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Ranganath Muniyappa

@muniyappar.bsky.social
170 followers 187 following 35 posts

Senior Clinician and Endocrinologist NIDDK with an interest in diabetes, obesity, and cardiovascular disease. Views/comments my own.

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Ranganath Muniyappa @muniyappar.bsky.social · 27/09/2026
Shocked why?
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Daniel Drucker @danieljdrucker.bsky.social · 25/07/2026
Challenged by the complexity of explaining GLP-1 medicines to friends and family? Gustav Hållén the talented producer of Zero Order has figured it out. Have a listen www.youtube.com/watch?v=VCIW...
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Philip Ball @philipcball.bsky.social · 17/04/2026
I reviewed On the Future of Species by Adrian Woolfson for @thelancet.com. Adrian has now responded to my review here. www.thelancet.com/journals/lan...
thelancet.com
On the computability of biological machines
In the book Natural Theology (1802), the English philosopher and theologian William Paley argued that the complexity of an organism, similar to that of a watch, implied the handiwork of a designer.1 H...
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Ranganath Muniyappa @muniyappar.bsky.social · 02/04/2026
Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts www.statnews.com/2026/04/02/b... via @statnews.com
statnews.com
Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts
A new way to define obesity aims to sharpen the diagnosis. Critics warn it could delay care, exclude diabetes, and deepen inequities in accessing treatment.
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Ranganath Muniyappa @muniyappar.bsky.social · 02/04/2026
Guideline communication raises concerns on Lancet obesity report
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Ranganath Muniyappa @muniyappar.bsky.social · 02/04/2026
New Endocrine Society guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy. Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...
academic.oup.com
Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework
Abstract. The Lancet Diabetes & Endocrinology Commission undertook the complex task of addressing limitations in existing definitions and classificatio
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 27/02/2026
no quarter can or should be given to hold this evil to account
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Harmit Singh Malik @harmitmalik.bsky.social · 27/02/2026
I feel like reading the news should now come with a trigger warning. The degree of sociopathy and deceit on display by ICE agents is astounding and in any normal civil society would lead to multiple arrests at all levels of this despotic organization. And these are only the cases we know about…
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Daniel Drucker @danieljdrucker.bsky.social · 21/02/2026
Studies in mice demonstrate the importance of glutamatergic neurons in GPR75’s regulation of food intake and protection from #obesity www.cell.com/cell-reports...
cell.com
GPR75 in glutamatergic neurons regulates body weight
Wyler, S.C. et al. identify a critical neuronal population that is required for GPR75 to exert its obesogenic effects using targeted deletion and reactivation of Gpr75 in glutamatergic neurons.
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Anil Seth @anilseth.bsky.social · 21/02/2026
The danger of superhuman AI is not what you think. This essay in @noemamag.com by @shannonvallor.bsky.social is brilliant. Well worth a read. www.noemamag.com/the-danger-o...
noemamag.com
The Danger Of Superhuman AI Is Not What You Think | NOEMA
The rhetoric over “superhuman” AI implicitly erases what’s most important about being human.
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Ranganath Muniyappa @muniyappar.bsky.social · 20/02/2026
This is the essence of being an American. That is why we can not give up the fight to preserve and protect American values.
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Eric Topol @erictopol.bsky.social · 20/02/2026
The $100 whole human genome sequence finally reached! www.sandiegouniontribune.com/2026/02/19/s...
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Jeremy Berg @jeremymberg.bsky.social · 20/02/2026
My quote of the day A journey is a person in itself; no two are alike. And all plans, safeguards, policing, and coercion are fruitless. We find that after years of struggle that we do not take a trip; a trip takes us. John Steinbeck
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Aaron Rupar @atrupar.com · 20/02/2026
Neal Katyal: "In America, the chief justice said only Congress can impose taxes on the American people, and that's what tariffs are. Tariffs are taxes."
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 20/02/2026
well said - indeed a peer review system in crisis hard to find someone to review burden of review duplication and waste misuse/corruption of peer review www.kidneynews.org/view/journal... in @asnpublications.bsky.social Kidney News #NephSky
snapshot of edirorial - peer review system in crisis
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 19/02/2026
this isn't my faith tradition, but the idea that you are duty-bound to help others resonates with me it's a sin to walk past, never mind to exploit the victim further
The Parable of the Good Samaritan

25 On one occasion an expert in the law stood up to test Jesus. “Teacher,” he asked, “what must I do to inherit eternal life?”

26 “What is written in the Law?” he replied. “How do you read it?”

27 He answered, “‘Love the Lord your God with all your heart and with all your soul and with all your strength and with all your mind’[a]; and, ‘Love your neighbor as yourself.’[b]”

28 “You have answered correctly,” Jesus replied. “Do this and you will live.”

29 But he wanted to justify himself, so he asked Jesus, “And who is my neighbor?”

30 In reply Jesus said: “A man was going down from Jerusalem to Jericho, when he was attacked by robbers. They stripped him of his clothes, beat him and went away, leaving him half dead. 31 A priest happened to be going down the same road, and when he saw the man, he passed by on the other side. 32 So too, a Levite, when he came to the place and saw him, passed by on the other side. 33 But a Samaritan, as he traveled, came where the man was; and when he saw him, he took pity on him. 34 He went to him and bandaged his wounds, pouring on oil and wine. Then he put the man on his own donkey, brought him to an inn and took care of him. 35 The next day he took out two denarii[c] and gave them to the innkeeper. ‘Look after him,’ he said, ‘and when I return, I will reimburse you for any extra expense you may have.’

36 “Which of these three do you think was a neighbor to the man who fell into the hands of robbers?”

37 The expert in the law replied, “The one who had mercy on him.”

Jesus told him, “Go and do likewise.”
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Ranganath Muniyappa @muniyappar.bsky.social · 19/02/2026
Rather focus on expanding subcutaneous tissue as well.
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Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 18/02/2026
Almost done with my next lecture, so going back now to work on some new memes
Mental gymnastics meme.
TOP: Regression mental gymnastics. The effect is significant...even when I adjust for...everything we have measured.
BOTTOM: Causal Inference Mental Gymnastics.
unmeasured confounds could explain the effect
the sample might suffer from selection bias
differential measurement error!
SUTVA violation!
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Children's Hyperinsulinism Charity UK and Ireland @chcharityuk.bsky.social · 06/02/2026
❤️‍🩹 CHI Superhero Mohammedzayn on Hyperinsulinism: “My state of mind changes, like the waves in the ocean; the higher waves will always come crashing down. My brain is a victim to my bloods, headaches, weariness, turning on and off the bulb of intelligence and wonder.”
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Jeremy Berg @jeremymberg.bsky.social · 05/02/2026
My quote of the day My dream is of a place and a time where America will once again be seen as the last best hope of earth. Abraham Lincoln
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Daniel Drucker @danieljdrucker.bsky.social · 04/02/2026
Studies in cells and mice reveal that the human GLP1R A316T variant exhibits characteristics of constitutive activation but dampened GLP-1RA responses www.science.org/doi/10.1126/...
science.org
In vivo functional profiling and structural characterization of the human GLP1R A316T variant
The GLP1R A316T missense variant displays improved glucose tolerance but impaired pharmacological incretin responses in vivo.
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Daniel Drucker @danieljdrucker.bsky.social · 29/12/2025
Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro ⁦‪‬⁩ ⁦‪‬⁩ www.wsj.com/health/pharm...
wsj.com
Joel Habener, Whose Research Helped Develop Weight-Loss Drugs, Dies at 88
Habener led research that discovered the GLP-1 hormone, a key ingredient in Ozempic and Mounjaro.
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Jeremy Berg @jeremymberg.bsky.social · 17/11/2025
My quote of the day If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith. Ehsan Sehgal
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Jonathan Slater @jonathanslater.bsky.social · 14/11/2025
One of my fav tik tok accounts was chandler and his grandma.
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Children's Hyperinsulinism Charity UK and Ireland @chcharityuk.bsky.social · 19/10/2025
📣Understanding Hyperinsulinism and sharing our links is valuable because it leads to: ✅ Better support and understanding for individuals with HI ✅ Early Diagnosis and Prompt Intervention ✅New families are reached ✅New connections are made linktr.ee/chcharityuk
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Mattan S. Ben-Shachar @mattansb.msbstats.info · 12/10/2025
Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs. 🧵
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Sarah Kendzior @sarahkendzior.bsky.social · 10/05/2025
There is LOT more where that came from. If you like THEY KNEW, please spread the word about the $2.99 sale! I don't make hardly any money off this. I only want people to read the book and know the truth about our country, our past, and our future. Thank you!
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Megan Ranney MD MPH @meganranney.bsky.social · 10/05/2025
This is must-listen for all of us who are scientists - and all who question science
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Harmit Singh Malik @harmitmalik.bsky.social · 10/05/2025
I once asked a scientist whom I respect enormously her advice for a successful career and life in science. Her advice: Leave every place better than you found it. It surprises me that many people would try hard to do the compete opposite … and we would elect them to run the country.
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The New York Times @nytimes.com · 25/04/2025
Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.
nytimes.com
‘Vaguely Threatening’: Federal Prosecutor Queries Leading Medical Journal
The New England Journal of Medicine received a letter suggesting that it was biased and compromised by external pressure. Other journals have also received the letter.
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Catherine Rampell @crampell.bsky.social · 24/04/2025
Ah yes, the government asking Jews to register as Jewish, in the name of protecting the Jews. No way that could go wrong www.nytimes.com/2025/04/23/n...
nytimes.com
U.S. Texts Barnard Employees and Asks if They Are Jewish
A questionnaire from a federal commission also inquired about whether professors and other college staff members had been harassed.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 22/04/2025
Here’s the interview
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 22/04/2025
www.nytimes.com/2025/04/21/n... “Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour.” No sense of decency.
nytimes.com
Mahmoud Khalil’s Son Arrives After ICE Refuses to Let Him Attend Birth (Gift Article)
Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour.
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Jeremy Berg @jeremymberg.bsky.social · 20/04/2025
Yet here we are…
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Daniel Drucker @danieljdrucker.bsky.social · 05/04/2025
How might polygenic risk scores enhance the management of type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...
link.springer.com
Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities - Diabetologia
Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hypergly...
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Mark Cuban @mcuban.bsky.social · 28/03/2025
I think there is going to be a Red Rural Recession and soon if all the cuts continue as is All the firings, cancelling of grants and contracts with companies , the closing of offices, disproportionately impact small towns, cities and states. Their finances will be turned upside
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Carl T. Bergstrom @carlbergstrom.com · 23/03/2025
No books. No teachers. Just a centralized AI that serves as intercessor between each child and the world's knowledge. It's literally a pre-reformation view, with Grok in the place of Yahweh.
Chrisman tweet: Forcing kids to read any book is a failure and a form of torture.
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Jason Moore @moorejh.bsky.social · 23/03/2025
Can we all just tell big tech no already? www.pcworld.com/article/2644... #privacy #security
pcworld.com
Do you want Microsoft Copilot sniffing your OneDrive files? Too late
Microsoft said that it's turning on Copilot for OneDrive on consumer accounts, giving its AI analytical tools access to the files you've stored in the cloud.
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Eric Topol @erictopol.bsky.social · 23/03/2025
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
graph of NIH basisfor new drugs
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Ranganath Muniyappa @muniyappar.bsky.social · 23/03/2025
The U.S. knew COVID was airborne by Jan 2020. Taiwan flagged it Dec 31, 2019. The President admitted it “goes through the air” in Feb, and likely briefed in early Jan. Cloth masks and 6-ft rules were never going to work—and they knew it. But this elite Prof thinks she convinced Dr. Fauci?👇 😦
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Eric Topol @erictopol.bsky.social · 22/03/2025
I've reviewed 10 consumer-facing companies that are in the business of promoting longevity and healthspan erictopol.substack.com/p/the-busine... Open-access, in the new edition of Ground Truths
Table of 10 companies selling longevity and extended healthspan
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Eric Topol @erictopol.bsky.social · 21/03/2025
Great plain English essay open-access @science.org by @melaniemitchell.bsky.social on large reasoning models www.science.org/doi/10.1126/...
science.org
Artificial intelligence learns to reason
Julia has two sisters and one brother. How many sisters does her brother Martin have?Solving this tiny puzzle requires a bit of thinking. You might mentally picture the family of three girls and one b...
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Holden Thorp @holdenthorp.bsky.social · 15/03/2025
Strong column from @nytimes.com editorial board. “The people who are attacking higher education are talking nonstop,” said Holden Thorp. “And the people leading higher education are not saying very much.” www.nytimes.com/2025/03/15/o...
nytimes.com
Opinion | The Authoritarian Endgame on Higher Education
This is a moment to trumpet the strengths of higher education and address its weaknesses.
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Dorothy Bishop @deevybee.bsky.social · 16/03/2025
Hot off the press: my review of Csaba Szabo's book Unreliable; deevybee.blogspot.com/2025/03/book...
deevybee.blogspot.com
Book Review: Unreliable: Bias, Fraud, and the Reproducibility Crisis in Biomedical Research
by Csaba Szabo, Columbia University Press, 2025  This is a rollicking good read, written in an informal style, and enlivened by cartoons, wh...
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 15/03/2025
it’s the cruelest form of irony
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Ranganath Muniyappa @muniyappar.bsky.social · 11/03/2025
During rounds at the NIH Clinical Center: Why can't we use GLP-1 receptor agonists (GLP-1RAs) in patients with lipodystrophy? Here’s the answer to that question.
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Ranganath Muniyappa @muniyappar.bsky.social · 02/03/2025
Fathers
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Ranganath Muniyappa @muniyappar.bsky.social · 02/03/2025
Counterproductive
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Daniel Drucker @danieljdrucker.bsky.social · 27/02/2025
Secretagogin Is Highly Expressed in Enteroendocrine K Cells and Plays a Critical Role in Nutrient-Induced GIP Secretion academic.oup.com/jes/article/...
academic.oup.com
Secretagogin Is Highly Expressed in Enteroendocrine K Cells and Plays a Critical Role in Nutrient-Induced GIP Secretion
AbstractContext. Incretin hormones, primarily composed of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are secre
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Daniel Drucker @danieljdrucker.bsky.social · 25/02/2025
In the GRADE study, liraglutide led to the greatest increases in ISR, glucose sensitivity and potentiation, remaining above baseline at study end. However, with all therapies, β-cell function progressively declined after initial improvement #diabetes diabetesjournals.org/care/article...
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