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Nucleic Acids Research @narjournal.bsky.social · 01/10/2026

The Human Genome Project didn’t end genomics—it opened the door. Its sequence helped fuel #precisionmedicine, #cancergenomics, #genetherapy and #genomeediting. And it revealed a deeper question: 🧬 How is the genome regulated? Enter the world of #Epigenetics. #HumanGenomeProject #HGP #Genomics

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Nucleic Acids Research @narjournal.bsky.social · 29/09/2026

⭐ #NARBreakthrough ⭐ What if we could bring ancient proteins back to life? 🧬 Prof. Stoddard’s lab @fredhutch.org found that ~10% of homing endonucleases remain functional, and ancestral reconstruction reveals how these enzymes evolved new targets. Read the article here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 16/09/2026

✨NAR Molecular Medicine✨ ⚠️ What happens when #DNArepair can no longer keep up? A study shows that increasing exposure to #NDMA can saturate #MGMT, triggering a burst of #mutations. A striking example of how dose shapes #DNAdamage and #cancerrisk. doi.org/10.1093/narm... @mitpress.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 28/08/2026

Congratulations to Edan Mortman and @sternberglab.bsky.social @shsternberg.bsky.social on this fascinating and important achievement! 🎉 Your work provides a compelling look at how selfish genetic elements balance their own propagation with the survival of their host. @columbiauniversity.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 28/08/2026

⭐ #NARBreakthrough ⭐ How do #IStrons juggle 3 competing functions from a single sequence? #Newstudy reveals an RNA-level #tug-of-war between #self-preservation and #hostprotection, shaped by #RNAfolding 🔬Read the article here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 31/07/2026

📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...

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Nucleic Acids Research @narjournal.bsky.social · 16/07/2026

New research in #NARMolecularMedicine shows that #musclestemcells retain intrinsic #inflammatory changes, with aberrant #TNFα signaling and reduced #H3.3 impairing muscle regeneration, pointing to #newtherapeutic opportunities in #dermatomyositis beyond #interferon. 🧬 doi.org/10.1093/narm...

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Nucleic Acids Research @narjournal.bsky.social · 14/07/2026

📣The 24th annual NAR Web Server Issue is now online! 📣Explore 47 new web servers spanning a range of scientific and medical applications. Congratulations and thanks to all authors, editors and reviewers for your contributions!🧬 #NARWebServer #MolecularBiology #OpenAccessIssue

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Nucleic Acids Research @narjournal.bsky.social · 08/07/2026

📣 Applications are open for the next NAR Early Career Investigator (ECI) Advisory Board cohort! Work with Executive Editors, help shape journal strategy, and gain insight into peer review during a 2-year term. Apply by 1 Nov 2026: lnkd.in/g233ZCAf #ECR #NAR #AcademicPublishing #MolecularBiology

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Nucleic Acids Research @narjournal.bsky.social · 23/06/2026

⭐ #NARBreakthrough ⭐ 🩸🔬 Unexpected role for #ZEB1 in #redbloodcell development! ZEB1 cooperates with KLF1 to regulate #erythroidmaturation and #enucleation, revealing a new regulatory axis essential for #erythropoiesis. 🧬✨ Read the article here: doi.org/10.1093/nar/... @igmm-montpel.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 22/06/2026

🎉Congratulations to the first authors Isidro Álvarez-Escribano and Manuel Brenes-Álvarez on their publication! Their study in the lab of Alicia M. Muro-Pastor presents a fascinating example of how RNA-based regulation fine-tunes #geneexpression 👏🔬 @ibvf-sevilla.bsky.social @unisevilla.us.es

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Nucleic Acids Research @narjournal.bsky.social · 22/06/2026

⭐ #NARBreakthrough ⭐ 🔬 How do #cyanobacteria avoid overreacting to stress? New research shows that antisense RNAs keep the #stress-response gene nblA off under normal conditions, preventing damage while enabling rapid adaptation when nutrients become limiting. 📖 Read here doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 19/06/2026

⭐ #NARBreakthrough ⭐ 🔬New research reveals that #Trypanosomabrucei CRK9 and human CDK11 share a role in #RNAsplicing through #SF3B1 phosphorylation. An unexpected link with implications for #antiparasitic drug development. 📖 Read the article here: doi.org/10.1093/nar/... @uconnhealth.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 15/05/2026

📣 Applications are open for the next Editor‑in‑Chief of NAR Cancer! 📣 Lead an open‑access journal at the forefront of nucleic acids and cancer research. We welcome applications until 1st Aug 2026. More details: academic.oup.com/narcancer/pa... #NARCancer #EditorInChief #CancerResearch

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Nucleic Acids Research @narjournal.bsky.social · 15/05/2026

⭐ #NARBreakthrough! ⭐ New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding. 📖 Read here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 13/05/2026

⭐ #NARBreakthrough! ⭐ 🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity. 📖 Read the article: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 12/05/2026

How do memories last a lifetime when proteins turn over in months? A new NAR review by Peter Cook suggests long‑term memory may stem from transcriptional gene clusters and even pyrophosphate shaping calcium signals. 📖 doi.org/10.1093/nar/... #LongTermMemory #Transcription #ReviewArticle

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Nucleic Acids Research @narjournal.bsky.social · 06/05/2026

🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA

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Nucleic Acids Research @narjournal.bsky.social · 29/04/2026

🎉 Congratulations to the first authors Rhyker Ranallo-Benavidez and Yue Hao on generating the first chromosome-level, phased genome assemblies for BJ and IMR-90 in the lab of Prof. Floris Barthel @tgenresearch.bsky.social @yuehao.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 29/04/2026

⭐ #NARBreakthrough ⭐ New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource

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Nucleic Acids Research @narjournal.bsky.social · 27/04/2026

🎉 Congratulations to first authors Carter Wheat and Zihao Qi on uncovering a new mechanism of ssDNA annealing. Their work in Prof. Charles E. Bell’s lab advances our understanding of RAD52 and its therapeutic potential in BRCA-mutant cancers. 🧬🔬 @ohiostatepress.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 27/04/2026

⭐ #NARBreakthrough! ⭐ 🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers. 📖 Read here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 22/04/2026

🔬 Modern #bioinformatics workflows are complex and hard to reproduce. #systemPipeR helps researchers design, run, and track analysis #pipelines in one framework, integrating R + bioinformatics tools, HPC support, and automated #reports for #transparency. Read more doi.org/10.1093/narg... #NARGAB

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Nucleic Acids Research @narjournal.bsky.social · 16/04/2026

✨A new review in #NARMolecularMedicine explores how #mitochondrialDNA inheritance, copy number changes, and coordination with the nuclear genome shape development, and how #AssistedReproductiveTechnologies may disrupt this balance. Read the review here: doi.org/10.1093/narm... #EditorsChoice

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Nucleic Acids Research @narjournal.bsky.social · 01/04/2026

⭐ #NARBreakthrough ⭐ 🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 24/03/2026

📣 New NARMME collection: Targeting & Harnessing Nucleic Acids for Therapeutic Discovery. Submit work on nucleic acid chemistry, delivery, mechanisms, safety, targeting & therapeutic applications. Info: lnkd.in/eipeJmaw Submit: lnkd.in/ej9GNs3B #DrugDiscovery #TherapeuticInnovation

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Nucleic Acids Research @narjournal.bsky.social · 24/03/2026

📣 NAR Cancer Call for Papers: Seeds of Cancer, Decades of Silence. Submit work on early cancer initiation, ageing, environment, clonal evolution, genome maintenance and more before July 2026. 👉 academic.oup.com/narcancer/pa... #NARCancer #CancerResearch #Genomics #Epigenetics

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Nucleic Acids Research @narjournal.bsky.social · 18/03/2026

⭐NAR Breakthrough! ⭐ Back-to-back NAR studies show #Palbociclib binds #HIV TAR RNA with low affinity & striking specificity. Induced-fit RNA refolding creates a #druggable pocket, blocking #SEC recruitment.📖 Read the articles here: doi.org/10.1093/nar/... doi.org/10.1093/nar/... #DrugDiscovery

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Nucleic Acids Research @narjournal.bsky.social · 06/03/2026

🎉 Congratulations to HaiyangDong and Yongfeng Jin on their new publication! An exciting step forward in understanding the complexity of RNA-mediated gene regulation! 👏 Well done to the entire team.

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Nucleic Acids Research @narjournal.bsky.social · 06/03/2026

⭐ #NARBreakthrough! ⭐ 🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨ Read the full article here: doi.org/10.1093/nar/... #AlternativeSplicing

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Nucleic Acids Research @narjournal.bsky.social · 04/03/2026

🎉 Congratulations to the first authors, Priyanka Aggarwal and Manmohan Sharma! Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80

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Nucleic Acids Research @narjournal.bsky.social · 04/03/2026

⭐NAR Breakthrough! ⭐ 🧬 New #cryo-EM work shows the #humanINO80 motor adapts to DNA unwrapping and can remodel altered particles like #hexasomes - highlighting its versatility across #nucleosome states. 🔬✨ @lmu.de @genecenter-lmu.bsky.social Read the full article here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 02/03/2026

#SpinalMuscularAtrophy (SMA) is treated with the ASO Nusinersen (Spinraza™) to restore SMN via SMN2 splicing. 🧬 New work reveals diverse off-target effects linked to its chemistry—and shows how to mitigate them. 🚀 #NARMolecularMedicine #RNATherapeutics #ASO 🔗 Read here: doi.org/10.1093/narm...

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Nucleic Acids Research @narjournal.bsky.social · 25/02/2026

⭐ #NARBreakthrough! ⭐ 🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency. @stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 20/02/2026

🧬 #NARGAB New Research Spotlight Direct #RNA #nanopore sequencing reveals the most detailed #m6A map to date across Human immunodeficiency virus 1 transcripts #HIV-1. @cnrs.fr @i2bcparissaclay.bsky.social 👉 Read the full paper: doi.org/10.1093/narg...

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Nucleic Acids Research @narjournal.bsky.social · 15/02/2026

🔬 New study highlights a novel siRNA polypeptide #nanoparticle targeting TGF β1 and VEGFR2 to overcome ICI resistance in #melanoma. In mice, it cut tumor growth, improved survival, and reduced #metastasis. Read the full article here: doi.org/10.1093/narc... #NARCAncer #Immunotherapy

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Nucleic Acids Research @narjournal.bsky.social · 13/02/2026

🧬 A common ID3 gene variant, rs11574, found in up to 30% of some populations, alters the #ID3protein and disrupts its interaction with E12. ✨ New research shows this change affects gene expression and cell function, offering insight into #diseaserisk. 🔗 Read the paper here: doi.org/10.1093/narm...

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Nucleic Acids Research @narjournal.bsky.social · 12/02/2026

⭐ Explore the NARCAN 5th Anniversary Symposium Collection! 🔬 Featuring exciting work on Polθ, HR, PARP inhibitors, emerging targets, and more! Read here: lnkd.in/ezznFh2f #NARCancer #DNARepair #CancerResearch #TherapeuticTargets #GenomicInstability

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Nucleic Acids Research @narjournal.bsky.social · 12/02/2026

⭐ NARGAB Editor’s Choice: DecoDen integrates multiple epigenomic assays to correct chromatin‑related noise, giving cleaner data and clearer insights. 👉 doi.org/10.1093/narg... #NARGAB #Epigenetics #Genomics #Bioinformatics #PrecisionMedicine

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Nucleic Acids Research @narjournal.bsky.social · 04/02/2026

⭐NAR Breakthrough! ⭐ #RNAtherapeutics show strong promise for #CNSdisorders 🧠. #Preclinical studies reveal that very high doses of #oligonucleotides can cause brief, reversible neuronal activation driven by metal ion interactions 🧪. Read the full article here: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 21/01/2026

⭐NAR Breakthrough ⭐ New study identifies a 6-nt miR-17 site in the #PKD1 3′UTR that limits PKD1 expression. Targeting this site boosts PKD1 protein and reduces cyst burden in #ADPKD models—highlighting a promising oligo-based strategy @vishal-d-patel.bsky.social 🧬Read more: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 19/01/2026

⭐NAR Breakthrough! ⭐ 🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/... #NARBreakthrough

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Nucleic Acids Research @narjournal.bsky.social · 19/01/2026

🌟 2026 Nucleic Acids Research Database issue 🧬 182 papers, 84 new databases, plus Breakthrough Articles on JoGo (global long‑read haplotypes) and So3D (3D spatial genomics). Browse the issue and Editorial: academic.oup.com/nar/issue/54... academic.oup.com/nar/article/... @danielrigden.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 23/12/2025

⭐NAR Breakthrough! ⭐ 🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival. 🧬Read more: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 22/12/2025

👏 Congratulations to @helena-stafflinger.bsky.social Helena Stafflinger, @en-hxnu-enment.bsky.social Hermann Schindelin, Jens Wöhnert and their team on this elegant and paradigm-shifting study uncovering unexpected principles of RNA G-quadruplex formation! @uniinnsbruck.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · 22/12/2025

⭐NAR Breakthrough! ⭐ 🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/... #NARBreaktrhough #RNA #StructuralBiology

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Nucleic Acids Research @narjournal.bsky.social · 15/12/2025

🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/... #NARBreakthrough #RibosomeBiogenesis

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Nucleic Acids Research @narjournal.bsky.social · 25/11/2025

⭐ NAR Breakthrough! ⭐ 🦠 New study shows phage X1 hijacks Yersinia's enterocolitica flagellum to inject its DNA directly into the cytosol. Yersinia, though, strikes back! 🦠 A fascinating look at the #dualrole of #flagella in #viralentry and #bacterialimmunity. 🧬 Read more: doi.org/10.1093/nar/...

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Nucleic Acids Research @narjournal.bsky.social · 24/11/2025

⭐ NAR Breakthrough! ⭐ 🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race. 🧬 Read more: doi.org/10.1093/nar/... #NARBreakthrough #Microbiology #PhageBiology #BacterialDefense

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