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Ruben Dörfel

@rdoerfel.bsky.social
786 followers 933 following 93 posts

Interested in aging, neuroimaging, and machine learning. PhD student at Karolinska Institutet, NRU Rigshospitalet, and DIKU UCPH

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Reposted by Ruben Dörfel
Paul Taylor @afni-pt.bsky.social · 31/08/2026
Have you ever felt like something was missing from your #fmri results? Have you been worried about potential reproducibility issues? Well, this new @natmethods.nature.com article with 40+ coauthors shows how the simple change to transparent thresholding helps both. Go Figure! rdcu.be/B4tikBETdQZa
A comparison of old and new thresholding approaches for fMRI data. The newer, transparent thresholding allows for interpreting context, more complete modeling, a reduction of biases and an increase in meaningful content. This all leads to more accurate interpretations and improved reproducibility evaluations.
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Reposted by Ruben Dörfel
Ruben Dörfel @rdoerfel.bsky.social · 12/05/2026
Another great article by Grødem et al., giving more insight into the issues we see with cross-sectional brain age. www.medrxiv.org/content/10.6...
medrxiv.org
Reconsidering Brain Age: Why Age-Prediction Models Fail as Measures of Brain Aging
Brain age models - machine-learning predictions of chronological age from brain imaging - are widely interpreted as markers of accelerated brain aging. Here we show that this interpretation cannot be ...
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Ruben Dörfel @rdoerfel.bsky.social · 12/05/2026
Another great article by Grødem et al., giving more insight into the issues we see with cross-sectional brain age. www.medrxiv.org/content/10.6...
medrxiv.org
Reconsidering Brain Age: Why Age-Prediction Models Fail as Measures of Brain Aging
Brain age models - machine-learning predictions of chronological age from brain imaging - are widely interpreted as markers of accelerated brain aging. Here we show that this interpretation cannot be ...
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Reposted by Ruben Dörfel
Oxford University Centre for Integrative Neuroimaging (OxCIN) @oxcin.bsky.social · 18/03/2026
Register now for the in-person FSL Course 2026 in Bordeaux, France! 🗓️ June 22-26, 2026 🧠 Covering: lectures & hands-on practicals on structural, functional, diffusion and resting state brain image analysis 🔗 open.oxcin.ox.ac.uk/pages/fslcou...
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Ruben Dörfel @rdoerfel.bsky.social · 15/03/2026
The phrase “It is straight forward to show that…” should be removed from this world.
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Ruben Dörfel @rdoerfel.bsky.social · 03/02/2026
Nahh, just remove them
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Ruben Dörfel @rdoerfel.bsky.social · 02/02/2026
First generation (methylation) aging clocks (2011) were developed after brain age (2010). The aging field has subsequently moved on and is now in its third or fourth generation. Yet, in the neuroimaging field, we are still stuck with brain age, essentially a first generation clock.
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Ruben Dörfel @rdoerfel.bsky.social · 24/01/2026
IMO there is no reason to rely on LLMs to generate citations. Overloaf integrates very well with Zotero and Mendeley, and if you use other editors, most reference managers export bibtex files. So why would I require an LLM to generate my citations.
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Reposted by Ruben Dörfel
Eiko Fried @eikofried.bsky.social · 07/01/2026
After 5 years of data collection, our WARN-D machine learning competition to forecast depression onset is now LIVE! We hope many of you will participate—we have incredibly rich data. If you share a single thing of my lab this year, please make it this competition. eiko-fried.com/warn-d-machi...
eiko-fried.com
WARN-D machine learning competition is live » Eiko Fried
If you share one single thing of our team in 2026—on social media or per email with your colleagues—please let it be this machine learning competition. It was half a decade of work to get here, especi...
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Reposted by Ruben Dörfel
Ruben Dörfel @rdoerfel.bsky.social · 05/01/2026
I'm excited to share our pre-registered phase IIa pilot study on rapamycin treatment in early Alzheimer's disease, using multimodal neuroimaging and CSF biomarkers to assess safety and feasibility! doi.org/10.64898/202... (1/6)
doi.org
Evaluation of rapamycin as a neuroprotective treatment in Alzheimer’s disease: a six-month single-arm open-label clinical pilot trial
Background Rapamycin has demonstrated neuroprotective effects in preclinical Alzheimer’s disease (AD) models, yet clinical data remain limited. Here, we conducted a pilot trial to assess the feasibili...
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Ruben Dörfel @rdoerfel.bsky.social · 05/01/2026
Interestingly, levels of certain CSF biomarkers increased (total tau, neurofilament light, and Aβ40/42), while the p-tau/total tau ratio decreased. These unexpected findings warrant further investigation to determine their implications for drug administration and potential long-term effects. (6/6)
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Ruben Dörfel @rdoerfel.bsky.social · 05/01/2026
There was also a positive correlation between the drug's blood concentration and increased brain metabolism, although the sample size is small and definitive conclusions are difficult to draw. (5/6)
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Ruben Dörfel @rdoerfel.bsky.social · 05/01/2026
Rapamycin was well tolerated with no serious adverse events. Glucose metabolism in our primary regions showed no decline and perhaps even increased in exploratory regions, in contrast to what would be expected from the natural disease progression. (4/6)
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Ruben Dörfel @rdoerfel.bsky.social · 05/01/2026
We measured brain glucose metabolism using FDG PET, measured blood flow using ASL MRI, tested for CSF biomarkers, measured volumetric changes on MRI, and performed cognitive assessments before and after treatment. (3/6)
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Ruben Dörfel @rdoerfel.bsky.social · 05/01/2026
Rapamycin is a well-known putative geroprotective compound that extends life- and healthspan in preclinical models, but human clinical data remain limited. In this study, we enrolled 14 participants with early Alzheimer’s disease who received a weekly dose of oral rapamycin for 26 weeks. (2/6)
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Ruben Dörfel @rdoerfel.bsky.social · 05/01/2026
I'm excited to share our pre-registered phase IIa pilot study on rapamycin treatment in early Alzheimer's disease, using multimodal neuroimaging and CSF biomarkers to assess safety and feasibility! doi.org/10.64898/202... (1/6)
doi.org
Evaluation of rapamycin as a neuroprotective treatment in Alzheimer’s disease: a six-month single-arm open-label clinical pilot trial
Background Rapamycin has demonstrated neuroprotective effects in preclinical Alzheimer’s disease (AD) models, yet clinical data remain limited. Here, we conducted a pilot trial to assess the feasibili...
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Reposted by Ruben Dörfel
Chiasm @chiasm.bsky.social · 06/12/2025
When you can't give a simple answer to that question... something needs to be redesigned! I have never seen a conference need to make a video to explain *character limits*. 🤔
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Ruben Dörfel @rdoerfel.bsky.social · 05/12/2025
@euripsconf.bsky.social
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Ruben Dörfel @rdoerfel.bsky.social · 05/12/2025
Love it EurIPA #EurIPS
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Reposted by Ruben Dörfel
Darren Dahly @statsepi.bsky.social · 09/08/2024
I think that many people interested in explainable/interpretable "AI" in medicine and health mean well but misunderstand the nature and value of prediction. This focus, imo, is also a distraction from much more needed efforts to ensure that AI based predictions are actually useful.
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Ruben Dörfel @rdoerfel.bsky.social · 04/12/2025
No hand-drawn slides? ;D
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Reposted by Ruben Dörfel
Frank Harrell @f2harrell.bsky.social · 16/11/2025
A lot of crap research is being done with the microbiome. At the heart of much of the research is fundamentally unreliable data.
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Ruben Dörfel @rdoerfel.bsky.social · 30/11/2025
More open journals like TMLR. IMO the peer review process is much better anyway.
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Reposted by Ruben Dörfel
Johan Edstedt @parskatt.bsky.social · 27/11/2025
Alt.
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Ruben Dörfel @rdoerfel.bsky.social · 07/11/2025
Not surprising, as both are on that paper as well :D
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Ruben Dörfel @rdoerfel.bsky.social · 07/11/2025
Very much in line with work by Vidal-Pineiro et al., 2021 (eLife) and Smith et al., 2025 (Imaging Neuroscience).
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Ruben Dörfel @rdoerfel.bsky.social · 07/11/2025
Interesting paper showing that "much inter-individual differences in neuroanatomical volumes almost exclusively reflects stable differences between individuals" before 60 years, rather than age-related changes. www.biorxiv.org/content/10.1...
biorxiv.org
Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes
Differences in the volumes of brain structures between individuals are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains u...
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Ruben Dörfel @rdoerfel.bsky.social · 07/11/2025
Prompt to Chat: "Please explain [insert methodology] to me like I'm 10 years old and stupid"
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Ruben Dörfel @rdoerfel.bsky.social · 06/11/2025
Issue 3: "While cross-sectional studies can provide valuable snapshots of developmental differences, they are insufficient for testing hypotheses about the speed, timing, or trajectory of brain development"
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Ruben Dörfel @rdoerfel.bsky.social · 06/11/2025
Issue 1: "Existing research has not established what degree of variability in BAG is typical, and what may reflect substantially accelerated or decelerated development"
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Ruben Dörfel @rdoerfel.bsky.social · 06/11/2025
Pretty good perspective paper on brain age in kids: www.nature.com/articles/s41... I think a lot of the points / issues are relevant to the entire field, not only brain age in younger populations.
nature.com
Current challenges and future directions for brain age prediction in children and adolescents - Nature Communications
This Perspective outlines how brain-age prediction models are increasingly applied to child and adolescent populations and examines the specific challenges this entails. It offers practical recommenda...
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Ruben Dörfel @rdoerfel.bsky.social · 06/11/2025
Pretty cool development! New high-res neuro-PET scanner. Look at the cortical ribbon and the small subcortical regions and nuclei! link.springer.com/article/10.1...
link.springer.com
Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT - European Journal of Nuclear Medicine and Molecular Imaging
Purpose Current brain-dedicated positron emission tomography (PET) systems (e.g., the High-Resolution Research Tomograph, HRRT) are unable to accurately and precisely measure pharmacologically-specifi...
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Reposted by Ruben Dörfel
NeurIPS Europe @neuripseurope.bsky.social · 08/10/2025
Registration opened just 1 week ago and we already have 390+ registrations from more than 25 countries and presenting 85+ papers! We are very excited to see the community support the #EurIPS initiative and look forward to meeting you all in Copenhagen 🙌
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Reposted by Ruben Dörfel
NeurIPS Europe @neuripseurope.bsky.social · 19/09/2025
Congratulations to everyone who got their @neuripsconf.bsky.social papers accepted 🎉🎉🎉 At #EurIPS we are looking forward to welcoming presentations of all accepted NeurIPS papers, including a new “Salon des Refusés” track for papers which were rejected due to space constraints!
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Ruben Dörfel @rdoerfel.bsky.social · 19/09/2025
Exactly! EurIPS just announced that they will accept submission of those rejected papers.
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Ruben Dörfel @rdoerfel.bsky.social · 19/09/2025
I think the point is that papers got rejected because of venue constraints, while at the same time, alternative venues are endorsed this year.
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Reposted by Ruben Dörfel
NeurIPS Europe @neuripseurope.bsky.social · 27/08/2025
In short, world-class research from NeurIPS accessible in Europe. EurIPS takes place over 3 days + 2 workshop days, at the same time as NeurIPS in San Diego. Follow this account for more updates, and see you in wonderful Copenhagen 📅 eurips.cc
eurips.cc
EurIPS Copenhagen 2025 - A NeurIPS-endorsed conference in Europe
A NeurIPS-endorsed conference in Europe held in Copenhagen, Denmark
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Ruben Dörfel @rdoerfel.bsky.social · 09/08/2025
We might be able to save this when we agree that we are dealing with a well-behaved, compact domain. I'd be willing to agree to that!
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Ruben Dörfel @rdoerfel.bsky.social · 08/08/2025
Does it, though? It's been a while since I read calculus and analysis, but as far as I remember, the existence of a min does not imply the existence of a max?
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Ruben Dörfel @rdoerfel.bsky.social · 06/08/2025
So, fewer time points and longer duration. They also show that this increases power and, with that, decreases the amount of people you need to scan.
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Ruben Dörfel @rdoerfel.bsky.social · 06/08/2025
Interesting paper by Vidal-Piñeiro et al. doi.org/10.1162/imag.... They show that "Increasing the follow-up time was associated with a substantial increase in longitudinal reliability, while the impact of increasing the number of observations was comparatively minor."
doi.org
Reliability of structural brain change in cognitively healthy adult samples
Abstract. In neuroimaging research, tracking individuals over time is key to understanding the interplay between brain changes and genetic, environmental, or cognitive factors across the lifespan. Yet...
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Ruben Dörfel @rdoerfel.bsky.social · 31/07/2025
As a junior researcher at a university that covers OA APCs in most conventional and top-tier journals, I have little incentive to not publish there. Morally, I would, of course, like to publish with non-profit orgs etc., but unfortunately, this is more expensive for me than publishing in Nature.
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Reposted by Ruben Dörfel
NeurIPS Europe @neuripseurope.bsky.social · 28/07/2025
EurIPS includes a call for both Workshops and Affinity Workshops! We look forward to making #EurIPS a diverse and inclusive event with you. The submission deadlines are August 22nd, AoE. More information at: eurips.cc/call-for-wor... eurips.cc/call-for-aff...
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Reposted by Ruben Dörfel
Ruben Dörfel @rdoerfel.bsky.social · 10/07/2025
Updated my Python project setup guide - originally created for my students but might be useful for other researchers and data scientists. Covers pyenv, poetry, git, and project structure best practices. Open to suggestions for improvements. rdoerfel.github.io/blog/2025/En...
rdoerfel.github.io
Setting up a Scientific Python Project from Scratch | Ruben P. Dörfel
A guide to set up a scientific Python project from scratch, covering version control, virtual environments, and project structure.
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Ruben Dörfel @rdoerfel.bsky.social · 10/07/2025
Updated my Python project setup guide - originally created for my students but might be useful for other researchers and data scientists. Covers pyenv, poetry, git, and project structure best practices. Open to suggestions for improvements. rdoerfel.github.io/blog/2025/En...
rdoerfel.github.io
Setting up a Scientific Python Project from Scratch | Ruben P. Dörfel
A guide to set up a scientific Python project from scratch, covering version control, virtual environments, and project structure.
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Ruben Dörfel @rdoerfel.bsky.social · 04/07/2025
Similar setup here. Also looking for suggestions. Especially on something like report generation
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Ruben Dörfel @rdoerfel.bsky.social · 15/06/2025
Lol. Nothing more American than that.
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Ruben Dörfel @rdoerfel.bsky.social · 08/06/2025
Such a danish thing to do!
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Reposted by Ruben Dörfel
Max Korbmacher @maxkorbmacher.bsky.social · 16/04/2025
New article out at Human Brain Mapping showing that brain age ≠ brain ageing (estimating brain age on all available features). This is not the only article showcasing this. Brain age is still useful, but be careful about the longitudinal claims. doi.org/10.1002/hbm....
doi.org
Cross‐Sectional Brain Age Assessments Are Limited in Predicting Future Brain Change
Multimodal imaging data of 39,325 UK Biobank participants with 2,520 follow-ups provide insufficient evidence to conclude that brain age reflects the rate of anatomical brain aging. However, modality...
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Reposted by Ruben Dörfel
FOMO25: Foundation Model Challenge for Brain MRI @fomochallenge.bsky.social · 22/04/2025
FOMO25 accepted at #MICCAI2025! 🚀 Excited to announce the first challenge at MICCAI focusing on the development of self-supervised pretraining of foundation models for brain MRI! 🧠 With access to a large-scale dataset, codebase, cash prices and multiple tracks. Read more ⬇️
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