Sign in

Yongdeng Zhang

@yongdengzhang.bsky.social
100 followers 162 following 9 posts

PI @ Westlake University working on super-resolution microscopy. lifesciences.westlake.edu.cn/facult…

PostsRepliesMedia
Yongdeng Zhang @yongdengzhang.bsky.social · 01/08/2026
The images are amazing!
000
Reposted by Yongdeng Zhang
Luke Lavis @rhodamine110.bsky.social · 15/04/2026
Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...
nature.com
A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods
A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...
216763
Yongdeng Zhang @yongdengzhang.bsky.social · 31/03/2026
We introduce mirror-enhanced 4Pi-SMLM (me4Pi-SMLM), a streamlined single-objective configuration that leverages mirror-based retroreflection of the illumination beam to achieve near-isotropic localization precision of 2–3 nm, enabling unambiguous resolution of diverse ultrastructural features.
0134
Reposted by Yongdeng Zhang
Reto Fiolka @retof.bsky.social · 02/01/2026
The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from @seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online. 20 targets across an entire cell. Mr. Snouty also joined the fun. www.biorxiv.org/content/10.6...
14113
Reposted by Yongdeng Zhang
Nature Methods @natmethods.nature.com · 03/12/2025
4Pi-SIMFLUX is a single-molecule localization microscopy approach that achieves near-isotropic resolution. @yongdengzhang.bsky.social www.nature.com/articles/s41...
nature.com
4Pi-SIMFLUX: 4Pi single-molecule localization microscopy with structured illumination - Nature Methods
4Pi-SIMFLUX is a single-molecule localization microscopy approach that achieves a near-isotropic resolution below 10 nm in whole mammalian cells.
072
Yongdeng Zhang @yongdengzhang.bsky.social · 21/11/2025
We are happy to share our latest work, 4Pi-SIMFLUX, which combines structured illumination with interferometric detection to achieve near-isotropic 3D localization precision of 2–3 nm and resolve sub-10 nm structural features across whole mammalian cells. www.nature.com/articles/s41... rdcu.be/eQVxt
nature.com
4Pi-SIMFLUX: 4Pi single-molecule localization microscopy with structured illumination - Nature Methods
4Pi-SIMFLUX is a single-molecule localization microscopy approach that achieves a near-isotropic resolution below 10 nm in whole mammalian cells.
0299
Reposted by Yongdeng Zhang
Reto Fiolka @retof.bsky.social · 06/10/2025
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues. www.biorxiv.org/content/10.1...
512344
Reposted by Yongdeng Zhang
Christophe 🔬 Leterrier @christlet.bsky.social · 17/09/2025
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11
614149
Reposted by Yongdeng Zhang
Sauer Lab @sauer-lab.bsky.social · 19/08/2025
🚨 New Preprint! Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons. ▶️ www.biorxiv.org/content/10.1...
14920
Reposted by Yongdeng Zhang
Florian Schueder @florianschueder.bsky.social · 31/07/2025
🚨 2 × PhD positions @EPFL! 🚨 Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch #PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT
12320
Reposted by Yongdeng Zhang
Eli Slenders @elislenders.bsky.social · 04/07/2025
Excited to share our paper on ISM-FLUX, our new #MINFLUX-based technology. Achieve sub-10 nm localization uncertainty on single molecules using a straightforward #confocal-based setup with an array detector. 1/6 www.nature.com/articles/s41...
nature.com
Array detection enables large localization range for simple and robust MINFLUX - Light: Science & Applications
Light: Science & Applications - Array detection enables large localization range for simple and robust MINFLUX
1124
Reposted by Yongdeng Zhang
James Manton @jamesdmanton.bsky.social · 12/02/2025
We present: Direct-view oblique plane microscopy www.biorxiv.org/content/10.1...
biorxiv.org
Direct-view oblique plane microscopy
The ability to rapidly image mesoscopic samples is critically important for many areas of biological research. Owing to its high throughput and gentle, volumetric imaging nature, light-sheet fluoresce...
45715
Yongdeng Zhang @yongdengzhang.bsky.social · 17/02/2025
This is fantastic!
010
Reposted by Yongdeng Zhang
Zach Marin @zacsimile.bsky.social · 24/12/2024
Incredible new work from Yongdeng Zhang demonstrating live 4Pi SIM--and in two colors! www.nature.com/articles/s41...
nature.com
Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM - Nature Methods
The 4Pi-SIM microscope combines the benefits of structured illumination microscopy with 4Pi geometry for improved axial resolution, offering isotropic, multicolor super-resolution imaging of dynamic p...
23613