Reposted by Ranganath MuniyappaDaniel Drucker @danieljdrucker.bsky.social · 25/07/2026Challenged by the complexity of explaining GLP-1 medicines to friends and family? Gustav Hållén the talented producer of Zero Order has figured it out. Have a listen www.youtube.com/watch?v=VCIW... 081
Reposted by Ranganath MuniyappaPhilip Ball @philipcball.bsky.social · 17/04/2026I reviewed On the Future of Species by Adrian Woolfson for @thelancet.com. Adrian has now responded to my review here. www.thelancet.com/journals/lan...thelancet.comOn the computability of biological machinesIn the book Natural Theology (1802), the English philosopher and theologian William Paley argued that the complexity of an organism, similar to that of a watch, implied the handiwork of a designer.1 H... 1135
Ranganath Muniyappa @muniyappar.bsky.social · 02/04/2026Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts www.statnews.com/2026/04/02/b... via @statnews.comstatnews.comProposed ‘preclinical obesity’ diagnosis ignites global debate among expertsA new way to define obesity aims to sharpen the diagnosis. Critics warn it could delay care, exclude diabetes, and deepen inequities in accessing treatment. 021
Ranganath Muniyappa @muniyappar.bsky.social · 02/04/2026Guideline communication raises concerns on Lancet obesity report 000
Ranganath Muniyappa @muniyappar.bsky.social · 02/04/2026New Endocrine Society guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy. Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...academic.oup.comDefining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity frameworkAbstract. The Lancet Diabetes & Endocrinology Commission undertook the complex task of addressing limitations in existing definitions and classificatio 011
Reposted by Ranganath MuniyappaPrasad Jallepalli, MD, PhD @prasad.bsky.social · 27/02/2026no quarter can or should be given to hold this evil to account 623591
Reposted by Ranganath MuniyappaHarmit Singh Malik @harmitmalik.bsky.social · 27/02/2026I feel like reading the news should now come with a trigger warning. The degree of sociopathy and deceit on display by ICE agents is astounding and in any normal civil society would lead to multiple arrests at all levels of this despotic organization. And these are only the cases we know about… 1465
Reposted by Ranganath MuniyappaDaniel Drucker @danieljdrucker.bsky.social · 21/02/2026Studies in mice demonstrate the importance of glutamatergic neurons in GPR75’s regulation of food intake and protection from #obesity www.cell.com/cell-reports...cell.comGPR75 in glutamatergic neurons regulates body weightWyler, S.C. et al. identify a critical neuronal population that is required for GPR75 to exert its obesogenic effects using targeted deletion and reactivation of Gpr75 in glutamatergic neurons. 074
Reposted by Ranganath MuniyappaAnil Seth @anilseth.bsky.social · 21/02/2026The danger of superhuman AI is not what you think. This essay in @noemamag.com by @shannonvallor.bsky.social is brilliant. Well worth a read. www.noemamag.com/the-danger-o...noemamag.comThe Danger Of Superhuman AI Is Not What You Think | NOEMAThe rhetoric over “superhuman” AI implicitly erases what’s most important about being human. 66826
Ranganath Muniyappa @muniyappar.bsky.social · 20/02/2026This is the essence of being an American. That is why we can not give up the fight to preserve and protect American values. 000
Reposted by Ranganath MuniyappaEric Topol @erictopol.bsky.social · 20/02/2026The $100 whole human genome sequence finally reached! www.sandiegouniontribune.com/2026/02/19/s... 1125477
Reposted by Ranganath MuniyappaJeremy Berg @jeremymberg.bsky.social · 20/02/2026My quote of the day A journey is a person in itself; no two are alike. And all plans, safeguards, policing, and coercion are fruitless. We find that after years of struggle that we do not take a trip; a trip takes us. John Steinbeck 1349
Reposted by Ranganath MuniyappaAaron Rupar @atrupar.com · 20/02/2026Neal Katyal: "In America, the chief justice said only Congress can impose taxes on the American people, and that's what tariffs are. Tariffs are taxes." 877213766274
Reposted by Ranganath MuniyappaSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 20/02/2026well said - indeed a peer review system in crisis hard to find someone to review burden of review duplication and waste misuse/corruption of peer review www.kidneynews.org/view/journal... in @asnpublications.bsky.social Kidney News #NephSky 472
Reposted by Ranganath MuniyappaPrasad Jallepalli, MD, PhD @prasad.bsky.social · 19/02/2026this isn't my faith tradition, but the idea that you are duty-bound to help others resonates with me it's a sin to walk past, never mind to exploit the victim further 1112
Ranganath Muniyappa @muniyappar.bsky.social · 19/02/2026Rather focus on expanding subcutaneous tissue as well. 000
Reposted by Ranganath MuniyappaRichard McElreath 🐈⬛ @rmcelreath.bsky.social · 18/02/2026Almost done with my next lecture, so going back now to work on some new memes 415218
Reposted by Ranganath MuniyappaChildren's Hyperinsulinism Charity UK and Ireland @chcharityuk.bsky.social · 06/02/2026❤️🩹 CHI Superhero Mohammedzayn on Hyperinsulinism: “My state of mind changes, like the waves in the ocean; the higher waves will always come crashing down. My brain is a victim to my bloods, headaches, weariness, turning on and off the bulb of intelligence and wonder.” 001
Reposted by Ranganath MuniyappaJeremy Berg @jeremymberg.bsky.social · 05/02/2026My quote of the day My dream is of a place and a time where America will once again be seen as the last best hope of earth. Abraham Lincoln 27110
Reposted by Ranganath MuniyappaDaniel Drucker @danieljdrucker.bsky.social · 04/02/2026Studies in cells and mice reveal that the human GLP1R A316T variant exhibits characteristics of constitutive activation but dampened GLP-1RA responses www.science.org/doi/10.1126/...science.orgIn vivo functional profiling and structural characterization of the human GLP1R A316T variantThe GLP1R A316T missense variant displays improved glucose tolerance but impaired pharmacological incretin responses in vivo. 084
Reposted by Ranganath MuniyappaDaniel Drucker @danieljdrucker.bsky.social · 29/12/2025Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro www.wsj.com/health/pharm...wsj.comJoel Habener, Whose Research Helped Develop Weight-Loss Drugs, Dies at 88Habener led research that discovered the GLP-1 hormone, a key ingredient in Ozempic and Mounjaro. 2235
Reposted by Ranganath MuniyappaJeremy Berg @jeremymberg.bsky.social · 17/11/2025My quote of the day If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith. Ehsan Sehgal 1153
Reposted by Ranganath MuniyappaJonathan Slater @jonathanslater.bsky.social · 14/11/2025One of my fav tik tok accounts was chandler and his grandma. 913612
Reposted by Ranganath MuniyappaChildren's Hyperinsulinism Charity UK and Ireland @chcharityuk.bsky.social · 19/10/2025📣Understanding Hyperinsulinism and sharing our links is valuable because it leads to: ✅ Better support and understanding for individuals with HI ✅ Early Diagnosis and Prompt Intervention ✅New families are reached ✅New connections are made linktr.ee/chcharityuk 001
Reposted by Ranganath MuniyappaMattan S. Ben-Shachar @mattansb.msbstats.info · 12/10/2025Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs. 🧵 43311
Reposted by Ranganath MuniyappaSarah Kendzior @sarahkendzior.bsky.social · 10/05/2025There is LOT more where that came from. If you like THEY KNEW, please spread the word about the $2.99 sale! I don't make hardly any money off this. I only want people to read the book and know the truth about our country, our past, and our future. Thank you! 511160
Reposted by Ranganath MuniyappaMegan Ranney MD MPH @meganranney.bsky.social · 10/05/2025This is must-listen for all of us who are scientists - and all who question science 2283
Reposted by Ranganath MuniyappaHarmit Singh Malik @harmitmalik.bsky.social · 10/05/2025I once asked a scientist whom I respect enormously her advice for a successful career and life in science. Her advice: Leave every place better than you found it. It surprises me that many people would try hard to do the compete opposite … and we would elect them to run the country. 16758123
Reposted by Ranganath MuniyappaThe New York Times @nytimes.com · 25/04/2025Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.nytimes.com‘Vaguely Threatening’: Federal Prosecutor Queries Leading Medical JournalThe New England Journal of Medicine received a letter suggesting that it was biased and compromised by external pressure. Other journals have also received the letter. 20632711524
Reposted by Ranganath MuniyappaCatherine Rampell @crampell.bsky.social · 24/04/2025Ah yes, the government asking Jews to register as Jewish, in the name of protecting the Jews. No way that could go wrong www.nytimes.com/2025/04/23/n...nytimes.comU.S. Texts Barnard Employees and Asks if They Are JewishA questionnaire from a federal commission also inquired about whether professors and other college staff members had been harassed. 39993003255
Reposted by Ranganath MuniyappaAlt NIH Bluesky 🧪 @altnih4science.bsky.social · 22/04/2025Here’s the interview 0112
Reposted by Ranganath MuniyappaPrasad Jallepalli, MD, PhD @prasad.bsky.social · 22/04/2025www.nytimes.com/2025/04/21/n... “Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour.” No sense of decency.nytimes.comMahmoud Khalil’s Son Arrives After ICE Refuses to Let Him Attend Birth (Gift Article)Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour. 0115
Reposted by Ranganath MuniyappaJeremy Berg @jeremymberg.bsky.social · 20/04/2025Yet here we are… 0175
Reposted by Ranganath MuniyappaDaniel Drucker @danieljdrucker.bsky.social · 05/04/2025How might polygenic risk scores enhance the management of type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...link.springer.comClinical use of polygenic scores in type 2 diabetes: challenges and possibilities - DiabetologiaResulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hypergly... 053
Reposted by Ranganath MuniyappaMark Cuban @mcuban.bsky.social · 28/03/2025I think there is going to be a Red Rural Recession and soon if all the cuts continue as is All the firings, cancelling of grants and contracts with companies , the closing of offices, disproportionately impact small towns, cities and states. Their finances will be turned upside 4275506398925
Reposted by Ranganath MuniyappaCarl T. Bergstrom @carlbergstrom.com · 23/03/2025No books. No teachers. Just a centralized AI that serves as intercessor between each child and the world's knowledge. It's literally a pre-reformation view, with Grok in the place of Yahweh. 3142082
Reposted by Ranganath MuniyappaJason Moore @moorejh.bsky.social · 23/03/2025Can we all just tell big tech no already? www.pcworld.com/article/2644... #privacy #securitypcworld.comDo you want Microsoft Copilot sniffing your OneDrive files? Too lateMicrosoft said that it's turning on Copilot for OneDrive on consumer accounts, giving its AI analytical tools access to the files you've stored in the cloud. 152
Reposted by Ranganath MuniyappaEric Topol @erictopol.bsky.social · 23/03/2025A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved 5940151641
Ranganath Muniyappa @muniyappar.bsky.social · 23/03/2025The U.S. knew COVID was airborne by Jan 2020. Taiwan flagged it Dec 31, 2019. The President admitted it “goes through the air” in Feb, and likely briefed in early Jan. Cloth masks and 6-ft rules were never going to work—and they knew it. But this elite Prof thinks she convinced Dr. Fauci?👇 😦 110
Reposted by Ranganath MuniyappaEric Topol @erictopol.bsky.social · 22/03/2025I've reviewed 10 consumer-facing companies that are in the business of promoting longevity and healthspan erictopol.substack.com/p/the-busine... Open-access, in the new edition of Ground Truths 1927259
Reposted by Ranganath MuniyappaEric Topol @erictopol.bsky.social · 21/03/2025Great plain English essay open-access @science.org by @melaniemitchell.bsky.social on large reasoning models www.science.org/doi/10.1126/...science.orgArtificial intelligence learns to reasonJulia has two sisters and one brother. How many sisters does her brother Martin have?Solving this tiny puzzle requires a bit of thinking. You might mentally picture the family of three girls and one b... 610614
Reposted by Ranganath MuniyappaHolden Thorp @holdenthorp.bsky.social · 15/03/2025Strong column from @nytimes.com editorial board. “The people who are attacking higher education are talking nonstop,” said Holden Thorp. “And the people leading higher education are not saying very much.” www.nytimes.com/2025/03/15/o...nytimes.comOpinion | The Authoritarian Endgame on Higher EducationThis is a moment to trumpet the strengths of higher education and address its weaknesses. 38436
Reposted by Ranganath MuniyappaDorothy Bishop @deevybee.bsky.social · 16/03/2025Hot off the press: my review of Csaba Szabo's book Unreliable; deevybee.blogspot.com/2025/03/book...deevybee.blogspot.comBook Review: Unreliable: Bias, Fraud, and the Reproducibility Crisis in Biomedical Researchby Csaba Szabo, Columbia University Press, 2025 This is a rollicking good read, written in an informal style, and enlivened by cartoons, wh... 47532
Reposted by Ranganath MuniyappaPrasad Jallepalli, MD, PhD @prasad.bsky.social · 15/03/2025it’s the cruelest form of irony 3202
Ranganath Muniyappa @muniyappar.bsky.social · 11/03/2025During rounds at the NIH Clinical Center: Why can't we use GLP-1 receptor agonists (GLP-1RAs) in patients with lipodystrophy? Here’s the answer to that question. 010
Reposted by Ranganath MuniyappaDaniel Drucker @danieljdrucker.bsky.social · 27/02/2025Secretagogin Is Highly Expressed in Enteroendocrine K Cells and Plays a Critical Role in Nutrient-Induced GIP Secretion academic.oup.com/jes/article/...academic.oup.comSecretagogin Is Highly Expressed in Enteroendocrine K Cells and Plays a Critical Role in Nutrient-Induced GIP SecretionAbstractContext. Incretin hormones, primarily composed of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are secre 012
Reposted by Ranganath MuniyappaDaniel Drucker @danieljdrucker.bsky.social · 25/02/2025In the GRADE study, liraglutide led to the greatest increases in ISR, glucose sensitivity and potentiation, remaining above baseline at study end. However, with all therapies, β-cell function progressively declined after initial improvement #diabetes diabetesjournals.org/care/article... 062