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Navtej Toor

@navtejtoor.bsky.social
785 followers 3.4K following 2 posts

RNA Structural Biology Associate Professor UC San Diego Department of Chemistry and Biochemistry ORC ID: 0000-0002-6134-163X 🇨🇦🇺🇦

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Reposted by Navtej Toor
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 29/04/2025
A positive vision for how to move forward, CA cannot replace the national investment needed to remain the global leader in science and technology but maybe we can help keep the US competitive. sd11.senate.ca.gov/news/trump-g...
sd11.senate.ca.gov
As Trump Guts Federal Science Agencies, Senator Wiener Introduces Legislation to Create New Science Institute and Authorize Vaccine Purchase and Production
Official website of Senator Scott Wiener, representing California Senate District 11.
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Reposted by Navtej Toor
Mark Carney @mark-carney.bsky.social · 04/04/2025
CBC/Radio-Canada is a pillar of our Canadian identity.    We’re going to strengthen our public broadcaster with more long-term funding, and a modernized mandate — to deliver more local news and keep Canadians better informed during emergencies.
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Reposted by Navtej Toor
Deni Szokoli @szokoli.bsky.social · 19/12/2024
Out now in @NAR_Open ! A #ribozyme can self-integrate into and hydrolyze ss- & dsDNA, offering a new avenue for the development of protein-free genome editing tools, and hinting at the possibility of a pre-translation origin of group II introns (G2Is). 🧬🧵 (1/7) #intron #RNAworld
academic.oup.com
Protein-free catalysis of DNA hydrolysis and self-integration by a ribozyme
Abstract. Group II introns are ancient self-splicing ribozymes and retrotransposons. Though long speculated to have originated before translation, their de
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Reposted by Navtej Toor
Arne Elofsson @handle.invalid · 24/03/2025
www.nature.com/articles/d41...
nature.com
RNA function follows form – why is it so hard to predict?
AlphaFold’s highly accurate structural models transformed protein biology,but RNA lags behind.
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Reposted by Navtej Toor
Mark Carney @mark-carney.bsky.social · 24/03/2025
Canada is everything.
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Reposted by Navtej Toor
Maya Voichek @mayavoichek.bsky.social · 17/03/2025
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇
Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte
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Ardem Patapoutian @ardemp.bskyverified.social · 25/02/2025
OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs." www.sandiegouniontribune.com/2025/02/25/o...
sandiegouniontribune.com
Opinion: Science funding cuts are based on flawed logic. Here’s the truth.
Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 23/02/2025
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John Rubinstein @johnrubinstein.bsky.social · 22/02/2025
🚨 Amazing Opportunity 🚨 U Alberta is looking for a director for their new #cryoEM facility Support excellent researchers (who are really nice people) using state-of-the-art infrastructure. + reasonable cost of living + near some of most beautiful places in world + 🇨🇦 apps.ualberta.ca/careers/post...
Public domain photo of Banff national park in Alberta, Canada.
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D’Epitomee of 92% @epitomee.bsky.social · 15/02/2025
cc: @Gavin Newsome It’s time to build a CDC & NIH in California with the folks who were fired from the feds. In fact, I think each blue state governor needs to scoop up these scientists, healthcare workers and laboratory workers asap. @gavinnewsom.bsky.social
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Navtej Toor @navtejtoor.bsky.social · 11/02/2025
Does anyone know what’s happening with the communications blackout at NIH? A program officer just told me that she can’t discuss anything due to a “communications pause.” I had thought this blackout was over.
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Reposted by Navtej Toor
Mark Cuban @mcuban.bsky.social · 09/02/2025
This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...
globalnews.ca
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
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Reposted by Navtej Toor
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 06/02/2025
Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏 www.nature.com/articles/s41...
Graphic showing modification of mRNA with ADP-ribose mediated by bacterial enzyme cmdTAC
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Andy Fraser @andyfraser.bsky.social · 04/02/2025
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)
rdcu.be
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.
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Gary Swergold MD, PhD @gs314.bsky.social · 31/01/2025
🧪 If I were Canadian PM I would immediately: 1. Create a new $15B science fund 2. Offer any credentialed US scientist funding for lab startup and replacement of NIH grants if they move to Canada 3. Immediate permanent residency 4. Citizenship after 2 years Overnight a science superpower
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Science News @scinews.bsky.social · 26/01/2025
Ten simple rules for developing good reading habits during graduate school and beyond journals.plos.org/ploscompbiol...
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Navtej Toor @navtejtoor.bsky.social · 22/01/2025
Congratulations to Dan Haack and Boris Rudolfs on the new paper from our lab about the development of a scaffold enabling high resolution cryo-EM structure determination of protein-free RNAs. www.nature.com/articles/s41...
nature.com
Scaffold-enabled high-resolution cryo-EM structure determination of RNA - Nature Communications
Determining structures of small, protein-free RNAs by cryo-EM has been challenging. Here, the authors use a group II intron scaffold to achieve high-resolution RNA structures, visualize ligand-induced...
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Reposted by Navtej Toor
Nathan Lewis @natelewis3.bsky.social · 14/01/2025
I don't think that 101 years ago, Otto Warburg was aware how broadly relevant his discovery was. Check out our new paper out today in Nature Metabolism, wherein we engineered the Warburg effect out of mammalian cells to improve biologics production urldefense.com/v3/__https:/...
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Aude Bernheim @audeber.bsky.social · 09/01/2025
What is the diversity of antiphage systems out there ? We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families. Leb by E. Mordret. www.biorxiv.org/content/10.1... Interactive UMAP to have fun mdmparis.github.io/antiphage-la...
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