iiinova — where your digital self keeps evolving

Ani Deshpande Lab @anideshpande.bsky.social · 25/01/2026

Do medicines from nature fascinate you? Catch our latest Discovery Dialogues episode on how plant poisons have been transformed into life-saving medicines. Featuring @nirbarzilaimd.bsky.social (Einstein), David Nathan (MGH) and a lovely cameo from Ambarish Satwik. youtu.be/7Gq94-0wnNA

youtu.be

From Plant Poisons to Medicines

YouTube video by Discovery Dialogues

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Ani Deshpande Lab @anideshpande.bsky.social · 20/09/2025

A 60 second video clip of Episode 5 in which we chronicle the fascinating story behind Continuous Glucose Monitors (CGMs) and of Adam Heller the man who built technologies that advanced these devices.

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Sanford Burnham Prebys @sbpdiscovery.bsky.social · 10/09/2025

🔬 New research from the @anideshpande.bsky.social Deshpande lab at Sanford Burnham Prebys. The study demonstrates how public genomic screening data can be used to uncover a new genetic vulnerability in synovial sarcoma. 👏 Shout out to Rema Iyer, PhD lead author of the manuscript.

Sizing up a weakness in synovial sarcoma’s genes

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Ani Deshpande Lab @anideshpande.bsky.social · 18/08/2025

Really excited that our manuscript on Synovial Sarcoma is now online. Link to Open Access PDF: tinyurl.com/55bnssws A summary🧵 :

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Ani Deshpande Lab @anideshpande.bsky.social · 11/08/2025

Sugar is the fuel of life, but we are drowning in it in the modern world. Where does all that excess sugar go, and what quiet damage might it be causing inside us?

youtube.com

E4 Diabetes - A Secret in Your Blood

YouTube video by Discovery Dialogues

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Ani Deshpande Lab @anideshpande.bsky.social · 02/07/2025

I’m excited to share that as of July 1, I’ve been promoted to Full Professor. I am immensely grateful for the support of my trainees, mentors, letter writers and colleagues who supported me in reaching this milestone and for those who made this journey meaningful and worthwhile.

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euanashley @euanashley.bsky.social · 14/06/2025

Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.

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Ani Deshpande Lab @anideshpande.bsky.social · 07/06/2025

Always a bittersweet moment when a PhD student from the lab graduates.Terrific work and what a thesis defense talk Rema Iyer ! Congratulations on your degree!

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Sen. Adam Schiff @schiff.senate.gov · 28/05/2025

Science is under attack. The NIH, the NSF, and our research universities. So today, I have a message for America's scientists: youtu.be/MeoZDPy5cIY?...

youtu.be

A Message to Scientists

YouTube video by Sen. Adam Schiff

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 24/05/2025

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏 youtu.be/8YhJM6zxYDw?...

youtu.be

Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

YouTube video by Amanpour and Company

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Ani Deshpande Lab @anideshpande.bsky.social · 24/05/2025

Venoms can kill, but can they also heal? Here's Episode 3 of The Discovery Dialogues Podcast 𝗬𝗼𝘂𝗧𝘂𝗯𝗲: tinyurl.com/u7p3r8n9 𝗦𝗽𝗼𝘁𝗶𝗳𝘆: tinyurl.com/mryvvjsr 𝗔𝗽𝗽𝗹𝗲: tinyurl.com/bswzh583

tinyurl.com

E3 Diabetes - Venoms Lethal or Lifesaving?

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

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Epigenetics Podcast @epigeneticspod.bsky.social · 23/05/2025

In this episode, we talked with @anideshpande.bsky.social from @sbpdiscovery.bsky.social about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. #epigenetics #podcast #chromatin #cancer #leukemia Listen here: activemotif.com/podcasts-ani...

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Harmit Singh Malik @harmitmalik.bsky.social · 22/05/2025

We live in such a golden age of science with so much potential for discovery and alleviating some of the most severe human diseases. And we are going to piss it all away because … I’m not exactly sure why. No one has made a convincing case why this helps anyone, red or blue or purple.

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Dr. Glaucomflecken @glaucomflecken.bsky.social · 11/05/2025

I’m fascinated by scientific breakthroughs that were universally hailed in the moment, like pasteurization, that are now vilified by some people. Is this a uniquely American thing? Anybody written a book about why/how this happens? Like the psychology behind it. I’d love to learn more.

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Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 03/05/2025

Ben Franklin on inoculation, after his son died from smallpox. “In 1736, I lost one of my sons, a fine boy of four years old, by the small-pox, taken in the common way. I long regretted bitterly, and still regret that I had not given it to him by inoculation”.

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Jo Wolff @jowolff.bsky.social · 03/05/2025

Every now again it’s useful to repeat advice about accessing papers that are behind a paywall that excludes you. Email the author. My estimate is that 90% of academics are so thrilled that a living, breathing, possibly even reading, person shows interest that they will swiftly send you a copy.

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Ani Deshpande Lab @anideshpande.bsky.social · 17/04/2025

In Episode 2 of the Discovery Dialogues Podcast, we recount the fascinating story of the race to clone the first human gene. Featuring Herb Boyer and Keiichi Itakura. 🎥YouTube: tinyurl.com/4x7fkzzu 🎧 Spotify: tinyurl.com/3af8zrt8 🎧 Apple Podcasts: tinyurl.com/2st95bb9

tinyurl.com

E2 Diabetes The Race for Human Insulin

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

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Arjun Raj @arjunraj.bsky.social · 15/04/2025

I feel like the conference talk format has gotten so stale, even for those who are good at it. How can we switch it up? One idea we've been toying with is an "interview" style, where after a 5 minute presentation, an interviewer who has read the paper engages in a structured conversation. Thoughts?

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Ani Deshpande Lab @anideshpande.bsky.social · 21/03/2025

I have always felt there is a monumental disconnect between how transformative science has been in improving the human condition, and how it is generally perceived. With this in mind, we are launching The Discovery Dialogues Podcast. Please listen/share.

youtube.com

E1 Diabetes Roots

YouTube video by Discovery Dialogues

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Ani Deshpande Lab @anideshpande.bsky.social · 19/03/2025

Listening to the Airborne audiobook by @carlzimmer.com while driving to work and it makes you want to stay in the car even when you have arrived at your destination and keep listening. What a terrific piece of science writing!

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Eric Topol @erictopol.bsky.social · 11/03/2025

Genome editing success for the first time in nine patients with alpha-1 antitrypsin deficiency, a heritable disease which can cause cirrhosis and emphysema, affecting ~100,000 Americans, which is similar to the prevalence of sickle cell disease www.nytimes.com/2025/03/10/h...

nytimes.com

Mutated DNA Restored to Normal in Gene Therapy Advance

The small study in patients with a rare disorder that causes liver and lung damage showed the potential for precisely targeted infusions.

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Fyodor Urnov @urnov.bsky.social · 09/03/2025

Emily Whitehead's life was saved by an "academic" team at Penn Medicine - this yielded an approved therapy, Kymriah, since used by Novartius to treat ~20,000 patients with cancer. = science at research universities saves lives. Pls read second subunit below. www.cnn.com/2025/03/07/h...

cnn.com

Cancer survivor warns against threats to health funding | CNN

Emily Whitehead and Tom Whitehead join The Lead

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Ardem Patapoutian @ardemp.bskyverified.social · 07/03/2025

I heard some folks try Bluesky, don’t get enough engagement, and go back to Twitter! Be generous with posts you like—it doesn’t cost a dime!

media.tenor.com

a red heart with the number 994 on it

ALT: a red heart with the number 994 on it

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Ani Deshpande Lab @anideshpande.bsky.social · 24/02/2025

There are thousands of studies published on the cancer-causing protein MYC – but some big pieces of the puzzle have been missing. I am excited to share a preprint of one of the coolest studies I have seen go from inception to completion from my colleague Anindya Bagchi's Lab. tinyurl.com/447f2jur

tinyurl.com

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements

MYC-driven (MYC+) cancers are aggressive and often fatal. MYC dysregulation is a key event in these cancers, but overexpression of MYC alone is not always enough to cause cancer. Plasmocytoma Variant ...

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Fleur Ferguson @fleurmferguson.bsky.social · 08/01/2025

Please share widely - we are hiring, come join our team!

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Ani Deshpande Lab @anideshpande.bsky.social · 23/12/2024

Maybe a bit passive aggressive this messaging from me. Should tone it down?

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Ani Deshpande Lab @anideshpande.bsky.social · 16/12/2024

Today, the lab turned 10 years old. After a shaky beginning, we embarked on some really fun projects, made discoveries, and trained extraordinary people. I am particularly excited by upcoming studies in our lab, and it looks like the fun has just begun. Looking forward to the next 10 and more.

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Ani Deshpande Lab @anideshpande.bsky.social · 04/12/2024

Fabulous Deshpande/Adams/Bagchi/Dhar joint lab holiday trip to the Anza Borrego desert near San Diego. Those who are traveling to #ASH24 this week can expect this winter weather!

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Ani Deshpande Lab @anideshpande.bsky.social · 02/12/2024

Our institute is excited to host The Myeloid Precursor this Thursday, a fun mini symposium on AML with great talks, a panel discussion on AML therapeutics, and a poster session. If you are in San Diego this Thursday and interested, please register here. forms.office.com/r/Sq59VV1vh7

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Ani Deshpande Lab @anideshpande.bsky.social · 16/09/2024

Turning a paper into a podcast! Here's a summary of the manuscript we published last year on HOX gene regulation in AML (Google NotebookLM). Bit over the top, but cool to hear a Sal Khan-soundalike explain your own paper to you in an NPR-like fashion! youtu.be/944UIdCfCR0?...

youtu.be

Screening for HOX Regulators in AML Podcast

YouTube video by Aniruddha Jayant Deshpande

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Vikram Paralkar @paralkarlab.bsky.social · 20/04/2024

So deeply saddened to hear of Daniel Dennett’s death. An incredibly influential philosopher, and someone whose writings I always found provocative and illuminating. A monumental loss!

nytimes.com

Daniel C. Dennett, Widely Read and Fiercely Debated Philosopher, Dies at 82

Espousing his ideas in best sellers, he insisted that religion was an illusion, free will was a fantasy and evolution could only be explained by natural selection.

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Ani Deshpande Lab @anideshpande.bsky.social · 13/02/2024

From here it looks like a recently graduated mouse.

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