iiinova — where your digital self keeps evolving

Reposted by Paul A. Northcott, PhD

Stem Cell Podcast @stemcellpodcast.com · 25/07/2025

Drs. @kylessmith.bsky.social, Yiran Li, and a team in @doctorpauln77.bsky.social's lab at @sjcenos.bsky.social analyzed previously published #scRNAseq data and found no evidence of transitional cerebellar progenitors. Read the article: go.nature.com/46iVgyl Listen to the discussion: bit.ly/3IGfUP1

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Reposted by Paul A. Northcott, PhD

Brian Liau @brianliau.bsky.social · 12/02/2025

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

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Reposted by Paul A. Northcott, PhD

Scientific Writer @ CENOS St. Jude Children's Research Hospital @sjcenos.bsky.social · 08/01/2025

The location and type of mutation in ZIC1 determines medulloblastoma subtype and can be targeted to suppress cancer growth. Read about the collaboration between the Northcott, Taylor, and Huang labs at St. Jude, Baylor, and Mayo: tinyurl.com/y9dbkrsw @stjuderesearch.bsky.social

tinyurl.com

ZIC1 gene drives distinct medulloblastoma types in different ways

Discover research showing how the context of distinct & opposing mutations in the ZIC1 gene drive Group 4 (G4) and sonic hedgehog (SHH) medulloblastoma types.

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Reposted by Paul A. Northcott, PhD

rantao2023.bsky.social @rantao2023.bsky.social · 07/01/2025

Thrilled to share our recent work published in @naturegenet.bsky.social, where we uncover how ZIC1 is regulated by distinct genetic and epigenetic mechanisms in SHH vs. Group 4 medulloblastoma—revealing it as a context-dependent driver. tinyurl.com/2c3jnhn2

tinyurl.com

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip - Nature Genetics

Analysis of medulloblastomas in humans and mice shows that the functional consequences of ZIC1 mutations are exquisitely dependent on the cells of origin that give rise to different subgroups of medul...

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