: It’s time for public resistance.

Regular physical activity induces a variety of health benefits, preventing and counteracting diseases caused by a sedentary lifestyle. However, the mo…

Many countries face an unprecedented challenge in aging demographics. This has led to an exponential growth in research of aging, which, coupled to a massive financial influx of funding in the private and public sectors, has resulted in seminal insights into the underpinnings of this biological process. However, critical validation in humans have been hampered by the limited translatability of results obtained in model organisms, additionally confined by the need for extremely time-consuming clinical studies in the ostensible absence of robust biomarkers that would allow monitoring in shorter time frames. In the future, molecular parameters might hold great promise in this regard. In contrast, biomarkers centered on function, resilience and frailty are available at the present time, with proven predictive value for morbidity and mortality. In this review, the current knowledge of molecular and physiological aspects of human aging, potential anti-aging strategies, and the basis, evidence, and potential application of physiological biomarkers in human aging are discussed.

Withdrawal from WHO and the Paris Agreements. USAID shuttered and aid halted, ceasing health programmes globally. A freeze on US$3 trillion worth of federal grants and loans, jeopardising the function...

Early clinical trials suggest that people who lose weight with drugs like Ozempic lose lean mass as well as fat, which could have consequences for older adults at risk of muscle loss.

Exercise training involves repeated exposure to increases in metabolic, thermal, mechanical, and oxidative stress. This exposure stimulates physiological adaptations that improve tolerance to similar ...

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.

Elon Musk ist der reichste Mensch der Welt, einer der engsten Gefährten des bald mächtigsten Menschen der Welt und er besitzt mit X ein gewaltiges Sprachrohr: Er braucht keine Fürsprecher. Dass etablierte Medien statt ihm strengstens auf die Finger zu schauen – wie es unser Auftrag wäre – ihn vor Empörungen verteidigen, ist stossend.

A quick getting started guide created by Jonny for using BlueSky, aimed primarily at scientists, particularly those interested in open science and research culture. You can follow Rippling Ideas here....

Abstract figure legend Prehabilitative exercise is the process of preparing, through structured exercise, for anticipated disuse (e.g. bed rest or limb immobilization). Despite positive findings in c...

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