Sign in

NiceLab

@nicelab.bsky.social
244 followers 280 following 17 posts

We study antiviral immune responses of the intestinal epithelium, especially interferon lambda. We focus on how they are specialized for the gut, interactions with normal microbiota at homeostasis, and how they may go awry during inflammatory diseases.

PostsRepliesMedia
NiceLab @nicelab.bsky.social · 22/09/2026
Intestinal plasmacytoid dendritic cells preferentially produce interferon lambda, contributing to localized innate immune responses | PNAS www.pnas.org/doi/10.1073/...
pnas.org
Intestinal plasmacytoid dendritic cells preferentially produce interferon lambda, contributing to localized innate immune responses | PNAS
The healthy intestine maintains homeostasis in part via immune responses to microbiota, which includes basal production of interferon cytokines. Pr...
141
Reposted by NiceLab
Jonathan Pruneda @jnpruneda.bsky.social · 04/05/2026
Interested in microbiology, immunology, and host-pathogen interactions? Come work with us! Our department at OHSU is opening a search for a new tenure-track faculty position. See the job advertisement for details. Please share within your networks! www.nature.com/naturecareer...
nature.com
Faculty Position in Molecular Microbiology and Immunology - Portland, Oregon job with Oregon Health & Science University (OHSU) - Molecular Microbiology and Immunology | 12858852
The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.
03336
Reposted by NiceLab
OHSU-MMI @ohsummi.bsky.social · 28/04/2026
The Department of Molecular Microbiology and Immunology is looking to grow! We opened a position for an assistant or associate professor, please distribute ! facultycareers-ohsu.icims.com/jobs/39006/a...
facultycareers-ohsu.icims.com
Faculty Portal | OHSU
01215
Reposted by NiceLab
Bahareh Ajami Lab @baharehajami.bsky.social · 15/04/2026
#Hiring Staff Scientist: Seeking expertise in: Microglial biology, ALS (required), Neuroimmunology / single-cell / spatial approaches. iPSCs, CRISPER. Thrilled to share our lab has been awarded its first NIH R01 #NOA! Project: α5 integrin mechanisms in #ALS pathology.
132
Reposted by NiceLab
Ryan Langlois @langloislab.bsky.social · 26/10/2025
Excited to announce that we have a new faculty search opening in the Department of Microbiology and Immunology at the University of Minnesota for a tenure track Assistant Professor in RNA Virology. More info can be found here: hr.myu.umn.edu/jobs/ext/365...
hr.myu.umn.edu
Careers
Minimum qualifications:PhD, MD, or equivalent in a relevant field of study, plus applicable postdoctoral experience.
0109
Reposted by NiceLab
Ryan Hernandez @rdhernand.bsky.social · 09/10/2025
There are unprecedented challenges for science, calling for bold action and collective effort. Training the next generation of scientific leaders has never been more important. Join us as we grow National PROPEL to answer this call. Learn more: propelscholars.org @propelscholars.bsky.social 🧪🧬🖥️🧵
Building a community of PROPEL-affiliated programs at UCSF, U. Utah, UCSC, MUSC, U. Iowa, UW/Fred Hutch, OHSU, and Stanford!
12113
Reposted by NiceLab
OHSU-MMI @ohsummi.bsky.social · 15/09/2025
Last week we had another amazing department retreat, expertly organized by @laurenrodda.bsky.social and @jnpruneda.bsky.social . Thank you to our fantastic invited speaker @harmitmalik.bsky.social and all the trainees for a day of wonderful science discussions.
A group foto of the MMI department at the 2025 retreat
073
Reposted by NiceLab
Waggoner Lab @labwaggoner.bsky.social · 30/08/2025
@biorxivpreprint.bsky.social TGF-β triggers IFN-λ from intestine plasmacytoid DCs at homeostasis, contributing to tonic localized innate immune responses www.biorxiv.org/content/10.1...
062
NiceLab @nicelab.bsky.social · 30/08/2025
Excited to share the most recent work from our lab! In which we seek out the cellular source of homeostatic IFNL in the gut and find that gut pDC are ‘rewired’ to produce IFNL over type I IFNs.
184
Reposted by NiceLab
Jonathan Pruneda @jnpruneda.bsky.social · 26/08/2025
Come be my boss! We’re looking for a passionate and supportive leader for our Department of Molecular Microbiology and Immunology. Research in MMI spans diverse models and systems of host-pathogen interactions. Come join us in the beautiful Pacific NW! facultycareers-ohsu.icims.com/jobs/35624/c...
facultycareers-ohsu.icims.com
Faculty Portal | OHSU
23223
Reposted by NiceLab
International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · 25/06/2025
Abstract deadline extended to Monday, June 30! And travel grants are still available to student and post-doc members. Don't miss out - REPOST to share the info with others.
1109
Reposted by NiceLab
Christin Herrmann @christinviral.bsky.social · 25/06/2025
Excited to share with you my postdoctoral work published today in Nature Microbiology! www.nature.com/articles/s41... We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.
nature.com
Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology
Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...
6325
Reposted by NiceLab
Ram Savan @ramlabuw.bsky.social · 25/06/2025
Cytokines 2025: Submit your abstract for an oral or poster presentation by June 30th! Student and post-doctoral travel grants are still available. Don’t miss out! seattle.cytokinesociety.org #Cytokines #Immunology #innate #adaptive #conferences #Seattle
095
Reposted by NiceLab
Julie Pfeiffer @jkpfeiff.bsky.social · 25/06/2025
Valerie Rodriguez Irizarry’s tour de force paper on murine norovirus adaptation/egress is now out in peer-reviewed form ‪@plosbiology.org‬. It highlights the power of forward genetics in virology research. 🧵 1/10 journals.plos.org/plosbiology/...
Drawing of a cell showing mitochondria in the cytoplasm, with murine norovirus virions exiting the cell through damage to the plasma membrane. Image credit: Valerie Rodriguez IrizarryPhoto of Valerie Rodriguez Irizarry
23313
Reposted by NiceLab
OHSU-MMI @ohsummi.bsky.social · 24/05/2025
This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!
054
Reposted by NiceLab
Cadwell Lab @cadwelllab.bsky.social · 17/05/2025
Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n
kwnsfk27.r.eu-west-1.awstrack.me
4216
Reposted by NiceLab
PLOS Biology @plosbiology.org · 24/04/2025
Norovirus tropism depends partly on entry receptors, but what is the role of cellular #lipids? @orchardlab.bsky.social &co show that TMEM30a-mediated lipid asymmetry is crucial for murine #norovirus infection, influencing membrane fluidity, viral binding & entry @plosbiology.org 🧪 plos.io/4409MtI
Left: Based on electron microscopic (EM) imagery, this three-dimensional (3D) illustration provides a graphical representation of a ingle norovirus virion, set against a beige background. The different colors represent different regions of the organism’s outer protein shell, or capsid (credit: Unsplash user CDC). Right: BV2 or BV2ΔTMEM30a cells were infected with MNVCR6-HiBiT at an MOI 0.5 in the presence of DMSO, 500 µM GCDCA, or 50 µM C2 ceramide. Sixteen hours post-infection cells were lysed and infection was measured using Nano-Glo HiBiT Lytic Detection System (Promega) post-lysis. Samples are normalized to BV2 cells treated with DMSO.
051
Reposted by NiceLab
Tera Levin @teralevin.bsky.social · 28/03/2025
💐 To NIH and NSF program officers, and anyone else trying to keep those institutions alive: Thank you for trying to do an impossible job in an impossible time. I’m sorry for all of us that this is the world we’re living in. 1/n
116856
Reposted by NiceLab
International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · 26/03/2025
Co-Chairs, Michael Gale, Jr. and @ramlabuw.bsky.social invite abstract submissions for Cytokines2025. Topics include adaptive immunity, cytokine signaling, interferon stimulated genes, structure- function, and more. Submit: seattle.cytokinesociety.org/call-for-abs... Deadline is May 18, 2025.
01511
Reposted by NiceLab
International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · 26/03/2025
Repost if you're planning to go.
032
Reposted by NiceLab
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/... Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
science.org
Rewilding catalyzes maturation of the humoral immune system
Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.
47720
Reposted by NiceLab
The American Association of Immunologists @aai.org · 05/03/2025
Today, immunologists nationwide are making their voices heard! Our AAI Public Policy Fellows are on Capitol Hill, advocating for critical research funding and policies. Join them by participating in our letter-writing campaign: ow.ly/QLvQ50VaY23. #PPFPHillDay #SciPol #Advocacy
A purple background with text "Join the Biomedical Research Community and Make Your Voice Heard on Capitol Hill!" in smaller capital letters "PROTECT FUNDING FOR BIOMEDICAL RESEARCH!" and images of blood cells, the US Capitol, and lab equipment. "ACT NOW" button.
051
Reposted by NiceLab
Usha Lee McFarling @usha.bsky.social · 05/03/2025
NEW: In every way, shape, form, actions being taken say ‘don’t go into science,’ Donna Ginther told me as NIH forced to cancel programs to train future researchers. More than 1,000 students, including one who emailed 60 PIs, now scrambling to find positions. www.statnews.com/2025/03/05/t...
statnews.com
Cancellation of NIH summer internships disrupts ‘vital’ training program for U.S. scientists
The NIH cancelled an internship program that gave more than 1,000 college students hands-on research training each summer
33929
Reposted by NiceLab
Bella Rauch @rauchlab.bsky.social · 04/03/2025
@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new... It was signed by over 450 OHSU researchers! It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
bizjournals.com
Opinion: Scientists on how NIH cuts will hurt all Oregonians. - Portland Business Journal
"These cuts will cripple biomedical research and drug development in the U.S. We should be investing more in science, not less."
12011
Reposted by NiceLab
Siyuan Ding @sding88.bsky.social · 03/03/2025
First post on Bluesky! Excited to share the first paper from our lab in 2025! cell.com/cell-host-mi.... Our study demonstrates that UV-inactivated replication-defective rotaviruses can cause diarrhea in neonatal mice, suggesting the host response also contributes to diarrhea to flush out the virus.
cell.com
Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea
Hou et al. demonstrate in an infant mouse model that innate immune sensing of enteric viruses induces IFN-λ signaling, which downregulates an apical chloride exchanger that leads to increased intestin...
042
Reposted by NiceLab
Stand Up for Science! @standupforscience.net · 01/03/2025
Today is Rare Disease Day, and a great reminder of the importance of NIH and science funding in driving hope 🧬⬇️ www.rarediseaseday.org
rarediseaseday.org
Rare Disease Day 2025 – Raising awareness for people living with rare diseases and their families worldwide.
214746
Reposted by NiceLab
International Cytokine & Interferon Society (ICIS) @cytokinesociety.bsky.social · 18/01/2025
Mark your calendars Cytokines 2025 Westin Seattle! Abstract submission is opening soon. Make sure to note these important deadlines: -Abstract Submission deadline: Wednesday 18 June -Early-Bird Registration Deadline: Friday 25 July Group room rate $236 seattle.cytokinesociety.org for more details
01810
Reposted by NiceLab
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 23/02/2025
39669
Reposted by NiceLab
Jeremy Berg @jeremymberg.bsky.social · 17/02/2025
The restriction on Federal Register posts appear to be still in effect. This is blocking the (legal) scheduling of study sections and, soon, advisory council meetings. I have heard that some study section meetings that had been scheduled have been cancelled. 4/n
media.tenor.com
a white cat is sitting on a box with the words `` why why '' written above it .
ALT: a white cat is sitting on a box with the words `` why why '' written above it .
35023
Reposted by NiceLab
Dave Levitan @davelevitan.bsky.social · 12/02/2025
Internal NIH guidance updated yesterday. Just canceling stuff each day from here on out I guess, pending new guidance. Killing science off both slowly and incredibly rapidly.
Effective February 10:

NIH Federal Advisory Committee meeting notices to the Office of the Federal Registare are now on hold. This affects NIH's ability to move forward with National Advisory Council/Board meetings that were previously noticed as having open and closed sessions and with Scientific Review Group (study sections and Special Emphasis Panels) meetings and Boards of Scientific Counselors that had not yet been noticed with a Federal Register Notice. As such, NIH will cancel those meetings on a day-by-day basis until additional guidance is received. Scientific Review Group meetings and Boards of Scientific Counselors that were previously noticed are moving forward.
715274
Reposted by NiceLab
Vaughn Cooper @vscooper.micropopbio.org · 17/02/2025
No new NIH study sections have been announced in the Federal Register since Jan 21. But I hear that colleagues have been asked to serve. Does your meeting appear in these announcements? If this applies to you, please check and reply here with info! www.federalregister.gov/documents/se...
federalregister.gov
Document Search Results for 'center for scientific review'
Search, browse and learn about the Federal Register. Federal Register 2.0 is the unofficial daily publication for rules, proposed rules, and notices of Federal agencies and organizations, as well as e...
213031
NiceLab @nicelab.bsky.social · 04/02/2025
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports... Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
cell.com
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda
Enteric viral infections are a major public health problem in newborns. Ramirez Reyes et al. find that the immature intestinal epithelium of newborn mice is developmentally programmed for the homeosta...
1134
Reposted by NiceLab
CNBC @cnbc.com · 23/01/2025
Norovirus is raging across the U.S. this winter. Moderna might soon have a vaccine for it.
cnbc.com
A norovirus vaccine could be on the horizon as cases rise
Moderna is testing a norovirus vaccine in a phase three trial. Results could be available as soon as this year.
791160167
Reposted by NiceLab
Dave Baltrus 🦦 @surtlab.bsky.social · 23/01/2025
Gentle reminder that if you truly value diversity in the workforce, top down executive orders may/will change implementation but it shouldn’t change your dedication to building the best possible team/group/cohort/generation of researchers
422171
Reposted by NiceLab
Steve Munger @stevenmunger.bsky.social · 23/01/2025
Want to see the numbers for how NIH funding impacts your state? Remind your Representatives, Senators, and fellow citizens how federally-funded biomedical research advances health, created jobs, and fosters innovation and economic growth. www.unitedformedicalresearch.org/nih-in-your-...
unitedformedicalresearch.org
NIH In Your State - United For Medical Research
Select a state on the map to see the impact of NIH funding across America.
313399
Reposted by NiceLab
Steeve Boulant @boulantlab.bsky.social · 23/01/2025
Some months ago, I received the great news that my #NIH RO1 grant received a likely fundable score. With the NIH not being able to hold meetings and take decision, I found out that the council meeting is canceled (it was planned next week). 🧵/1
43211
Reposted by NiceLab
Ilan Schwartz @germhuntermd.bsky.social · 22/01/2025
Scientific advancements aside, this is economically irresponsible Every $1 spent by NIH generates $2.46 For example, in 2023, $47B in NIH spending generated ~$93B Halting NIH spending will LOSE the US a lot of money (and talent)
An image of NIH campus. Text says : With annual budget of more than $47 billion, NIH is the largest single public funder of biomedical and behavioural research in the world. In fiscal year 2023, NIH funding generated an estimated $92.89 billion in economic activityEvery state and almost every congressional district received a share of NIH investment
Each year, NIH awards over 60,000 grants that directly support more than 300,000 researchers at more than 2,500 different institutions
In fiscal year 2023, every $1 of NIH funding generated approximately $2.46 of economic activity
591945947
Reposted by NiceLab
Dr. Deanna Santer @drdeannasanter.bsky.social · 21/01/2025
With recent 💰, we are recruiting a postdoctoral fellow & an #immunology PhD student to start this year! We have 1 summer undergrad position open too. Sadly, our university is not reviewing international student apps due to permit cuts. See here for the current team: sites.google.com/view/thesant...
sites.google.com
THE SANTER LAB - People
pi: DEANNA SANTER, pH.d
117
NiceLab @nicelab.bsky.social · 21/01/2025
So excited to share our recent work! We find that hyper-local 'hot pockets' of innate immune response within the intestine are correlated with local abundance of bacterial microbiota and their recognition by leukocytes. www.tandfonline.com/doi/full/10....
tandfonline.com
Homeostatic pockets of interferon lambda-stimulated gene production in the intestine are associated with localized exposure to bacterial microbiota
Tolerance of enteric microbiota and clearance of potential pathogens is critical for gut homeostasis. We previously found that the healthy small intestine of mice contains discrete pockets of antiv...
142