Lifestyle interventions can preserve the independence of older adults. Here the authors show that multimorbidity patterns influenced the efficacy of a multicomponent lifestyle intervention targeting m...

The cGAS-STING signaling pathway contributes to low-grade inflammation in several tissues during aging; however, its role in the ovary was unclear. Here the authors show that aging oocytes leak mitoch...

Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. CCR5 blockade ...

Patients are arriving in primary care with questions about geroscience that medicine has not prepared clinicians to answer. Here, primary care physician Dean Ariel argues that the profession should pr...

Demonstrating a role for cyclic GMP–AMP synthase (cGAS) in chromatin organization, Martinez, Morandini and colleagues report that cGAS-knockout mice exhibit compromised heterochromatin organization, L...

Senescence contributes to aging and cancer-treatment-related decline, and is increasingly viewed as a therapeutic target. In this issue, Rajesh et al. and Wang et al. identify cyclin D–CDK4–CDK6 (CDK4...

Rajesh and colleagues report that the cell cycle regulators cyclin D1 and CDK6 regulate the inflammatory phenotype of senescent cells, via DNA damage and cGAS–STING activation. Blocking this pathway w...

Wang et al. report that the cell cycle regulators CDK4/6 also regulate the inflammatory phenotype of senescent cells, via modulation of retinoic acid signaling and NF-κB. Pharmacologically targeting t...

The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...

Cole and colleagues identify fructose as a component of the secretome in therapy-induced senescent ovarian cancer cells that drives metastasis. Fructose metabolically reprograms neighboring cancer cel...

Cellular senescence was originally identified in tissue culture as an essentially irreversible proliferative arrest in primary cells in response to exhaustive ...

This Perspective proposes a senotype framework for classifying senescent cells by their origins, molecular features and effects, which will foster comparison of diverse senescent states, including tho...

Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

The ovarian stroma becomes increasingly stiff with age, impairing ovarian function. The mechanisms that underlie this process are only partly understood. Here, the authors show that IL-11, which is el...

Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in telomerase-deficient and physiolog...

Ovarian cycles of follicle development, ovulation and tissue regeneration require cooperative functions of constituent cells. Here the authors provide a spatial atlas of the aging mouse ovary, reveali...

The authors apply deep learning to histological and transcriptomic data from female reproductive organs from over 300 donors aged 20–70 years, reporting distinct and asynchronous aging trajectories, d...

Single-cell profiling of nearly 1,000 individuals reveals that immune aging follows distinct cellular and transcriptional trajectories in female and male adults, with stronger cellular and molecular remodeling in female than male participants.

Nature Aging - To dissect lncRNA functions in aging, here the authors perform a CRISPRi-based single-nucleus multiomics screen systematically perturbing 32 aging- and senescence-associated lncRNAs...

Turquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly...

Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

In this issue of Nature Aging, Chaofan Yang, Heng Du and colleagues show that excessive expression of LINE-1 in the heart leads to cGAS–STING...

Chiche, Djoual, Charifou and colleagues identify a dual role for cell senescence in postpartum tissue remodeling: senescent cells drive mammary gland involution, yet create a permissive niche for tumo...

LINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genet...

Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau...

The prostate is an important part of the male reproductive system whose aging process is incompletely understood. Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show that...

In this technical report Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. scMORE revealed regulators...