Black et al. identify the L. pneumophila effector SidL as an adenylyltransferase that targets host glycolysis. SidL covalently modifies the glycolytic intermediate 3-phosphoglycerate (3PG) with AMP, g...

Research provides insight into how yeast cells respond to stressful conditions with implications for larger organisms that share the same proteins.

Background All organisms experience stress and must rapidly respond to changing conditions. Thus, cells have evolved sophisticated rapid-response mechanisms such as post-translational protein modifica...

Proteins stalled during endoplasmic reticulum translocation clog Sec61 channels and require translocon quality control (TQC) mechanisms for clearance. Genetic screens implicated the derlin Dfm1 in TQC...

Nature Reviews Molecular Cell Biology, Published online: 30 June 2026; doi:10.1038/s41580-026-00998-6In this Tools of the Trade, Chen & Cheng (Barna lab) describe the development of Ribo-Tweezer, a method that enables the targeted degradation of individual ribosomal proteins of the cytoplasmic ribosome.

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Scientist at U of U; lab revolves around dsRNA. Love the Utah land. Views are my own.