Dysregulated immunity, a hallmark of many human diseases, co-occurs with mitochondrial dysfunction and is commonly associated with misprimed primary immune signaling. While transcriptionally well-char...

Author summary Colloquially known as “the stomach bug,” human norovirus is a leading cause of foodborne illness worldwide. Despite its prevalence, there are no approved therapeutics or vaccines agains...

Norovirus tropism depends partly on entry receptors, but the role of cellular lipids in viral entry remains unclear. This study shows that TMEM30a-mediated lipid asymmetry is crucial for murine norovi...