iiinova — where your digital self keeps evolving

Das Lab @rdaslab.bsky.social · 27/08/2026

Our paper with @eternagame, 5 AI teams, and cryo-EM collabs on de novo design of #RNA pseudoknots with #deeplearning is out in @science.org! Comes with a provocative commentary on RNA structure prediction by @amustoe.bsky.social lab! doi.org/10.1126/scie... doi.org/10.1126/scie...

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Das Lab @rdaslab.bsky.social · 18/08/2026

Finally, 3D #cryoEM structure of a nucleotide polymerizing #RNA that copies #RNA to #RNA: tC19z, evolved at @mrclmb.ac.uk 15 y ago! www.biorxiv.org/content/10.6... @szokoli.bsky.social Jason Hingey, Dan Haack, Vivian Wu Nick Spellmon @navtejtoor.bsky.social @hhmijanelia.bsky.social

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Das Lab @rdaslab.bsky.social · 25/07/2026

RNA flexible? Maybe we can model that. First blind test of RNA 3D *ensemble* prediction — ligand-free SAMURI ribozyme (displayed on a group II intron scaffold) -- #MD and #deeplearning methods welcome, deadline Aug 22, 2026: predictioncenter.org/casp17/targe...

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Das Lab @rdaslab.bsky.social · 14/07/2026

Pseudoknots, AI, and preview of Eterna's first RNA replicase results at EternaCon 12, virtual on Sunday July 26, 2026! Preregister for free at: eternagame.org/eternacon/2026

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Das Lab @rdaslab.bsky.social · 15/05/2026

Third (& last?) intense week of #RNA server-only targets on #CASP17: small molecule binding ribozymes and aptamers & more group II introns in multiple states. Strange mix of natural and non-natural RNA and compounds and proteins. Looking forward to less crazy pace in next weeks.

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Das Lab @rdaslab.bsky.social · 09/05/2026

The 2nd week of #CASP17 is closing, with more group II introns and some other RNAmake synthetic designs — the dimer targets for both kinds of targets seem challenging! And more #RNA targets are coming in week 3: predictioncenter.org/news.cgi#557

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Das Lab @rdaslab.bsky.social · 05/05/2026

Latest #CASP17 #RNA targets are a tiny aptamer for tryptophan selected by Yarus lab @colorado.edu, a miniTTR by RNAmake @josephyesselman.bsky.social, and 2 singlet glycine riboswitches discovered by Breaker & Strobel labs. Note first one: 25-nt RNA by #cryoEM? predictioncenter.org/casp17/targe...

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Das Lab @rdaslab.bsky.social · 02/05/2026

First natural #RNA in #CASP17 is a group II self-splicing intron, and it’s also the season's 1st multistate target! Will server algorithms detect homologous group II intron structures to help modeling? Can servers model both unspliced and spliced states? predictioncenter.org/casp17/targe...

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Das Lab @rdaslab.bsky.social · 30/04/2026

More #CASP17 #RNA targets: OpenKnot @eternagame molecules from AI designers @rosettacommons.bsky.social @chaitjo.bsky.social & triphosphorylating ribozyme selected by Muller lab. All 8 RNA targets are non-natural — how will modeling methods do without MSAs, templates, homologous training examples?

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Das Lab @rdaslab.bsky.social · 27/04/2026

First two targets in #CASP17 are #RNA, and they're designs from the online videogame @eternagame.org. Hope the bots preparing for CASP have been playing Eterna!

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Das Lab @rdaslab.bsky.social · 31/03/2026

Results are in for @stanfordmedicine.bsky.social Kaggle #RNA 3D Folding, Part 2! Top teams team_cp and AyPy together just outperform the best template oracle, another milestone in computational biology. Come join the conversation as we prepare for #CASP17: www.kaggle.com/c/stanford-r...

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Das Lab @rdaslab.bsky.social · 24/01/2026

In 2 weeks, 9 Kaggle teams have beat AlphaFold 3 score (0.372) in predicting hidden 3D structures of #RNA, including complexes with small molecules & proteins. What will it take to beat the best template oracle (0.554)? www.kaggle.com/c/stanford-r...

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Das Lab @rdaslab.bsky.social · 11/11/2025

#MD blind predictions of water/ions around Tetrahymena ribozyme #RNA matched cryo-EM data better than our baselines! Congrats #CASP16 + @rachael-kretsch.bsky.social + 23 brave groups. Still a ways to go — time for #DeepLearning of water? Community paper: doi.org/10.1002/prot...

R1260 CASP target, water and ions around RNA. Ground truth on left, blind prediction from SoutheRNA MD simulations on right.

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Das Lab @rdaslab.bsky.social · 30/10/2025

Assessment of blind 3D structure modeling of #RNA and nucleic acid complexes now out in the #CASP16 special issue, led by @RachaelKretsch. We hope this benchmark, paper, metrics, and expert baselines drive much-needed progress by #CASP17 (May 2026)! doi.org/10.1002/prot...

Overlay of top blind model and cryo-EM structure for OLE RNA complex, only CASP16 RNA target showing strong improvements over prior templates

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Das Lab @rdaslab.bsky.social · 24/09/2025

The results are in: top codes in Stanford #RNA 3D Folding @kaggle.com competition are competitive with CASP16-leading humans Vfold, beat AlphaFold 3. Top team’s trick was template-based modeling, not #DeepLearning. Congrats: john, odat, Eigen, + all 1706 participants! www.kaggle.com/competitions...

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