iiinova — where your digital self keeps evolving

fdadf.bsky.social @fdadf.bsky.social · 14/09/2026

🚨 Can DNA that does nothing become a cell’s Achilles’ heel? 🧬 Cas9 selectively killed human cells carrying a non-functional target sequence, sparing cells without it. www.sciencedirect.com/science/arti... #CRISPR #DNARepair

sciencedirect.com

Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome

The CRISPR/Cas9 technology is a powerful and versatile tool to disrupt genes’ functions by introducing sequence-specific DNA double-strand breaks (DSB…

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fdadf.bsky.social @fdadf.bsky.social · 20/08/2026

🚨 Can broken DNA generate a new protein? Our study independently confirms that DSBs trigger transcription from the break—and shows, for the first time, that the resulting RNA can be translated. Could this generate neoantigens after radio/chemotherapy? www.nature.com/articles/s42...

nature.com

Site-specific DNA double-strand break induces local transcription in cis and protein expression - Communications Biology

DNA double-strand breaks function as promoter-like elements that drive transcription and protein synthesis of polyadenylated RNAs from otherwise silent DNA regions.

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fdadf.bsky.social @fdadf.bsky.social · 14/08/2026

#IPF has no cure. Median survival: 4 years. Lung transplant is the only real option. Our new paper shows this might be about to change. 🧵

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fdadf.bsky.social @fdadf.bsky.social · 30/06/2026

www.nature.com/articles/s43... Using telomeric #antisense #oligonucleotides (tASOs)vwe restored hematopoietic #stem cell fitness, improved #vaccination responses, reduced #senescence and #inflammation, and improved the function of aged human hematopoietic stem cells. Without elongating #telomeres.

nature.com

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fdadf.bsky.social @fdadf.bsky.social · 30/06/2026

What drives the pathological consequences of #telomere dysfunction? So far elomere shortening has been considered the central issue. In our new nataging.nature.com study, we show that telomeric DNA damage signalling itself is a causal driver of hematopoietic decline. www.nature.com/articles/s43...

nature.com

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging - Nature Aging

Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in telomerase-deficient and physiolog...

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fdadf.bsky.social @fdadf.bsky.social · 31/01/2026

Happy to share our deep characterization of #LLPS events modulating the DNA damage response (#DDR) through #53BP1 condensation promoted by #dincRNA www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by @fdadf.bsky.social

The EMBO Journal @embojournal.org · 22/09/2025

Aging increases both #telomeric DNA damage and #Alzheimer’s disease risk. Fabrizio d'Adda di Fagagna and coworkers now find that these processes are linked, with Aβ42 oligomers triggering ROS-mediated telomeric damage that in turn increases neurotoxicity www.embopress.org/doi/full/10....

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fdadf.bsky.social @fdadf.bsky.social · 21/09/2025

embopress.org/doi/full/10.10… Today on World Alzheimer's Day we published in @EMBO Journal that #Alzheimer's diseases (#AD) is associated with DNA damage at #telomeres and that inhibition of telomeric DNA damage signaling with telomeric #ASO improves neurons cell viability

embopress.org

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fdadf.bsky.social @fdadf.bsky.social · 20/03/2025

Here is the link rdcu.be/eb9Kq for everybody to read our most recent Review on #aging and #cancer published in Nature Aging coauthored with Lucrezia Trastus - happy to read your comments. www.nature.com/articles/s43587-025-00827-z

rdcu.be

The complex interplay between aging and cancer

Nature Aging - This Review explores the intersection between cancer and aging, illustrating shared causal mechanisms including genome instability, telomere dysfunction, cellular senescence and...

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fdadf.bsky.social @fdadf.bsky.social · 09/03/2025

I had the incredible opportunity to speak at #TEDxRoma. It was an intense and unforgettable experience. If you attended or watched the talk, feel free to share your thoughts with me! #Aging #longevity #telomere youtu.be/yTGj-5BVLXs?...

youtu.be

We know why we age | Fabrizio D'Adda | TEDxRoma

YouTube video by TEDx Talks

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