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Ruben Dörfel

@rdoerfel.bsky.social
786 followers 933 following 93 posts

Interested in aging, neuroimaging, and machine learning. PhD student at Karolinska Institutet, NRU Rigshospitalet, and DIKU UCPH

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Reposted by Ruben Dörfel
Paul Taylor @afni-pt.bsky.social · 31/08/2026
Have you ever felt like something was missing from your #fmri results? Have you been worried about potential reproducibility issues? Well, this new @natmethods.nature.com article with 40+ coauthors shows how the simple change to transparent thresholding helps both. Go Figure! rdcu.be/B4tikBETdQZa
A comparison of old and new thresholding approaches for fMRI data. The newer, transparent thresholding allows for interpreting context, more complete modeling, a reduction of biases and an increase in meaningful content. This all leads to more accurate interpretations and improved reproducibility evaluations.
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Ruben Dörfel @rdoerfel.bsky.social · 12/05/2026
Another great article by Grødem et al., giving more insight into the issues we see with cross-sectional brain age. www.medrxiv.org/content/10.6...
medrxiv.org
Reconsidering Brain Age: Why Age-Prediction Models Fail as Measures of Brain Aging
Brain age models - machine-learning predictions of chronological age from brain imaging - are widely interpreted as markers of accelerated brain aging. Here we show that this interpretation cannot be ...
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Ruben Dörfel @rdoerfel.bsky.social · 12/05/2026
Another great article by Grødem et al., giving more insight into the issues we see with cross-sectional brain age. www.medrxiv.org/content/10.6...
medrxiv.org
Reconsidering Brain Age: Why Age-Prediction Models Fail as Measures of Brain Aging
Brain age models - machine-learning predictions of chronological age from brain imaging - are widely interpreted as markers of accelerated brain aging. Here we show that this interpretation cannot be ...
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Reposted by Ruben Dörfel
Oxford University Centre for Integrative Neuroimaging (OxCIN) @oxcin.bsky.social · 18/03/2026
Register now for the in-person FSL Course 2026 in Bordeaux, France! 🗓️ June 22-26, 2026 🧠 Covering: lectures & hands-on practicals on structural, functional, diffusion and resting state brain image analysis 🔗 open.oxcin.ox.ac.uk/pages/fslcou...
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Ruben Dörfel @rdoerfel.bsky.social · 15/03/2026
The phrase “It is straight forward to show that…” should be removed from this world.
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Ruben Dörfel @rdoerfel.bsky.social · 02/02/2026
First generation (methylation) aging clocks (2011) were developed after brain age (2010). The aging field has subsequently moved on and is now in its third or fourth generation. Yet, in the neuroimaging field, we are still stuck with brain age, essentially a first generation clock.
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Reposted by Ruben Dörfel
Eiko Fried @eikofried.bsky.social · 07/01/2026
After 5 years of data collection, our WARN-D machine learning competition to forecast depression onset is now LIVE! We hope many of you will participate—we have incredibly rich data. If you share a single thing of my lab this year, please make it this competition. eiko-fried.com/warn-d-machi...
eiko-fried.com
WARN-D machine learning competition is live » Eiko Fried
If you share one single thing of our team in 2026—on social media or per email with your colleagues—please let it be this machine learning competition. It was half a decade of work to get here, especi...
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Ruben Dörfel @rdoerfel.bsky.social · 05/01/2026
I'm excited to share our pre-registered phase IIa pilot study on rapamycin treatment in early Alzheimer's disease, using multimodal neuroimaging and CSF biomarkers to assess safety and feasibility! doi.org/10.64898/202... (1/6)
doi.org
Evaluation of rapamycin as a neuroprotective treatment in Alzheimer’s disease: a six-month single-arm open-label clinical pilot trial
Background Rapamycin has demonstrated neuroprotective effects in preclinical Alzheimer’s disease (AD) models, yet clinical data remain limited. Here, we conducted a pilot trial to assess the feasibili...
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Ruben Dörfel @rdoerfel.bsky.social · 05/01/2026
I'm excited to share our pre-registered phase IIa pilot study on rapamycin treatment in early Alzheimer's disease, using multimodal neuroimaging and CSF biomarkers to assess safety and feasibility! doi.org/10.64898/202... (1/6)
doi.org
Evaluation of rapamycin as a neuroprotective treatment in Alzheimer’s disease: a six-month single-arm open-label clinical pilot trial
Background Rapamycin has demonstrated neuroprotective effects in preclinical Alzheimer’s disease (AD) models, yet clinical data remain limited. Here, we conducted a pilot trial to assess the feasibili...
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Reposted by Ruben Dörfel
Chiasm @chiasm.bsky.social · 06/12/2025
When you can't give a simple answer to that question... something needs to be redesigned! I have never seen a conference need to make a video to explain *character limits*. 🤔
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Ruben Dörfel @rdoerfel.bsky.social · 05/12/2025
Love it EurIPA #EurIPS
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Darren Dahly @statsepi.bsky.social · 09/08/2024
I think that many people interested in explainable/interpretable "AI" in medicine and health mean well but misunderstand the nature and value of prediction. This focus, imo, is also a distraction from much more needed efforts to ensure that AI based predictions are actually useful.
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Frank Harrell @f2harrell.bsky.social · 16/11/2025
A lot of crap research is being done with the microbiome. At the heart of much of the research is fundamentally unreliable data.
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Johan Edstedt @parskatt.bsky.social · 27/11/2025
Alt.
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Ruben Dörfel @rdoerfel.bsky.social · 07/11/2025
Interesting paper showing that "much inter-individual differences in neuroanatomical volumes almost exclusively reflects stable differences between individuals" before 60 years, rather than age-related changes. www.biorxiv.org/content/10.1...
biorxiv.org
Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes
Differences in the volumes of brain structures between individuals are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains u...
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Ruben Dörfel @rdoerfel.bsky.social · 06/11/2025
Pretty good perspective paper on brain age in kids: www.nature.com/articles/s41... I think a lot of the points / issues are relevant to the entire field, not only brain age in younger populations.
nature.com
Current challenges and future directions for brain age prediction in children and adolescents - Nature Communications
This Perspective outlines how brain-age prediction models are increasingly applied to child and adolescent populations and examines the specific challenges this entails. It offers practical recommenda...
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Ruben Dörfel @rdoerfel.bsky.social · 06/11/2025
Pretty cool development! New high-res neuro-PET scanner. Look at the cortical ribbon and the small subcortical regions and nuclei! link.springer.com/article/10.1...
link.springer.com
Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT - European Journal of Nuclear Medicine and Molecular Imaging
Purpose Current brain-dedicated positron emission tomography (PET) systems (e.g., the High-Resolution Research Tomograph, HRRT) are unable to accurately and precisely measure pharmacologically-specifi...
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Reposted by Ruben Dörfel
NeurIPS Europe @neuripseurope.bsky.social · 08/10/2025
Registration opened just 1 week ago and we already have 390+ registrations from more than 25 countries and presenting 85+ papers! We are very excited to see the community support the #EurIPS initiative and look forward to meeting you all in Copenhagen 🙌
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NeurIPS Europe @neuripseurope.bsky.social · 19/09/2025
Congratulations to everyone who got their @neuripsconf.bsky.social papers accepted 🎉🎉🎉 At #EurIPS we are looking forward to welcoming presentations of all accepted NeurIPS papers, including a new “Salon des Refusés” track for papers which were rejected due to space constraints!
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NeurIPS Europe @neuripseurope.bsky.social · 27/08/2025
In short, world-class research from NeurIPS accessible in Europe. EurIPS takes place over 3 days + 2 workshop days, at the same time as NeurIPS in San Diego. Follow this account for more updates, and see you in wonderful Copenhagen 📅 eurips.cc
eurips.cc
EurIPS Copenhagen 2025 - A NeurIPS-endorsed conference in Europe
A NeurIPS-endorsed conference in Europe held in Copenhagen, Denmark
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Ruben Dörfel @rdoerfel.bsky.social · 06/08/2025
Interesting paper by Vidal-Piñeiro et al. doi.org/10.1162/imag.... They show that "Increasing the follow-up time was associated with a substantial increase in longitudinal reliability, while the impact of increasing the number of observations was comparatively minor."
doi.org
Reliability of structural brain change in cognitively healthy adult samples
Abstract. In neuroimaging research, tracking individuals over time is key to understanding the interplay between brain changes and genetic, environmental, or cognitive factors across the lifespan. Yet...
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Reposted by Ruben Dörfel
NeurIPS Europe @neuripseurope.bsky.social · 28/07/2025
EurIPS includes a call for both Workshops and Affinity Workshops! We look forward to making #EurIPS a diverse and inclusive event with you. The submission deadlines are August 22nd, AoE. More information at: eurips.cc/call-for-wor... eurips.cc/call-for-aff...
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Ruben Dörfel @rdoerfel.bsky.social · 10/07/2025
Updated my Python project setup guide - originally created for my students but might be useful for other researchers and data scientists. Covers pyenv, poetry, git, and project structure best practices. Open to suggestions for improvements. rdoerfel.github.io/blog/2025/En...
rdoerfel.github.io
Setting up a Scientific Python Project from Scratch | Ruben P. Dörfel
A guide to set up a scientific Python project from scratch, covering version control, virtual environments, and project structure.
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Ruben Dörfel @rdoerfel.bsky.social · 10/07/2025
Updated my Python project setup guide - originally created for my students but might be useful for other researchers and data scientists. Covers pyenv, poetry, git, and project structure best practices. Open to suggestions for improvements. rdoerfel.github.io/blog/2025/En...
rdoerfel.github.io
Setting up a Scientific Python Project from Scratch | Ruben P. Dörfel
A guide to set up a scientific Python project from scratch, covering version control, virtual environments, and project structure.
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Max Korbmacher @maxkorbmacher.bsky.social · 16/04/2025
New article out at Human Brain Mapping showing that brain age ≠ brain ageing (estimating brain age on all available features). This is not the only article showcasing this. Brain age is still useful, but be careful about the longitudinal claims. doi.org/10.1002/hbm....
doi.org
Cross‐Sectional Brain Age Assessments Are Limited in Predicting Future Brain Change
Multimodal imaging data of 39,325 UK Biobank participants with 2,520 follow-ups provide insufficient evidence to conclude that brain age reflects the rate of anatomical brain aging. However, modality...
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Reposted by Ruben Dörfel
FOMO25: Foundation Model Challenge for Brain MRI @fomochallenge.bsky.social · 22/04/2025
FOMO25 accepted at #MICCAI2025! 🚀 Excited to announce the first challenge at MICCAI focusing on the development of self-supervised pretraining of foundation models for brain MRI! 🧠 With access to a large-scale dataset, codebase, cash prices and multiple tracks. Read more ⬇️
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Ruben Dörfel @rdoerfel.bsky.social · 18/03/2025
I'm happy to share our latest pre-print on assessing the clinical validity of brain age as a biomarker of aging-related diseases and structural and memory decline in the brain! www.medrxiv.org/content/10.1... (1/7)
medrxiv.org
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Predicting brain age from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. Ideally, as a clinically valid biomarker, brain age should indicate...
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Ruben Dörfel @rdoerfel.bsky.social · 18/03/2025
I'm happy to share our latest pre-print on assessing the clinical validity of brain age as a biomarker of aging-related diseases and structural and memory decline in the brain! www.medrxiv.org/content/10.1... (1/7)
medrxiv.org
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Predicting brain age from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. Ideally, as a clinically valid biomarker, brain age should indicate...
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Melanie Ganz @melanieganzben1.bsky.social · 17/03/2025
Remember the whole #narps (www.narps.info) splash? We are very interested in how to utilize the multiverse in neuroimaging. Because no matter how we process biological data, if we do something reasonable, the underlying results shouldn't change too much - because biology doesn't change, right?
Screenshot of the Imaging neuroscience paper linked above
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Max Korbmacher @maxkorbmacher.bsky.social · 15/03/2025
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages Led by @rdoerfel.bsky.social doi.org/10.1101/2025...
doi.org
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Predicting brain age from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. Ideally, as a clinically valid biomarker, brain age should indicate...
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Reposted by Ruben Dörfel
Der Volksverpetzer @volksverpetzer.de · 19/02/2025
Hier das Fazit - aber wie immer: So eine Grafik erzählt nicht die ganze Geschichte, schaut rein und guckt die Quellen an - überprüft gern alles selbst.
Volksverpetzer Faktencheck der Wahlarena. Unser Fazit:
Falsch: Merz 2, Scholz 1, Weidel 14, Habeck 0
Irreführend: Merz 6, Scholz 1, Weidel 3, Habeck 0
Fehlender Kontext: Merz 0, Scholz 2, Weidel 3, Habeck 1
Unbelegt: Merz: 0, Scholz: 2, Weidel: 0, Habeck 1
Gesamt Merz 8, Scholz 6, Weidel 18, Habeck 2
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Ruben Dörfel @rdoerfel.bsky.social · 14/02/2025
Great review by Svensson et al. on how to systematically evaluate geroprotective interventions in humans! link.springer.com/article/10.1... 1/3
link.springer.com
In vivo medical imaging for assessing geroprotective interventions in humans - GeroScience
There is a growing interest in developing drugs with a general geroprotective effect, aimed at slowing down aging. Several compounds have been shown to increase the lifespan and reduce the incidence o...
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Ruben Dörfel @rdoerfel.bsky.social · 14/02/2025
Great review by Svensson et al. on how to systematically evaluate geroprotective interventions in humans! link.springer.com/article/10.1... 1/3
link.springer.com
In vivo medical imaging for assessing geroprotective interventions in humans - GeroScience
There is a growing interest in developing drugs with a general geroprotective effect, aimed at slowing down aging. Several compounds have been shown to increase the lifespan and reduce the incidence o...
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Jonathan Jarry @jonathanjarry.bsky.social · 10/02/2025
Health pseudoscience in a nutshell: A non-expert uses in vitro/animal studies to infer a revolutionary understanding of a disease, then sells a dietary supplement whose effectiveness likewise rests on preliminary studies done in cells in culture flasks. Every. Frickin'. Time.
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Ruben Dörfel @rdoerfel.bsky.social · 05/02/2025
An amazing educational piece on the evolution of aging, and why natural selection does NOT favor longevity: www.youtube.com/watch?v=1_Jb...
youtube.com
Simulating the Evolution of Aging
YouTube video by Primer
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Melanie Ganz @melanieganzben1.bsky.social · 03/02/2025
📢 Call for Papers: Fairness of AI in Medical Imaging (MELBA Journal Special Issue) We invite submissions for our special issue on fairness in AI for medical imaging in MELBA, an open-access journal at the intersection of machine learning & biomedical imaging. faimi-workshop.github.io/2024-melba/
faimi-workshop.github.io
Fairness of AI in Medical Imaging
MELBA Special Issue
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Der Volksverpetzer @volksverpetzer.de · 24/01/2025
AfD Sachsen: Sogar gerichtlich bestätigt gesichert rechtsextrem und verfassungsfeindlich CDU Sachsen: Wir sollten die AfD Sachsen jetzt nicht vorverurteilen und sie in Posten wählen oder beim Holocaustgedenken sprechen lassen! Leute, die AfD Sachsen IST zu verurteilen! Die Ergebnisse sind da!
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Ruben Dörfel @rdoerfel.bsky.social · 03/01/2025
If you're looking for something to occupy the final days before the grind begins again, I highly recommend this blog post: It explains how and when flow matching and diffusion are equivalent, unifying both frameworks so that you can use the best of both worlds! diffusionflow.github.io
diffusionflow.github.io
Diffusion Meets Flow Matching
Flow matching and diffusion models are two popular frameworks in generative modeling. Despite seeming similar, there is some confusion in the community about their exact connection. In this post, we a...
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Ruben Dörfel @rdoerfel.bsky.social · 28/12/2024
This looks like quite a comprehensive overview of linear models! arxiv.org/abs/2401.00649
arxiv.org
Linear Model and Extensions
I developed the lecture notes based on my ``Linear Model'' course at the University of California Berkeley over the past seven years. This book provides an intermediate-level introduction to the linea...
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BrunetLab @brunetlab.bsky.social · 18/12/2024
Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵
rdcu.be
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
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Ruben Dörfel @rdoerfel.bsky.social · 13/12/2024
Reminds me very much of @imagingneurosci.bsky.social! Or, to be more correct, the story of Imaging Neuroscience reminds me very much of JMLR :D I think that's the right way to go. Are there any other journals with similar stories that I'm not aware of?
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Melanie Ganz @melanieganzben1.bsky.social · 11/12/2024
☺️ Thank you #ACNP2024, it's been a pleasure to attend the conference and participate in a study group. And anyone interested in data sharing after our session? 👇 Check out the @bidsstandard.bsky.social website: bids-website.readthedocs.io/en/latest/?b... and start to standardize some of your data!
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Richard Riley (R²) @richarddriley.bsky.social · 06/12/2024
This is exactly why we called our 3 paper BMJ series: "Evaluation of clinical prediction models ..." (shameless links to plug our work follow ...) www.bmj.com/content/384/... www.bmj.com/content/384/... www.bmj.com/content/384/...
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Ruben Dörfel @rdoerfel.bsky.social · 04/12/2024
In light of the upcoming NeurIPS conference, a gem from the 3(!) Edition: Optimal Brain Damage by @ylecun.bsky.social et al. 1989 This is one of the early works on pruning in artificial neural networks. proceedings.neurips.cc/paper/1989/h... (1/4)
proceedings.neurips.cc
Optimal Brain Damage
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Rose 🌹 @rose.bsky.team · 26/11/2024
You wanted starter packs to be searchable. Our engineers are busy keeping us online, so in the meantime, an independent developer built a new searchable library of starter packs. This is the beauty of building in the open 🦋
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Ruben Dörfel @rdoerfel.bsky.social · 24/11/2024
This is an interesting paper investigating changes in the BOLD response with age. According to this paper, "neurovascular and vascular changes are sufficient to explain age effects on the BOLD response in the ROIs and task considered here." (1/3) onlinelibrary.wiley.com/doi/abs/10.1...
onlinelibrary.wiley.com
Evaluating Models of the Ageing BOLD Response
Linear and nonlinear methods for estimating the BOLD response in the sensorimotor task from a large dataset show important effects of adult age on response features and biophysical parameters, some o...
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ELLIS @ellis.eu · 22/11/2024
Check out the ELLIS Pre-NeurIPS Fest event today in...🇩🇰Copenhagen! ELLIS Unit Copenhagen is holding their event at the Pioneer Center for AI showcasing #NeurIPS posters and other Denmark-affiliated papers in #AI and #ML. More info: bit.ly/4fRFrAh
bit.ly
ELLIS Pre-NeurIPS Fest 2024: Celebrate, Connect, Collaborate
The ELLIS mission is to create a diverse European network that promotes research excellence and advances breakthroughs in AI, as well as a pan-European PhD program to educate the next generation of AI...
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Martin Trapp @trappmartin.eurosky.social · 20/11/2024
For those who don’t know yet, I am organising an online talk series together with Arno Solin on “Advances in Probabilistic Machine Learning (APML)”. It’s free for everyone to join and support early career researchers! You can register and check out the schedule here: aaltoml.github.io/apml/
aaltoml.github.io
Seminar on Advances in Probabilistic Machine Learning
This seminar series aims to provide a platform for young researchers (PhD student or post-doc level) to give invited talks about their research, intending to have a diverse set of talks & speakers on ...
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