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Vikram Paralkar

@paralkarlab.bsky.social
2.7K followers 848 following 678 posts

Physician-Scientist | University of Pennsylvania | Pol I, rRNA, Ribosomes, Chromatin, Transcription | Hematopoiesis and Leukemia | 🩸🔬🧪🧬 paralkarlab.med.upenn.edu

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Vikram Paralkar @paralkarlab.bsky.social · 10/10/2026
Multiplexed chocolate screen! 😮
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Nobel Prize @nobelprize.org · 08/10/2026
Learn more about the 2026 #NobelPrize in Literature: bit.ly/4iyhLFJ
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Vikram Paralkar @paralkarlab.bsky.social · 06/10/2026
Congratulations! 👏🏼👏🏼👏🏼
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Vikram Paralkar @paralkarlab.bsky.social · 28/09/2026
😵‍💫😵‍💫😵‍💫
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Vikram Paralkar @paralkarlab.bsky.social · 19/09/2026
😢😢😢
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Vikram Paralkar @paralkarlab.bsky.social · 17/09/2026
GENIUS
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Kevin A. Scott, PhD @sculpturatus.bsky.social · 17/09/2026
found at ucsf
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Vijay Ramani @vram142.bsky.social · 14/09/2026
Everything you wanted to know about single-molecule epigenomics but were too afraid to ask! Wonderful to co-write (h/t ENORMOUS lift by @arnaudkr.bsky.social) this primer on our nascent field. Also, a 💯 example of wonderful colleagues building something *together*, not in competition =)
nature.com
A practical guide to studying genome function using single-molecule genomics
Nature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling...
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Vikram Paralkar @paralkarlab.bsky.social · 08/09/2026
Buy why do they need to listen to music during the class? 😕
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Vikram Paralkar @paralkarlab.bsky.social · 24/08/2026
Great to see Brie's paper out! Congratulations!
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Tobias Wilson-Bates @phdhurtbrain.bsky.social · 21/08/2026
James Bond: you think I haven’t faced death before? Supervillain: oh, I don’t expect you to die, Mr. Bond. I expect you to suffer. *opens travel funding reimbursement software I think you will find your motorboat rental and casino reservations especially complex James Bond: no. no. pls kill me
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Vijay G. Sankaran @bloodgenes.bsky.social · 06/08/2026
🚨👇 Check out this wonderful collaborative work identifying a new 3D genome regulator - Matchmakers - with the incredible @andersshansen.bsky.social ! Fantastic work led by Varshini Ramanathan and Chun-Jie Guo!
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Adam Phillippy @aphillippy.bsky.social · 06/08/2026
For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨‍🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15]
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Vikram Paralkar @paralkarlab.bsky.social · 29/07/2026
I like my meals intrinsically disordered!
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Stirling Churchman @stirlingchurchman.bsky.social · 28/07/2026
RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...
biorxiv.org
Analog intrinsic recoding measures RNA dynamics without chemical conversion
Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...
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Vikram Paralkar @paralkarlab.bsky.social · 28/07/2026
😮😮😮
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Vikram Paralkar @paralkarlab.bsky.social · 27/07/2026
Except the malignant ones! 😱
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samuel mehr @mehr.nz · 21/07/2026
the most realistic scene in Jurassic Park is when two scientists make a questionable decision — traveling to an undisclosed location with a strange man — on the promise of three years of modest funding
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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · 19/07/2026
THE MYELOID WORKSHOP IS ON! We listened to your feedback and packed more talks in; will start 1 hr earlier. The ASH website will list workshops soon, stay tuned for how to request speaking slots @steidluli.bsky.social
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Costa Samaras @costasamaras.com · 19/07/2026
Could Excel be conscious? We surveyed more than Jan 1 1900 people to find out.
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Vikram Paralkar @paralkarlab.bsky.social · 16/07/2026
The word "honorific" and "horrific" are too close together. Who designed this language?
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Vikram Paralkar @paralkarlab.bsky.social · 15/07/2026
Awesome, Ani!
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Ani Deshpande Lab @anideshpande.bsky.social · 14/07/2026
Excited to share our latest preprint on AML, now on bioRxiv - biorxiv.org/content/10.6... A🧵
biorxiv.org
Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes
Acute myeloid leukemia (AML) cells rely on an actively maintained, chromatin-encoded transcriptional program to sustain their malignant identity, offering a potential therapeutic vulnerability. Using ...
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Vikram Paralkar @paralkarlab.bsky.social · 11/07/2026
It's "trending towards significance..."
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Vikram Paralkar @paralkarlab.bsky.social · 11/07/2026
Or as bad!
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Vikram Paralkar @paralkarlab.bsky.social · 05/07/2026
I'm a fan of Post Malone's early music. When he was Pre Malone.
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Vikram Paralkar @paralkarlab.bsky.social · 03/07/2026
Awesome, Faraz! Looking forward to digging into this!
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Faraz Mardakheh @mardakheh.bsky.social · 03/07/2026
🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...
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Vikram Paralkar @paralkarlab.bsky.social · 03/07/2026
Q: What do you call a group of parrots? A: Polly-ploid.
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Karla Neugebauer @karlaneugebauer.bsky.social · 01/07/2026
I am excited and proud to be an organizer of this fantastic meeting. I always walk away with new friends and colleagues and having learned so much. Hope to see you there!
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Vikram Paralkar @paralkarlab.bsky.social · 01/07/2026
!!!
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Nikolai Slavov @slavov-n.bsky.social · 30/06/2026
A deeper dive into the article we published last week in @nature.com. I will start with the framing and methodology as they are key to understanding the surprising results: Most proteomics experiments begin with an assumption. www.nature.com/articles/s41... 1/
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Vikram Paralkar @paralkarlab.bsky.social · 29/06/2026
What I like about preprints: They don't come with any baked-in impact-factor-like imprimatur that elevates some over others. What would be valuable: An AI-based system that learns a user's scientific questions, and converts the firehose of preprints into a gentle, personally-curated stream.
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Vikram Paralkar @paralkarlab.bsky.social · 27/06/2026
Best kind!
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Vikram Paralkar @paralkarlab.bsky.social · 23/06/2026
Biting satire about our increasing reliance on LLMs! 😳
inpreparation.substack.com
Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination
By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University
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Anders Sejr Hansen @andersshansen.bsky.social · 22/06/2026
(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...
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Vikram Paralkar @paralkarlab.bsky.social · 21/06/2026
This is so awesome!
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Polly Mackenzie @pollymackenzie.bsky.social · 21/06/2026
My nine year old asked for a Rosetta Stone cake for his birthday
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Vikram Paralkar @paralkarlab.bsky.social · 18/06/2026
Seriously! What?!? 😂
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The R Foundation @r-foundation.bsky.social · 17/06/2026
The 2026 Rousseeuw Prize for Statistics has been awarded to the R Project. #RStats www.rousseeuwprize.org/2026
rousseeuwprize.org
The Rousseeuw Prize for Statistics
The Rousseeuw Prize for Statistics is a biennial prize to celebrate outstanding contributions to statistics research.
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Vikram Paralkar @paralkarlab.bsky.social · 17/06/2026
Congratulations! We use R every day in our work! It's such an incredible contribution to the scientific world!
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Peter Dalgaard @pdalgd.bsky.social · 17/06/2026
I am deeply honoured to be a laureate of the 2026 Rousseeuw Prize, which has been awarded to the R Project. I have been on the R Core Team for almost 30 years, We built and maintained R with a vision to make statistical tools freely available and extendable. Congratulations to entire team!
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Vikram Paralkar @paralkarlab.bsky.social · 16/06/2026
The answer is always Yes!
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Vikram Paralkar @paralkarlab.bsky.social · 06/06/2026
Had a nightmare that I triple-booked inpatient clinical service with a university lecture and a PhD thesis committee defense, and became aware of the conflicts the night before! Now I'm awake and relieved this wasn't real, but have a fresh new anxiety that I might do this some day! 😅
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Vikram Paralkar @paralkarlab.bsky.social · 04/06/2026
Nooooo 😢
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Vikram Paralkar @paralkarlab.bsky.social · 03/06/2026
Such a pleasure to see you, Jen! And thanks for the wonderful seminar - beautiful work!
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Jennifer Trowbridge @trowbridgelab.bsky.social · 03/06/2026
1/3 Delighted to have visited the University of Pennsylvania this week, hosted by the fantastic Dr. Bobby Bowman who has built an exciting research program on the origins of myeloid malignancies and leukemia relapse.
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Vikram Paralkar @paralkarlab.bsky.social · 30/05/2026
Awesome, Daniel. Really fascinating work!
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Daniel Lipka @dblipka.bsky.social · 29/05/2026
🧵 NEW PAPER in @bloodjournal.bsky.social! Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? 🤔 #AML #Epigenetics Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇
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Vikram Paralkar @paralkarlab.bsky.social · 29/05/2026
That's a good approach!
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