Reposted by Vikram ParalkarNobel Prize @nobelprize.org · 08/10/2026Learn more about the 2026 #NobelPrize in Literature: bit.ly/4iyhLFJ 08822
Reposted by Vikram ParalkarKevin A. Scott, PhD @sculpturatus.bsky.social · 17/09/2026found at ucsf 9561118
Reposted by Vikram ParalkarVijay Ramani @vram142.bsky.social · 14/09/2026Everything you wanted to know about single-molecule epigenomics but were too afraid to ask! Wonderful to co-write (h/t ENORMOUS lift by @arnaudkr.bsky.social) this primer on our nascent field. Also, a 💯 example of wonderful colleagues building something *together*, not in competition =)nature.comA practical guide to studying genome function using single-molecule genomicsNature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling... 07526
Vikram Paralkar @paralkarlab.bsky.social · 08/09/2026Buy why do they need to listen to music during the class? 😕 060
Vikram Paralkar @paralkarlab.bsky.social · 24/08/2026Great to see Brie's paper out! Congratulations! 010
Reposted by Vikram ParalkarTobias Wilson-Bates @phdhurtbrain.bsky.social · 21/08/2026James Bond: you think I haven’t faced death before? Supervillain: oh, I don’t expect you to die, Mr. Bond. I expect you to suffer. *opens travel funding reimbursement software I think you will find your motorboat rental and casino reservations especially complex James Bond: no. no. pls kill me 382278468
Reposted by Vikram ParalkarVijay G. Sankaran @bloodgenes.bsky.social · 06/08/2026🚨👇 Check out this wonderful collaborative work identifying a new 3D genome regulator - Matchmakers - with the incredible @andersshansen.bsky.social ! Fantastic work led by Varshini Ramanathan and Chun-Jie Guo! 0104
Reposted by Vikram ParalkarAdam Phillippy @aphillippy.bsky.social · 06/08/2026For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15] 3203106
Reposted by Vikram ParalkarStirling Churchman @stirlingchurchman.bsky.social · 28/07/2026RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...biorxiv.orgAnalog intrinsic recoding measures RNA dynamics without chemical conversionSteady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro... 215461
Reposted by Vikram Paralkarsamuel mehr @mehr.nz · 21/07/2026the most realistic scene in Jurassic Park is when two scientists make a questionable decision — traveling to an undisclosed location with a strange man — on the promise of three years of modest funding 355713846
Reposted by Vikram Paralkarernstlaboratory.bsky.social @ernstlaboratory.bsky.social · 19/07/2026THE MYELOID WORKSHOP IS ON! We listened to your feedback and packed more talks in; will start 1 hr earlier. The ASH website will list workshops soon, stay tuned for how to request speaking slots @steidluli.bsky.social 151
Reposted by Vikram ParalkarCosta Samaras @costasamaras.com · 19/07/2026Could Excel be conscious? We surveyed more than Jan 1 1900 people to find out. 114137702876
Vikram Paralkar @paralkarlab.bsky.social · 16/07/2026The word "honorific" and "horrific" are too close together. Who designed this language? 000
Reposted by Vikram ParalkarAni Deshpande Lab @anideshpande.bsky.social · 14/07/2026Excited to share our latest preprint on AML, now on bioRxiv - biorxiv.org/content/10.6... A🧵biorxiv.orgDisrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML SubtypesAcute myeloid leukemia (AML) cells rely on an actively maintained, chromatin-encoded transcriptional program to sustain their malignant identity, offering a potential therapeutic vulnerability. Using ... 251
Vikram Paralkar @paralkarlab.bsky.social · 05/07/2026I'm a fan of Post Malone's early music. When he was Pre Malone. 000
Vikram Paralkar @paralkarlab.bsky.social · 03/07/2026Awesome, Faraz! Looking forward to digging into this! 010
Reposted by Vikram ParalkarFaraz Mardakheh @mardakheh.bsky.social · 03/07/2026🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6... 25024
Vikram Paralkar @paralkarlab.bsky.social · 03/07/2026Q: What do you call a group of parrots? A: Polly-ploid. 121
Reposted by Vikram ParalkarKarla Neugebauer @karlaneugebauer.bsky.social · 01/07/2026I am excited and proud to be an organizer of this fantastic meeting. I always walk away with new friends and colleagues and having learned so much. Hope to see you there! 276
Reposted by Vikram ParalkarNikolai Slavov @slavov-n.bsky.social · 30/06/2026A deeper dive into the article we published last week in @nature.com. I will start with the framing and methodology as they are key to understanding the surprising results: Most proteomics experiments begin with an assumption. www.nature.com/articles/s41... 1/ 1205
Vikram Paralkar @paralkarlab.bsky.social · 29/06/2026What I like about preprints: They don't come with any baked-in impact-factor-like imprimatur that elevates some over others. What would be valuable: An AI-based system that learns a user's scientific questions, and converts the firehose of preprints into a gentle, personally-curated stream. 010
Vikram Paralkar @paralkarlab.bsky.social · 23/06/2026Biting satire about our increasing reliance on LLMs! 😳inpreparation.substack.comOpinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is DiscriminationBy Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University 020
Reposted by Vikram ParalkarAnders Sejr Hansen @andersshansen.bsky.social · 22/06/2026(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6... 215377
Reposted by Vikram ParalkarPolly Mackenzie @pollymackenzie.bsky.social · 21/06/2026My nine year old asked for a Rosetta Stone cake for his birthday 602218042559
Reposted by Vikram ParalkarThe R Foundation @r-foundation.bsky.social · 17/06/2026The 2026 Rousseeuw Prize for Statistics has been awarded to the R Project. #RStats www.rousseeuwprize.org/2026rousseeuwprize.orgThe Rousseeuw Prize for StatisticsThe Rousseeuw Prize for Statistics is a biennial prize to celebrate outstanding contributions to statistics research. 2280106
Vikram Paralkar @paralkarlab.bsky.social · 17/06/2026Congratulations! We use R every day in our work! It's such an incredible contribution to the scientific world! 040
Reposted by Vikram ParalkarPeter Dalgaard @pdalgd.bsky.social · 17/06/2026I am deeply honoured to be a laureate of the 2026 Rousseeuw Prize, which has been awarded to the R Project. I have been on the R Core Team for almost 30 years, We built and maintained R with a vision to make statistical tools freely available and extendable. Congratulations to entire team! 47411
Vikram Paralkar @paralkarlab.bsky.social · 06/06/2026Had a nightmare that I triple-booked inpatient clinical service with a university lecture and a PhD thesis committee defense, and became aware of the conflicts the night before! Now I'm awake and relieved this wasn't real, but have a fresh new anxiety that I might do this some day! 😅 010
Vikram Paralkar @paralkarlab.bsky.social · 03/06/2026Such a pleasure to see you, Jen! And thanks for the wonderful seminar - beautiful work! 010
Reposted by Vikram ParalkarJennifer Trowbridge @trowbridgelab.bsky.social · 03/06/20261/3 Delighted to have visited the University of Pennsylvania this week, hosted by the fantastic Dr. Bobby Bowman who has built an exciting research program on the origins of myeloid malignancies and leukemia relapse. 193
Reposted by Vikram ParalkarDaniel Lipka @dblipka.bsky.social · 29/05/2026🧵 NEW PAPER in @bloodjournal.bsky.social! Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? 🤔 #AML #Epigenetics Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇 2329