iiinova — where your digital self keeps evolving

Razvan Borza @rborza.bsky.social · 08/07/2025

🚀 My first Cryo-EM structures are OUT on the PDB! 🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌 🔁Thank you for sharing!❤️ Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/... ⬇️ 2nd video

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Reposted by Razvan Borza

📢 Ready for this? A new way to think about Gene Regulation! 🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬 💪Proud to be part of this work led by @daaninthelab.bsky.social Read more: science.org/doi/10.1126/science.adv2861

3D render of a Zincore complex locking ZFP91 onto DNA, promoting gene activation.
Made in Blender with Molecular Nodes.

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Razvan Borza @rborza.bsky.social · 22/07/2026

Amazing structure!! Congratulations!

Danielle Bianchi @daaninthelab.bsky.social · 04/07/2025

Reposted by Razvan Borza

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

science.org

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 28/09/2025

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions. Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

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Razvan Borza @rborza.bsky.social · 29/09/2025

⚠️Don't forget! You have FREE alternatives! 🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov 📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.

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Razvan Borza @rborza.bsky.social · 28/09/2025

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions. Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 23/01/2025

📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉 👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️ www.cell.com/trends/cell-...

A metallic arm holding a protein, simulating a GPI-anchored protein attached to the surface of a membrane.

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Reposted by Razvan Borza

Lidia Atencia Taboada @latencia.bsky.social · 15/07/2025

🚨 New strategy against colorectal cancer! Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪 ➡️Read more: www.nature.com/articles/s41...

nature.com

GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells - Oncogenesis

Oncogenesis - GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells

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Razvan Borza @rborza.bsky.social · 15/07/2025

👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀 💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement. ❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁 Read it: www.jbc.org/article/S002...

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Reposted by Razvan Borza

Razvan Borza @rborza.bsky.social · 16/04/2025

🚨New Article Out!! 📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒 🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance ♥️ Thanks for your support Read more here: doi.org/10.1016/j.bm...

Type VI inhibitor targeting both the catalytic site and the tunnel of Autotaxin (ATX). PDB ID: 9FXW

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Razvan Borza @rborza.bsky.social · 10/07/2025

Really crazy work!! wow.. Congratulation! 👏🏼

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Congratulation on your work! 👏🏼

This is amazing!! wow! 👏🏼

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Such a satisfying structure to look at! hahaha

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Congratulation on you preprint! 👏🏼

This looks impressive!! 👏🏼

I hope your presentation went well! 💪🏼

Cool image!! and Congratulations on your preprint! 👏🏼

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That is a huge structure... Congratulations! 👏🏼

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Amazing resolution for Cryo-EM!! 👏🏼

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This sounds really really interesting. I might have a look at folddisco

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I get you.... I really do hahahaha

Congratulation for you preprint!! KRAB containing ZNFs are exciting!

I'm more of a Beta Beta Alpha helix zinc finger guy... hahaha

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I've come across this huge ZNFs hahaha. Amazing AF3 prediction. Congratulation for you work! 👏🏼

Very interesting!! I'm impressed how much work is done in Drosophila related to ZNFs. What is the similarity to human ZNFS?

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Amazing paper! Congratulations! 👏🏼