Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...

Single-cell transcriptional profiling of in vitro human pancreatic β-cell differentiation reveals progenitor and terminal fates, produces a detailed time course of endocrine induction and underpins a ...

How different islet lineages emerge within pancreatic islets remains largely unknown. Here, using hPSC and mouse models, the authors identify mechanisms that influence islet versus enterochromaffin li...

How different islet lineages emerge within pancreatic islets remains largely unknown. Here, using hPSC and mouse models, the authors identify mechanisms that influence islet versus enterochromaffin li...

How different islet lineages emerge within pancreatic islets remains largely unknown. Here, using hPSC and mouse models, the authors identify mechanisms that influence islet versus enterochromaffin li...

Chapter 19: Metabolic Acidosis. Part One, The Show

Acute cellular rejection (ACR) is a key contributor to chronic lung allograft dysfunction (CLAD) following transplantation; while treatable, traditional immunosuppressive (IS) therapies are associated...

I am an academic nephrologist practicing for more than 10 years in a tertiary medical center. A 55-year-old man presented to my clinic with concerns about poor appetite and abnormal kidney function pe...

Hypoxia impairs the efficacy of stem cell-derived islet cell therapy, making it a potential barrier for treatment of type 1 diabetes. Wang et al. identify EDN3 as a key factor that preserves β cell id...

YouTube video by Ottawa Nephrology

A simple pill to treat or even cure diabetes could be possible, thanks to University of Alberta research — and funding that is laying vital groundwork.