iiinova — where your digital self keeps evolving

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DrLachie @drlachie.bsky.social · 16/10/2026

Haven't done an animation in a while. Lucky for me @amsikking.bsky.social came up with a "Dual-Grind" snouty light sheet objective - amsikking.github.io/idv-snouty_l.... I happily present a look into their manufacture.

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Julian Gargiulo @nano-juli.bsky.social · 15/10/2026

PAPER ALERT! This week marks the end of a journey that began with an empty lab and a crazy idea during the pandemic, and ended with a microscope that allows 5 hours of brain imaging in a living fly. I hope you enjoy it reading as much as I enjoyed working on it! doi.org/10.1021/acsp... #Snouty

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 27/09/2026

I try to be a peer reviewer who reviews the paper presented, not the imaginary one it could be with many years of work. Sometimes work, even from labs I respect, doesn't meet the standard. Today I re-reviewed a paper & was impressed at how the authors did the work to solidify their claims. Kudos 1/n

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Jörg Enderlein @joergenderlein.bsky.social · 28/09/2026

Excited to share our new minireview in @ChemBioChem on "Nanorulers for Super-Resolution Microscopy"! 🔬✨As optical nanoscopy pushes past single-digit nanometer limits toward Ångström precision, accurate calibration is everything. Check out the open-access paper here: doi.org/10.1002/cbic...

doi.org

Nanorulers for Super‐Resolution Microscopy

Nanorulers serve as essential calibration standards to validate optical super-resolution microscopy down to the Ångström scale. Complementary DNA-, protein-, and virus-based scaffolds provide unique ...

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Julian Gargiulo @nano-juli.bsky.social · 21/05/2026

Buscamos candidato/a para presentar a beca doctoral CONICET en Fundación Instituto Leloir Desarrollando técnicas ópticas de bioimaging para experimentos en neurociencias. El objetivo es obtener imágenes 3D de neuronas durante horas en moscas vivas, como muestra el gif. Por favor difundir!

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Julian Gargiulo @nano-juli.bsky.social · 01/05/2026

Beautiful! Did you create your own LUT for this?

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Julian Gargiulo @nano-juli.bsky.social · 28/04/2026

Ah, cooler than I thought! 😂

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Julian Gargiulo @nano-juli.bsky.social · 28/04/2026

What is the white thing? Something to prevent oil dripping?

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Julian Gargiulo @nano-juli.bsky.social · 04/04/2026

Did you buy it online? Can you share a link? It's an illustrative thing to have near the microscope for visitors

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Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 16/02/2026

Chocolate peanut butter brownies, but make them *sparkly*.

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FocalPlane @focalplane.bsky.social · 15/12/2025

ICYMI, our #preprint list is now up on FocalPlane, highlighting the latest research using #microscopy to answer questions in #biology. As always, send us any recommendations for preprints that we've missed: focalplane.biologists.com/2025/12/12/m...

focalplane.biologists.com

Microscopy preprints - applications in biology - FocalPlane

Microscopy preprints - applications in biology - News

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FocalPlane @focalplane.bsky.social · 28/11/2025

📢Our latest #preprint list is now up on FocalPlane This week we highlight the latest tools and techniques in microscopy. Drop us a note if we’ve missed a preprint that you’ve enjoyed reading. focalplane.biologists.com/2025/11/28/m...

focalplane.biologists.com

Microscopy preprints – new tools and techniques in imaging - FocalPlane

Microscopy preprints – new tools and techniques in imaging - News

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FocalPlane @focalplane.bsky.social · 18/11/2025

📢Check out our latest #preprint list on FocalPlane This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one! focalplane.biologists.com/2025/11/14/m...

focalplane.biologists.com

Microscopy preprints – bioimage analysis - FocalPlane

Microscopy preprints – bioimage analysis - News

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Julian Gargiulo @nano-juli.bsky.social · 20/11/2025

So happy to work with this great team. Please check out our latest article.

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Julian Gargiulo @nano-juli.bsky.social · 19/10/2025

This is great news for Argentina! Luciano is one of the most talented and successful researchers I've ever met, and Argentina's optics community is lucky to have him back! Bienvenido!!!

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Julian Gargiulo @nano-juli.bsky.social · 16/10/2025

We are seeking assistance in locating a missing researcher in Germany. If anyone is based in Germany or has contacts in the area who might be able to help, please get in touch as soon as possible. Any information or support you can provide would be greatly appreciated.

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Leonel Malacrida @malacridalab.bsky.social · 15/10/2025

Extremely excited to share quite an achievement for our group. Two years ago, we started #PhasorPy (www.phasorpy.org, now in our v0.8). In parallel, Bruno Pannunzio, in collaboration with Marcelo Zoccoller, led the hashtag#Napari_Phasors plugin v0.1 for FLIM & HSI phasor analysis.

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Torsten Wittmann @microtubule.bsky.social · 08/10/2025

Playing around with how to represent volume in #Snouty light sheet data. Here is a dividing hiPSC with endogenously tagged histone in all three orthogonal projections. Bluer is further away. If anything, it distracts from politics.

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Luciano A. Masullo @lumasullo.bsky.social · 30/09/2025

Happy to share this article with my views on @elislenders.bsky.social and @vicidominilab.bsky.social work and discussing current developments in single-molecule localization combining structured excitation and detection. So many exciting perspectives in the field! www.nature.com/articles/s41...

nature.com

Localization of single molecules with structured illumination and structured detection - Light: Science & Applications

Light: Science & Applications - Localization of single molecules with structured illumination and structured detection

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Tanner Fadero @tanner-fadero.bsky.social · 20/08/2025

Here's a six-month time-lapse of me building the single objective light sheet fluorescence microscope at the UCSF Center for Advanced Light Microscopy! Also pictured is @nicostuurman.bsky.social and @kahsage.bsky.social. #snouty

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Reto Fiolka @retof.bsky.social · 22/07/2025

Happy Pi day to those who like to arrange units by order of magnitude.

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Jorge Aliaga @jorgeluisaliaga.bsky.social · 27/06/2025

Un submarino español usa una pila de hidrógeno basada en un proceso que desarrolló Miguel Laborde. Acá lo cuenta con @aleberco en @pasaroncosas899 El problema no es el sistema de ciencia y tecnología sino el modelo de desarrollo. radiocut.fm/audiocut/ent...

radiocut.fm

Entrevista Miguel Laborde, tecnólogo argentino

Miguel Laborde cuenta la situación actual del sistema de ciencia y técnica y su participación en el desarrollo de una pila que usa un submarino español.

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Ariel Waisman @waisman-ar.bsky.social · 07/06/2025

Thrilled to share that my first #micropublication is out! 🧬🔬 I created a user-friendly ImageJ/FIJI plugin for nuclear segmentation and multi-channel fluorescence analysis that doesn't require programming skills. www.micropublication.org/journals/bio...

micropublication.org

Multi-Channel Nuclear Analysis: An ImageJ/FIJI Plugin for Automated Nuclear Segmentation and Multi-Channel Fluorescence Analysis | microPublication

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Luciano A. Masullo @lumasullo.bsky.social · 07/05/2025

Very excited to present our latest work: SPINNA, an analysis framework and software package for single-protein resolution data! 🖥️🤩 We can directly quantify stoichiometry and oligomerization from super-res (DNA-PAINT, RESI) images!! 🧬🎨

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Julian Gargiulo @nano-juli.bsky.social · 07/05/2025

Getting ready for #TOPFOT 2025 Check the program here sites.google.com/view/eeoftop...

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MwahahahahahadScientist @mads100tist.bsky.social · 22/04/2025

Read preprints. Cite preprints. Email people and tell them you loved their preprint. Email people you hated their preprint. Embrace preprints, preprints are good.

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Reto Fiolka @retof.bsky.social · 02/04/2025

Our manuscript on accelerating the acquisition rate in oblique plane microscopy (OPM) is online now: opg.optica.org/boe/fulltext... Our work addresses the issue that an OPM PSF is tilted, and as such it leaves a lot of "empty space" in Fourier space (FFT of experimental data on the right)... 1/n

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Alfred Millett-Sikking @amsikking.bsky.social · 01/04/2025

Another nice example from the 1st Snouty light-sheet microscope! -> Here we show a mammalian cell with 2 fluorescent reporters imaged at ~1 volume per second. The speed and gentleness of the microscope make it ideal for 3D tracking and segmentation! Prepared and imaged by @jlazzaridean.bsky.social

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Julian Gargiulo @nano-juli.bsky.social · 01/04/2025

Hi #SnoutClub and microscopy people. Can you suggest python software for 3D registration? I want to find the axial shift between two z-stacks Thanks!!

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Jorge M. @jorgenomefui.bsky.social · 26/03/2025

HILO: Hace instantes se publicó nuestro nuevo trabajo del LANSAB-UNAHUR por Magalí di Meglio, Daniela Maza Vega y yo. Es un editorial sobre las chances reales y desafíos de la nanotecnología para tratar la leishmaniasis: www.tandfonline.com/doi/full/10.... 1/4

tandfonline.com

How could the translation of nanotechnology-based therapies revolutionize cutaneous leishmaniasis treatments?

Published in Nanomedicine (Ahead of Print, 2025)

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Julian Gargiulo @nano-juli.bsky.social · 19/03/2025

📣SEMINARIO INS El investigador Alberto Scarpettini charlará sobre nanoestructuras híbridas núcleo-satélite formadas por satélites plasmónicos de oro soportados sobre núcleos magnéticos de óxidos de hierro para la remediación asistida por luz solar de agua que contiene arsénico

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Danihila @danihila.bsky.social · 03/03/2025

Con @marieldemente.bsky.social y @agmendez.bsky.social grabamos un nuevo episodio de Ocultonas, sobre posesiones, exorcismos y discernimiento de espíritus. No se lo pierdan que quedó geniallll open.spotify.com/episode/5dte...

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Randall Munroe @xkcd.com · 04/03/2025

What if the wise men kept walking after Jesus’s birth? Watch the latest What If? video collaboration with MinuteEarth! youtu.be/YL2VNtus4xk

youtu.be

What if the wise men kept walking after Jesus’s birth?

YouTube video by xkcd's What If?

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Julian Gargiulo @nano-juli.bsky.social · 03/03/2025

Congratulations Gustavo! Proud to be your friend!

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Andrea Bragas @abragas.bsky.social · 28/02/2025

🧪💡🔉📢 We are happy to announce that Phonons 2025 will be held in Buenos Aires, Argentina, from 1 to 5 December 2025 at the University of Buenos Aires (UBA). Checkout the list of the prestigious plenary and invited speakers: phonons2025.com

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Mica Rodríguez-Caron @micarodriguezc.bsky.social · 26/02/2025

On wednesdays we wear gfp 💐🪰

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Julian Gargiulo @nano-juli.bsky.social · 26/02/2025

It's been a long journey, only possible thanks to my lovely co-authors who are not (yet) in Bluesky. Big thanks also to @amsikking.bsky.social , @andrewgyork.bsky.social and @lumasullo.bsky.social, they have always been there to help. Stay tuned for new imaging on living Drosophila! 6/6

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Julian Gargiulo @nano-juli.bsky.social · 26/02/2025

In addition, we can do 2 colours imaging... Here the membrane is labelled in green (GFP), and dense core vesicles are labeled in magenta (mCherry). We also show mitochondria imaging in the manuscript. 5/6

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Julian Gargiulo @nano-juli.bsky.social · 26/02/2025

And what about the photobleaching? We can image the fly for 30 minutes without bleaching it, and can get 10 times more images than with confocal microscopy! Also, we don't rely on phototoxic pulsed infrared lasers like in 2-photon microscopy. 4/6

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Julian Gargiulo @nano-juli.bsky.social · 26/02/2025

We imaged the axonal projections of small lateral ventral neurons (known as s-LNvs) in living adult flies. The NA=1.1 allowed high spatial resolution. Here, a line intensity profile showing features as small as 360 nm. 3/6

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Julian Gargiulo @nano-juli.bsky.social · 26/02/2025

We used a Single Objective Light-Sheet (#Snouty, for the friends). It is less invasive than a lattice light sheet because it requires a smaller dissection area on the head´s cuticula, as it is only necessary to accommodate the light cone of a single objective. And it is simpler. 2/6

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