Reposted by Ofer YizharBejaLabTechnion @bejalab.bsky.social · 01/03/2026The International Conference on Retinal Proteins (ICRP2026) registration and abstract submission are now opened!!! www.congressi.unisi.it/retinalprote... 062
Reposted by Ofer YizharThe Transmitter @thetransmitter.bsky.social · 19/11/2025The field is buzzing about work on brain-computer interfaces for speech, the mechanism of psychedelics, a broader definition of hippocampal representations and more. www.thetransmitter.org/community/th... #neuroskyence #StateOfNeurosciencethetransmitter.orgThe buzziest neuroscience papers of 2023, 2024The field took note of work on brain-computer interfaces for speech, the mechanism of psychedelics, defining hippocampal representations, and more. 0218
Reposted by Ofer YizharKarl Deisseroth @deisseroth.bsky.social · 18/11/2025Our microbial-opsin work (and most of the field ) is basic science, but it was intriguing to review clinical progress–direct & indirect–with a wonderful team of co-authors t.co/JrJen2WGBV & adapt a fig. of PMID:28912215 (2017) with my long-time collaborator Peter Hegemann (pic: a memory from 2017). 0286
Ofer Yizhar @oyiz.bsky.social · 18/09/2025Really cool stuff! Engineered excitatory opsins responding to 15nW light 0135
Reposted by Ofer YizharNiv Reggev ניב רגב نيڤ ريچيڤ @nivreggev.bsky.social · 15/09/2025Breaking a hiatus to post this. A group of Israeli Social Psychologists, myself included, wrote a letter to speak out clearly against the Israeli government’s decisions and the resulting devastation in Gaza. docs.google.com/document/d/1... In hopes of peace and safety for all, and soondocs.google.comA Letter by Israeli Social PsychologistsDear friends of the Social Psychology community, After October 7, a group of Israeli social psychologists, including many of us, wrote a letter expressing our deep shock at the massacre, abuse, rape,... 1235
Ofer Yizhar @oyiz.bsky.social · 12/09/2025Follow @dzelmanoff.bsky.social who led this work and just joined the bsky party! 130
Reposted by Ofer YizharCedric Boeckx @cedricboeckx.bsky.social · 12/09/2025Very cool study by @oyiz.bsky.social using optogenetics to shed light on how oxytocin signaling regulates vocalization to maintain maternal bonds (with nice write-up by @bellonec.bsky.social, “Cries into ties” indeed) 🧪 www.science.org/doi/10.1126/...science.orgCries into tiesOxytocin neurons in mouse pups regulate vocalization to maintain maternal bonds 2116
Ofer Yizhar @oyiz.bsky.social · 12/09/2025Many thanks to my amazing team at @weizmanninstitute.bsky.social, our colleagues at the Dept. of Brain Sciences and at the Dept. of Molecular Neuroscience and the generous support of @erc.europa.eu and the NIH BRAIN Initiative 350
Ofer Yizhar @oyiz.bsky.social · 12/09/2025And this article at the Transmitter by Claudia Lopez: www.thetransmitter.org/oxytocin/oxy...thetransmitter.orgOxytocin shapes both mouse mom and pup behaviorDistressed pups emit distinct cries for help, which depend on oxytocin neurons in their hypothalamus. 150
Ofer Yizhar @oyiz.bsky.social · 12/09/2025See also this really nice write-up by @bellonec.bsky.social : www.science.org/doi/10.1126/...science.orgCries into tiesOxytocin neurons in mouse pups regulate vocalization to maintain maternal bonds 140
Ofer Yizhar @oyiz.bsky.social · 12/09/2025This study was led by my fantastic PhD student Daniel Zelmanoff and a wonderful team from the lab. Check out the full paper here: www.science.org/doi/10.1126/...science.orgOxytocin signaling regulates maternally directed behavior during early lifeOxytocin is essential in shaping social behavior across the lifespan. Although the role of oxytocin signaling in parental care has been widely investigated, little is known about its function in socia... 140
Ofer Yizhar @oyiz.bsky.social · 12/09/2025Using this approach, we were able to show that silencing oxytocin neurons specifically alters the vocal behaviors of pups when they are separated from their dam and littermates, and also alters their vocal behavior upon reunion. 160
Ofer Yizhar @oyiz.bsky.social · 12/09/2025Since optogenetic manipulations are very difficult to perform at such a young age, we devised a new approach that uses our mosquito opsin eOPN3, which is red-shifted and highly light-sensitive, for transcranial silencing of hypothalamic oxytocin cells in freely-behaving pups. 180
Ofer Yizhar @oyiz.bsky.social · 12/09/2025We found that oxytocin neurons are activated during a 3-hour separation from the home cage, and are also transiently recruited during the emission of ultrasonic vocalization bouts. 130
Ofer Yizhar @oyiz.bsky.social · 12/09/2025This study was ignited by the discovery that oxytocin receptors reach peak expression in the brain during early life - both in humans and rodents! In mice, P14-21 and in humans from birth to 3 years. We wondered how oxytocin contributes to behavior at this critical period in an animal's lifetime. 160
Ofer Yizhar @oyiz.bsky.social · 12/09/2025Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15). 410734
Reposted by Ofer YizharJonathan Kadmon @kadmonj.bsky.social · 27/07/2025In the past year and a half, we have been intensively protesting and fighting the Israeli government in an attempt to stop the war, secure the release of all hostages, and prevent the ongoing humanitarian crisis. Until now, our protests have primarily been focused internally. 2186
Reposted by Ofer YizharSPIE @spie.org · 26/01/2025What time is it? ⏰ Time to talk about the brain! 🧠 Opening the Neurotechnologies plenary session is @oyiz.bsky.social of Weizmann Inst. of Science. He is discussing new tools that allow highly light-sensitive silencing AND facilitate spectral multiplexing for modulation + imaging. #PhotonicsWest 1241
Reposted by Ofer YizharYulong Li Lab @yulonglilab.bsky.social · 24/12/2024First post on Bluesky!✨ (1/7) Far-red dopamine sensor is coming! Excited to introduce our chemigenetic DA sensor, HaloDA1.0! #Dopamine #FarRedSensors, #GRAB www.biorxiv.org/content/10.1...biorxiv.org 39417
Reposted by Ofer YizharJonas Wietek @jwietek.bsky.social · 23/12/2024Optogenetics 7.0 🍾 Cheers 🥂 @johvierock.bsky.social @oyiz.bsky.social @deisseroth.bsky.social 1215
Reposted by Ofer YizharLuke Sjulson @lukesjulson.bsky.social · 13/12/2024Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵youtube.comNeuroscience methods - YouTubeNanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici... 19437215
Reposted by Ofer YizharJB Manent @jbmanent.bsky.social · 14/11/2024Related to this, I created a starter pack for those interested/involved in Epilepsy research. Many of the DBS folks may also be interested. go.bsky.app/B8pPi1n 4124
Reposted by Ofer YizharAndreas Horn @andreashorn.org · 13/11/2024Upon popular demand I created a started pack for people interested in Deep Brain Stimulation! Lmk if you'd like to be added! go.bsky.app/B9A9Cho 63614
Reposted by Ofer YizharNikolas Karalis @nikolaskaralis.bsky.social · 17/11/2024How to rebuild your network on @bsky.app and improve your experience here? I made a short starter guide with resources. www.neuronaldynamics.eu/resources/bl... Also, a thread 🧵 below. 27334
Reposted by Ofer YizharMathias Mahn @mmahn.bsky.social · 29/11/2024One difference is that the DIO approach leads to the permanent removal of DNA, making it irreversible. For SIO an equilibrium between forward and reverse recombinantion is created. However the reverse probability is low, creating a bias to the activated state. In practice expression levels are good. 082
Ofer Yizhar @oyiz.bsky.social · 28/11/2024The actual link in the text works. Not sure why the one below is broken - it’s auto-generated by the app 🤷🏻♂️ 010
Reposted by Ofer YizharBen Hayden @benhayden.bsky.social · 22/11/2024Important paper! www.biorxiv.org/content/bior... Im not sure the Discussion fully delineates its radical implications. No more... * Place cells * Grid cells, splitter cells, border cells * Mirror neurons * Reward neurons * Conflict cells (continued)biorxiv.org 1325471
Ofer Yizhar @oyiz.bsky.social · 28/11/2024Added to reading list! Congrats Pierre, Marie and the team! 120
Reposted by Ofer YizharKarl Deisseroth @deisseroth.bsky.social · 28/11/2024A moment in time: Dieter Oesterhelt passed away in Münich on this day (November 28) in 2022. He identified the 1st microbial rhodopsin more than 50 years ago, with far-reaching impact that could hardly have been imagined. laskerfoundation.org/in-memoriam-... 210018
Ofer Yizhar @oyiz.bsky.social · 28/11/2024The size of the DIO cassette in our AAVs is 300bp, while the SIO is only 120bp. Functionally, we haven't seen any difference between them. 050
Ofer Yizhar @oyiz.bsky.social · 28/11/2024The lox66/71 idea is not new - it came from this paper: pmc.ncbi.nlm.nih.gov/articles/PMC... by Beat Lutz. It was just never used in AAV as far as we know. The idea is that after Cre recombination between these two sites, the resulting sites are no longer recognized by Cre and can't recombine again 220
Ofer Yizhar @oyiz.bsky.social · 28/11/2024So Mathias found a clever way to create an alternative Cre-dependent cassette. He used two mutated lox sites at inverse orientations, called lox66 and lox71, generating the "SIO": 120
Ofer Yizhar @oyiz.bsky.social · 28/11/2024The DIO cassette, which people typically use, includes two pairs of lox (Cre recognition) sites to prevent constant recombination, but it's quite large and it also contains a few cryptic stop codons which might reduce expression. 110
Ofer Yizhar @oyiz.bsky.social · 28/11/2024SIO is an acronym for "single-floxed inverted ORF (open reading frame" (which makes it a nested acronym!) - @mmahn.bsky.social made these vectors when he was trying to optimize Cre-based AAV expression. 210
Ofer Yizhar @oyiz.bsky.social · 28/11/2024Many people have asked me what's the deal with "SIO" in our Addgene vectors (www.addgene.org/Ofer_Yizhar/) - we use these in most of our Cre-dependent AAVs - so here's a brief explanation of how it works.addgene.org 46017
Reposted by Ofer YizharJonas Wietek @jwietek.bsky.social · 19/11/2024PdCO has now been distributed 100x via @addgene.bsky.social 🥳🥳🥳🙏🙏🙏 0288
Reposted by Ofer YizharDr. Liz Kirby @thekirbylab.bsky.social · 15/11/2024Announcing a new open access textbook for entry level behavioral neuro. Funded by NSF. Written by a collection of 26 neuro experts. Method demonstration videos and author interviews too. Consider using it in your courses to reduce financial barriers to education. openstax.org/details/book... 20251109
Reposted by Ofer YizharBenjamin Judkewitz @benjulab.bsky.social · 03/11/2024We’re seeking a postdoc/student excited about animal communication, brain-wide circuits, microscopy, singing fish (Danionella), wacky ideas and who likes to: get things done, experiment, analyze, ask, learn, help and cooperate. jlab.berlin 14532
Ofer Yizhar @oyiz.bsky.social · 13/11/2024Hello bluesky please accept this offering of a picture from my recent run with @franklandlab.bsky.social 090