Interferon signaling is essential for antiviral defense in the central nervous system, yet sustained neuronal STAT1 phosphorylation (pSTAT1) can promote immune-mediated synaptic and network injury. In...

IgLON5-antibody disease occupies a unique position at the interface between autoimmunity and neurodegeneration.1 By typically presenting with multiple, slo

Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...

Panx1 channels mediate sex-specific immune mechanisms in neuropathic pain: leptin from CD8+ T cells drives pain in females, while VEGF from microglia mediates pain in males. Panx1-targeted therapies o...

Chimeric antigen receptor trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain.

Maudes et al. have developed a mouse model of anti-NMDAR encephalitis, an autoimmune disease mediated by autoantibodies against the GluN1 subunit of the NM